product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
GCN5L2 (C26A10) Rabbit mAb
catalog :
3305
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C26A10
reactivity :
human, mouse, rat, bovine
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - free floating section, other
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3g
Feng L, Chen M, Li Y, Li M, Hu S, Zhou B, et al. Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. Cell Death Dis. 2021;12:405 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 4h
  • immunoprecipitation; mouse; 1:1000; loading ...; fig 4e
  • western blot; mouse; 1:1000; loading ...; fig 4e
Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, et al. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018;25:1625-1637 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6f
Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed publisher
  • western blot; human; 1:1000; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; fig 2
Montgomery D, Sorum A, Guasch L, Nicklaus M, Meier J. Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors. Chem Biol. 2015;22:1030-1039 pubmed publisher
  • western blot; human; fig 6
Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015;290:11108-18 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:100
  • immunoprecipitation; mouse; 20 ug/ mg bead
  • western blot; mouse; 1:1000
Stilling R, Rönicke R, Benito E, Urbanke H, Capece V, Burkhardt S, et al. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J. 2014;33:1912-27 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
Liu X, Xiao W, Wang X, Li Y, Han J, Li Y. The p38-interacting protein (p38IP) regulates G2/M progression by promoting ?-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem. 2013;288:36648-61 pubmed publisher
  • western blot; human
Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher
Lee J, Ko Y, Chung Y, Yun N, Kim M, Kim K, et al. The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons. Sci Rep. 2018;8:13676 pubmed publisher
Damiani E, Puebla Osorio N, Lege B, Liu J, Neelapu S, Ullrich S. Platelet activating factor-induced expression of p21 is correlated with histone acetylation. Sci Rep. 2017;7:41959 pubmed publisher
Wu Y, Ma S, Xia Y, Lu Y, Xiao S, Cao Y, et al. Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim. Cell Death Dis. 2017;8:e2570 pubmed publisher
Gazdag E, Jacobi U, van Kruijsbergen I, Weeks D, Veenstra G. Activation of a T-box-Otx2-Gsc gene network independent of TBP and TBP-related factors. Development. 2016;143:1340-50 pubmed publisher
Biswas A, Mitchell D, Johnson D. E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res. 2014;74:3369-77 pubmed publisher
product information
SKU :
3305S
Product-Name :
GCN5L2 (C26A10) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, (B, Hr)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
94
Host :
Rabbit
Target :
GCN5L2
Primary-Protein :
GCN5
Alt-Names :
GCN5,GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2,GCN5L2,General control of amino acid synthesis protein 5-like 2,General control of amino acid synthesis, yeast, homolog-like 2,HGCN5,Histone acetyltransferase GCN5,Histone acetyltransferase KAT2A,HsGCN5,K(lysine) acetyltransferase 2A,KAT2A,Lysine acetyltransferase 2A,MGC102791,PCAF-b,STAF97
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.