| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:200; fig 4d
| Portal C, Wang Z, Scott D, Wolosin J, Iomini C. The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair. Invest Ophthalmol Vis Sci. 2022;63:3 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6b
| Wang R, Yang D, Liu Y, Ding J, Guo Y, Ding W, et al. Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after experimental traumatic brain injury. Neural Regen Res. 2022;17:130-136 pubmed publisher |
- western blot; human; 1:1000; fig 1c
| Wang Y, Liu I, Chen K, Wu H. NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck. Oncogenesis. 2021;10:59 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1n
| Liang F, Wang B, Geng J, You G, Fa J, Zhang M, et al. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. elife. 2021;10: pubmed publisher |
- western blot; human; 1:500; loading ...; fig 4a
| Liu L, Tao T, Liu S, Yang X, Chen X, Liang J, et al. An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness. Nat Commun. 2021;12:2693 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2d
| Nishad R, Mukhi D, Singh A, Motrapu M, Chintala K, Tammineni P, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12:342 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Ni W, Chen Z, Zhou X, Yang R, Yu M, Lu J, et al. Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma. Signal Transduct Target Ther. 2021;6:27 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:250; loading ...; fig 2b
- immunocytochemistry; human; loading ...; fig 3a
| Zhang P, Ishikawa M, Doyle A, Nakamura T, He B, Yamada Y. Pannexin 3 regulates skin development via Epiprofin. Sci Rep. 2021;11:1779 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1
| Tendler S, Kanter L, Lewensohn R, Ortiz Villalón C, Viktorsson K, De Petris L. The prognostic implications of Notch1, Hes1, Ascl1, and DLL3 protein expression in SCLC patients receiving platinum-based chemotherapy. PLoS ONE. 2020;15:e0240973 pubmed publisher |
- western blot; human; loading ...; fig 6a
- western blot; mouse; loading ...; fig 1c
| Tan Y, Sementino E, Liu Z, Cai K, Testa J. Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis. Sci Rep. 2020;10:15837 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3d2d, 3h
| Kuang Y, Golan O, Preusse K, Cain B, Christensen C, Salomone J, et al. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. elife. 2020;9: pubmed publisher |
- western blot; human; fig 1d
| Chandrasekaran B, Dahiya N, Tyagi A, Kolluru V, Saran U, Baby B, et al. Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. 2020;9:23 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1c
| Hu J, Yu J, Gan J, Song N, Shi L, Liu J, et al. Notch1/2/3/4 are prognostic biomarker and correlated with immune infiltrates in gastric cancer. Aging (Albany NY). 2020;12:2595-2609 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Liu H, Mei F, Yang W, Wang H, Wong E, Cai J, et al. Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling. Sci Adv. 2020;6:eaay3566 pubmed publisher |
- western blot; human; loading ...; fig s1a, s1b
| Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019;18:156 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 2i
- immunohistochemistry; human; 1:200; loading ...; fig 8b
- western blot; human; 1:1000; loading ...; fig 4h
| Wang J, Xu S, Duan J, Yi L, Guo Y, Shi Y, et al. Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Nat Neurosci. 2019;22:91-105 pubmed publisher |
- western blot; human; 1:1000; fig 2c
| Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839 pubmed publisher |
- western blot; human; 1:1000; fig 2a
| Frank S, Berger P, Ljungman M, Miranti C. Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC. J Cell Sci. 2017;130:1952-1964 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Mandl M, Zhang S, Ulrich M, Schmoeckel E, Mayr D, Vollmar A, et al. Inhibition of Cdk5 induces cell death of tumor-initiating cells. Br J Cancer. 2017;116:912-922 pubmed publisher |
- western blot; human; 1:1000; fig s11a
| Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Revandkar A, Perciato M, Toso A, Alajati A, Chen J, Gerber H, et al. Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence. Nat Commun. 2016;7:13719 pubmed publisher |
- immunohistochemistry; mouse; 1:250; loading ...; fig 3b
- western blot; mouse; 1:2000; loading ...; fig 3a
- western blot; human; 1:2000; loading ...; fig 4c
| Zhang Q, Zhang Y, Parsels J, Lohse I, Lawrence T, Pasca di Magliano M, et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia. 2016;18:666-673 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 3b
| Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed |
- immunocytochemistry; human; loading ...; fig e6a
| Jordan N, Bardia A, Wittner B, Benes C, Ligorio M, Zheng Y, et al. HER2 expression identifies dynamic functional states within circulating breast cancer cells. Nature. 2016;537:102-106 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6a
| Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed publisher |
- western blot; human; fig 6d
| Zhang P, He D, Chen Z, Pan Q, Du F, Zang X, et al. Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer. Biochem Pharmacol. 2016;118:18-30 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Fan C, Jia L, Zheng Y, Jin C, Liu Y, Liu H, et al. MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network. Stem Cell Reports. 2016;7:236-48 pubmed publisher |
- immunocytochemistry; rat; 1:200; loading ...; fig 3b
- western blot; rat; 1:1000; loading ...; fig 3a
| Zeng J, Jing Y, Shi R, Pan X, Lai F, Liu W, et al. Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway. Cell Cycle. 2016;15:1602-10 pubmed publisher |
- western blot; human; fig 6
| Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed publisher |
| Zhang Y, Yu J, Lee C, Xu B, Sartor M, Koenig R. Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein. Oncotarget. 2015;6:40418-32 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; fig 3
| Liu Z, Brunskill E, Varnum Finney B, Zhang C, Zhang A, Jay P, et al. The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development. 2015;142:2452-63 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:25
| Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt A, et al. Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies. Oncotarget. 2015;6:21522-32 pubmed |
- western blot; human; fig f4
- western blot; mouse; fig f6
| Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed |
- chromatin immunoprecipitation; mouse; fig 1
| Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, et al. A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. J Immunol. 2015;194:243-51 pubmed publisher |
- immunohistochemistry - paraffin section; rat
- immunohistochemistry - paraffin section; human
| Yoshida R, Nagata M, Nakayama H, Niimori Kita K, Hassan W, Tanaka T, et al. The pathological significance of Notch1 in oral squamous cell carcinoma. Lab Invest. 2013;93:1068-81 pubmed publisher |
- immunohistochemistry; human; 1:100
| El Hindy N, Keyvani K, Pagenstecher A, Dammann P, Sandalcioglu I, Sure U, et al. Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme. Neuro Oncol. 2013;15:1366-78 pubmed publisher |
- immunohistochemistry - paraffin section; human; 0.7 ug/ml
| Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher |
| Kałafut J, Czapinski J, Przybyszewska Podstawka A, Czerwonka A, Odrzywolski A, Sahlgren C, et al. Optogenetic control of NOTCH1 signaling. Cell Commun Signal. 2022;20:67 pubmed publisher |
| Im D, Joselin A, Svoboda D, Takano T, Rousseaux M, Callaghan S, et al. Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition. BMC Biol. 2022;20:115 pubmed publisher |
| Greenough M, Lane D, Balez R, Anastacio H, Zeng Z, Ganio K, et al. Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations. Cell Death Differ. 2022;: pubmed publisher |
| Diaz Cuadros M, Wagner D, Budjan C, Hubaud A, Tarazona O, Donelly S, et al. In vitro characterization of the human segmentation clock. Nature. 2020;580:113-118 pubmed publisher |
| Onodera Y, Teramura T, Takehara T, Itokazu M, Mori T, Fukuda K. Inflammation-associated miR-155 activates differentiation of muscular satellite cells. PLoS ONE. 2018;13:e0204860 pubmed publisher |
| Wang Q, Yan R, Pinnell N, McCarter A, Oh Y, Liu Y, et al. Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Blood. 2018;: pubmed publisher |
| Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, et al. Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation. Sci Rep. 2018;8:2021 pubmed publisher |
| Zheng Y, Wang Z, Ding X, Zhang W, Li G, Liu L, et al. A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma. Cancer Cell Int. 2018;18:6 pubmed publisher |
| Mack J, Mosqueiro T, Archer B, Jones W, Sunshine H, Faas G, et al. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017;8:1620 pubmed publisher |
| Court H, Ahearn I, Amoyel M, Bach E, Philips M. Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. J Cell Biol. 2017;216:4165-4182 pubmed publisher |
| Takeuchi H, Yu H, Hao H, Takeuchi M, Ito A, Li H, et al. O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking. J Biol Chem. 2017;292:15964-15973 pubmed publisher |
| Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher |
| Fujiki K, Inamura H, Miyayama T, Matsuoka M. Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure. J Biol Chem. 2017;292:7942-7953 pubmed publisher |
| Taniguchi K, Moroishi T, de Jong P, Krawczyk M, Grebbin B, Luo H, et al. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:1643-1648 pubmed publisher |
| Britton G, Ambler R, Clark D, Hill E, Tunbridge H, McNally K, et al. PKC? links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton. elife. 2017;6: pubmed publisher |
| Kikuchi H, Sakakibara Konishi J, Furuta M, Yokouchi H, Nishihara H, Yamazaki S, et al. Expression of Notch1 and Numb in small cell lung cancer. Oncotarget. 2017;8:10348-10358 pubmed publisher |
| Zhou W, He Q, Zhang C, He X, Cui Z, Liu F, et al. BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. elife. 2016;5: pubmed publisher |
| Chen Y, Liu Y, Wei H, Lv K, Fu P. Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells. Oncotarget. 2016;7:59604-59617 pubmed publisher |
| Ezratty E, Pasolli H, Fuchs E. A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. J Cell Biol. 2016;214:89-101 pubmed publisher |
| Huang W, Martin E, Burman B, Gonzalez M, Kleer C. The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells. Oncotarget. 2016;7:25180-93 pubmed publisher |
| Faronato M, Nguyen V, Patten D, Lombardo Y, Steel J, Patel N, et al. DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation. Oncotarget. 2015;6:22467-79 pubmed |
| Hwang S, Palin A, Li L, Song K, Lee J, Herz J, et al. TCR ITAM multiplicity is required for the generation of follicular helper T-cells. Nat Commun. 2015;6:6982 pubmed publisher |
| Otti G, Saleh L, Velicky P, Fiala C, Pollheimer J, Knöfler M. Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy. PLoS ONE. 2014;9:e112723 pubmed publisher |
| Matulic M, Skelin J, Radić Kristo D, Kardum Skelin I, Grcevic D, Antica M. Notch affects the prodifferentiating effect of retinoic acid and PMA on leukemic cells. Cytometry A. 2015;87:129-36 pubmed publisher |
| Fujiki K, Inamura H, Matsuoka M. Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells. Cell Death Dis. 2014;5:e1378 pubmed publisher |
| Wolfe A, Singh K, Zhong Y, Drewe P, Rajasekhar V, Sanghvi V, et al. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014;513:65-70 pubmed publisher |
| Harjes U, Bridges E, McIntyre A, Fielding B, Harris A. Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells. J Biol Chem. 2014;289:23168-76 pubmed publisher |
| Lombardo Y, Faronato M, Filipovic A, Vircillo V, Magnani L, Coombes R. Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. Breast Cancer Res. 2014;16:R62 pubmed publisher |
| Zhang S, Chung W, Wu G, Egan S, Xu K. Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia. 2014;16:158-67 pubmed publisher |
| Hagenbeek T, Wu X, Choy L, Sanchez Irizarry C, Seshagiri S, Stinson J, et al. Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and ?c/TCR signals for thymic exit. Cancer Lett. 2014;346:237-48 pubmed publisher |
| Liu J, Fan H, Ma Y, Liang D, Huang R, Wang J, et al. Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas. PLoS ONE. 2013;8:e56141 pubmed publisher |
| Chen S, Xu Y, Chen Y, Li X, Mou W, Wang L, et al. SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells. PLoS ONE. 2012;7:e36326 pubmed publisher |
| Choi P, van Riggelen J, Gentles A, Bachireddy P, Rakhra K, Adam S, et al. Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction. Proc Natl Acad Sci U S A. 2011;108:17432-7 pubmed publisher |
