product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
DR5 Antibody
catalog :
3696
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
more info or order :
Cell Signaling Technology product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2b
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  • western blot; human; loading ...; fig s1
Hartwig T, Montinaro A, von Karstedt S, Sevko A, Surinova S, Chakravarthy A, et al. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell. 2017;65:730-742.e5 pubmed publisher
  • western blot; human; fig 2
Crowder R, Dicker D, El Deiry W. The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death. J Biol Chem. 2016;291:5960-70 pubmed publisher
  • western blot; human; fig s3
Yang B, Zhang M, Gao J, Li J, Fan L, Xiang G, et al. Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer. Oncotarget. 2015;6:37613-25 pubmed publisher
Majkut J, Sgobba M, Holohan C, Crawford N, Logan A, Kerr E, et al. Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly. Nat Commun. 2014;5:3350 pubmed publisher
Beug S, Tang V, LaCasse E, Cheung H, Beauregard C, Brun J, et al. Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat Biotechnol. 2014;32:182-90 pubmed publisher
Meijer A, Kruyt F, van der Zee A, Hollema H, Le P, Ten Hoor K, et al. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. Br J Cancer. 2013;109:2685-95 pubmed publisher
Tian X, Ye J, Alonso Basanta M, Hahn S, Koumenis C, Dorsey J. Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2011;286:29408-16 pubmed publisher
Finlay D, Richardson R, Landberg L, Howes A, Vuori K. Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis. PLoS ONE. 2010;5:e13375 pubmed publisher
product information
SKU :
3696S
Product-Name :
DR5 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
40, 48
Host :
Rabbit
Target :
DR5,Trail-R2
Primary-Protein :
TRAIL-R2
Alt-Names :
DR5,KILLER,TNFRSF10B,TRAILR2,TRICK2,ZTNFR9,tumor necrosis factor receptor superfamily, member 10b
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.