| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; fig 1
- western blot knockout validation; mouse; fig 4
- immunohistochemistry - frozen section; mouse; fig 1
| Tsuchiya Y, Minami Y, Umemura Y, Watanabe H, Ono D, Nakamura W, et al. Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse. Genes Cells. 2015;20:992-1005 pubmed publisher |
- western blot knockout validation; mouse; 1:500; loading ...; fig 1s1a
- immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1s1b
| Lavery L, Ure K, Wan Y, Luo C, Trostle A, Wang W, et al. Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome. elife. 2020;9: pubmed publisher |
- western blot knockout validation; human; loading ...; fig 1e
- immunocytochemistry; human; loading ...; fig 1h
| Bu Q, Wang A, Hamzah H, Waldman A, Jiang K, Dong Q, et al. CREB Signaling Is Involved in Rett Syndrome Pathogenesis. J Neurosci. 2017;37:3671-3685 pubmed publisher |
- immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 4g
| Matagne V, Ehinger Y, Saidi L, Borges Correia A, Barkats M, Bartoli M, et al. A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome. Neurobiol Dis. 2017;99:1-11 pubmed publisher |
- immunohistochemistry knockout validation; mouse; fig 1
- immunohistochemistry - free floating section; mouse; fig 1
| Meng X, Wang W, Lu H, He L, Chen W, Chao E, et al. Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. elife. 2016;5: pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:150; loading ...; fig 1b
- western blot; mouse; 1:2000; loading ...; fig 6a
| Villani C, Carli M, Castaldo A, Sacchetti G, Invernizzi R. Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin. Sci Rep. 2021;11:14690 pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 5a
| Uchida K, Hasuoka K, Fuse T, Kobayashi K, Moriya T, Suzuki M, et al. Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period. Sci Rep. 2021;11:6723 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 1a
| Zhang Y, Zhu Y, Cao S, Sun P, Yang J, Xia Y, et al. MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning. elife. 2020;9: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a
| Fukuoka M, Takahashi M, Fujita H, Chiyo T, Popiel H, Watanabe S, et al. Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain. Mol Ther Nucleic Acids. 2018;11:79-90 pubmed publisher |
- chromatin immunoprecipitation; mouse; fig 6f
| Ka M, Kim W. ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway. Neurobiol Dis. 2018;111:138-152 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Maphis N, Jiang S, Binder J, Wright C, Gopalan B, Lamb B, et al. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Front Mol Neurosci. 2017;10:69 pubmed publisher |
- immunohistochemistry; mouse; 1:200
| Ure K, Lu H, Wang W, Ito Ishida A, Wu Z, He L, et al. Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. elife. 2016;5: pubmed publisher |
- chromatin immunoprecipitation; human; loading ...; fig 4e
- immunoprecipitation; human; loading ...; fig 4b
- western blot; human; loading ...; fig 4a
| Xu M, Bian S, Li J, He J, Chen H, Ge L, et al. MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells. Oncotarget. 2016;7:14476-85 pubmed publisher |
- immunoprecipitation; mouse; fig 2
- western blot; mouse; 1:10,000; fig 2
| Tai D, Liu Y, Hsu W, Ma Y, Cheng S, Liu S, et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016;7:10552 pubmed publisher |
- immunocytochemistry; mouse; 1:500; fig 3
| Kishi N, MacDonald J, Ye J, Molyneaux B, Azim E, Macklis J. Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice. Nat Commun. 2016;7:10520 pubmed publisher |
- immunohistochemistry; African green monkey; fig 1
- western blot; African green monkey; fig 1
| Liu Z, Li X, Zhang J, Cai Y, Cheng T, Cheng C, et al. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature. 2016;530:98-102 pubmed publisher |
- western blot; mouse; fig 1c
| Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, et al. MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms. PLoS ONE. 2015;10:e0130183 pubmed publisher |
- immunohistochemistry; mouse; 1:200; fig 1
| Bedogni F, Cobolli Gigli C, Pozzi D, Rossi R, Scaramuzza L, Rossetti G, et al. Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016;26:2517-2529 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:500; fig 2
- western blot; mouse; 1:1000; fig 2
| Zhang R, Huang M, Cao Z, Qi J, Qiu Z, Chiang L. MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol Pain. 2015;11:19 pubmed publisher |
- western blot; mouse; 1:1000
| Subbanna S, Nagre N, Shivakumar M, Umapathy N, Psychoyos D, Basavarajappa B. Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. Neuroscience. 2014;258:422-32 pubmed publisher |
| Arora S, Saini S, Fukuhara S, Majid S, Shahryari V, Yamamura S, et al. MicroRNA-4723 inhibits prostate cancer growth through inactivation of the Abelson family of nonreceptor protein tyrosine kinases. PLoS ONE. 2013;8:e78023 pubmed publisher |
- western blot; human; 1:1000
| Cheng J, Huang M, Zhu Y, Xin Y, Zhao Y, Huang J, et al. SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development. J Neurochem. 2014;128:798-806 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Ma P, Pan H, Montgomery R, Olson E, Schultz R. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proc Natl Acad Sci U S A. 2012;109:E481-9 pubmed publisher |
| Mellén M, Ayata P, Heintz N. 5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes. Proc Natl Acad Sci U S A. 2017;114:E7812-E7821 pubmed publisher |
| Pandey S, Simmons G, Malyarchuk S, Calhoun T, Pruitt K. A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1. Genes Cancer. 2015;6:408-21 pubmed |
| Sadegh M, Ekman M, Krawczyk K, Svensson D, Göransson O, Dahan D, et al. Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. PLoS ONE. 2015;10:e0116784 pubmed publisher |
| Hess Homeier D, Fan C, Gupta T, Chiang A, Certel S. Astrocyte-specific regulation of hMeCP2 expression in Drosophila. Biol Open. 2014;3:1011-9 pubmed publisher |
| Heckman L, Chahrour M, Zoghbi H. Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice. elife. 2014;3: pubmed publisher |
| Lang M, Wither R, Colic S, Wu C, Monnier P, Bardakjian B, et al. Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation. Hum Mol Genet. 2014;23:303-18 pubmed publisher |
| Wither R, Lang M, Zhang L, Eubanks J. Regional MeCP2 expression levels in the female MeCP2-deficient mouse brain correlate with specific behavioral impairments. Exp Neurol. 2013;239:49-59 pubmed publisher |
| Zocchi L, Sassone Corsi P. SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression. Epigenetics. 2012;7:695-700 pubmed publisher |
| Bihaqi S, Zawia N. Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro. Curr Alzheimer Res. 2012;9:555-62 pubmed |
| Brendel C, Belakhov V, Werner H, Wegener E, Gartner J, Nudelman I, et al. Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model. J Mol Med (Berl). 2011;89:389-98 pubmed publisher |
