product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
IRE1α (14C10) Rabbit mAb
catalog :
3294P
quantity :
40 ul
price :
123 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 52
Published Application/Species/DilutionReference
  • western blot (knockdown validation); mouse; fig 2C
Wang Z, Liu N, Liu K, Zhou G, Gan J, Wang Z, et al. Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis. Autophagy. 2015;11:2358-69 pubmed publisher
  • western blot; mouse; 1:1000; fig 4b
Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs S, Diehl J. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Liu J, Ma Y, Sun C, Li S, Wang J. High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A. Biomed Res Int. 2016;2016:4130834 pubmed publisher
  • western blot; human; fig 4
Chusri P, Kumthip K, Hong J, Zhu C, Duan X, Jilg N, et al. HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response. Sci Rep. 2016;6:22487 pubmed publisher
  • western blot; rat; fig 4
Bejaoui M, Pantazi E, De Luca V, Panisello A, Folch-Puy E, Hotter G, et al. Carbonic Anhydrase Protects Fatty Liver Grafts against Ischemic Reperfusion Damage. PLoS ONE. 2015;10:e0134499 pubmed publisher
  • western blot; human
D'Osualdo A, Anania V, Yu K, Lill J, Kaufman R, Matsuzawa S, et al. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0130635 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
  • immunocytochemistry; human; fig s2
  • immunoprecipitation; human; fig 3
  • western blot; human; 1:2000; fig 1
  • western blot; mouse; 1:2000; fig 1
Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher
  • western blot; mouse
Krokowski D, Jobava R, Guan B, Farabaugh K, Wu J, Majumder M, et al. Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity. J Biol Chem. 2015;290:17822-37 pubmed publisher
  • immunoprecipitation; human; fig 1
Plumb R, Zhang Z, Appathurai S, Mariappan M. A functional link between the co-translational protein translocation pathway and the UPR. elife. 2015;4: pubmed publisher
  • western blot; human; fig 1,2,3,5,6,7
  • western blot; mouse; fig 1,2,4,7
So J, Cho S, Min S, Kimball S, Lee A. IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol. 2015;35:2761-70 pubmed publisher
  • western blot; human; fig 1
Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed publisher
  • western blot; human; fig 5
Cui J, Sun W, Hao X, Wei M, Su X, Zhang Y, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int. 2015;15:4 pubmed publisher
  • immunocytochemistry; human; 1.5:1000
Copeland A, Altamura L, Van Deusen N, Schmaljohn C. Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene. J Virol. 2013;87:11659-69 pubmed publisher
Klein W, Westendorf C, Schmidt A, Conill-Cortés M, Rutz C, Blohs M, et al. Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study. PLoS ONE. 2015;10:e0120886 pubmed publisher
Ming J, Ruan S, Wang M, Ye D, Fan N, Meng Q, et al. A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1. Oncotarget. 2015;6:40692-703 pubmed publisher
Yanagawa Y, Hiraide S, Matsumoto M, Shimamura K, Togashi H. Enhanced transglutaminase 2 expression in response to stress-related catecholamines in macrophages. Immunobiology. 2014;219:680-6 pubmed publisher
Herrmann M, Lennerz J, Bullinger L, Bartholomae S, Holzmann K, Westhoff M, et al. Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression. Exp Hematol. 2014;42:90-100 pubmed publisher
Obri A, Makinistoglu M, Zhang H, Karsenty G. HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol. 2014;205:771-80 pubmed publisher
Jing Y, Cui D, Guo W, Jiang J, Jiang B, Lu Y, et al. Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition. Cancer Lett. 2014;348:135-45 pubmed publisher
Watanabe M, Nakatsuka A, Murakami K, Inoue K, Terami T, Higuchi C, et al. Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy. PLoS ONE. 2014;9:e92647 pubmed publisher
Yang N, Liu Y, Pan C, Sun K, Wei X, Mao X, et al. Pretreatment with andrographolide pills(®) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Microcirculation. 2014;21:703-16 pubmed publisher
Coffey E, Beckel J, Laties A, Mitchell C. Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP. Neuroscience. 2014;263:111-24 pubmed publisher
Chapiro J, Sur S, Savic L, Ganapathy-Kanniappan S, Reyes J, Duran R, et al. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer. Clin Cancer Res. 2014;20:6406-17 pubmed publisher
Di Carli M, Tanno B, Capodicasa C, Villani M, Salzano A, Scaloni A, et al. Proteome changes induced by c-myb silencing in human chronic myeloid leukemia cells suggest molecular mechanisms and putative biomarkers of hematopoietic malignancies. J Proteomics. 2014;96:200-22 pubmed publisher
Hu Y, Li S, Yang M, Yan C, Fan D, Zhou Y, et al. Sorcin silencing inhibits epithelial-to-mesenchymal transition and suppresses breast cancer metastasis in vivo. Breast Cancer Res Treat. 2014;143:287-99 pubmed publisher
Voll E, Ogden I, Pavese J, Huang X, Xu L, Jovanovic B, et al. Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression. Oncotarget. 2014;5:2648-63 pubmed
Davidson B, Rosenfeld Y, Holth A, Hellesylt E, Trope C, Reich R, et al. VICKZ2 protein expression in ovarian serous carcinoma effusions is associated with poor survival. Hum Pathol. 2014;45:1520-8 pubmed publisher
Zhao Y, Ma X, Wang J, Zhu Y, Li R, Wang J, et al. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway. Fitoterapia. 2014;99:318-27 pubmed publisher
Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, et al. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. PLoS ONE. 2014;9:e102831 pubmed publisher
Xu J, Yao Q, Hou Y, Xu M, Liu S, Yang L, et al. MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation. Biomed Pharmacother. 2013;67:381-6 pubmed publisher
Gu C, Banasavadi-Siddegowda Y, Joshi K, Nakamura Y, Kurt H, Gupta S, et al. Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner. Stem Cells. 2013;31:870-81 pubmed publisher
Qi W, Spier C, Liu X, Agarwal A, Cooke L, Persky D, et al. Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment. Leuk Res. 2013;37:434-9 pubmed publisher
Arens J, Duong T, Dehmelt L. A morphometric screen identifies specific roles for microtubule-regulating genes in neuronal development of P19 stem cells. PLoS ONE. 2013;8:e79796 pubmed publisher
Seervi M, Sobhan P, Joseph J, Ann Mathew K, Santhoshkumar T. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013;4:e968 pubmed publisher
Jiang Y, Rumble J, Gleixner A, Unnithan A, Pulugulla S, Posimo J, et al. N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner. Neuroscience. 2013;255:19-32 pubmed publisher
Perez-Pinera P, Ousterout D, Brunger J, Farin A, Glass K, Guilak F, et al. Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods. 2013;10:239-42 pubmed publisher
Linke R, Pries R, Könnecke M, Bruchhage K, Böscke R, Gebhard M, et al. Glycogen synthase kinase 3 in chronic rhinosinusitis: two faces of a single enzyme in one disease. Ann Allergy Asthma Immunol. 2013;110:101-6 pubmed publisher
Obitsu S, Sakata K, Teshima R, Kondo K. Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell Death Dis. 2013;4:e674 pubmed publisher
Gebhard A, Jain P, Nair R, Emmons M, Argilagos R, Koomen J, et al. MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. Mol Cancer Ther. 2013;12:2446-58 pubmed publisher
Nishimura T, Zhao X, Gan H, Koyasu S, Remold H. The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis. FASEB J. 2013;27:3827-36 pubmed publisher
Okemoto K, Wagner B, Meisen H, Haseley A, Kaur B, Chiocca E. STAT3 activation promotes oncolytic HSV1 replication in glioma cells. PLoS ONE. 2013;8:e71932 pubmed publisher
Stubbendorff M, Deuse T, Hua X, Phan T, Bieback K, Atkinson K, et al. Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue. Stem Cells Dev. 2013;22:2619-29 pubmed publisher
Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012;491:125-8 pubmed publisher
Li H, Panina S, Kaur A, Ruano M, Sánchez-González P, la Cour J, et al. Regulation of the ligand-dependent activation of the epidermal growth factor receptor by calmodulin. J Biol Chem. 2012;287:3273-81 pubmed publisher
Ye Y, Gao J, Tian H, Yearsley K, Lange A, Robertson F, et al. Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7. Mol Cancer Res. 2012;10:713-26 pubmed publisher
Yang S, Wang C. The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis. Bone. 2012;51:407-17 pubmed publisher
Okamoto M. Immunoreactivity of the amino-terminal portion of the amyloid-beta precursor protein in the nucleolus. Neurosci Lett. 2012;521:82-7 pubmed publisher
Qi W, Liu X, Cooke L, Persky D, Miller T, Squires M, et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012;130:2997-3005 pubmed publisher
Van de Wouwer M, Couzinié C, Serrano-Palero M, Gonzalez-Fernandez O, Galmés-Varela C, Menéndez-Antolí P, et al. Activation of the BRCA1/Chk1/p53/p21(Cip1/Waf1) pathway by nitric oxide and cell cycle arrest in human neuroblastoma NB69 cells. Nitric Oxide. 2012;26:182-91 pubmed publisher
Bhowmick R, Halder U, Chattopadhyay S, Chanda S, Nandi S, Bagchi P, et al. Rotaviral enterotoxin nonstructural protein 4 targets mitochondria for activation of apoptosis during infection. J Biol Chem. 2012;287:35004-20 pubmed publisher
De Raedt T, Walton Z, Yecies J, Li D, Chen Y, Malone C, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011;20:400-13 pubmed publisher
de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould H. Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS ONE. 2012;7:e32967 pubmed publisher
product information
SKU :
3294P
Product-Name :
IRE1α (14C10) Rabbit mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M
Applications :
Immunoprecipitation
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
130
Host :
Rabbit
Target :
IRE1
Primary-Protein :
IRE1
Alt-Names :
ER to nucleus signalling 1,ERN1,Endoplasmic reticulum-to-nucleus signaling 1,Endoribonuclease,FLJ30999,IRE1,IRE1P,IRE1a,Inositol-requiring protein 1,Ire1-alpha,MGC163277,MGC163279,Serine/threonine-protein kinase,Serine/threonine-protein kinase/endoribonuclease IRE1,endoplasmic reticulum to nucleus signaling 1,endoplasmic reticulum to nucleus signalling 1,hIRE1p,inositol-requiring 1,protein kinase/endoribonuclease
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.