product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-DRP1 (Ser616) Antibody
catalog :
3455
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 7c
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, et al. Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease. Nat Commun. 2021;12:5305 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5c
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1b
Park G, Lee J, Han H, An H, Jin Z, Jeong E, et al. Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death Dis. 2021;12:445 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2e
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 2b
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
  • western blot; rat; loading ...; fig 2b
Zhuan B, Wang X, Wang M, Li Z, Yuan Q, Xie J, et al. Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress. Aging (Albany NY). 2020;12:23684-23697 pubmed publisher
  • western blot; human; fig 5a
Okur M, Fang E, Fivenson E, Tiwari V, Croteau D, Bohr V. Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling. Aging Cell. 2020;19:e13268 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher
  • western blot; rat; loading ...; fig 7a
Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, et al. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. Biomed Pharmacother. 2019;118:109188 pubmed publisher
  • western blot; human; loading ...; fig 4a, 8a
Zheng J, Croteau D, Bohr V, Akbari M. Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. Nucleic Acids Res. 2019;: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5e
Yeshaw W, van der Zwaag M, Pinto F, Lahaye L, Faber A, Gómez Sánchez R, et al. Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
  • immunocytochemistry; pigs ; 1:1000; loading ...; fig 5d
Li H, Feng J, Zhang Y, Feng J, Wang Q, Zhao S, et al. Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3β-p53 signalling pathway. Redox Biol. 2019;20:261-274 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7a
De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui A, Saha S, et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. J Biol Chem. 2018;293:19740-19760 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6e
Velázquez Villegas L, Perino A, Lemos V, Zietak M, Nomura M, Pols T, et al. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nat Commun. 2018;9:245 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Zhao Y, Tian J, Sui S, Yuan X, Chen H, Qu C, et al. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Sci Rep. 2017;7:7169 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 7a
Merdzo I, Rutkai I, Sure V, McNulty C, Katakam P, Busija D. Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes. J Vasc Res. 2017;54:1-12 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Upadhyay M, Agarwal S, Bhadauriya P, Ganesh S. Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models. Neurobiol Dis. 2017;100:39-51 pubmed publisher
  • western blot; human; loading ...; fig 6a
Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed publisher
  • flow cytometry; human; fig 4
Jung J, Ravi S, Lee D, McFadden K, Kamradt M, Toussaint L, et al. NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion. Curr Biol. 2016;26:3288-3302 pubmed publisher
  • western blot; human; loading ...; fig sf3
Lee J, Westrate L, Wu H, Page C, Voeltz G. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016;540:139-143 pubmed publisher
  • western blot; human; loading ...; fig 3d
Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, et al. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Mol Med. 2016;8:1019-38 pubmed publisher
  • immunohistochemistry; mouse; fig 3
  • western blot; mouse; fig 3
Kim H, Lee J, Park K, Kim W, Roh G. A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death. BMC Neurosci. 2016;17:33 pubmed publisher
  • western blot; mouse; 1:800; fig 4
Kumari S, Mehta S, Milledge G, Huang X, Li H, Li P. Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening. Int J Biol Sci. 2016;12:688-700 pubmed publisher
  • western blot; human; loading ...; fig 1c
Swiader A, Nahapetyan H, Faccini J, D Angelo R, Mucher E, Elbaz M, et al. Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Oncotarget. 2016;7:28821-35 pubmed publisher
  • western blot; mouse; 1:1000; fig 5b
Prieto J, León M, Ponsoda X, Sendra R, Bort R, Ferrer Lorente R, et al. Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nat Commun. 2016;7:11124 pubmed publisher
  • western blot; mouse; fig s2
Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
Laker R, Drake J, Wilson R, Lira V, Lewellen B, Ryall K, et al. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun. 2017;8:548 pubmed publisher
Monterisi S, Lobo M, Livie C, Castle J, Weinberger M, Baillie G, et al. PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. elife. 2017;6: pubmed publisher
Qiao A, Jin X, Pang J, Moskophidis D, Mivechi N. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017;216:723-741 pubmed publisher
Saito K, Asai T, Fujiwara K, Sahara J, Koguchi H, Fukuda N, et al. Tumor-selective mitochondrial network collapse induced by atmospheric gas plasma-activated medium. Oncotarget. 2016;7:19910-27 pubmed publisher
product information
SKU :
3455S
Product-Name :
Phospho-DRP1 (Ser616) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, (M, R, Mk)
Applications :
Flow cytometry
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
78-82
Host :
Rabbit
Target :
DRP1 (Ser616) phosphate
Primary-Protein :
DRP1
Alt-Names :
DLP1,DNM1L,DRP1,DVLP,DYNIV-11,Dnm1p/Vps1p-like protein,Dymple,Dynamin family member proline-rich carboxyl-terminal domain less,Dynamin-1-like protein,Dynamin-like protein,Dynamin-like protein 4,Dynamin-like protein IV,Dynamin-related protein 1,FLJ41912,HdynIV,VPS1,dynamin 1-like
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.