| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:500; loading ...; fig 6g
| Chafe S, Vizeacoumar F, Venkateswaran G, Nemirovsky O, Awrey S, Brown W, et al. Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Sci Adv. 2021;7: pubmed publisher |
- western blot; mouse; loading ...; fig 3e
| Lee H, Donati A, Feliers D, Sun Y, Ding Y, Madesh M, et al. Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging Cell. 2021;20:e13407 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Hung C, Lombardo P, Malik N, Brun S, Hellberg K, Van Nostrand J, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021;7: pubmed publisher |
- western blot; bovine; loading ...; fig 3a
| Guo Z, Zhao K, Feng X, Yan D, Yao R, Chen Y, et al. mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells. Biomed Res Int. 2019;2019:5196028 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2c
| Shi Y, Lim S, Liang Q, Iyer S, Wang H, Wang Z, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019;567:341-346 pubmed publisher |
- western blot; human; loading ...; fig s4a
| Hinchy E, Gruszczyk A, Willows R, Navaratnam N, Hall A, Bates G, et al. Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. J Biol Chem. 2018;293:17208-17217 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s2c
| Li T, Song L, Sun Y, Li J, Yi C, Lam S, et al. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018;9:1916 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1h
| Zhang Z, Zi Z, Lee E, Zhao J, Contreras D, South A, et al. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018;24:617-627 pubmed publisher |
- western blot; mouse; fig 2g
| Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher |
- western blot; mouse; loading ...; fig 6
| Ohba K, Sinha R, Singh B, Iannucci L, Zhou J, Kovalik J, et al. Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. Thyroid. 2017;27:852-860 pubmed publisher |
- western blot; human; fig 1b
| Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, et al. AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol. 2017;216:1107-1121 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Wolfson R, Chantranupong L, Wyant G, Gu X, Orozco J, Shen K, et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017;543:438-442 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 5a
| Tongluan N, Ramphan S, Wintachai P, Jaresitthikunchai J, Khongwichit S, Wikan N, et al. Involvement of fatty acid synthase in dengue virus infection. Virol J. 2017;14:28 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher |
- western blot; human; loading ...; fig 4i
| Dey P, Baddour J, Muller F, Wu C, Wang H, Liao W, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017;542:119-123 pubmed publisher |
- western blot; human; fig 2e
| Boß M, Newbatt Y, Gupta S, Collins I, Brüne B, Namgaladze D. AMPK-independent inhibition of human macrophage ER stress response by AICAR. Sci Rep. 2016;6:32111 pubmed publisher |
| Kawamoto E, Koshinaka K, Yoshimura T, Masuda H, Kawanaka K. Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation. Physiol Rep. 2016;4: pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher |
| Zinkhan E, Zalla J, Carpenter J, Yu B, Yu X, Chan G, et al. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016;4: pubmed publisher |
- western blot; human; loading ...; fig 2c, 5f, 5g
- western blot; rat; loading ...; fig 5h
| Yin C, He D, Chen S, Tan X, Sang N. Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate. Oncotarget. 2016;7:47494-47510 pubmed publisher |
- western blot; mouse; fig 5
| Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher |
- western blot; mouse; 1:2000; fig 4
| Thomas A, Belaidi E, Aron Wisnewsky J, van der Zon G, Levy P, Clement K, et al. Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. Sci Rep. 2016;6:24618 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Liu X, Xiao Z, Han L, Zhang J, Lee S, Wang W, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18:431-42 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Senol Cosar O, Flach R, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, et al. Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion. Nat Commun. 2016;7:10686 pubmed publisher |
- western blot; human; loading ...; fig 1c, s3b
- western blot; mouse; loading ...; fig 3d, s4d,
| Toyama E, Herzig S, Courchet J, Lewis T, Losón O, Hellberg K, et al. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016;351:275-281 pubmed publisher |
- western blot; human; fig 1
| Audet Walsh Ã, Papadopoli D, Gravel S, Yee T, Bridon G, Caron M, et al. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016;14:920-931 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5c
| Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher |
- western blot; mouse; fig st1
| Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, et al. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016;36:1176-86 pubmed publisher |
- western blot; mouse; fig 4a
| Lee Y, Yun M, Kim H, Jeon B, Park B, Lee B, et al. Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK. Int J Obes (Lond). 2016;40:356-65 pubmed publisher |
| Dungan C, Li Z, Wright D, Williamson D. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle. Muscle Nerve. 2016;53:107-17 pubmed publisher |
- western blot; mouse; fig 7
- western blot; human; fig 7
| Li S, Oh Y, Yue P, Khuri F, Sun S. Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells. Oncogene. 2016;35:642-50 pubmed publisher |
| McGuire C, Forgac M. Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling. J Biol Chem. 2018;293:9113-9123 pubmed publisher |
| Nwadike C, Williamson L, Gallagher L, Guan J, Chan E. AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Mol Cell Biol. 2018;38: pubmed publisher |
| Bartolomé A, García Aguilar A, Asahara S, Kido Y, Guillen C, Pajvani U, et al. MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Mol Cell Biol. 2017;37: pubmed publisher |
| Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017;546:168-172 pubmed publisher |
| Rollins M, Huard S, Morettin A, Takuski J, Pham T, Fullerton M, et al. Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet. 2017;13:e1006626 pubmed publisher |
| Xiao H, Zhang J, Xu Z, Feng Y, Zhang M, Liu J, et al. Metformin is a novel suppressor for transforming growth factor (TGF)-β1. Sci Rep. 2016;6:28597 pubmed publisher |
| Karantanos T, Karanika S, Wang J, Yang G, Dobashi M, Park S, et al. Caveolin-1 regulates hormone resistance through lipid synthesis, creating novel therapeutic opportunities for castration-resistant prostate cancer. Oncotarget. 2016;7:46321-46334 pubmed publisher |
| Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, et al. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. 2017;36:254-262 pubmed publisher |
| Kirchner H, Sinha I, Gao H, Ruby M, Schönke M, Lindvall J, et al. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients. Mol Metab. 2016;5:171-183 pubmed publisher |
| Burkart A, Tan K, Warren L, Iovino S, Hughes K, Kahn C, et al. Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. Sci Rep. 2016;6:22788 pubmed publisher |
