SHP-2 (D50F2) Rabbit mAb | Cell Signaling Technology 3397 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

SHP-2 (D50F2) Rabbit mAb

catalog :

3397

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

D50F2

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay, other, immunohistochemistry knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:200; loading ...; fig s2a immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig s2a, s2d immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s1a western blot; human	Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
western blot; human; 1:500; loading ...; fig 5d	Vemulapalli V, Chylek L, Erickson A, Pfeiffer A, Gabriel K, LaRochelle J, et al. Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. elife. 2021;10: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s9a western blot; human; 1:1000; loading ...; fig s2f	Wang Y, Mohseni M, Grauel A, Diez J, Guan W, Liang S, et al. SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms. Sci Rep. 2021;11:1399 pubmed publisher
western blot; human; 1:1000; loading ...	Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
western blot; mouse; loading ...; fig s5d	Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
western blot; mouse; 1:1000; fig 6a	Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, et al. CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget. 2016;7:63730-63746 pubmed publisher
western blot; mouse; loading ...; fig 2f	Zhu L, Luo T, Xu X, Guo Y, Zhao X, Wang T, et al. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. J Exp Med. 2016;213:1555-70 pubmed publisher
western blot; mouse; 1:1000; fig 1	Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
other; mouse; loading ...; fig 6g proximity ligation assay; mouse; loading ...; fig 6j western blot; human; 1:1000; loading ...; fig S6a	Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher
western blot; human	Zhou X, Wang H, Burg M, Ferraris J. High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1. Am J Physiol Renal Physiol. 2013;305:F362-9 pubmed publisher
	Zheng J, Umikawa M, Cui C, Li J, Chen X, Zhang C, et al. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature. 2012;485:656-60 pubmed publisher

product information

SKU :

3397S

Product-Name :

SHP-2 (D50F2) Rabbit mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Immunoprecipitation

Product-Category :

MAP Kinase Signaling

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

SHP-2

Primary-Protein :

SHP-2

Alt-Names :

BPTP3,CFC,MGC14433,NS1,PTN11,PTP-1D,PTP-2C,PTP2C,PTPN11,Protein-tyrosine phosphatase 1D,Protein-tyrosine phosphatase 2C,SH-PTP2,SH-PTP3,SHP-2,SHPTP2,Shp2,Tyrosine-protein phosphatase non-receptor type 11,protein tyrosine phosphatase, non-receptor type 11,protein tyrosine phosphatase-2

more info or order :

Cell Signaling Technology product webpage