| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; loading ...; fig 1b
- western blot knockout validation; mouse; loading ...; fig 1a
| Filliol A, Piquet Pellorce C, Le Seyec J, Farooq M, Genet V, Lucas Clerc C, et al. RIPK1 protects from TNF-α-mediated liver damage during hepatitis. Cell Death Dis. 2016;7:e2462 pubmed publisher |
- western blot knockout validation; human; 1:1000; fig 3f
| Cuchet Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, CURTIS J, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018;361:810-813 pubmed publisher |
- western blot knockout validation; mouse; loading ...; fig 3c
| Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar A, et al. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A. 2017;114:11944-11949 pubmed publisher |
- western blot; human; loading ...; fig 2e
| Gao C, Deng J, Zhang H, Li X, Gu S, Zheng M, et al. HSPA13 facilitates NF-κB-mediated transcription and attenuates cell death responses in TNFα signaling. Sci Adv. 2021;7:eabh1756 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Zhu Y, Xie J, Shi J. Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis. BMC Biol. 2021;19:140 pubmed publisher |
- western blot; mouse; loading ...; fig 3c
| Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed publisher |
- western blot; mouse; loading ...
| Li X, Zhang M, Huang X, Liang W, Li G, Lu X, et al. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. 2020;11:6364 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig s3-1
- western blot; mouse; 1:1000; loading ...; fig 1c
| Li D, Ai Y, Guo J, Dong B, Li L, Cai G, et al. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. elife. 2020;9: pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4a, 4b
- western blot; human; loading ...; fig 5a, 5c
| Hu H, Wu G, Shu Z, Yu D, Nan N, Yuan F, et al. ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling. Front Cell Dev Biol. 2020;8:595253 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Zhou S, Zhang W, Cai G, Ding Y, Wei C, Li S, et al. Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Cell Res. 2020;30:1063-1077 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1a
| Alegre Cortés E, Muriel González A, Canales Cortés S, Uribe Carretero E, Martínez Chacón G, Aiastui A, et al. Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel). 2020;9: pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1a
- western blot; human; 1:1000; loading ...; fig 2i
- immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 3e
- western blot; mouse; 1:1000; loading ...; fig 3f
| Duan X, Liu X, Liu N, Huang Y, Jin Z, Zhang S, et al. Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation. Cell Death Dis. 2020;11:134 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2a, 3d
| Xie Y, Chen H, Luo D, Yang X, Yao J, Zhang C, et al. Inhibiting Necroptosis of Spermatogonial Stem Cell as a Novel Strategy for Male Fertility Preservation. Stem Cells Dev. 2020;29:475-487 pubmed publisher |
- western blot; mouse; loading ...; fig e4d, e4g
- western blot; human; loading ...; fig e5b
| Lalaoui N, Boyden S, Oda H, Wood G, Stone D, Chau D, et al. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020;577:103-108 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s1e
| Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, et al. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020;21:30-41 pubmed publisher |
- western blot; rat; loading ...; fig 7a
| Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, et al. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. Biomed Pharmacother. 2019;118:109188 pubmed publisher |
- western blot; mouse; loading ...; fig 3d
| Vredevoogd D, Kuilman T, Ligtenberg M, Boshuizen J, Stecker K, de Bruijn B, et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019;178:585-599.e15 pubmed publisher |
- western blot; mouse; 1:3000; loading ...; fig 5b
| Wang Z, Feng J, Yu J, Chen G. FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. J Cell Sci. 2019;132: pubmed publisher |
- western blot; mouse; loading ...; fig 3b
| Yang Z, Li C, Wang Y, Yang J, Yin Y, Liu M, et al. Melatonin attenuates chronic pain related myocardial ischemic susceptibility through inhibiting RIP3-MLKL/CaMKII dependent necroptosis. J Mol Cell Cardiol. 2018;125:185-194 pubmed publisher |
- western blot; mouse; loading ...; fig 2c
- western blot; human; loading ...; fig 4a
| Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, et al. Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A. 2018;115:E2001-E2009 pubmed publisher |
- immunoprecipitation; human; fig 5c
- western blot; human; fig 5c
| Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5c
| Button R, Roberts S, Willis T, Hanemann C, Luo S. Accumulation of autophagosomes confers cytotoxicity. J Biol Chem. 2017;292:13599-13614 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Franz S, Rennert P, Woznik M, Grützke J, Lüdde A, Arriero Pais E, et al. Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes. J Virol. 2017;91: pubmed publisher |
- immunoprecipitation; human; loading ...; fig 4b
- western blot; human; loading ...; fig 4b
- immunoprecipitation; rat; loading ...; fig 4c
- western blot; rat; loading ...; fig 4c
| Fettweis G, Di Valentin E, L homme L, Lassence C, Dequiedt F, Fillet M, et al. RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochim Biophys Acta Mol Cell Res. 2017;1864:113-124 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed |
- western blot; mouse; fig 1
| Lin J, Kumari S, Kim C, Van T, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124-128 pubmed publisher |
- western blot; mouse; loading ...; fig 6g
| Günther C, He G, Kremer A, Murphy J, Petrie E, Amann K, et al. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest. 2016;126:4346-4360 pubmed publisher |
- western blot; human; loading ...; fig 3f
| Choi Y, Shembade N, Parvatiyar K, Balachandran S, Harhaj E. TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS. Mol Cell Biol. 2017;37: pubmed publisher |
| Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
| Fan T, Warmoes M, Sun Q, Song H, Turchan Cholewo J, Martin J, et al. Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator ?-glucan in a two-case ex vivo non-small-cell lung cancer study. Cold Spring Harb Mol Case Stud. 2016;2:a000893 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Davis M, Delaney J, Patel C, Storgard R, Stupack D. Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings. Drug Des Devel Ther. 2016;10:1837-46 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1a
- western blot; human; loading ...; fig 1c
| Seifert L, Werba G, Tiwari S, Giao Ly N, Alothman S, Alqunaibit D, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532:245-9 pubmed publisher |
- immunoprecipitation; human; fig 5d
- western blot; human; 1:1000; fig 5d
| Ranjan K, Pathak C. FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016;6:22787 pubmed publisher |
- western blot; human; 1:1000; fig 7
| Button R, Vincent J, Strang C, Luo S. Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis. Oncotarget. 2016;7:5157-75 pubmed publisher |
- western blot; human; fig 10
- western blot; mouse; fig 1
| Wang S, Ni H, Dorko K, Kumer S, Schmitt T, Nawabi A, et al. Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury. Oncotarget. 2016;7:17681-98 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Chhibber Goel J, Coleman Vaughan C, Agrawal V, Sawhney N, Hickey E, Powell J, et al. γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling. J Biol Chem. 2016;291:5971-85 pubmed publisher |
- western blot; mouse; loading ...; fig 5k
| Vincendeau M, Hadian K, Messias A, Brenke J, Hålander J, Griesbach R, et al. Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Sci Rep. 2016;6:18934 pubmed publisher |
- western blot; mouse; fig 1b
| Deutsch M, Graffeo C, Rokosh R, Pansari M, Ochi A, Levie E, et al. Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury. Cell Death Dis. 2015;6:e1759 pubmed publisher |
| Hu H, Wu X, Wu G, Nan N, Zhang J, Zhu X, et al. RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif. Cell Death Differ. 2021;28:251-266 pubmed publisher |
| Matsuzawa Ishimoto Y, Shono Y, Gómez L, Hubbard Lucey V, Cammer M, Neil J, et al. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J Exp Med. 2017;214:3687-3705 pubmed publisher |
| Kerr M, Gomez G, Ferguson C, Tanzer M, Murphy J, Yap A, et al. Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis. Nat Commun. 2017;8:14729 pubmed publisher |
| Pollock G, Oates C, Giogha C, Wong Fok Lung T, Ong S, Pearson J, et al. Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli. Infect Immun. 2017;85: pubmed publisher |
| Wang Y, Chang J, Liu X, Zhang X, Zhang S, Zhang X, et al. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY). 2016;8:2915-2926 pubmed publisher |
| Afonso M, Rodrigues P, Simão A, Ofengeim D, Carvalho T, Amaral J, et al. Activation of necroptosis in human and experimental cholestasis. Cell Death Dis. 2016;7:e2390 pubmed publisher |
| Guo X, Yin H, Chen Y, Li L, Li J, Liu Q. TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints. Cell Death Dis. 2016;7:e2381 pubmed publisher |
| Bullova P, Cougnoux A, Abunimer L, Kopacek J, Pastorekova S, Pacak K. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models. Oncotarget. 2016;7:40531-40545 pubmed publisher |
| Zhao M, Lu L, Lei S, Chai H, Wu S, Tang X, et al. Inhibition of Receptor Interacting Protein Kinases Attenuates Cardiomyocyte Hypertrophy Induced by Palmitic Acid. Oxid Med Cell Longev. 2016;2016:1451676 pubmed publisher |
| Zilberman Rudenko J, Shawver L, Wessel A, Luo Y, Pelletier M, Tsai W, et al. Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:1612-7 pubmed publisher |
| Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher |
| Nisar R, Hanson P, He L, Taylor R, Blain P, Morris C. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015;89:1811-25 pubmed publisher |
| McCabe K, Bacos K, Lu D, Delaney J, Axelrod J, Potter M, et al. Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. Cell Death Dis. 2014;5:e1496 pubmed publisher |
| Gao S, Andreeva K, Cooper N. Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway. Mol Vis. 2014;20:1374-87 pubmed |
| Hussain S, Sangtian S, Anderson S, Snyder R, Marshburn J, Rice A, et al. Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts. Part Fibre Toxicol. 2014;11:28 pubmed publisher |
| Whilding L, Archibald K, Kulbe H, Balkwill F, Oberg D, McNeish I. Vaccinia virus induces programmed necrosis in ovarian cancer cells. Mol Ther. 2013;21:2074-86 pubmed publisher |
| Bai J, Lei P, Zhang J, Zhao C, Liang R. Sulfite exposure-induced hepatocyte death is not associated with alterations in p53 protein expression. Toxicology. 2013;312:142-8 pubmed publisher |
| van Raam B, Ehrnhoefer D, Hayden M, Salvesen G. Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. Cell Death Differ. 2013;20:86-96 pubmed publisher |
