| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; rat; loading ...; fig 4a
| Agostino M, Rooney J, Herat L, Matthews J, Simonds A, Northfield S, et al. TNFSF14-Derived Molecules as a Novel Treatment for Obesity and Type 2 Diabetes. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; human; 1:500; loading ...; fig 6g
| Chafe S, Vizeacoumar F, Venkateswaran G, Nemirovsky O, Awrey S, Brown W, et al. Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Sci Adv. 2021;7: pubmed publisher |
- western blot; mouse; 1:2000; loading ...
| Vieira Lara M, Dommerholt M, Zhang W, Blankestijn M, Wolters J, Abegaz F, et al. Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload. BMC Biol. 2021;19:154 pubmed publisher |
- western blot; mouse; loading ...; fig 3e
| Lee H, Donati A, Feliers D, Sun Y, Ding Y, Madesh M, et al. Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury. Aging Cell. 2021;20:e13407 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4h, 5d
| Yan C, Zeng T, Lee K, Nobis M, Loh K, Gou L, et al. Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity. Nat Commun. 2021;12:2622 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Hung C, Lombardo P, Malik N, Brun S, Hellberg K, Van Nostrand J, et al. AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy. Sci Adv. 2021;7: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
| Grissi M, Boudot C, Assem M, Candellier A, Lando M, Poirot Leclercq S, et al. Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease. Sci Rep. 2021;11:7464 pubmed publisher |
- western blot; human; loading ...; fig 3s3a
| Stephenson Z, Harvey R, Pryde K, Mistry S, Hardy R, Serreli R, et al. Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I. elife. 2020;9: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2e
| Lahiguera Á, Hyroššová P, Figueras A, Garzón D, Moreno R, Soto Cerrato V, et al. Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors. EMBO Mol Med. 2020;12:e11217 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2a
- western blot; human; 1:1000; loading ...; fig 3d
| Palomo Guerrero M, Fadó R, Casas M, Pérez Montero M, Baena M, Helmer P, et al. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. elife. 2019;8: pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 6s1b, 6s1c, 6s2a
- western blot; rat; 1:2000; loading ...; fig 6s1a
| Currais A, Huang L, Goldberg J, Petrascheck M, Ates G, Pinto Duarte A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. elife. 2019;8: pubmed publisher |
- western blot; rat; 1:200; loading ...; fig 3e
| Presby D, Checkley L, Jackman M, Higgins J, Jones K, Giles E, et al. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019;317:R684-R695 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a
| Shan C, Lu Z, Li Z, Sheng H, Fan J, Qi Q, et al. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death Dis. 2019;10:525 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2c
| Shi Y, Lim S, Liang Q, Iyer S, Wang H, Wang Z, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019;567:341-346 pubmed publisher |
- western blot; fission yeast; 1:1000; loading ...; fig 4a
| Forte G, Davie E, Lie S, Franz Wachtel M, Ovens A, Wang T, et al. Import of extracellular ATP in yeast and man modulates AMPK and TORC1 signalling. J Cell Sci. 2019;132: pubmed publisher |
- western blot; human; loading ...; fig 6b
| Yambire K, Fernández Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, et al. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. elife. 2019;8: pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Ducommun S, Deak M, Zeigerer A, Göransson O, Seitz S, Collodet C, et al. Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates. Cell Signal. 2019;57:45-57 pubmed publisher |
- western blot; human; loading ...; fig s2b
| Haikala H, Anttila J, Marques E, Raatikainen T, Ilander M, Hakanen H, et al. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019;10:620 pubmed publisher |
- western blot; rat; loading ...; fig 4a
| Zhang N, Wei W, Liao H, Yang Z, Hu C, Wang S, et al. AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload. J Mol Med (Berl). 2018;96:1345-1357 pubmed publisher |
- western blot; human; loading ...; fig 7b
- western blot; mouse; loading ...; fig 2a
| Hinchy E, Gruszczyk A, Willows R, Navaratnam N, Hall A, Bates G, et al. Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly. J Biol Chem. 2018;293:17208-17217 pubmed publisher |
- western blot; mouse; loading ...; fig s7a
| Matesanz N, Nikolic I, Leiva M, Pulgarín Alfaro M, Santamans A, Bernardo E, et al. p38α blocks brown adipose tissue thermogenesis through p38δ inhibition. PLoS Biol. 2018;16:e2004455 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig s1d
- western blot; human; 1:1000; loading ...; fig s1c
| Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig s9e
- western blot; mouse; 1:1000; loading ...; fig 1h
| Zhang Z, Zi Z, Lee E, Zhao J, Contreras D, South A, et al. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018;24:617-627 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; mouse; fig 2g
| Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher |
- western blot; human; fig s2a
| Chung E, Efstathiou N, Konstantinou E, Maidana D, Miller J, Young L, et al. AICAR suppresses TNF-α-induced complement factor B in RPE cells. Sci Rep. 2017;7:17651 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1
| Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, et al. Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner. Environ Toxicol Pharmacol. 2017;56:15-20 pubmed publisher |
- western blot; mouse; loading ...; fig 6
| Ohba K, Sinha R, Singh B, Iannucci L, Zhou J, Kovalik J, et al. Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. Thyroid. 2017;27:852-860 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5c
| Krag T, Ruiz Ruiz C, Vissing J. Glycogen Synthesis in Glycogenin 1-Deficient Patients: A Role for Glycogenin 2 in Muscle. J Clin Endocrinol Metab. 2017;102:2690-2700 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig st6
| Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher |
- western blot; human; fig 1c
| Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, et al. AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol. 2017;216:1107-1121 pubmed publisher |
- western blot; human; loading ...; fig 2c
| Wolfson R, Chantranupong L, Wyant G, Gu X, Orozco J, Shen K, et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017;543:438-442 pubmed publisher |
- western blot; mouse; loading ...; fig 1c
| Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher |
- western blot; mouse; 1:1000; fig 4g
| Cederquist C, Lentucci C, Martinez Calejman C, Hayashi V, Orofino J, GUERTIN D, et al. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017;6:125-137 pubmed publisher |
- western blot; mouse; loading ...; fig 8a
| Wang Q, Wu S, Zhu H, Ding Y, Dai X, Ouyang C, et al. Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L. Autophagy. 2017;13:404-422 pubmed publisher |
- western blot; human; loading ...
| Hill S, Nesser N, Johnson Camacho K, Jeffress M, Johnson A, Boniface C, et al. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017;4:73-83.e10 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher |
- western blot; mouse; fig 3
| Hinds T, Burns K, Hosick P, McBeth L, Nestor Kalinoski A, Drummond H, et al. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?. J Biol Chem. 2016;291:25179-25191 pubmed |
- western blot; mouse; loading ...; fig 3b, 4a, 5b, 6a, 7a
| Bultot L, Jensen T, Lai Y, Madsen A, Collodet C, Kviklyte S, et al. Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. Am J Physiol Endocrinol Metab. 2016;311:E706-E719 pubmed publisher |
- western blot; human; fig 1b
| Boß M, Newbatt Y, Gupta S, Collins I, Brüne B, Namgaladze D. AMPK-independent inhibition of human macrophage ER stress response by AICAR. Sci Rep. 2016;6:32111 pubmed publisher |
- western blot; human; fig 6
| Weikel K, Cacicedo J, Ruderman N, Ido Y. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016;36: pubmed publisher |
- western blot; mouse; fig 5
| Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher |
| Kim J, Hong S, Park C, Park J, Choi S, Woo S, et al. Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction. PLoS ONE. 2016;11:e0158067 pubmed publisher |
- western blot; mouse; loading ...; fig 1a
| Krag T, Pinós T, Nielsen T, Duran J, GarcÃa Rocha M, Andreu A, et al. Differential glucose metabolism in mice and humans affected by McArdle disease. Am J Physiol Regul Integr Comp Physiol. 2016;311:R307-14 pubmed publisher |
- western blot; human; fig 1
| Sundararaman A, Amirtham U, Rangarajan A. Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation. J Biol Chem. 2016;291:14410-29 pubmed publisher |
- western blot; mouse; loading ...; fig 1f
| Rao E, Zhang Y, Li Q, Hao J, Egilmez N, Suttles J, et al. AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Oncotarget. 2016;7:33783-95 pubmed publisher |
- western blot; human; fig 1
| Taniguchi T, Iizumi Y, Watanabe M, Masuda M, Morita M, Aono Y, et al. Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. Cell Death Dis. 2016;7:e2211 pubmed publisher |
- western blot; mouse; 1:1000; fig 4
| Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher |
- western blot; mouse; 1:2000; fig s3
| Thomas A, Belaidi E, Aron Wisnewsky J, van der Zon G, Levy P, Clement K, et al. Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. Sci Rep. 2016;6:24618 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Liu X, Xiao Z, Han L, Zhang J, Lee S, Wang W, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18:431-42 pubmed publisher |
- western blot; human; loading ...
| Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher |
- western blot; mouse; fig 1
| Han X, Tai H, Wang X, Wang Z, Zhou J, Wei X, et al. AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell. 2016;15:416-27 pubmed publisher |
- western blot; human; 1:2000; fig 2
| Di Magno L, Basile A, Coni S, Manni S, Sdruscia G, D Amico D, et al. The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint. Oncotarget. 2016;7:9538-49 pubmed publisher |
- western blot; human; loading ...; fig 1c, s3b
- western blot; mouse; loading ...; fig 3d, s4d,
| Toyama E, Herzig S, Courchet J, Lewis T, Losón O, Hellberg K, et al. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 2016;351:275-281 pubmed publisher |
- western blot; human; fig 1
| Audet Walsh Ã, Papadopoli D, Gravel S, Yee T, Bridon G, Caron M, et al. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016;14:920-931 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Wu H, Shi L, Wang Q, Cheng L, Zhao X, Chen Q, et al. Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells. Sci Rep. 2016;6:19507 pubmed publisher |
- western blot; mouse; 1:10,000; loading ...; fig 5c
| Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher |
- western blot; human; 1:1000; fig s5
| Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich M, Lim R, et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature. 2016;529:216-20 pubmed publisher |
- western blot; mouse; fig 4a
| Lee Y, Yun M, Kim H, Jeon B, Park B, Lee B, et al. Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK. Int J Obes (Lond). 2016;40:356-65 pubmed publisher |
| Dungan C, Li Z, Wright D, Williamson D. Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle. Muscle Nerve. 2016;53:107-17 pubmed publisher |
| Willows R, Navaratnam N, Lima A, Read J, Carling D. Effect of different γ-subunit isoforms on the regulation of AMPK. Biochem J. 2017;474:1741-1754 pubmed publisher |
| Guo L, Costanzo Garvey D, Smith D, Neilsen B, MacDonald R, Lewis R. Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis. Mol Metab. 2017;6:194-205 pubmed publisher |
| Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, et al. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE. J Biol Chem. 2017;292:64-79 pubmed publisher |
| Xiao H, Zhang J, Xu Z, Feng Y, Zhang M, Liu J, et al. Metformin is a novel suppressor for transforming growth factor (TGF)-β1. Sci Rep. 2016;6:28597 pubmed publisher |
| Burkart A, Tan K, Warren L, Iovino S, Hughes K, Kahn C, et al. Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. Sci Rep. 2016;6:22788 pubmed publisher |
