product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PDI (C81H6) Rabbit mAb
catalog :
3501
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C81H6
reactivity :
African green monkey, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 39
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3d, 3f
Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, et al. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun. 2020;11:1304 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4d
Herranen A, Ikäheimo K, Lankinen T, Pakarinen E, Fritzsch B, Saarma M, et al. Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss. Cell Death Dis. 2020;11:100 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Nakamura Y, Dryanovski D, Kimura Y, Jackson S, Woods A, Yasui Y, et al. Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig s6e
van Heesch S, Witte F, Schneider Lunitz V, Schulz J, Adami E, Faber A, et al. The Translational Landscape of the Human Heart. Cell. 2019;: pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 1a
Almeida F, Tognarelli S, Marcais A, Kueh A, Friede M, Liao Y, et al. A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets. Oncoimmunology. 2018;7:e1475875 pubmed publisher
  • western blot; human; loading ...; fig 8d
Bagashev A, Sotillo E, Tang C, Black K, Perazzelli J, Seeholzer S, et al. CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum. Mol Cell Biol. 2018;38: pubmed publisher
  • immunohistochemistry; human; 1:1500; loading ...; fig s2c
NGUYEN J, Ray C, Fox A, Mendonça D, Kim J, Krebsbach P. Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. Sci Adv. 2018;4:eaao5838 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig s7
Cox N, Unlu G, Bisnett B, Meister T, Condon B, Luo P, et al. Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. Biochemistry. 2018;57:91-107 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3d
Tarling E, Clifford B, Cheng J, Morand P, Cheng A, Lester E, et al. RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. J Clin Invest. 2017;127:3741-3754 pubmed publisher
  • western blot; mouse; loading ...; fig 5j
Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 5H
Winship A, Sorby K, Correia J, Rainczuk A, Yap J, Dimitriadis E. Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice. Placenta. 2017;53:92-100 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Tamura Y, Matsunaga Y, Kitaoka Y, Hatta H. Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle. J Gerontol A Biol Sci Med Sci. 2017;72:299-308 pubmed publisher
  • immunocytochemistry; African green monkey; 1:4000; loading ...
Makita N, Sato T, Yajima Shoji Y, Sato J, Manaka K, Eda Hashimoto M, et al. Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist. J Biol Chem. 2016;291:22460-22471 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 4b
Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
  • western blot; mouse; fig 3g
  • western blot; rat; fig 3e
Krawczyk K, Ekman M, Rippe C, Grossi M, Nilsson B, Albinsson S, et al. Assessing the contribution of thrombospondin-4 induction and ATF6? activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep. 2016;6:32449 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 2
Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed publisher
  • immunocytochemistry; human; fig 8
Laura R, Dong D, Reynolds W, Maki R. T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation. PLoS ONE. 2016;11:e0149391 pubmed publisher
  • immunocytochemistry; human; fig 4
Pankow S, Bamberger C, Calzolari D, Martínez Bartolomé S, Lavallée Adam M, Balch W, et al. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015;528:510-6 pubmed publisher
  • western blot; mouse; 1:1000; fig 1c
Ostapchenko V, Chen M, Guzman M, Xie Y, Lavine N, Fan J, et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci. 2015;35:15157-69 pubmed publisher
  • western blot; human; 1:1000; fig 1
  • western blot; mouse; 1:1000; fig 3
Kyathanahalli C, Organ K, Moreci R, Anamthathmakula P, Hassan S, Caritis S, et al. Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent. Proc Natl Acad Sci U S A. 2015;112:14090-5 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Palao T, Swärd K, Jongejan A, Moerland P, de Vos J, van Weert A, et al. Gene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER Stress. PLoS ONE. 2015;10:e0137027 pubmed publisher
  • immunocytochemistry; mouse; fig s6
Ruas M, Davis L, Chen C, Morgan A, Chuang K, Walseth T, et al. Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J. 2015;34:1743-58 pubmed publisher
  • western blot; rat; 1:1000; fig 5
Wong M, Nicholson C, Holloway A, Hardy D. Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta. PLoS ONE. 2015;10:e0122295 pubmed publisher
  • western blot; mouse; 1:1000
Gomez Cavazos J, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J Cell Biol. 2015;208:671-81 pubmed publisher
  • western blot; mouse; fig s1
  • western blot; rat; fig 1
Wang S, Park S, Kodali V, Han J, Yip T, Chen Z, et al. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Mol Biol Cell. 2015;26:594-604 pubmed publisher
  • western blot; human; 1:500
Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht E, Aberdeen G, et al. Cross-species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon. Endocrinology. 2013;154:4873-84 pubmed publisher
  • western blot; mouse; 1:1000
Kang E, Kwon I, Koo J, Kim E, Kim C, Lee J, et al. Treadmill exercise represses neuronal cell death and inflammation during A?-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis. 2013;18:1332-1347 pubmed publisher
  • western blot; human; 1:1000; fig s1
Gurkar A, Chu K, Raj L, Bouley R, Lee S, Kim Y, et al. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun. 2013;4:2189 pubmed publisher
Peterman E, Gibieža P, Schafer J, Skeberdis V, Kaupinis A, Valius M, et al. The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation. Nat Commun. 2019;10:3181 pubmed publisher
Obr A, Kumar S, Chang Y, Bulatowicz J, Barnes B, Birge R, et al. Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. Breast Cancer Res. 2018;20:138 pubmed publisher
Saegusa K, Sato M, Morooka N, Hara T, Sato K. SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. J Cell Biol. 2018;217:2073-2085 pubmed publisher
Elenbaas J, Bragazzi Cunha J, Azuero Dajud R, Nelson B, Oral E, Williams J, et al. Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F. Gastroenterology. 2018;154:1625-1629.e8 pubmed publisher
Smith M, Harley M, Kemp A, Wills J, Lee M, Arends M, et al. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 2018;44:217-232.e11 pubmed publisher
Thomson B, Souma T, Tompson S, Onay T, Kizhatil K, Siggs O, et al. Angiopoietin-1 is required for Schlemm's canal development in mice and humans. J Clin Invest. 2017;127:4421-4436 pubmed publisher
Lee W, Higuchi H, Ikeda S, Macke E, Takimoto T, Pattnaik B, et al. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. elife. 2016;5: pubmed publisher
Mardakheh F, Sailem H, Kümper S, Tape C, McCully R, Paul A, et al. Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). Mol Biosyst. 2016;13:92-105 pubmed
Shah P, Beverly L. Regulation of VCP/p97 demonstrates the critical balance between cell death and epithelial-mesenchymal transition (EMT) downstream of ER stress. Oncotarget. 2015;6:17725-37 pubmed
Kosakowska Cholody T, Lin J, Srideshikan S, Scheffer L, Tarasova N, Acharya J. HKH40A downregulates GRP78/BiP expression in cancer cells. Cell Death Dis. 2014;5:e1240 pubmed publisher
Stafa K, Trancikova A, Webber P, Glauser L, West A, Moore D. GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet. 2012;8:e1002526 pubmed publisher
product information
SKU :
3501S
Product-Name :
PDI (C81H6) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
57
Host :
Rabbit
Target :
PDI
Primary-Protein :
PDIA1
Alt-Names :
Cellular thyroid hormone-binding protein,DSI,ERBA2L,GIT,P4HB,P4Hbeta,PDI,PDIA1,PHDB,PO4DB,PO4HB,PROHB,Prolyl 4-hydroxylase subunit beta,Protein disulfide-isomerase,collagen prolyl 4-hydroxylase beta,glutathione-insulin transhydrogenase,p55,procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide,prolyl 4-hydroxylase, beta polypeptide,protein disulfide isomerase family A, member 1,protein disulfide isomerase-associated 1,protein disulfide isomerase/oxidoreductase,protocollagen hydroxylase,thyroid hormone-binding protein p55,v-erb-a avian erythroblastic leukemia viral oncogene homolog 2-like
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.