product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Connexin 43 Antibody
catalog :
3512
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other, western blot knockout validation
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig s8a
Tan H, Yong Y, Xue Y, Liu H, Furihata T, Shankar E, et al. cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model. iScience. 2022;25:104404 pubmed publisher
  • western blot knockout validation; mouse; 1:850; loading ...; fig 1s2c
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3b, 3g
  • immunocytochemistry; mouse; 1:100; loading ...; fig 2s1b
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 5a
Vicario N, Denaro S, Turnaturi R, Longhitano L, Spitale F, Spoto S, et al. Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain. Int J Mol Sci. 2022;23: pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 6d
  • western blot; mouse; 1:1000; fig 6b
Gupta A, Mandal K, Singh P, Sarkar R, Majumdar S. Declining levels of miR-382-3p at puberty trigger the onset of spermatogenesis. Mol Ther Nucleic Acids. 2021;26:192-207 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 6a
  • western blot; mouse; 1:1000; loading ...; fig 8a
Rode K, Langeheine M, Seeger B, Brehm R. Connexin43 in Germ Cells Seems to Be Dispensable for Murine Spermatogenesis. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; loading ...; fig 2e
Kim Y, Lee J, Kim H, Jang J, Choung Y. Gap Junction-Mediated Intercellular Communication of cAMP Prevents CDDP-Induced Ototoxicity via cAMP/PKA/CREB Pathway. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7h, 7i
  • western blot; human; 1:1000; loading ...; fig 5g, s6a
Dufeys C, Daskalopoulos E, Castanares Zapatero D, Conway S, Ginion A, Bouzin C, et al. AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism. Basic Res Cardiol. 2021;116:10 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig s4d
Liu X, Schneble L xf6 hnert N, Kristofova M, Qing X, Labisch J, Hofmann S, et al. The N-terminal BRCT domain determines MCPH1 function in brain development and fertility. Cell Death Dis. 2021;12:143 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5d
Zhong L, Yao L, Tower R, Wei Y, Miao Z, Park J, et al. Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. elife. 2020;9: pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1e
  • western blot; mouse; 1:200; loading ...; fig 4c
Pelz L, Purfürst B, Rathjen F. The cell adhesion molecule BT-IgSF is essential for a functional blood-testis barrier and male fertility in mice. J Biol Chem. 2017;292:21490-21503 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Le Dour C, Macquart C, Sera F, Homma S, Bonne G, Morrow J, et al. Decreased WNT/?-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene. Hum Mol Genet. 2017;26:333-343 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 8a
Bosch P, Fuller L, Sleeth C, Weiner J. Akirin2 is essential for the formation of the cerebral cortex. Neural Dev. 2016;11:21 pubmed
  • immunohistochemistry; human; fig 2C
He Z, Forest F, Gain P, Rageade D, Bernard A, Acquart S, et al. 3D map of the human corneal endothelial cell. Sci Rep. 2016;6:29047 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4c
Li W, Jin D, Hata M, Takai S, Yamanishi K, Shen W, et al. Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice. Am J Physiol Heart Circ Physiol. 2016;311:H313-25 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 2
  • immunocytochemistry; human; 1:75; fig 4
  • western blot; human; 1:1000; fig 3
Yu J, Berga S, Johnston MacAnanny E, Sidell N, Bagchi I, Bagchi M, et al. Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. Endocrinology. 2016;157:2432-46 pubmed publisher
  • other; rat; 1:100; tbl 2
  • western blot; rat; 1:1000; tbl 2
Li N, Mruk D, Mok K, Li M, Wong C, Lee W, et al. Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption. FASEB J. 2016;30:1436-52 pubmed publisher
  • western blot; rat; fig 6
Morgan K, Black L. Investigation into the effects of varying frequency of mechanical stimulation in a cycle-by-cycle manner on engineered cardiac construct function. J Tissue Eng Regen Med. 2017;11:342-353 pubmed publisher
Augustin H, McGourty K, Allen M, Madem S, Adcott J, Kerr F, et al. Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol. 2017;15:e2001655 pubmed publisher
Omatsu Kanbe M, Nozuchi N, Nishino Y, Mukaisho K, Sugihara H, Matsuura H. Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death. Sci Rep. 2017;7:41318 pubmed publisher
product information
SKU :
3512S
Product-Name :
Connexin 43 Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, Z, (Dg, Pg)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Adhesion/ECM
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
39, 41, 43, 44
Host :
Rabbit
Target :
Connexin-43
Primary-Protein :
Cx43
Alt-Names :
CXA1,Connexin-43,Cx43,DFNB38,GJA1,GJAL,Gap junction 43 kDa heart protein,Gap junction alpha-1 protein,HSS,ODDD,connexin 43,gap junction protein, alpha 1, 43kDa,gap junction protein, alpha-like
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.