product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p27 Kip1 (D69C12) XP® Rabbit mAb
catalog :
3686S
quantity :
100 ul
price :
260 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 19
Published Application/Species/DilutionReference
  • western blot (knockdown validation); human; fig 5
He M, Yuan H, Tan B, Bai R, Kim H, Bae S, et al. SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi. Oncotarget. 2016;: pubmed publisher
  • western blot; human; fig 7
Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher
  • western blot; human; fig 3
Kan H, Huang Y, Li X, Liu D, Chen J, Shu M. Zinc finger protein ZBTB20 is an independent prognostic marker and promotes tumor growth of human hepatocellular carcinoma by repressing FoxO1. Oncotarget. 2016;7:14336-49 pubmed publisher
  • western blot; human; 1:1000; fig 6
Fan C, Jia L, Zheng Y, Jin C, Liu Y, Liu H, et al. MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network. Stem Cell Reports. 2016;7:236-48 pubmed publisher
  • western blot; human
Wang Y, Han A, Chen E, Singh R, Chichester C, Moore R, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol. 2015;46:1924-34 pubmed publisher
  • western blot; human; 1:1000; fig s8
Ross J, Huh D, Noble L, Tavazoie S. Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer. Nat Cell Biol. 2015;17:651-64 pubmed publisher
  • western blot; human
Galoian K, Qureshi A, D'Ippolito G, Schiller P, Molinari M, Johnstone A, et al. Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1. Int J Oncol. 2015;47:465-72 pubmed publisher
  • western blot; human; 1:1000; fig 3
Van Brocklyn J, Wojton J, Meisen W, Kellough D, Ecsedy J, Kaur B, et al. Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma. Cancer Res. 2014;74:5364-70 pubmed publisher
  • western blot; human
Ram R, Mendiratta S, Bodemann B, Torres M, Eskiocak U, White M. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol Cell Biol. 2014;34:2350-8 pubmed publisher
  • western blot; human; 1:1000
Qiu M, Liu L, Chen L, Tan G, Liang Z, Wang K, et al. microRNA-183 plays as oncogenes by increasing cell proliferation, migration and invasion via targeting protein phosphatase 2A in renal cancer cells. Biochem Biophys Res Commun. 2014;452:163-9 pubmed publisher
  • western blot; human; 1:1000
  • immunocytochemistry; human
Tanaka T, Iino M. Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. Cell Signal. 2014;26:2071-85 pubmed publisher
  • western blot; human; 1:1000
Miyake M, Goodison S, Urquidi V, Gomes Giacoia E, Rosser C. Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1/2 and EGF pathways. Lab Invest. 2013;93:768-78 pubmed publisher
  • immunocytochemistry; mouse
McGowan S, McCoy D. Platelet-derived growth factor-A regulates lung fibroblast S-phase entry through p27(kip1) and FoxO3a. Respir Res. 2013;14:68 pubmed publisher
Fallahi-Sichani M, Moerke N, Niepel M, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015;11:797 pubmed publisher
Zhang N, Ying M, Wu Y, Zhou Z, Ye Z, Li H, et al. Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells. PLoS ONE. 2014;9:e98973 pubmed publisher
Poindessous V, Ouaret D, El Ouadrani K, Battistella A, Mégalophonos V, Kamsu-Kom N, et al. EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies. Clin Cancer Res. 2011;17:6522-30 pubmed publisher
Yang S, Xiao X, Meng X, Leslie K. A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PLoS ONE. 2011;6:e26343 pubmed publisher
Stein C, Riedl S, Rüthnick D, Nötzold R, Bauer U. The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids Res. 2012;40:9522-33 pubmed publisher
Negrotto S, Hu Z, Alcazar O, Ng K, Triozzi P, Lindner D, et al. Noncytotoxic differentiation treatment of renal cell cancer. Cancer Res. 2011;71:1431-41 pubmed publisher
product information
SKU :
3686S
Product-Name :
p27 Kip1 (D69C12) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, R, Mk
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
27
Host :
Rabbit
Target :
p27 Kip1
Primary-Protein :
p27Kip1
Alt-Names :
CDKN1B,CDKN4,CDN1B,Cyclin-dependent kinase inhibitor 1B,Cyclin-dependent kinase inhibitor p27,KIP1,MEN1B,MEN4,cyclin-dependent kinase inhibitor 1B (p27, Kip1),p27Kip1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.