| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig s8e
| Wang W, Wang Y, Qu C, Wang S, Zhou J, Cao W, et al. The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response. Hepatology. 2018;67:2096-2112 pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 1n
- western blot; rat; 1:1000; loading ...; fig 1i
| Wang P, Li N, Wang X, Chen J, Geng C, Liu Z, et al. RIG-I, a novel DAMPs sensor for myoglobin activates NF-κB/caspase-3 signaling in CS-AKI model. Mil Med Res. 2021;8:37 pubmed publisher |
- western blot; human; 1:1000; loading ...
| Guo G, Gao M, Gao X, Zhu B, Huang J, Luo K, et al. SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal Transduct Target Ther. 2021;6:119 pubmed publisher |
- western blot; human; loading ...; fig 6s1a
| Colpitts C, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng C, et al. Hepatitis C virus exploits cyclophilin A to evade PKR. elife. 2020;9: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3d
| Szymura S, Bernal G, Wu L, Zhang Z, Crawley C, Voce D, et al. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy. BMC Biol. 2020;18:32 pubmed publisher |
- western blot; mouse; loading ...; fig s4f
| Liu Y, You Y, Lu Z, Yang J, Li P, Liu L, et al. N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019;365:1171-1176 pubmed publisher |
- western blot; human; loading ...; fig 2h
| Zhang W, Wang G, Xu Z, Tu H, Hu F, Dai J, et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019;: pubmed publisher |
- western blot; mouse; loading ...; fig s3a
| Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher |
- western blot; mouse; loading ...
| Witteveldt J, Knol L, Macias S. MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response. elife. 2019;8: pubmed publisher |
- western blot; mouse; loading ...; fig 7e
| Ishizuka J, Manguso R, Cheruiyot C, Bi K, Panda A, Iracheta Vellve A, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019;565:43-48 pubmed publisher |
- western blot; human; loading ...; fig s6x
| Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin F, et al. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Sci Adv. 2018;4:eaar2824 pubmed publisher |
- western blot; human; loading ...; fig 3f
| Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher |
- western blot; mouse; loading ...; fig 2c
| Kazak L, Chouchani E, Stavrovskaya I, Lu G, Jedrychowski M, Egan D, et al. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc Natl Acad Sci U S A. 2017;114:7981-7986 pubmed publisher |
- immunocytochemistry; human; 1:500; loading ...; fig 3f
- western blot; human; 1:500; loading ...; fig s5f
- immunoprecipitation; mouse; loading ...; fig 4f
- western blot; mouse; 1:500; loading ...; fig 3b
| Song Y, Lai L, Chong Z, He J, Zhang Y, Xue Y, et al. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses. Nat Commun. 2017;8:14654 pubmed publisher |
- western blot; African green monkey; loading ...; fig 1c
- western blot; mouse; loading ...; fig 1c
| Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proc Natl Acad Sci U S A. 2016;113:10950-5 pubmed publisher |
- western blot; human; loading ...; fig 7c
| Zhang X, Zheng Z, Liu X, Shu B, Mao P, Bai B, et al. Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway. J Neuroinflammation. 2016;13:209 pubmed publisher |
- western blot; mouse; loading ...; fig 3d
| Wang W, Jiang M, Liu S, Zhang S, Liu W, Ma Y, et al. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci U S A. 2016;113:9581-6 pubmed publisher |
- western blot; human; fig 1
| Hou Z, Zhang J, Han Q, Su C, Qu J, Xu D, et al. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. Sci Rep. 2016;6:26150 pubmed publisher |
- western blot; human; loading ...; fig 1f
| Sanchez David R, Combredet C, Sismeiro O, Dillies M, Jagla B, Coppée J, et al. Comparative analysis of viral RNA signatures on different RIG-I-like receptors. elife. 2016;5:e11275 pubmed publisher |
| Panas M, Kedersha N, McInerney G. Methods for the characterization of stress granules in virus infected cells. Methods. 2015;90:57-64 pubmed publisher |
- western blot; mouse; fig 1
| West A, Khoury Hanold W, Staron M, Tal M, Pineda C, Lang S, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520:553-7 pubmed publisher |
- immunoprecipitation; human; fig 3
| Liedmann S, Hrincius E, Guy C, Anhlan D, Dierkes R, Carter R, et al. Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nat Commun. 2014;5:5645 pubmed publisher |
| Yang S, Deng P, Zhu Z, Zhu J, Wang G, Zhang L, et al. Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs. J Immunol. 2014;193:3436-45 pubmed publisher |
| Chattergoon M, Latanich R, Quinn J, Winter M, Buckheit R, Blankson J, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014;10:e1004082 pubmed publisher |
- western blot; human; 1:1,000
| Xia M, Gonzalez P, Li C, Meng G, Jiang A, Wang H, et al. Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J Virol. 2014;88:5152-64 pubmed publisher |
| Wienert B, Shin J, Zelin E, Pestal K, Corn J. In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway. PLoS Biol. 2018;16:e2005840 pubmed publisher |
| Zhang Y, Dittmer D, Mieczkowski P, Host K, Fusco W, Duncan J, et al. RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. MBio. 2018;9: pubmed publisher |
| Chen C, Fan W, Li J, Zheng W, Zhang S, Yang L, et al. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. Front Cell Infect Microbiol. 2018;8:127 pubmed publisher |
| Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, et al. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018;9:1243 pubmed publisher |
| Tan P, He L, Cui J, Qian C, Cao X, Lin M, et al. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Mol Cell. 2017;68:293-307.e5 pubmed publisher |
| Huang C, Kolokoltsova O, Mateer E, Koma T, Paessler S. Highly Pathogenic New World Arenavirus Infection Activates the Pattern Recognition Receptor Protein Kinase R without Attenuating Virus Replication in Human Cells. J Virol. 2017;91: pubmed publisher |
| Mura M, Combredet C, Najburg V, Sanchez David R, Tangy F, Komarova A. Nonencapsidated 5' Copy-Back Defective Interfering Genomes Produced by Recombinant Measles Viruses Are Recognized by RIG-I and LGP2 but Not MDA5. J Virol. 2017;91: pubmed publisher |
| Zhang H, Ye H, Liu S, Deng C, Li X, Shi P, et al. West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5. J Virol. 2017;91: pubmed publisher |
| Lamborn I, Jing H, Zhang Y, DRUTMAN S, Abbott J, Munir S, et al. Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. J Exp Med. 2017;214:1949-1972 pubmed publisher |
| Su C, Tseng C, Yu C, Lai M. SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 To Support Virus Replication. J Virol. 2016;90:4308-4319 pubmed publisher |
| Painter M, Morrison J, Zoecklein L, Rinkoski T, Watzlawik J, Papke L, et al. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2015;11:e1005311 pubmed publisher |
| Yuan D, Xia M, Meng G, Xu C, Song Y, Wei J. Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs. Oncotarget. 2015;6:29664-74 pubmed publisher |
| Dupuis Maurin V, Brinza L, Baguet J, Plantamura E, Schicklin S, Chambion S, et al. Overexpression of the transcription factor Sp1 activates the OAS-RNAse L-RIG-I pathway. PLoS ONE. 2015;10:e0118551 pubmed publisher |
| Kolokoltsova O, Grant A, Huang C, Smith J, Poussard A, Tian B, et al. RIG-I enhanced interferon independent apoptosis upon Junin virus infection. PLoS ONE. 2014;9:e99610 pubmed publisher |
| Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, et al. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014;211:313-28 pubmed publisher |
| Chiba Y, Mizoguchi I, Mitobe K, Higuchi K, Nagai H, Nishigori C, et al. IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner. PLoS ONE. 2013;8:e76159 pubmed publisher |
| Ordureau A, Enesa K, Nanda S, Le François B, Peggie M, Prescott A, et al. DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA. J Biol Chem. 2013;288:24569-80 pubmed publisher |
| Jin R, Zhu W, Cao S, Chen R, Jin H, Liu Y, et al. Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. PLoS ONE. 2013;8:e52909 pubmed publisher |
| Wang Y, Tong X, Ye X. Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation. J Immunol. 2012;189:5304-13 pubmed publisher |
