product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
β-Actin (8H10D10) Mouse mAb
catalog :
3700P
quantity :
40 ul
price :
123 USD
clonality :
monoclonal
host :
mouse
clone name :
8H10D10

The same clone is also sold as:
reactivity :
human, mouse, rat, dog
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry
citations: 60
Published Application/Species/DilutionReference
  • western blot; rat; 1:1000; fig 7B
Fang J, Jia C, Zheng Z, Ye X, Wei B, Huang L, et al. Periprostatic implantation of neural differentiated mesenchymal stem cells restores cavernous nerve injury-mediated erectile dysfunction. Am J Transl Res. 2016;8:2549-61 pubmed
  • western blot; mouse; 1:1000; fig 4
Mehrabian M, Brethour D, Williams D, Wang H, Arnould H, Schneider B, et al. Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue. PLoS ONE. 2016;11:e0156779 pubmed publisher
  • western blot; rat; 1:4000; fig 7
Dong Y, Bao C, Yu J, Liu X. Receptor-interacting protein kinase 3-mediated programmed cell necrosis in rats subjected to focal cerebral ischemia-reperfusion injury. Mol Med Rep. 2016;14:728-36 pubmed publisher
  • western blot; human; 1:5000; fig 3
Li Q, Guo Y, Chen F, Liu J, Jin P. Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing. Exp Ther Med. 2016;12:45-50 pubmed
  • western blot; mouse; 1:1000; fig 1
Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Andersson P, et al. Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism. Nat Commun. 2016;7:12680 pubmed publisher
  • western blot; human; fig 3
Zhang J, Lachance V, Schaffner A, Li X, Fedick A, Kaye L, et al. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genet. 2016;12:e1005848 pubmed publisher
  • western blot; human; fig 8
Yu J, Berga S, Johnston-MacAnanny E, Sidell N, Bagchi I, Bagchi M, et al. Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. Endocrinology. 2016;157:2432-46 pubmed publisher
  • western blot; human; fig 4
Zhuang L, Yang Y, Ma X, Han B, Wang Z, Zhao Q, et al. MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. Cell Death Dis. 2016;7:e2203 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Ma Y, Guo H, Zhang L, Tao L, Yin A, Liu Z, et al. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Sci Rep. 2016;6:21467 pubmed publisher
  • western blot; human; fig s3
  • western blot; mouse; fig 4
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher
  • western blot; human; fig 5
Mester T, Raychaudhuri N, Gillespie E, Chen H, Smith T, Douglas R. CD40 Expression in Fibrocytes Is Induced by TSH: Potential Synergistic Immune Activation. PLoS ONE. 2016;11:e0162994 pubmed publisher
  • western blot; mouse; 1:10,000; fig 7
Velázquez R, Shaw D, Caccamo A, Oddo S. Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease. Mol Neurodegener. 2016;11:52 pubmed publisher
  • western blot; human; 1:5000; fig 2
Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
  • western blot; human; 1:20,000; fig 2
Wood L, Cox N, Phelps C, Lai S, Poddar A, Talbot C, et al. Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome. Sci Rep. 2016;6:19857 pubmed publisher
  • western blot; rat; 1:20,000; fig 6
Li J, Su Y, Wang H, Zhao Y, Liao X, Wang X, et al. Repeated Blockade of NMDA Receptors During Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex. Front Mol Neurosci. 2016;9:17 pubmed publisher
  • western blot; human; fig 1
Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips J, et al. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α. Cancer Res. 2016;76:2231-42 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Zhang H, Kang E, Wang Y, Yang C, Yu H, Wang Q, et al. Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016;7: pubmed publisher
  • western blot; human; fig 1
Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed publisher
  • western blot; mouse; 1:3000; fig 4
Dinger K, Kasper P, Hucklenbruch-Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  • western blot; human; fig 1
  • western blot; mouse; fig 6
Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Jiao K, Zeng G, Niu L, Yang H, Ren G, Xu X, et al. Activation of α2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint. Sci Rep. 2016;6:30085 pubmed publisher
  • western blot; mouse; 1:2000; fig 2
Miao H, Ou J, Peng Y, Zhang X, Chen Y, Hao L, et al. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nat Commun. 2016;7:11716 pubmed publisher
  • western blot; mouse; 1:1000; fig s5b
He W, Bai G, Zhou H, Wei N, White N, Lauer J, et al. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2015;526:710-4 pubmed publisher
  • western blot; human
Meadows S, Cleaver O. Annexin A3 Regulates Early Blood Vessel Formation. PLoS ONE. 2015;10:e0132580 pubmed publisher
  • western blot; human; fig 2
Zucal C, D'Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed publisher
  • western blot; human; 1:750; fig 4
Boros G, Miko E, Muramatsu H, Weissman D, Emri E, van der Horst G, et al. Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA. PLoS ONE. 2015;10:e0131141 pubmed publisher
  • western blot; rat; 1:1000
Jin S, Liu Y, Deng S, Liao L, Lin T, Ning Q, et al. Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2/fibroleukin prothrombinase and the inhibition of pro-inflammatory cytokine. Int J Mol Med. 2015;35:1199-212 pubmed publisher
  • western blot; human; fig 2
Momeny M, Saunus J, Marturana F, McCart Reed A, Black D, Sala G, et al. Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget. 2015;6:3932-46 pubmed
  • western blot; mouse
Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher
  • western blot; human; fig 1a
Moniz S, Bandarra D, Biddlestone J, Campbell K, Komander D, Bremm A, et al. Cezanne regulates E2F1-dependent HIF2α expression. J Cell Sci. 2015;128:3082-93 pubmed publisher
  • western blot; mouse
Wu C, Niu L, Yan Z, Wang C, Liu N, Dai Y, et al. Pcdh11x Negatively Regulates Dendritic Branching. J Mol Neurosci. 2015;56:822-8 pubmed publisher
  • western blot; human; fig 2
Crauwels P, Bohn R, Thomas M, Gottwalt S, Jäckel F, Krämer S, et al. Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell-mediated parasite elimination. Autophagy. 2015;11:285-97 pubmed publisher
  • western blot; human; 1:5000
Grice S, Sleigh J, Motley W, Liu J, Burgess R, Talbot K, et al. Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology. Hum Mol Genet. 2015;24:4397-406 pubmed publisher
  • western blot; human
Hasanali Z, Epner E, Feith D, Loughran T, Sample C. Vorinostat downregulates CD30 and decreases brentuximab vedotin efficacy in human lymphocytes. Mol Cancer Ther. 2014;13:2784-92 pubmed publisher
  • western blot; human
Kainulainen M, Habjan M, Hubel P, Busch L, Lau S, Colinge J, et al. Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol. 2014;88:3464-73 pubmed publisher
  • western blot; human; fig 1
Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, et al. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle. 2014;13:3878-91 pubmed publisher
  • western blot; human
Chen H, Mester T, Raychaudhuri N, Kauh C, Gupta S, Smith T, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014;99:E1635-40 pubmed publisher
  • western blot; human; 1:5000
Warren C, Griffin L, Little A, Huang I, Farzan M, Pyeon D. The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus. PLoS ONE. 2014;9:e96579 pubmed publisher
  • western blot; rat; 1:1000
Killinger B, Shah M, Moszczynska A. Co-administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent rats. J Neurochem. 2014;128:764-75 pubmed publisher
  • western blot; mouse
Wen S, Jadhav K, Williamson D, Rideout T. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. J Lipids. 2013;2013:908048 pubmed publisher
Wright D, Renoir T, Smith Z, Frazier A, Francis P, Thorburn D, et al. N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease. Transl Psychiatry. 2015;5:e492 pubmed publisher
Hung M, Leonard J. Stabilization of exosome-targeting peptides via engineered glycosylation. J Biol Chem. 2015;290:8166-72 pubmed publisher
Park S, Yang J, Schmider A, Soberman R, Hsu V. Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42. Nature. 2015;521:529-32 pubmed publisher
Logan R, Kong A, Krise J. Time-dependent effects of hydrophobic amine-containing drugs on lysosome structure and biogenesis in cultured human fibroblasts. J Pharm Sci. 2014;103:3287-96 pubmed publisher
Gajdosechova L, Krskova K, Segarra A, Špolcová A, Suski M, Olszanecki R, et al. Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue. J Endocrinol. 2014;220:333-43 pubmed publisher
Burcham G, Cresswell G, Snyder P, Chen L, Liu X, Crist S, et al. Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis. Am J Pathol. 2014;184:3176-91 pubmed publisher
Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, et al. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014;111:222-7 pubmed publisher
Li M, Yang Y, He Z, Zhou Z, Yang T, Guo P, et al. MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromos. Drug Metab Dispos. 2014;42:44-61 pubmed publisher
Cai M, Liu P, Wei L, Wang J, Qi J, Feng S, et al. Atp6v1c1 may regulate filament actin arrangement in breast cancer cells. PLoS ONE. 2014;9:e84833 pubmed publisher
Zhou Q, Jiang L, Xu C, Luo D, Zeng C, Liu P, et al. Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis. Thromb Res. 2014;133:57-65 pubmed publisher
Logan R, Kong A, Krise J. Evaluating the roles of autophagy and lysosomal trafficking defects in intracellular distribution-based drug-drug interactions involving lysosomes. J Pharm Sci. 2013;102:4173-80 pubmed publisher
Siegfried A, Berchtold S, Manncke B, Deuschle E, Reber J, Ott T, et al. IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock. J Immunol. 2013;191:3913-21 pubmed publisher
Hu H, Li Z, Zhu X, Lin R, Lin J, Peng J, et al. Gua Lou Gui Zhi decoction suppresses LPS-induced activation of the TLR4/NF-κB pathway in BV-2 murine microglial cells. Int J Mol Med. 2013;31:1327-32 pubmed publisher
Tarassishin L, Suh H, Lee S. Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway. J Neuroinflammation. 2011;8:187 pubmed publisher
Ueno T, Endo S, Saito R, Hirose M, Hirai S, Suzuki H, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2013;21:155-64 pubmed publisher
Bracarense A, Lucioli J, Grenier B, Drociunas Pacheco G, Moll W, Schatzmayr G, et al. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br J Nutr. 2012;107:1776-86 pubmed publisher
Zheng Y, Zhang H, Zhang X, Feng D, Luo X, Zeng C, et al. MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene. 2012;31:80-92 pubmed publisher
Tarassishin L, Loudig O, Bauman A, Shafit-Zagardo B, Suh H, Lee S. Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*. Glia. 2011;59:1911-22 pubmed publisher
Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, et al. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS ONE. 2013;8:e53845 pubmed publisher
Liao R, Jung J, Tchaicha J, Wilkerson M, Sivachenko A, Beauchamp E, et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 2013;73:5195-205 pubmed publisher
product information
SKU :
3700P
Product-Name :
β-Actin (8H10D10) Mouse mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Dg
Applications :
Flow cytometry
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
45
Host :
Mouse
Target :
beta-Actin
Primary-Protein :
ACTB
Alt-Names :
ACTB,Actin, cytoplasmic 1,Actin, cytoplasmic 1, N-terminally processed,Beta-actin,PS1TP5-binding protein 1,PS1TP5BP1,actin, beta,beta actin,beta cytoskeletal actin
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.