product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
β-Actin (8H10D10) Mouse mAb
catalog :
3700
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8H10D10
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
Cell Signaling Technology product webpage
citations: 220
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2c
Huang D, Yang B, Yao Y, Liao M, Zhang Y, Zeng Y, et al. Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma. Front Pharmacol. 2021;12:659325 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4e
Pipathsouk A, Brunetti R, Town J, Graziano B, Breuer A, Pellett P, et al. The WAVE complex associates with sites of saddle membrane curvature. J Cell Biol. 2021;220: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1b
Xu K, Yin N, Peng M, Stamatiades E, Shyu A, Li P, et al. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021;371:405-410 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8f
Oliemuller E, Newman R, Tsang S, Foo S, Muirhead G, Noor F, et al. SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Shen S, Li B, Dai J, Wu Z, He Y, Wen L, et al. BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux. Front Pharmacol. 2020;11:618 pubmed publisher
  • western blot; mouse; 1:3000; fig 4d
Ma H, Qian W, Bambousková M, Collins P, Porter S, Byrum A, et al. Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. MBio. 2020;11: pubmed publisher
  • western blot; human; loading ...; fig 3c
Huang Z, Zhao J, Wang W, Zhou J, Zhang J. Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer's Disease. Front Cell Neurosci. 2020;14:28 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 1b
Ding H, Chen J, Su M, Lin Z, Zhan H, Yang F, et al. BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis. J Neuroinflammation. 2020;17:19 pubmed publisher
  • western blot; human; loading ...; fig 2j
Dai E, Han L, Liu J, Xie Y, Kroemer G, Klionsky D, et al. Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein. Autophagy. 2020;:1-15 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Choi S, Shin S, Lee H, Sohn K, Yoon S, Kim J. 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates chemoradiation-induced oral mucositis. Oral Dis. 2020;26:111-121 pubmed publisher
  • western blot; mouse; fig s10b
Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
  • western blot; human; loading ...; fig 2g
Hoj J, Mayro B, Pendergast A. A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Cell Rep. 2019;29:3421-3434.e8 pubmed publisher
  • western blot; human; loading ...; fig 4b
Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al. WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Zhang Y, Jin X, Liang J, Guo Y, Sun G, Zeng X, et al. Extracellular vesicles derived from ODN-stimulated macrophages transfer and activate Cdc42 in recipient cells and thereby increase cellular permissiveness to EV uptake. Sci Adv. 2019;5:eaav1564 pubmed publisher
  • western blot; mouse; loading ...; fig 1d
Chen R, Zeng L, Zhu S, Liu J, Zeh H, Kroemer G, et al. cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis. Sci Adv. 2019;5:eaav5562 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1s1a
Gaska J, Balev M, Ding Q, Heller B, Ploss A. Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus. elife. 2019;8: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 3a
Tang L, Sheraz M, McGrane M, Chang J, Guo J. DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA. PLoS Pathog. 2019;15:e1007742 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2s1d
Yan X, Tang B, Chen B, Shan Y, Yang H, Iorns E, et al. Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. elife. 2019;8: pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 1d
McCambridge G, Agrawal M, Keady A, Kern P, Hasturk H, Nikolajczyk B, et al. Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism. Biomolecules. 2019;9: pubmed publisher
  • western blot; human; loading ...; fig 7c
Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, et al. N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation. Nat Immunol. 2019;20:313-325 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
  • western blot; human; loading ...; fig 1b
Chen X, Hu L, Yang H, Ma H, Ye K, Zhao C, et al. DHHC protein family targets different subsets of glioma stem cells in specific niches. J Exp Clin Cancer Res. 2019;38:25 pubmed publisher
  • western blot; human; 1:1000; fig 5
Chi V, Garaud S, De Silva P, Thibaud V, Stamatopoulos B, Berehad M, et al. Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients. BMC Cancer. 2019;19:81 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
MacFarlane E, Parker S, Shin J, Kang B, Ziegler S, Creamer T, et al. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. J Clin Invest. 2019;129:659-675 pubmed publisher
  • western blot; human; loading ...; fig 2d
Sievers Q, Petzold G, Bunker R, Renneville A, Słabicki M, Liddicoat B, et al. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. 2018;362: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2
Everington E, Gibbard A, Swinny J, Seifi M. Molecular Characterization of GABA-A Receptor Subunit Diversity within Major Peripheral Organs and Their Plasticity in Response to Early Life Psychosocial Stress. Front Mol Neurosci. 2018;11:18 pubmed publisher
  • western blot; human; 1:5000; fig 5a
Krendl C, Shaposhnikov D, Rishko V, Ori C, Ziegenhain C, Sass S, et al. GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency. Proc Natl Acad Sci U S A. 2017;114:E9579-E9588 pubmed publisher
  • western blot; human; fig 1f
Jha S, Rollins M, Fuchs G, Procter D, HALL E, Cozzolino K, et al. Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase. Nature. 2017;546:651-655 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 2b
Guan X, Lapak K, Hennessey R, Yu C, Shakya R, Zhang J, et al. Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth. Mol Cancer Res. 2017;15:237-249 pubmed publisher
  • western blot; human; fig 5
Mester T, Raychaudhuri N, Gillespie E, Chen H, Smith T, Douglas R. CD40 Expression in Fibrocytes Is Induced by TSH: Potential Synergistic Immune Activation. PLoS ONE. 2016;11:e0162994 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Andersson P, et al. Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism. Nat Commun. 2016;7:12680 pubmed publisher
  • western blot; human; fig 1
Murakami Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, et al. SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Sci Rep. 2016;6:31615 pubmed publisher
  • western blot; human; 1:1000; fig 3
Sahu N, Stephan J, Cruz D, Merchant M, Haley B, Bourgon R, et al. Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs. Nat Commun. 2016;7:12351 pubmed publisher
  • western blot; human; fig 2
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Jiao K, Zeng G, Niu L, Yang H, Ren G, Xu X, et al. Activation of ?2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint. Sci Rep. 2016;6:30085 pubmed publisher
  • western blot; mouse; 1:10,000; fig 7
Velázquez R, Shaw D, Caccamo A, Oddo S. Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease. Mol Neurodegener. 2016;11:52 pubmed publisher
  • western blot; rat; 1:1000; fig 7B
Fang J, Jia C, Zheng Z, Ye X, Wei B, Huang L, et al. Periprostatic implantation of neural differentiated mesenchymal stem cells restores cavernous nerve injury-mediated erectile dysfunction. Am J Transl Res. 2016;8:2549-61 pubmed
  • western blot; human; 1:5000; fig 3
Li Q, Guo Y, Chen F, Liu J, Jin P. Stromal cell-derived factor-1 promotes human adipose tissue-derived stem cell survival and chronic wound healing. Exp Ther Med. 2016;12:45-50 pubmed
  • western blot; mouse; 1:1000; fig 4
Mehrabian M, Brethour D, Williams D, Wang H, Arnould H, Schneider B, et al. Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue. PLoS ONE. 2016;11:e0156779 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Zhang H, Kang E, Wang Y, Yang C, Yu H, Wang Q, et al. Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016;7: pubmed publisher
  • western blot; rat; 1:4000; fig 7
Dong Y, Bao C, Yu J, Liu X. Receptor-interacting protein kinase 3-mediated programmed cell necrosis in rats subjected to focal cerebral ischemia-reperfusion injury. Mol Med Rep. 2016;14:728-36 pubmed publisher
  • western blot; human; fig 1
Lim S, Liu H, Madeira da Silva L, Arora R, Liu Z, Phillips J, et al. Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1?. Cancer Res. 2016;76:2231-42 pubmed publisher
  • western blot; mouse; 1:2000; fig 2
Miao H, Ou J, Peng Y, Zhang X, Chen Y, Hao L, et al. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nat Commun. 2016;7:11716 pubmed publisher
  • western blot; human; fig s3
  • western blot; mouse; fig 4
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016;7:11385 pubmed publisher
  • western blot; human; fig 13
Ono M, Yamada K, Bensaddek D, Afzal V, Biddlestone J, Ortmann B, et al. Enhanced snoMEN Vectors Facilitate Establishment of GFP-HIF-1α Protein Replacement Human Cell Lines. PLoS ONE. 2016;11:e0154759 pubmed publisher
  • western blot; human; fig 3
Zhang J, Lachance V, Schaffner A, Li X, Fedick A, Kaye L, et al. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genet. 2016;12:e1005848 pubmed publisher
  • western blot; human; fig 4
Zhuang L, Yang Y, Ma X, Han B, Wang Z, Zhao Q, et al. MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. Cell Death Dis. 2016;7:e2203 pubmed publisher
  • western blot; rat; 1:2000; fig 7
Choh V, Gurdita A, Tan B, Prasad R, Bizheva K, Joos K. Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram Responses. Invest Ophthalmol Vis Sci. 2016;57:2140-51 pubmed publisher
  • western blot; mouse; 1:3000; fig 4
Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  • western blot; human; fig 8
Yu J, Berga S, Johnston MacAnanny E, Sidell N, Bagchi I, Bagchi M, et al. Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. Endocrinology. 2016;157:2432-46 pubmed publisher
  • western blot; human; 1:1000; fig 2
Ortuno D, Carlisle H, Miller S. Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?. F1000Res. 2016;5:137 pubmed publisher
  • western blot; rat; 1:20,000; fig 6
Li J, Su Y, Wang H, Zhao Y, Liao X, Wang X, et al. Repeated Blockade of NMDA Receptors During Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex. Front Mol Neurosci. 2016;9:17 pubmed publisher
  • western blot; human; fig 5
Xu X, Zhang Y, Jasper J, Lykken E, Alexander P, Markowitz G, et al. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. 2016;7:20381-94 pubmed publisher
  • western blot; human; 1:20,000; fig 2
Wood L, Cox N, Phelps C, Lai S, Poddar A, Talbot C, et al. Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome. Sci Rep. 2016;6:19857 pubmed publisher
  • western blot; mouse; 1:1000; fig s3
  • western blot; human; 1:1000; fig s3
Casasola A, Scalzo D, Nandakumar V, Halow J, Recillas Targa F, Groudine M, et al. Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders. Nucleus. 2016;7:84-102 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Ma Y, Guo H, Zhang L, Tao L, Yin A, Liu Z, et al. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Sci Rep. 2016;6:21467 pubmed publisher
  • western blot; human; fig 3
van der Mijn J, Broxterman H, Knol J, Piersma S, de Haas R, Dekker H, et al. Sunitinib activates Axl signaling in renal cell cancer. Int J Cancer. 2016;138:3002-10 pubmed publisher
  • western blot; human; 1:5000; fig 2
Ortmann B, Bensaddek D, Carvalhal S, Moser S, Mudie S, Griffis E, et al. CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells. J Cell Sci. 2016;129:191-205 pubmed publisher
  • western blot; human; fig 2
Zucal C, D Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed publisher
  • western blot; mouse; 1:1000; fig s5b
He W, Bai G, Zhou H, Wei N, White N, Lauer J, et al. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2015;526:710-4 pubmed publisher
  • western blot; human; 1:10,000; fig 1
  • western blot; mouse; fig 2
Caccamo A, Branca C, Talboom J, Shaw D, Turner D, Ma L, et al. Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:14042-56 pubmed publisher
  • western blot; mouse; fig 6
  • western blot; human; fig 1
Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
  • western blot; rat; fig 1
Hwang S, Disatnik M, Mochly Rosen D. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med. 2015;7:1307-26 pubmed publisher
  • western blot; rat; 1:20,000; fig 3
Geletu M, Guy S, Greer S, Raptis L. Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication. Exp Cell Res. 2015;336:223-31 pubmed publisher
  • western blot; human
Meadows S, Cleaver O. Annexin A3 Regulates Early Blood Vessel Formation. PLoS ONE. 2015;10:e0132580 pubmed publisher
  • western blot; human; fig 1a
Moniz S, Bandarra D, Biddlestone J, Campbell K, Komander D, Bremm A, et al. Cezanne regulates E2F1-dependent HIF2α expression. J Cell Sci. 2015;128:3082-93 pubmed publisher
  • western blot; mouse; 1:3000; fig s10
Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, et al. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015;6:7652 pubmed publisher
  • western blot; human; 1:750; fig 4
Boros G, Miko E, Muramatsu H, Weissman D, Emri E, van der Horst G, et al. Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA. PLoS ONE. 2015;10:e0131141 pubmed publisher
  • western blot; human; 1:10,000; fig 6
Wang H, Sharma L, Lu J, Finch P, Fletcher S, Prochownik E. Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion. Oncotarget. 2015;6:15857-70 pubmed
  • western blot; human; 1:2000; fig 1
Fan C, Wang Y, Liu Z, Sun Y, Wang X, Wei G, et al. Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer. Int J Mol Med. 2015;36:204-14 pubmed publisher
  • western blot; human; 1:5000
Grice S, Sleigh J, Motley W, Liu J, Burgess R, Talbot K, et al. Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology. Hum Mol Genet. 2015;24:4397-406 pubmed publisher
  • western blot; human; 1:3; fig s17
Chan Penebre E, Kuplast K, Majer C, Boriack Sjodin P, Wigle T, Johnston L, et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat Chem Biol. 2015;11:432-7 pubmed publisher
  • immunoprecipitation; human; fig 2a
  • western blot; human; fig 2a
Luo T, Fu J, Xu A, Su B, Ren Y, Li N, et al. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy. 2016;12:1355-71 pubmed publisher
  • western blot; human; fig 2
Crauwels P, Bohn R, Thomas M, Gottwalt S, Jäckel F, Krämer S, et al. Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell-mediated parasite elimination. Autophagy. 2015;11:285-97 pubmed publisher
  • western blot; rat; 1:1000
Jin S, Liu Y, Deng S, Liao L, Lin T, Ning Q, et al. Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2/fibroleukin prothrombinase and the inhibition of pro-inflammatory cyt. Int J Mol Med. 2015;35:1199-212 pubmed publisher
  • western blot; mouse; fig 2
  • western blot; human; fig 2
Lim J, Lachenmayer M, Wu S, Liu W, Kundu M, Wang R, et al. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015;11:e1004987 pubmed publisher
  • western blot; mouse
Wu C, Niu L, Yan Z, Wang C, Liu N, Dai Y, et al. Pcdh11x Negatively Regulates Dendritic Branching. J Mol Neurosci. 2015;56:822-8 pubmed publisher
  • western blot; human; fig 2
Momeny M, Saunus J, Marturana F, McCart Reed A, Black D, Sala G, et al. Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget. 2015;6:3932-46 pubmed
  • western blot; human; fig 1
Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, et al. PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle. 2014;13:3878-91 pubmed publisher
  • western blot; mouse
Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher
  • western blot; human
Hasanali Z, Epner E, Feith D, Loughran T, Sample C. Vorinostat downregulates CD30 and decreases brentuximab vedotin efficacy in human lymphocytes. Mol Cancer Ther. 2014;13:2784-92 pubmed publisher
  • western blot; human
Guerrouahen B, Pasquier J, Kaoud N, Maleki M, Beauchamp M, Yasmeen A, et al. Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer. Mol Cancer Ther. 2014;13:3123-36 pubmed publisher
  • western blot; human
Chen H, Mester T, Raychaudhuri N, Kauh C, Gupta S, Smith T, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014;99:E1635-40 pubmed publisher
  • western blot; human; 1:5000
Warren C, Griffin L, Little A, Huang I, Farzan M, Pyeon D. The antiviral restriction factors IFITM1, 2 and 3 do not inhibit infection of human papillomavirus, cytomegalovirus and adenovirus. PLoS ONE. 2014;9:e96579 pubmed publisher
  • western blot; human
Kainulainen M, Habjan M, Hubel P, Busch L, Lau S, Colinge J, et al. Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol. 2014;88:3464-73 pubmed publisher
  • western blot; human
Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, et al. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. 2014;10:257-68 pubmed publisher
  • western blot; rat; 1:1000
Killinger B, Shah M, Moszczynska A. Co-administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent rats. J Neurochem. 2014;128:764-75 pubmed publisher
  • western blot; mouse; 1:1000
Naidoo N, Davis J, Zhu J, Yabumoto M, Singletary K, Brown M, et al. Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism. Aging Cell. 2014;13:131-41 pubmed publisher
  • western blot; mouse
Wen S, Jadhav K, Williamson D, Rideout T. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. J Lipids. 2013;2013:908048 pubmed publisher
  • western blot; human
Gillespie E, Raychaudhuri N, Papageorgiou K, Atkins S, Lu Y, Charara L, et al. Interleukin-6 production in CD40-engaged fibrocytes in thyroid-associated ophthalmopathy: involvement of Akt and NF-?B. Invest Ophthalmol Vis Sci. 2012;53:7746-53 pubmed publisher
Kubícková B, Schenk J, Ramm F, Markuškienė K, Reetz J, Dremsek P, et al. A broadly cross-reactive monoclonal antibody against hepatitis E virus capsid antigen. Appl Microbiol Biotechnol. 2021;105:4957-4973 pubmed publisher
Koenig M, Agana B, Kaufman J, Sharpnack M, Wang W, Weigel C, et al. STK11/LKB1 loss of function is associated with global DNA hypomethylation and S-adenosyl-methionine depletion in human lung adenocarcinoma. Cancer Res. 2021;: pubmed publisher
Lu Y, Yang Q, Su Y, Ji Y, Li G, Yang X, et al. MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. Cell Death Dis. 2021;12:511 pubmed publisher
Takaichi Y, Chambers J, Takahashi K, Soeda Y, Koike R, Katsumata E, et al. Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus). Acta Neuropathol Commun. 2021;9:10 pubmed publisher
Ménard C, Wilson A, Dejda A, Miloudi K, Binet F, Crespo Garcia S, et al. miR-106b suppresses pathological retinal angiogenesis. Aging (Albany NY). 2020;12:24836-24852 pubmed publisher
De Souza C, Madden J, Minn D, Kumar V, Montoya D, Nambiar R, et al. The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression. Int J Mol Sci. 2020;21: pubmed publisher
Luthria G, Li R, Wang S, Prytyskach M, Kohler R, Lauffenburger D, et al. In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nat Commun. 2020;11:3521 pubmed publisher
Coryell P, Goraya S, Griffin K, Redick M, Sisk S, Purvis J. Autophagy regulates the localization and degradation of p16INK4a. Aging Cell. 2020;19:e13171 pubmed publisher
Xie H, Ge X, Yang F, Wang B, Li S, Duan J, et al. High-fidelity SaCas9 identified by directional screening in human cells. PLoS Biol. 2020;18:e3000747 pubmed publisher
Takaichi Y, Chambers J, Inoue H, Ano Y, Takashima A, Nakayama H, et al. Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy. Acta Neuropathol Commun. 2020;8:86 pubmed publisher
Ma X, Bian Y, Yuan H, Chen N, Pan Y, Zhou W, et al. Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis. Aging (Albany NY). 2020;12:10527-10543 pubmed publisher
Luo L, Xiao L, Lian G, Wang H, Xie L. miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension. Aging (Albany NY). 2020;12:9014-9030 pubmed publisher
Zou Y, Li H, Graham E, Deik A, Eaton J, Wang W, et al. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020;16:302-309 pubmed publisher
Moruno Manchon J, Lejault P, Wang Y, McCauley B, Honarpisheh P, Morales Scheihing D, et al. Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons. elife. 2020;9: pubmed publisher
Xu X, Kalac M, Markson M, Chan M, Brody J, Bhagat G, et al. Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL). Cell Death Dis. 2020;11:94 pubmed publisher
Li Y, Tong K, Lu J, Lin J, Li Z, Sang Y, et al. PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. Aging (Albany NY). 2020;12:2507-2529 pubmed publisher
Thibeault P, LeSarge J, Arends D, Fernandes M, Chidiac P, Stathopulos P, et al. Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4). J Biol Chem. 2020;295:2520-2540 pubmed publisher
Joshi A, Van Wassenhove L, Logas K, Minhas P, Andreasson K, Weinberg K, et al. Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology. Acta Neuropathol Commun. 2019;7:190 pubmed publisher
Zhao J, Nguyen L, Nguyen L, Dang X, Cao D, Khanal S, et al. ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. Front Immunol. 2019;10:2531 pubmed publisher
Feiner R, Teschner J, Teschner K, Radukic M, Baumann T, Hagen S, et al. rAAV Engineering for Capsid-Protein Enzyme Insertions and Mosaicism Reveals Resilience to Mutational, Structural and Thermal Perturbations. Int J Mol Sci. 2019;20: pubmed publisher
Bowen C, Calderón Giadrosic J, Burger Z, Rykiel G, Davis E, Helmers M, et al. Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome. J Clin Invest. 2019;: pubmed publisher
Kashyap A, Fernandez Rodriguez L, Zhao Y, Monaco G, Trefny M, Yoshida N, et al. GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Cell Rep. 2019;28:3367-3380.e8 pubmed publisher
Hashwah H, Bertram K, Stirm K, Stelling A, Wu C, Kasser S, et al. The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. EMBO Mol Med. 2019;11:e10576 pubmed publisher
Tian R, Gachechiladze M, Ludwig C, Laurie M, Hong J, Nathaniel D, et al. CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Neuron. 2019;104:239-255.e12 pubmed publisher
Ortiz M, Ahmed S, Burns M, Henssen A, Hollmann T, Macarthur I, et al. Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor. JCI Insight. 2019;4: pubmed publisher
Tonsing Carter E, Hernandez K, Kim C, Harkless R, Oh A, Bowie K, et al. Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. Breast Cancer Res. 2019;21:82 pubmed publisher
Povedano J, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, et al. Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification. Cell Chem Biol. 2019;26:1315-1321.e3 pubmed publisher
Wang X, Xu X, Peng C, Qin Y, Gao T, Jing J, et al. BRAFV600E-induced KRT19 expression in thyroid cancer promotes lymph node metastasis via EMT. Oncol Lett. 2019;18:927-935 pubmed publisher
Potapova T, Unruh J, Yu Z, Rancati G, Li H, Stampfer M, et al. Superresolution microscopy reveals linkages between ribosomal DNA on heterologous chromosomes. J Cell Biol. 2019;: pubmed publisher
Sarr A, Bré J, Um I, Chan T, Mullen P, Harrison D, et al. Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031. Sci Rep. 2019;9:7643 pubmed publisher
Lau C, Ho J, Lo P, Tin C. Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa. Mol Ther Nucleic Acids. 2019;16:637-649 pubmed publisher
Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, et al. Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Mol Cell. 2019;74:951-965.e13 pubmed publisher
Zou Y, Palte M, Deik A, Li H, Eaton J, Wang W, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10:1617 pubmed publisher
Zhao Y, Zagani R, Park S, Yoshida N, Shah P, Reinecker H. Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5. Nat Commun. 2019;10:1349 pubmed publisher
Amaral E, Costa D, Namasivayam S, Riteau N, Kamenyeva O, Mittereder L, et al. A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis. J Exp Med. 2019;216:556-570 pubmed publisher
Bunda S, Heir P, Metcalf J, Li A, Agnihotri S, Pusch S, et al. CIC protein instability contributes to tumorigenesis in glioblastoma. Nat Commun. 2019;10:661 pubmed publisher
Karasu M, Bouftas N, Keeney S, Wassmann K. Cyclin B3 promotes anaphase I onset in oocyte meiosis. J Cell Biol. 2019;218:1265-1281 pubmed publisher
Xiong L, Wu F, Wu Q, Xu L, Cheung O, Kang W, et al. Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Nat Commun. 2019;10:335 pubmed publisher
Atakpa P, van Marrewijk L, Apta Smith M, Chakraborty S, Taylor C. GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C. J Cell Sci. 2019;132: pubmed publisher
Fecková B, Kimáková P, Ilkovičová L, Szentpéteriová E, Macejová M, Kosuth J, et al. Methylation of the first exon in the erythropoietin receptor gene does not correlate with its mRNA and protein level in cancer cells. BMC Genet. 2019;20:1 pubmed publisher
Liu G, Lu Y, Liu Q, Zhou Y. Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation. J Virol. 2019;93: pubmed publisher
Song C, Kim N, Park M, Lee J, Oh K, Sim T. Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system. Biosci Rep. 2019;39: pubmed publisher
Kolb R, Kluz P, Tan Z, Borcherding N, Bormann N, Vishwakarma A, et al. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 2019;38:2351-2363 pubmed publisher
Briard B, Karki R, Malireddi R, Bhattacharya A, Place D, Mavuluri J, et al. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2019;4:316-327 pubmed publisher
Alimova I, Pierce A, Danis E, Donson A, Birks D, Griesinger A, et al. Inhibition of MYC attenuates tumor cell self-renewal and promotes senescence in SMARCB1-deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo. Int J Cancer. 2019;144:1983-1995 pubmed publisher
Wallace M, Green C, Roberts L, Lee Y, McCarville J, Sanchez Gurmaches J, et al. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018;14:1021-1031 pubmed publisher
Dubois F, Jean Jacques B, Roberge H, Benard M, Galas L, Schapman D, et al. A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control. Cell Commun Signal. 2018;16:66 pubmed publisher
Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018;9:4115 pubmed publisher
Hwang S, Mruk K, Rahighi S, Raub A, Chen C, Dorn L, et al. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nat Commun. 2018;9:4045 pubmed publisher
Paschkowsky S, Recinto S, Young J, Bondar A, Munter L. Membrane cholesterol as regulator of human rhomboid protease RHBDL4. J Biol Chem. 2018;293:15556-15568 pubmed publisher
Liu G, Lu Y, Thulasi Raman S, Xu F, Wu Q, Li Z, et al. Nuclear-resident RIG-I senses viral replication inducing antiviral immunity. Nat Commun. 2018;9:3199 pubmed publisher
Viswanathan S, Nogueira M, Buss C, Krill Burger J, Wawer M, Malolepsza E, et al. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet. 2018;50:937-943 pubmed publisher
Takeda D, Spisak S, Seo J, Bell C, O CONNOR E, Korthauer K, et al. A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer. Cell. 2018;174:422-432.e13 pubmed publisher
Tan H, Wu C, Jin L. A Possible Role for Long Interspersed Nuclear Elements-1 (LINE-1) in Huntington's Disease Progression. Med Sci Monit. 2018;24:3644-3652 pubmed publisher
Seamons A, Treuting P, Meeker S, Hsu C, Paik J, Brabb T, et al. Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice. Am J Pathol. 2018;188:1536-1554 pubmed publisher
Zhao J, Dang X, Zhang P, Nguyen L, Cao D, Wang L, et al. Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection. Cell Discov. 2018;4:16 pubmed publisher
Meyer zu Horste G, Przybylski D, Schramm M, Wang C, Schnell A, Lee Y, et al. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. 2018;48:556-569.e7 pubmed publisher
Lu Q, Sun Y, Duan Y, Li B, Xia J, Yu S, et al. Comprehensive microRNA profiling reveals potential augmentation of the IL1 pathway in rheumatic heart valve disease. BMC Cardiovasc Disord. 2018;18:53 pubmed publisher
Bonfim Melo A, Ferreira d, Mortara R. Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. Front Microbiol. 2018;9:360 pubmed publisher
Takada M, Parys M, Gregory Bryson E, Vilar Saavedra P, Kiupel M, Yuzbasiyan Gurkan V. A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. BMC Cancer. 2018;18:237 pubmed publisher
Yang H, Yu N, Xu J, Ding X, Deng W, Wu G, et al. SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells. J Exp Clin Cancer Res. 2018;37:24 pubmed publisher
Zhang Z, Shen M, Zhou G. Upregulation of CDCA5 promotes gastric cancer malignant progression via influencing cyclin E1. Biochem Biophys Res Commun. 2018;496:482-489 pubmed publisher
Weng H, Huang H, Wu H, Qin X, Zhao B, Dong L, et al. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2018;22:191-205.e9 pubmed publisher
Rodero M, Tesser A, Bartok E, Rice G, Della Mina E, Depp M, et al. Type I interferon-mediated autoinflammation due to DNase II deficiency. Nat Commun. 2017;8:2176 pubmed publisher
Chorba J, Galvan A, Shokat K. Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype. J Biol Chem. 2018;293:1875-1886 pubmed publisher
Yang M, Du Q, Goswami J, Varley P, Chen B, Wang R, et al. Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury. Hepatology. 2017;: pubmed publisher
Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher
Shyam R, Vachali P, Gorusupudi A, Nelson K, Bernstein P. All three human scavenger receptor class B proteins can bind and transport all three macular xanthophyll carotenoids. Arch Biochem Biophys. 2017;634:21-28 pubmed publisher
Zhang Y, Chen C, Jiang Y, Wang S, Wu X, Wang K. PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway. BMC Neurosci. 2017;18:69 pubmed publisher
Grey W, Ivey A, Milne T, Haferlach T, Grimwade D, Uhlmann F, et al. The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability. Biochim Biophys Acta Mol Cell Res. 2018;1865:105-116 pubmed publisher
Moruno Manchon J, Koellhoffer E, Gopakumar J, Hambarde S, Kim N, McCullough L, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9:1957-1970 pubmed publisher
Shyam R, Gorusupudi A, Nelson K, Horvath M, Bernstein P. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc Natl Acad Sci U S A. 2017;114:10882-10887 pubmed publisher
Chen M, Lei X, Shi C, Huang M, Li X, Wu B, et al. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017;127:3689-3701 pubmed publisher
Salazar S, Gallardo C, Kaufman A, Herber C, Haas L, Robinson S, et al. Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease. J Neurosci. 2017;37:9207-9221 pubmed publisher
Tang J, Salloum D, Carney B, Brand C, Kossatz S, Sadique A, et al. Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017;114:E7441-E7449 pubmed publisher
Klein Z, Takahashi H, Ma M, Stagi M, Zhou M, Lam T, et al. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron. 2017;95:281-296.e6 pubmed publisher
Li C, Lan Y, Krumlauf R, Jiang R. Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice. J Dent Res. 2017;96:1273-1281 pubmed publisher
Gu M, Zhang Y, Liu C, Wang D, Feng L, Fan S, et al. Morin, a novel liver X receptor ?/? dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases. Br J Pharmacol. 2017;174:3032-3044 pubmed publisher
Lan P, Fan Y, Zhao Y, Lou X, Monsour H, Zhang X, et al. TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 2017;127:2222-2234 pubmed publisher
Daley D, Mani V, Mohan N, Akkad N, Ochi A, Heindel D, et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med. 2017;23:556-567 pubmed publisher
Siddiqui A, Vazakidou M, Schwab A, Napoli F, Fernandez Molina C, Rapa I, et al. Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells. J Pathol. 2017;242:221-233 pubmed publisher
Frick C, Yarka C, Nunns H, Goentoro L. Sensing relative signal in the Tgf-?/Smad pathway. Proc Natl Acad Sci U S A. 2017;114:E2975-E2982 pubmed publisher
Zhang Y, Chidiac R, Delisle C, Gratton J. Endothelial NO Synthase-Dependent S-Nitrosylation of ?-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a. Mol Cell Biol. 2017;37: pubmed publisher
CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed publisher
Aykul S, Parenti A, Chu K, Reske J, Floer M, Ralston A, et al. Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic. J Biol Chem. 2017;292:4138-4151 pubmed publisher
Pohar J, Yamamoto C, Fukui R, Cajnko M, Miyake K, Jerala R, et al. Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA. J Immunol. 2017;198:2093-2104 pubmed publisher
Vonk J, Yeshaw W, Pinto F, Faber A, Lahaye L, Kanon B, et al. Drosophila Vps13 Is Required for Protein Homeostasis in the Brain. PLoS ONE. 2017;12:e0170106 pubmed publisher
Sendoel A, Dunn J, Rodriguez E, Naik S, Gomez N, Hurwitz B, et al. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017;541:494-499 pubmed publisher
Wang Q, Liberti M, Liu P, Deng X, Liu Y, Locasale J, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017;24:55-65 pubmed publisher
Baron L, Paatero A, Morel J, Impens F, Guenin Macé L, Saint Auret S, et al. Mycolactone subverts immunity by selectively blocking the Sec61 translocon. J Exp Med. 2016;213:2885-2896 pubmed
Lillo M, Nichols C, Perry C, Runke S, Krutilina R, Seagroves T, et al. Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017;37:417-425 pubmed publisher
Daley D, Zambirinis C, Seifert L, Akkad N, Mohan N, Werba G, et al. ?? T Cells Support Pancreatic Oncogenesis by Restraining ?? T Cell Activation. Cell. 2016;166:1485-1499.e15 pubmed publisher
Li J, Zheng X, Lou N, Zhong W, Yan D. Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol. J Lipid Res. 2016;57:1845-1853 pubmed
Di Franco S, Turdo A, Benfante A, Colorito M, Gaggianesi M, Apuzzo T, et al. ?Np63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis. Oncotarget. 2016;7:54157-54173 pubmed publisher
Poddar S, Hyde J, Gorman M, Farzan M, Diamond M. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. J Virol. 2016;90:8780-94 pubmed publisher
Lin R, Yu K, Li X, Tao J, Lin Y, Zhao C, et al. Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats. Mol Med Rep. 2016;14:225-33 pubmed publisher
Yang R, Zhong L, Yang X, Jiang K, Li L, Song H, et al. Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling. Mol Med Rep. 2016;13:4175-82 pubmed publisher
Binder A, Kosak J, Janardhan K, Janhardhan K, Moser G, Eling T, et al. Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation. PLoS ONE. 2016;11:e0146518 pubmed publisher
Wang H, Teriete P, Hu A, Raveendra Panickar D, Pendelton K, Lazo J, et al. Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids. Oncotarget. 2015;6:32380-95 pubmed publisher
Levring T, Kongsbak M, Rode A, Woetmann A, Ødum N, Bonefeld C, et al. Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis. Oncotarget. 2015;6:21853-64 pubmed
Korhonova M, Doricakova A, Dvorak Z. Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes. PLoS ONE. 2015;10:e0137720 pubmed publisher
Li J, Lam M. Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. elife. 2015;4:e06434 pubmed publisher
Park S, Yang J, Schmider A, Soberman R, Hsu V. Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42. Nature. 2015;521:529-32 pubmed publisher
Hung M, Leonard J. Stabilization of exosome-targeting peptides via engineered glycosylation. J Biol Chem. 2015;290:8166-72 pubmed publisher
Wright D, Renoir T, Smith Z, Frazier A, Francis P, Thorburn D, et al. N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease. Transl Psychiatry. 2015;5:e492 pubmed publisher
Baxter P, Lin Q, Mao H, Kogiso M, Zhao X, Liu Z, et al. Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun. 2014;2:160 pubmed publisher
Fortin D, Tillo S, Yang G, Rah J, Melander J, Bai S, et al. Live imaging of endogenous PSD-95 using ENABLED: a conditional strategy to fluorescently label endogenous proteins. J Neurosci. 2014;34:16698-712 pubmed publisher
Burcham G, Cresswell G, Snyder P, Chen L, Liu X, Crist S, et al. Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis. Am J Pathol. 2014;184:3176-91 pubmed publisher
Logan R, Kong A, Krise J. Time-dependent effects of hydrophobic amine-containing drugs on lysosome structure and biogenesis in cultured human fibroblasts. J Pharm Sci. 2014;103:3287-96 pubmed publisher
Torocsik D, Kovacs D, Camera E, Lovászi M, Cseri K, Nagy G, et al. Leptin promotes a proinflammatory lipid profile and induces inflammatory pathways in human SZ95 sebocytes. Br J Dermatol. 2014;171:1326-35 pubmed publisher
Wang F, Awan U, Wang Y, Wang L, Qing H, Ma H, et al. Damage of neuroblastoma cell SH-SY5Y mediated by MPP+ inhibits proliferation of T-cell leukemia Jurkat by co-culture system. Int J Mol Sci. 2014;15:10738-50 pubmed publisher
Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, et al. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014;111:222-7 pubmed publisher
Ueno T, Endo S, Saito R, Hirose M, Hirai S, Suzuki H, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2013;21:155-64 pubmed publisher
Cai M, Liu P, Wei L, Wang J, Qi J, Feng S, et al. Atp6v1c1 may regulate filament actin arrangement in breast cancer cells. PLoS ONE. 2014;9:e84833 pubmed publisher
Gajdosechova L, Krskova K, Segarra A, Špolcová A, Suski M, Olszanecki R, et al. Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue. J Endocrinol. 2014;220:333-43 pubmed publisher
Chiang H, Zhao Y, Song J, Liu S, Wang N, Terhorst C, et al. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol. 2014;15:63-71 pubmed publisher
Zhou Q, Jiang L, Xu C, Luo D, Zeng C, Liu P, et al. Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis. Thromb Res. 2014;133:57-65 pubmed publisher
Li M, Yang Y, He Z, Zhou Z, Yang T, Guo P, et al. MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X ch. Drug Metab Dispos. 2014;42:44-61 pubmed publisher
Siegfried A, Berchtold S, Manncke B, Deuschle E, Reber J, Ott T, et al. IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-? secretion and LPS-induced endotoxin shock. J Immunol. 2013;191:3913-21 pubmed publisher
Logan R, Kong A, Krise J. Evaluating the roles of autophagy and lysosomal trafficking defects in intracellular distribution-based drug-drug interactions involving lysosomes. J Pharm Sci. 2013;102:4173-80 pubmed publisher
Liao R, Jung J, Tchaicha J, Wilkerson M, Sivachenko A, Beauchamp E, et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 2013;73:5195-205 pubmed publisher
Hu H, Li Z, Zhu X, Lin R, Lin J, Peng J, et al. Gua Lou Gui Zhi decoction suppresses LPS-induced activation of the TLR4/NF-?B pathway in BV-2 murine microglial cells. Int J Mol Med. 2013;31:1327-32 pubmed publisher
Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, et al. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS ONE. 2013;8:e53845 pubmed publisher
Taghiabadi E, Imenshahidi M, Abnous K, Mosafa F, Sankian M, Memar B, et al. Protective Effect of Silymarin against Acrolein-Induced Cardiotoxicity in Mice. Evid Based Complement Alternat Med. 2012;2012:352091 pubmed publisher
Srivastava A, Srivastava P, Al Khedhairy A, Musarrat J, Shukla Y. Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice. Mutat Res. 2012;747:22-8 pubmed publisher
Tarassishin L, Suh H, Lee S. Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway. J Neuroinflammation. 2011;8:187 pubmed publisher
Tarassishin L, Loudig O, Bauman A, Shafit Zagardo B, Suh H, Lee S. Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*. Glia. 2011;59:1911-22 pubmed publisher
Lai Y, Cheng J, Cheng D, Feasel M, Beste K, Peng J, et al. SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells. BMC Cell Biol. 2011;12:50 pubmed publisher
Bracarense A, Lucioli J, Grenier B, Drociunas Pacheco G, Moll W, Schatzmayr G, et al. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br J Nutr. 2012;107:1776-86 pubmed publisher
Zheng Y, Zhang H, Zhang X, Feng D, Luo X, Zeng C, et al. MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene. 2012;31:80-92 pubmed publisher
product information
SKU :
3700S
Product-Name :
β-Actin (8H10D10) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Dg
Applications :
Flow cytometry
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
45
Host :
Mouse
Target :
beta-Actin
Primary-Protein :
ACTB
Alt-Names :
ACTB,Actin, cytoplasmic 1,Actin, cytoplasmic 1, N-terminally processed,Beta-actin,PS1TP5-binding protein 1,PS1TP5BP1,actin, beta,beta actin,beta cytoskeletal actin
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.