product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
HIF-1α Antibody
catalog :
3716
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
citations: 28
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1c
Liang H, Xiao J, Zhou Z, Wu J, Ge F, Li Z, et al. Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis. Oncogene. 2018;37:1961-1975 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8a
Caino M, Seo J, Wang Y, Rivadeneira D, Gabrilovich D, Kim E, et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017;127:3755-3769 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; 1:1000; fig 1
Li P, Deng J, Wei X, Jayasuriya C, Zhou J, Chen Q, et al. Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1? and MMP-13. Mol Med Rep. 2016;14:1475-82 pubmed publisher
  • western blot; human; loading ...; fig 5a
Ma X, Guo P, Qiu Y, Mu K, Zhu L, Zhao W, et al. Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway. Oncotarget. 2016;7:36185-36197 pubmed publisher
  • western blot; human; 1:500; fig 4
McDonnell F, Irnaten M, Clark A, O Brien C, Wallace D. Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGF?1 Expression in Human Trabecular Meshwork Cells. PLoS ONE. 2016;11:e0153354 pubmed publisher
  • western blot; human; fig 2
Jiang L, Shestov A, Swain P, Yang C, Parker S, Wang Q, et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature. 2016;532:255-8 pubmed publisher
  • western blot; human; fig 2
Li C, Jung S, Yang Y, Kim K, Lim J, Cheon C, et al. Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines. Int J Oncol. 2016;48:2639-46 pubmed publisher
  • western blot; human; fig 3
Tepper S, Jeschke J, Böttcher K, Schmidt A, Davari K, Müller P, et al. PARP activation promotes nuclear AID accumulation in lymphoma cells. Oncotarget. 2016;7:13197-208 pubmed publisher
  • western blot; human; 1:200; fig 3
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed publisher
  • western blot; human; loading ...; fig 4a
Lv H, Zhang Z, Wu X, Wang Y, Li C, Gong W, et al. Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent. PLoS ONE. 2016;11:e0145195 pubmed publisher
  • western blot; human; fig 1
Jung S, Li C, Duan J, Lee S, Kim K, Park Y, et al. TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition. Oncotarget. 2015;6:29060-75 pubmed publisher
  • immunohistochemistry; human; 1:1000; loading ...; fig 1g
Choi E, Byeon S, Kim S, Lee H, Kwon H, Ahn H, et al. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PLoS ONE. 2015;10:e0130839 pubmed publisher
  • western blot; human; fig 6
Li S, Wu X, Dong C, Xie X, Wu J, Zhang X. The differential expression of OCT4 isoforms in cervical carcinoma. PLoS ONE. 2015;10:e0118033 pubmed publisher
  • western blot; human; fig 7
Cho S, Yun S, Jo C, Lee D, Choi K, Song J, et al. SUMO1 promotes Aβ production via the modulation of autophagy. Autophagy. 2015;11:100-12 pubmed publisher
  • western blot; human
Kong B, Cho Y, Lee E. G protein-coupled estrogen receptor-1 is involved in the protective effect of protocatechuic aldehyde against endothelial dysfunction. PLoS ONE. 2014;9:e113242 pubmed publisher
  • western blot; human
Kolosenko I, Fryknäs M, Forsberg S, Johnsson P, Cheon H, Holvey Bates E, et al. Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs. Int J Cancer. 2015;136:E51-61 pubmed publisher
  • western blot; human; loading ...; fig 1b
Raimondi L, Amodio N, Di Martino M, Altomare E, Leotta M, Caracciolo D, et al. Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity. Oncotarget. 2014;5:3039-54 pubmed
  • western blot; human; 1:200
Lee J, Lai C, Yang W, Lee T. Increased expression of hypoxia-inducible factor-1? and metallothionein in varicocele and varicose veins. Phlebology. 2012;27:409-15 pubmed publisher
Zheng B, Mao J, Li X, Qian L, Zhu H, Gu D, et al. Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation. Sci Rep. 2016;6:29415 pubmed publisher
Kaliszczak M, Trousil S, Ali T, Aboagye E. AKT activation controls cell survival in response to HDAC6 inhibition. Cell Death Dis. 2016;7:e2286 pubmed publisher
Kagiya G, Ogawa R, Hyodo F, Yamashita K, Nakamura M, Ishii A, et al. Development of a real-time imaging system for hypoxic cell apoptosis. Mol Ther Methods Clin Dev. 2016;5:16009 pubmed publisher
Lee G, Won H, Lee Y, Choi J, Oh T, Jang J, et al. Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation. Sci Rep. 2016;6:18928 pubmed publisher
Man S, Zhu Q, Zhu L, Liu Z, Karki R, Malik A, et al. Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell. 2015;162:45-58 pubmed publisher
Anton L, Olarerin George A, Hogenesch J, Elovitz M. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. PLoS ONE. 2015;10:e0122707 pubmed publisher
Morifuji Y, Onishi H, Iwasaki H, Imaizumi A, Nakano K, Tanaka M, et al. Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling. Cancer Sci. 2014;105:324-33 pubmed publisher
Mak A, Blakely K, Williams R, Penttilä P, Shukalyuk A, Osman K, et al. CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. J Biol Chem. 2011;286:41046-56 pubmed publisher
Woods A, James C, Wang G, Dupuis H, Beier F. Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-alpha signalling in endochondral bone growth. J Cell Mol Med. 2009;13:3497-516 pubmed publisher
product information
SKU :
3716S
Product-Name :
HIF-1α Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H
Applications :
Western blot
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
120
Host :
Rabbit
Target :
HIF1A
Primary-Protein :
HIF1A
Alt-Names :
ARNT interacting protein,ARNT-interacting protein,BHLHE78,Basic-helix-loop-helix-PAS protein MOP1,Class E basic helix-loop-helix protein 78,HIF-1-alpha,HIF-1alpha,HIF1,HIF1-alpha,HIF1A,Hypoxia-inducible factor 1-alpha,MOP1,Member of PAS protein 1,PAS domain-containing protein 8,PASD8,hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor),hypoxia-inducible factor 1 alpha isoform I.3,hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor),member of PAS superfamily 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.