product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Smad4 (D3M6U) Rabbit mAb
catalog :
38454
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D3M6U
reactivity :
human, mouse, rat, bovine
application :
western blot, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 10
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; fig 1a
Gotovac J, Kader T, Milne J, Fujihara K, Lara Gonzalez L, Gorringe K, et al. Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett's Esophagus. Cell Mol Gastroenterol Hepatol. 2021;12:689-713 pubmed publisher
  • western blot; human; loading ...; fig 6a, 6c
Jacquet M, Hervouet E, Baudu T, Herfs M, Parratte C, Feugeas J, et al. GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback. Biology (Basel). 2021;10: pubmed publisher
  • western blot; rat; fig 5a
  • western blot; mouse; loading ...; fig 4a
Sun W, Byon C, Kim D, Choi H, Park J, Joo S, et al. Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88. Front Pharmacol. 2021;12:708575 pubmed publisher
  • western blot; bovine; 1:1000; loading ...; fig 3a
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c
Kushioka J, Kaito T, Okada R, Ishiguro H, Bal Z, Kodama J, et al. A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone. Bone Res. 2020;8:41 pubmed publisher
  • western blot; human; loading ...; fig s2
Shoemaker L, McCormick A, Allen B, Chang S. Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. Clin Transl Med. 2020;10:e99 pubmed publisher
  • western blot; human; loading ...; fig 6f
Cornell L, Wander S, Visal T, Wagle N, Shapiro G. MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Rep. 2019;26:2667-2680.e7 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig s2
Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
  • western blot; mouse; loading ...; fig 3c
Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, et al. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551:105-109 pubmed publisher
Forouhan M, Lim W, Zanetti Domingues L, Tynan C, Roberts T, Malik B, et al. AR cooperates with SMAD4 to maintain skeletal muscle homeostasis. Acta Neuropathol. 2022;143:713-731 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.