| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 3g
| Zhang S, Liang S, Wu D, Guo H, Ma K, Liu L. LncRNA coordinates Hippo and mTORC1 pathway activation in cancer. Cell Death Dis. 2021;12:822 pubmed publisher |
- western blot; human; loading ...
| Zhang Y, He L, Huang L, Yao S, Lin N, Li P, et al. Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway. Clin Transl Med. 2021;11:e503 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s1b, s3a
| Xu X, Shen X, Wang J, Feng W, Wang M, Miao X, et al. YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling. Aging Cell. 2021;20:e13465 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Zheng Z, Li C, Shao G, Li J, Xu K, Zhao Z, et al. Hippo-YAP/MCP-1 mediated tubular maladaptive repair promote inflammation in renal failed recovery after ischemic AKI. Cell Death Dis. 2021;12:754 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4g
| Chi X, Luo W, Song J, Li B, Su T, Yu M, et al. Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice. Cell Death Dis. 2021;12:604 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a
| Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, et al. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021;131: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5c
| Seo G, Han H, Vargas R, Yang B, Li X, Wang W. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Cell Rep. 2020;32:107860 pubmed publisher |
- western blot; human; loading ...; fig 4d
| Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, et al. The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Theranostics. 2020;10:4422-4436 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Choi S, Bae H, Jeong S, Park I, Cho H, Hong S, et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020;11:519 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Escoll M, Lastra D, Pajares M, Robledinos Antón N, Rojo A, Fernández Ginés R, et al. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Redox Biol. 2020;30:101425 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3b, 3j
| Park M, Kim A, Manandhar S, Oh S, Jang G, Kang L, et al. CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity. elife. 2019;8: pubmed publisher |
- western blot; human; loading ...; fig 1f
| Rausch V, Bostrom J, Park J, Bravo I, Feng Y, Hay D, et al. The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Curr Biol. 2019;29:242-255.e6 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Pan W, Moroishi T, Koo J, Guan K. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019;38:2595-2610 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 7a
| Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton B, et al. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018;9:2269 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher |
- immunocytochemistry; human; 1:600; loading ...; fig 5b
- western blot; human; 1:1000; loading ...; fig 5c
| Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. J Cell Sci. 2018;131: pubmed publisher |
- western blot; human; 1:500; fig 3b
| Zheng X, Dong Q, Zhang X, Han Q, Han X, Han Y, et al. The coiled-coil domain of oncogene RASSF 7 inhibits hippo signaling and promotes non-small cell lung cancer. Oncotarget. 2017;8:78734-78748 pubmed publisher |
- western blot; human; loading ...; fig 8c
| Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 1a
| Yamanishi E, Hasegawa K, Fujita K, Ichinose S, Yagishita S, Murata M, et al. A novel form of necrosis, TRIAD, occurs in human Huntington's disease. Acta Neuropathol Commun. 2017;5:19 pubmed publisher |
- western blot; human; loading ...; fig 2g
| Heidary Arash E, Shiban A, Song S, Attisano L. MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. EMBO Rep. 2017;18:420-436 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Chorzalska A, Kim J, Roder K, Tepper A, Ahsan N, Rao R, et al. Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia. Stem Cells Dev. 2017;26:656-677 pubmed publisher |
- western blot; mouse; 1:1000
- western blot; human; 1:1000; loading ...; fig 1b, 4d,ED1f
| Britschgi A, Duss S, Kim S, Couto J, Brinkhaus H, Koren S, et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature. 2017;541:541-545 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a
| Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed publisher |
- western blot; mouse; fig 1a
| Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher |
- western blot; human; loading ...; fig 4
| Galoian K, Luo S, Qureshi A, Patel P, Price R, Morse A, et al. Effect of cytostatic proline rich polypeptide-1 on tumor suppressors of inflammation pathway signaling in chondrosarcoma. Mol Clin Oncol. 2016;5:618-624 pubmed |
- western blot; mouse; fig 1
- western blot; human; fig 6
| Boro M, Singh V, Balaji K. Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses. Sci Rep. 2016;6:37695 pubmed publisher |
- western blot; mouse; 1:200; fig 4
- western blot; human; 1:200; fig 4
| Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed publisher |
- western blot; mouse; 1:1000; fig s3
| Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher |
- western blot; mouse; loading ...; fig 4b
- western blot; human; loading ...; fig 4a
| Sayedyahossein S, Li Z, Hedman A, Morgan C, Sacks D. IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity. J Biol Chem. 2016;291:19261-73 pubmed publisher |
- western blot; human; fig 2f
| Thongon N, Castiglioni I, Zucal C, Latorre E, D Agostino V, Bauer I, et al. The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level. Oncotarget. 2016;7:26551-66 pubmed publisher |
- western blot; human; fig 5
| Dai X, Zhuang L, Wang D, Zhou T, Chang L, Gai R, et al. Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells. Oncotarget. 2016;7:6933-47 pubmed publisher |
- western blot; mouse; fig 4
| Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, et al. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016;113:E71-80 pubmed publisher |
- western blot; human; 1:2000; fig 1
| Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Iglesias Bartolomé R, Torres D, Marone R, Feng X, Martin D, Simaan M, et al. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015;17:793-803 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher |
- immunoprecipitation; mouse; 1:300-1:600; fig 5
| Imajo M, Ebisuya M, Nishida E. Dual role of YAP and TAZ in renewal of the intestinal epithelium. Nat Cell Biol. 2015;17:7-19 pubmed publisher |
- western blot; mouse; fig 8
| Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher |
| Boin A, Couvelard A, Couderc C, Brito I, Filipescu D, Kalamarides M, et al. Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas. Neuro Oncol. 2014;16:1196-209 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Tumaneng K, Schlegelmilch K, Russell R, Yimlamai D, Basnet H, Mahadevan N, et al. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nat Cell Biol. 2012;14:1322-9 pubmed |
| Ito T, Nakamura A, Tanaka I, Tsuboi Y, Morikawa T, Nakajima J, et al. CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. Cancer Sci. 2019;110:2284-2295 pubmed publisher |
| Gill M, Christova T, Zhang Y, Gregorieff A, Zhang L, Narimatsu M, et al. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nat Commun. 2018;9:3510 pubmed publisher |
| Elosegui Artola A, Andreu I, Beedle A, Lezamiz A, Uroz M, Kosmalska A, et al. Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell. 2017;171:1397-1410.e14 pubmed publisher |
| Kim Y, Choe S, Cho K, Cho D, Kang J, Park C, et al. Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis. Exp Mol Med. 2017;49:e296 pubmed publisher |
| Taniguchi K, Moroishi T, de Jong P, Krawczyk M, Grebbin B, Luo H, et al. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:1643-1648 pubmed publisher |
| Jagannathan R, Schimizzi G, Zhang K, Loza A, Yabuta N, Nojima H, et al. AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol. Mol Cell Biol. 2016;36:2526-42 pubmed publisher |
| Gruber R, Panayiotou R, Nye E, Spencer Dene B, Stamp G, Behrens A. YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. Gastroenterology. 2016;151:526-39 pubmed publisher |
| Fesquet D, de Bettignies G, Bellis M, Espeut J, Devault A. Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites. PLoS ONE. 2015;10:e0117857 pubmed publisher |
| Zhi X, Zhao D, Zhou Z, Liu R, Chen C. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. Am J Pathol. 2012;180:2452-61 pubmed publisher |
| Habbig S, Bartram M, Müller R, Schwarz R, Andriopoulos N, Chen S, et al. NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol. 2011;193:633-42 pubmed publisher |
| Lu L, Li Y, Kim S, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010;107:1437-42 pubmed publisher |
