product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
DNMT3A (D23G1) Rabbit mAb
catalog :
3598
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D23G1
reactivity :
human, mouse, rat, bovine
application :
western blot, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunocytochemistry knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; mouse; 1:400; loading ...; fig 6c
  • western blot; human; 1:2000; loading ...; fig 1b
Cole C, Russler Germain D, Ketkar S, Verdoni A, Smith A, Bangert C, et al. Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies. J Clin Invest. 2017;127:3657-3674 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 3b
Yang S, Hollingshead M, Rubinstein L, Nguyen D, Larenjeira A, Kinders R, et al. TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models. J Hematol Oncol. 2021;14:83 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Sternbach S, West N, Singhal N, Clements R, Basu S, Tripathi A, et al. The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation. PLoS ONE. 2021;16:e0250486 pubmed publisher
  • western blot; human; loading ...; fig 4i
Sin Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, et al. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell. 2019;36:51-67.e7 pubmed publisher
  • western blot; mouse; 1:1000; fig 3e
Shi X, Kitano A, Jiang Y, Luu V, Hoegenauer K, Nakada D. Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells. Exp Hematol. 2018;64:33-44.e5 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2a
Gong Z, Zhou Q. Dnmt3a in the dorsal dentate gyrus is a key regulator of fear renewal. Sci Rep. 2018;8:5093 pubmed publisher
  • western blot; human; fig 4g
Jung J, Kim L, Wang X, Wu Q, Sanvoranart T, Hubert C, et al. Nicotinamide metabolism regulates glioblastoma stem cell maintenance. JCI Insight. 2017;2: pubmed publisher
  • western blot; human; fig 4a
Du M, Zhang Y, Mao Y, Mou J, Zhao J, Xue Q, et al. MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. Biochem Biophys Res Commun. 2017;482:582-589 pubmed publisher
  • immunoprecipitation; human; 1:50; fig 6b
Koh H, Scruggs A, Huang S. Transforming Growth Factor-β1 Increases DNA Methyltransferase 1 and 3a Expression through Distinct Post-transcriptional Mechanisms in Lung Fibroblasts. J Biol Chem. 2016;291:19287-98 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1a, 2a
Vispé S, Deroide A, Davoine E, Desjobert C, Lestienne F, Fournier L, et al. Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells. Oncotarget. 2015;6:15265-82 pubmed
  • western blot; human
Cho S, Park J, Kang Y. AGO2 and SETDB1 cooperate in promoter-targeted transcriptional silencing of the androgen receptor gene. Nucleic Acids Res. 2014;42:13545-56 pubmed publisher
  • western blot; mouse; 1:1000
Subbanna S, Nagre N, Shivakumar M, Umapathy N, Psychoyos D, Basavarajappa B. Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. Neuroscience. 2014;258:422-32 pubmed publisher
  • western blot; human; 1:3000
Valdez B, Nieto Y, Murray D, Li Y, Wang G, Champlin R, et al. Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines. Exp Hematol. 2012;40:800-10 pubmed publisher
Sun H, Zhao X, Zhang C, Zhang Z, Lun J, Liao W, et al. MiR-455-3p inhibits the degenerate process of chondrogenic differentiation through modification of DNA methylation. Cell Death Dis. 2018;9:537 pubmed publisher
Bihaqi S, Zawia N. Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro. Curr Alzheimer Res. 2012;9:555-62 pubmed
product information
SKU :
3598S
Product-Name :
DNMT3A (D23G1) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, B
Applications :
Immunoprecipitation
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
130
Host :
Rabbit
Target :
DNMT3A
Primary-Protein :
DNMT3A
Alt-Names :
DNA (cytosine-5)-methyltransferase 3A,DNA (cytosine-5-)-methyltransferase 3 alpha,DNA MTase HsaIIIA,DNA cytosine methyltransferase 3A2,DNA methyltransferase HsaIIIA,DNM3A,DNMT3A,DNMT3A2,M.HsaIIIA
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.