| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry; mouse; loading ...; fig 1d
| Lee Y, Gil E, Jeong I, Kim H, Jang J, Choung Y. Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress. Cells. 2021;10: pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Yan M, Wang Z, Xia T, Jin S, Liu Y, Hu H, et al. Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice. Biomedicines. 2021;9: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s2b
| Xu L, Zhang X, Xin Y, Ma J, Yang C, Zhang X, et al. Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. Cell Death Dis. 2021;12:710 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 1b
| Cho J, Lee J, Kim H, Lee H, Fang Z, Kwon H, et al. Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants (Basel). 2021;10: pubmed publisher |
- western blot; human; loading ...; fig 2f
| Ko P, Choi J, Song S, Keum S, Jeong J, Hwang Y, et al. Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; human; loading ...; fig 2f
| Prater M, Hamilton R, Wa Yung H, Sharkey A, Robson P, Abd Hamid N, et al. RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition. Biol Open. 2021;10: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3a
| Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2a
| Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 3g
- western blot; human; 1:1000; loading ...; fig 5d
| Ruan H, Li X, Xu X, Leibowitz B, Tong J, Chen L, et al. eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. elife. 2020;9: pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 2f
- western blot; human; 1:500; loading ...; fig s6
| von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher |
- western blot; human; loading ...; fig 4e
| Xu Y, Fulciniti M, Samur M, Ho M, Deng S, Liu L, et al. YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood. 2020;136:468-479 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4g
| Guo X, Aviles G, Liu Y, Tian R, Unger B, Lin Y, et al. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020;579:427-432 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2b, 3a
| Chen Z, Zhang J, Xue H, Qian M, Guo X, Gao X, et al. Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition. Integr Cancer Ther. 2020;19:1534735419900927 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7c
| Arc Chagnaud C, Py G, Fovet T, Roumanille R, Demangel R, Pagano A, et al. Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning. Front Physiol. 2020;11:71 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Garshott D, Sundaramoorthy E, Leonard M, Bennett E. Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. elife. 2020;9: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2b
| Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher |
- western blot; mouse; loading ...; fig s7a
| Wang W, Wang J, Lin W, Kao C, Hung M, Teng Y, et al. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020;19:e13090 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1f
- western blot; human; 1:1000; loading ...; fig 1g
| Zhu P, Khatiwada S, Cui Y, Reineke L, Dooling S, Kim J, et al. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019;366:843-849 pubmed publisher |
- western blot; rat; loading ...; fig 3a
| Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, et al. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. Biomed Pharmacother. 2019;118:109188 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5f
| Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher |
- western blot; mouse; loading ...; fig 1h
| Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher |
- western blot; mouse; loading ...; fig 6d
| Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3b
| Wong Y, Lebon L, Basso A, Kohlhaas K, Nikkel A, Robb H, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3b
| Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed publisher |
- western blot; human; loading ...; fig 3b
| Liu R, Moss B. Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified Antagonist of the Type I Interferon-Induced Antiviral State. J Virol. 2018;92: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s5c
| Nguyen A, Prado M, Schmidt P, Sendamarai A, Wilson Grady J, Min M, et al. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017;357: pubmed publisher |
- western blot; human; 1:3000; loading ...; fig 5a
| Xu X, Cui Y, Cao L, Zhang Y, Yin Y, Hu X. PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways. Exp Ther Med. 2017;13:1993-1999 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Potes Y, de Luxán Delgado B, Rodríguez González S, Guimarães M, Solano J, Fernández Fernández M, et al. Overweight in elderly people induces impaired autophagy in skeletal muscle. Free Radic Biol Med. 2017;110:31-41 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7a
| King B, Hershkowitz D, Eisenhauer P, Weir M, Ziegler C, Russo J, et al. A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). J Virol. 2017;91: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1c
| Biever A, Boubaker Vitre J, Cutando L, Gracia Rubio I, Costa Mattioli M, Puighermanal E, et al. Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum. Front Mol Neurosci. 2016;9:165 pubmed publisher |
- western blot; mouse; loading ...; fig 4d
| Newberry E, Xie Y, Kennedy S, Graham M, Crooke R, Jiang H, et al. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice. Hepatology. 2017;65:836-852 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1b
| Khoutorsky A, Sorge R, Prager Khoutorsky M, Pawlowski S, Longo G, Jafarnejad S, et al. eIF2? phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016;113:11949-11954 pubmed |
- western blot; human; loading ...; fig 4b
| Wang C, Zhang F, Cao Y, Zhang M, Wang A, Xu M, et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep. 2016;6:34330 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Yang Z, Tsuchiya H, Zhang Y, Lee S, Liu C, Huang Y, et al. REV-ERB? Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. Am J Pathol. 2016;186:2909-2920 pubmed publisher |
- western blot; mouse; fig 5
| Taniuchi S, Miyake M, Tsugawa K, Oyadomari M, Oyadomari S. Integrated stress response of vertebrates is regulated by four eIF2? kinases. Sci Rep. 2016;6:32886 pubmed publisher |
- western blot; rat; 1:500; fig 2a
| Wu J, Hu G, Lu Y, Zheng J, Chen J, Wang X, et al. Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein ?-CCAAT-enhancer-binding protein ? activation. Int J Biochem Cell Biol. 2016;79:181-193 pubmed publisher |
- western blot; human; fig 2b
| Boß M, Newbatt Y, Gupta S, Collins I, Brüne B, Namgaladze D. AMPK-independent inhibition of human macrophage ER stress response by AICAR. Sci Rep. 2016;6:32111 pubmed publisher |
- western blot; human; loading ...; fig 6c
| Mihailidou C, Panagiotou C, Kiaris H, Kassi E, Moutsatsou P. Crosstalk between C/EBP homologous protein (CHOP) and glucocorticoid receptor in lung cancer. Mol Cell Endocrinol. 2016;436:211-23 pubmed publisher |
- western blot; human; fig 4A
| Zhang M, Qi Y, Li H, Cui J, Dai L, Frank J, et al. AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 ? and IL-18. Oncoimmunology. 2016;5:e1160182 pubmed publisher |
- western blot; human; fig 8
| Liu R, Moss B. Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants. J Virol. 2016;90:7864-79 pubmed publisher |
- western blot; mouse; fig 3
| Berthoud V, Minogue P, Lambert P, Snabb J, Beyer E. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem. 2016;291:17569-78 pubmed publisher |
- western blot; mouse; 1:1000; fig s3
| Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher |
- immunohistochemistry; mouse; 1:250; fig 2
| Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, et al. Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9. Sci Rep. 2016;6:27354 pubmed publisher |
- western blot; human; fig 1a
| Chaveroux C, Sarcinelli C, Barbet V, Belfeki S, Barthelaix A, Ferraro Peyret C, et al. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. Sci Rep. 2016;6:27278 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield P, et al. Neuronal human BACE1 knockin induces systemic diabetes in mice. Diabetologia. 2016;59:1513-1523 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Rodriguez Ortiz C, Flores J, Valenzuela J, Rodriguez G, Zumkehr J, Tran D, et al. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016;186:1623-34 pubmed publisher |
- flow cytometry; mouse; 2 ug/ml; fig s1
| Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed publisher |
- western blot; human; fig 4
| Lyabin D, Ovchinnikov L. Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein. Sci Rep. 2016;6:22502 pubmed publisher |
- western blot; human; fig 1
| Sieber J, Hauer C, Bhuvanagiri M, Leicht S, Krijgsveld J, Neu Yilik G, et al. Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay. Mol Cell Proteomics. 2016;15:1584-97 pubmed publisher |
- western blot; mouse; loading ...; fig s2
| Liao K, Guo M, Niu F, Yang L, Callen S, Buch S. Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. J Neuroinflammation. 2016;13:33 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Baer A, Lundberg L, Swales D, Waybright N, Pinkham C, Dinman J, et al. Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. J Virol. 2016;90:3558-72 pubmed publisher |
- western blot; human; fig 4
- western blot; mouse; fig 4
| Yuen K, Xu B, Krantz I, Gerton J. NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Cell Rep. 2016;14:93-102 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Palam L, Gore J, Craven K, Wilson J, Korc M. Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma. Cell Death Dis. 2015;6:e1913 pubmed publisher |
- western blot; human; fig 4
| Wang J, Ma L, Tang X, Zhang X, Qiao Y, Shi Y, et al. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. 2015;6:24075-91 pubmed |
- western blot; mouse; fig f6
| Chung J, Bauer D, Ghamari A, Nizzi C, Deck K, Kingsley P, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015;8:ra34 pubmed publisher |
- western blot; mouse; 1:2000; fig 8
| Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, et al. A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Nat Commun. 2015;6:6693 pubmed publisher |
- western blot; human; fig 2
| Burgess H, Mohr I. Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses. Cell Host Microbe. 2015;17:332-344 pubmed publisher |
| Wang S, Chen X, Hu J, Jiang J, Li Y, Chan Salis K, et al. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015;14:877-88 pubmed publisher |
- western blot; human; fig 2
| Lin Y, Zhang H, Liang J, Li K, Zhu W, Fu L, et al. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-12 pubmed publisher |
- western blot; mouse; 1:1000
| Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed publisher |
- western blot; mouse; 1:1000
| Devi L, Ohno M. PERK mediates eIF2? phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiol Aging. 2014;35:2272-81 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Tape C, Norrie I, Worboys J, Lim L, Lauffenburger D, Jørgensen C. Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture. Mol Cell Proteomics. 2014;13:1866-76 pubmed publisher |
| Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2? phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher |
- western blot; mouse; 1:1000
| Devi L, Ohno M. Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher |
- western blot; rat; 1:1,000
| Hernandez A, Colvin E, Chen Y, Geiss S, Eller L, Fueger P. Upregulation of p21 activates the intrinsic apoptotic pathway in ?-cells. Am J Physiol Endocrinol Metab. 2013;304:E1281-90 pubmed publisher |
| Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, et al. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circ Res. 2017;121:1331-1345 pubmed publisher |
| Tsuyama T, Tsubouchi A, Usui T, Imamura H, Uemura T. Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation. J Cell Biol. 2017;216:815-834 pubmed publisher |
| Diamanti M, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski A, et al. IKK? controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med. 2017;214:423-437 pubmed publisher |
| Wang Z, Xiong F, Xie X, Chen D, Pan J, Cheng L. Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrol. 2015;16:44 pubmed publisher |
| Gao X, Wan J, Liu B, Ma M, Shen B, Qian S. Quantitative profiling of initiating ribosomes in vivo. Nat Methods. 2015;12:147-53 pubmed publisher |
| Blumenthal G, Gills J, Ballas M, Bernstein W, Komiya T, Dechowdhury R, et al. A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors. Oncotarget. 2014;5:8161-72 pubmed |
| Soderquist R, Danilov A, Eastman A. Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. J Biol Chem. 2014;289:16190-9 pubmed publisher |
| B chir W, Chaveroux C, Carraro V, Averous J, Maurin A, Jousse C, et al. Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation. Cell Signal. 2014;26:1385-91 pubmed publisher |
| Guo X, Dong Y, Yin S, Zhao C, Huo Y, Fan L, et al. Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation. Cell Death Dis. 2013;4:e822 pubmed publisher |
| Soderquist R, Pletnev A, Danilov A, Eastman A. The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis. 2014;19:201-9 pubmed publisher |
| Fujiki K, Inamura H, Matsuoka M. PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium. Arch Toxicol. 2014;88:403-14 pubmed publisher |
| Devi L, Alldred M, Ginsberg S, Ohno M. Mechanisms underlying insulin deficiency-induced acceleration of ?-amyloidosis in a mouse model of Alzheimer's disease. PLoS ONE. 2012;7:e32792 pubmed publisher |
| Devi L, Alldred M, Ginsberg S, Ohno M. Sex- and brain region-specific acceleration of ?-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease. Mol Brain. 2010;3:34 pubmed publisher |
