product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Bcl-2 (D17C4) Rabbit mAb (Mouse Preferred)
catalog :
3498
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D17C4
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5g
Lü Z, Liu H, Song N, Liang Y, Zhu J, Chen J, et al. METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1. Cell Death Dis. 2021;12:881 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Lee Y, Gil E, Jeong I, Kim H, Jang J, Choung Y. Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress. Cells. 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig s4c
Bhattarai K, Kim H, Chaudhary M, Ur Rashid M, Kim J, Kim H, et al. TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans. Redox Biol. 2021;47:102128 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3g
Zheleznyak A, Mixdorf M, Marsala L, Prior J, Yang X, Cui G, et al. Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways. Theranostics. 2021;11:7735-7754 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1l
Li S, Jin H, Sun G, Zhang C, Wang J, Xu H, et al. Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress. Front Pharmacol. 2021;12:634115 pubmed publisher
  • western blot; human; loading ...; fig 5b
  • western blot; mouse; 1:1000; loading ...; fig 5a
Bai Y, Pei W, Zhang X, Zheng H, Hua C, Min J, et al. ApoM is an important potential protective factor in the pathogenesis of primary liver cancer. J Cancer. 2021;12:4661-4671 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Park J, Kam T, Lee S, Park H, Oh Y, Kwon S, et al. Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:78 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7c
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, et al. Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development. Front Pharmacol. 2021;12:659597 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher
  • western blot; human; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 5b
Kim D, Park J, Choi H, Kim C, Bae E, Ma S, et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD. Cell Death Dis. 2021;12:320 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 7a
Zhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, et al. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging (Albany NY). 2020;12:5590-5611 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5c
  • western blot; mouse; loading ...; fig 1d
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Cui J, Duan J, Chu J, Guo C, Xi M, Li Y, et al. Chikusetsu saponin IVa protects pancreatic β cell against intermittent high glucose-induced injury by activating Wnt/β-catenin/TCF7L2 pathway. Aging (Albany NY). 2020;12:1591-1609 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Sul O, Rajasekaran M, Park H, Suh J, Choi H. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxid Med Cell Longev. 2019;2019:6018180 pubmed publisher
  • western blot; mouse; loading ...; fig s3d, s6c, s6f
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2h
Li H, Feng J, Zhang Y, Feng J, Wang Q, Zhao S, et al. Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3β-p53 signalling pathway. Redox Biol. 2019;20:261-274 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
LeBlanc L, Lee B, Yu A, Kim M, Kambhampati A, Dupont S, et al. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. elife. 2018;7: pubmed publisher
  • western blot; mouse; fig 1h
Zhao H, Pan W, Chen L, Luo Y, Xu R. Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation. J Mol Histol. 2018;49:599-613 pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Tan X, Banerjee P, Liu X, Yu J, Gibbons D, Wu P, et al. The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest. 2018;128:1267-1282 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4d
Cen M, Hu P, Cai Z, Fang T, Zhang J, Lu M. TIEG1 deficiency confers enhanced myocardial protection in the infarcted heart by mediating the Pten/Akt signalling pathway. Int J Mol Med. 2017;39:569-578 pubmed publisher
  • western blot; mouse; fig 1a
Su F, Myers V, Knezevic T, Wang J, Gao E, Madesh M, et al. Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury. JCI Insight. 2016;1:e90931 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5c
Li J, Chen K, Li S, Liu T, Wang F, Xia Y, et al. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS ONE. 2016;11:e0152570 pubmed publisher
  • western blot; mouse; fig 2
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  • western blot; mouse; fig 5
Antonucci L, Fagman J, Kim J, Todoric J, Gukovsky I, Mackey M, et al. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015;112:E6166-74 pubmed publisher
  • western blot; mouse; fig 2a
  • western blot; human; fig 2b
Bresin A, Callegari E, D Abundo L, Cattani C, Bassi C, Zagatti B, et al. miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model. Oncotarget. 2015;6:19807-18 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 6a
Chen W, Xu B, Xiao A, Liu L, Fang X, Liu R, et al. TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury. Mol Brain. 2015;8:11 pubmed publisher
  • western blot; mouse; 1:2000; fig 7
Tao W, Moore R, Smith E, Xu X. Hormonal induction and roles of Disabled-2 in lactation and involution. PLoS ONE. 2014;9:e110737 pubmed publisher
  • western blot; mouse
Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher
Shahbandi A, Rao S, Anderson A, Frey W, Olayiwola J, Ungerleider N, et al. BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer. Cell Death Differ. 2020;: pubmed publisher
Shin M, Yu J, Lee J, Ji Y, Joung H, Han Y, et al. A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and its Hepatoprotective Activity. Biomolecules. 2019;9: pubmed publisher
Shiozaki Y, Okamura K, Kohno S, Keenan A, Williams K, Zhao X, et al. The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP. J Biol Chem. 2018;293:17008-17020 pubmed publisher
Feng L, Vujicic S, Dietrich M, Litbarg N, Setty S, Antoni A, et al. Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis. J Biol Chem. 2018;293:10245-10263 pubmed publisher
Abdulrahman B, Abdelaziz D, Schatzl H. Autophagy regulates exosomal release of prions in neuronal cells. J Biol Chem. 2018;293:8956-8968 pubmed publisher
Li Y, Liang Y, Sang Y, Song X, Zhang H, Liu Y, et al. MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1. Cell Death Dis. 2018;9:14 pubmed publisher
Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, et al. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017;198:1066-1080 pubmed publisher
Weng X, Wang L, Chen H, Liu X, Qiu T, Chen Z. Ischemic postconditioning inhibits apoptosis in an in vitro proximal tubular cell model. Mol Med Rep. 2015;12:99-104 pubmed publisher
Sun H, Xu B, Chen W, Xiao A, Turlova E, Alibraham A, et al. Neuronal K(ATP) channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic-ischemic brain injury. Exp Neurol. 2015;263:161-71 pubmed publisher
Zhang C, Huang C, Tian Y, Li X. Polyol pathway exacerbated ischemia/reperfusion-induced injury in steatotic liver. Oxid Med Cell Longev. 2014;2014:963629 pubmed publisher
Fang F, Liu G, Zhou X, Yang S, Reich H, Williams V, et al. Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury. PLoS ONE. 2013;8:e71433 pubmed publisher
Baumgartner C, Yagita H, Malherbe L. A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. J Immunol. 2012;189:2309-17 pubmed publisher
product information
SKU :
3498S
Product-Name :
Bcl-2 (D17C4) Rabbit mAb (Mouse Preferred)
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Immunoprecipitation
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
26
Host :
Rabbit
Target :
Bcl-2
Primary-Protein :
Bcl-2
Alt-Names :
Apoptosis regulator Bcl-2,B-cell CLL/lymphoma 2,BCL2,Bcl-2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.