product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-LIMK1 (Thr508)/LIMK2 (Thr505) Antibody
catalog :
3841L
quantity :
300 ul
price :
658 USD
clonality :
polyclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, other
more info or order :
Cell Signaling Technology product webpage
citations: 16
Published Application/Species/DilutionReference
  • western blot; human; fig 5
D'Hulst G, Sylow L, Hespel P, Deldicque L. Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle. Eur J Appl Physiol. 2015;115:1219-31 pubmed publisher
  • other; mouse; 1:1000; fig s1
Chiang C, Uzoma I, Lane D, Memisevic V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher
  • western blot; human; 1:500; fig s1
Li G, Zhou J, Budhraja A, Hu X, Chen Y, Cheng Q, et al. Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis. Oncotarget. 2015;6:1834-49 pubmed
  • western blot; human; 1:1000
Shi L, Zhang B, Sun X, Lu S, Liu Z, Liu Y, et al. MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1. Br J Cancer. 2014;111:2316-27 pubmed publisher
Gamell C, Osses N, Bartrons R, Ruckle T, Camps M, Rosa J, et al. BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity. J Cell Sci. 2008;121:3960-70 pubmed publisher
Thirone A, Speight P, Zulys M, Rotstein O, Szaszi K, Pedersen S, et al. Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response. Am J Physiol Cell Physiol. 2009;296:C463-75 pubmed publisher
Pandey D, Goyal P, Bamburg J, Siess W. Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets. Blood. 2006;107:575-83 pubmed
Song X, Chen X, Yamaguchi H, Mouneimne G, Condeelis J, Eddy R. Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. J Cell Sci. 2006;119:2871-81 pubmed
Croft D, Olson M. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol. 2006;26:4612-27 pubmed
Misra U, Sharma T, Pizzo S. Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. J Immunol. 2005;175:2525-33 pubmed
Hsieh S, Ferraro G, Fournier A. Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. J Neurosci. 2006;26:1006-15 pubmed
Park J, Arakawa-Takeuchi S, Jinno S, Okayama H. Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway. J Biol Chem. 2011;286:23132-41 pubmed publisher
Heredia L, Helguera P, de Olmos S, Kedikian G, Sola Vigo F, LaFerla F, et al. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci. 2006;26:6533-42 pubmed
San Martin A, Lee M, Williams H, Mizuno K, LASSEGUE B, Griendling K. Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells. Circ Res. 2008;102:432-8 pubmed
Spratley S, Bastea L, Döppler H, Mizuno K, Storz P. Protein kinase D regulates cofilin activity through p21-activated kinase 4. J Biol Chem. 2011;286:34254-61 pubmed publisher
Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong A, et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol. 2006;26:4240-56 pubmed
product information
SKU :
3841L
Product-Name :
Phospho-LIMK1 (Thr508)/LIMK2 (Thr505) Antibody
Size :
300 ul
Price-(USD) :
658 USD
Species-x-Reactivity :
H, (M, R)
Applications :
Western blot
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
72
Host :
Rabbit
Target :
LIMK1 (Thr508) phosphate/LIMK2 (Thr505) phosphate
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.