| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig 1c
- western blot knockout validation; human; loading ...; fig 2a
| Liu Z, Li C, Kang N, Malhi H, Shah V, Maiers J. Transforming growth factor β (TGFβ) cross-talk with the unfolded protein response is critical for hepatic stellate cell activation. J Biol Chem. 2019;294:3137-3151 pubmed publisher |
- western blot knockout validation; human; 1:1000; loading ...; fig s1a
| Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, et al. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun. 2020;11:1304 pubmed publisher |
- western blot knockout validation; mouse; loading ...; fig 5a
| Hinte F, van Anken E, Tirosh B, Brune W. Repression of viral gene expression and replication by the unfolded protein response effector XBP1u. elife. 2020;9: pubmed publisher |
- western blot knockout validation; human; fig 3
| Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo R, et al. The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Cell Death Dis. 2018;9:374 pubmed publisher |
- western blot; human; fig 5f
| Bhattarai K, Kim H, Chaudhary M, Ur Rashid M, Kim J, Kim H, et al. TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans. Redox Biol. 2021;47:102128 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Yan M, Wang Z, Xia T, Jin S, Liu Y, Hu H, et al. Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice. Biomedicines. 2021;9: pubmed publisher |
- western blot; mouse; loading ...; fig 4c
| Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, et al. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021;24:102758 pubmed publisher |
- western blot; mouse; loading ...; fig 5k, s1h
| Wei Y, Chen J, Xu X, Li F, Wu K, Jiang Y, et al. Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity-Related Properties. Adv Sci (Weinh). 2021;8:2004319 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 5b
| Gaja Capdevila N, Hernández N, Zamanillo D, Vela J, Merlos M, Navarro X, et al. Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; human; loading ...; fig 2f
| Ko P, Choi J, Song S, Keum S, Jeong J, Hwang Y, et al. Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6h
| Zhou Y, Ye X, Zhang C, Wang J, Guan Z, Yan J, et al. Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis. J Genet Genomics. 2021;48:403-410 pubmed publisher |
- western blot; human; loading ...; fig 5d
| Liu Z, Li C, Zhang R, Wei D, Shang Y, Yong Y, et al. EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling. Mol Cancer. 2021;20:79 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5a
| Li Y, Chen L, Li L, Sottas C, Petrillo S, Lazaris A, et al. Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021;24:102457 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3a
| Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed publisher |
- western blot; mouse; loading ...; fig 11e
| Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, et al. Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cell Mol Gastroenterol Hepatol. 2021;12:633-651 pubmed publisher |
- western blot; mouse; fig 1a
| Lim Y, Kim S, Kim E. Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Mol Brain. 2021;14:65 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2c
| Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher |
- western blot; human; 1:1000; loading ...
| Brockway S, Wang G, Jackson J, Amici D, Takagishi S, Clutter M, et al. Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq. Nat Commun. 2020;11:5722 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4b
| Galeone A, Adams J, Matsuda S, Presa M, Pandey A, Han S, et al. Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation. elife. 2020;9: pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Batista A, Rodvold J, Xian S, Searles S, Lew A, Iwawaki T, et al. IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival. PLoS Biol. 2020;18:e3000687 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher |
- western blot; human; loading ...; fig s1c
| Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher |
- western blot; mouse; loading ...; fig s7a
| Wang W, Wang J, Lin W, Kao C, Hung M, Teng Y, et al. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020;19:e13090 pubmed publisher |
- immunoprecipitation; mouse; 1:100; loading ...; fig 4a
- western blot; mouse; loading ...; fig 1k
| Lee H, Lee G, Kim H, Lee Y, Chae H. Phosphatidylinositol 3-kinase-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. Br J Pharmacol. 2020;177:1556-1567 pubmed publisher |
- western blot; human; fig 7c
| Johnston B, Pringle E, McCormick C. KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. PLoS Pathog. 2019;15:e1008185 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1b
| Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 7a
| Wang X, Peng P, Pan Z, Fang Z, Lu W, Liu X. Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells. Biol Res. 2019;52:34 pubmed publisher |
- western blot; mouse; loading ...; fig 2a
| Hernández Alvarez M, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell. 2019;177:881-895.e17 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Mogilenko D, Haas J, L homme L, Fleury S, Quemener S, Levavasseur M, et al. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019;177:1201-1216.e19 pubmed publisher |
- western blot; mouse; 1:10,000; loading ...; fig 5a
| Brody M, Vanhoutte D, Bakshi C, Liu R, Correll R, Sargent M, et al. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. J Biol Chem. 2019;294:8918-8929 pubmed publisher |
- western blot; human; 1:200; loading ...; fig s2a
| Simic M, Moehle E, Schinzel R, Lorbeer F, Halloran J, Heydari K, et al. Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming. Sci Adv. 2019;5:eaaw0025 pubmed publisher |
- western blot; human; loading ...; fig 2h
- western blot; mouse; loading ...; fig 2e
| Schiattarella G, Altamirano F, Tong D, French K, Villalobos E, Kim S, et al. Nitrosative stress drives heart failure with preserved ejection fraction. Nature. 2019;568:351-356 pubmed publisher |
- western blot; mouse; loading ...; fig s6a
| Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, et al. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019;10:1492 pubmed publisher |
- western blot; human; loading ...; fig 2d
- western blot; mouse; 1:1000; loading ...; fig 2d
| Cao Y, Trillo Tinoco J, Sierra R, Anadon C, Dai W, Mohamed E, et al. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun. 2019;10:1280 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5c
| Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s14a
| Grootjans J, Krupka N, Hosomi S, Matute J, Hanley T, Saveljeva S, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019;363:993-998 pubmed publisher |
- western blot; mouse; loading ...; fig 1h
| Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher |
- western blot; mouse; loading ...; fig 6d
| Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher |
- immunoprecipitation; human; 1:1000; loading ...; fig 3b
- western blot; human; loading ...; fig 3b
| Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4d
| Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed publisher |
- western blot; mouse; loading ...; fig s2
| Homma T, Kurahashi T, Lee J, Nabeshima A, Yamada S, Fujii J. Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure. Oxid Med Cell Longev. 2018;2018:2812904 pubmed publisher |
- western blot; mouse; loading ...; fig 2e
| Millership S, Da Silva Xavier G, Choudhury A, Bertazzo S, Chabosseau P, Pedroni S, et al. Neuronatin regulates pancreatic β cell insulin content and secretion. J Clin Invest. 2018;128:3369-3381 pubmed publisher |
- western blot; mouse; loading ...; fig 4h
| Chapple R, Hu T, Tseng Y, Liu L, Kitano A, Luu V, et al. ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response. elife. 2018;7: pubmed publisher |
- western blot; human; loading ...; fig s4c
| Liang H, Xiao J, Zhou Z, Wu J, Ge F, Li Z, et al. Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis. Oncogene. 2018;37:1961-1975 pubmed publisher |
- western blot; mouse; fig 2d
| Ersoy B, Maner Smith K, Li Y, Alpertunga I, Cohen D. Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress. J Clin Invest. 2018;128:141-156 pubmed publisher |
- western blot; mouse; 1:1000; fig 9c
| Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Potes Y, de Luxán Delgado B, Rodríguez González S, Guimarães M, Solano J, Fernández Fernández M, et al. Overweight in elderly people induces impaired autophagy in skeletal muscle. Free Radic Biol Med. 2017;110:31-41 pubmed publisher |
- western blot; mouse; loading ...; fig s5e
| Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher |
- western blot; mouse; loading ...; fig s2b
| Tufanlı Ö, Telkoparan Akillilar P, Acosta Alvear D, Kocatürk B, Onat U, Hamid S, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017;114:E1395-E1404 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 5c
- western blot; human; 1:1000; loading ...; fig 4a
| Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability. Nat Commun. 2017;8:14186 pubmed publisher |
- western blot; human; fig 2a
| Geraghty P, Baumlin N, SALATHE M, Foronjy R, D Armiento J. Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. Mediators Inflamm. 2016;2016:9461289 pubmed publisher |
- western blot; mouse; loading ...; fig 4c
| Mukhopadhyay C, Triplett A, Bargar T, HECKMAN C, Wagner K, Naramura M. Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation. Proc Natl Acad Sci U S A. 2016;113:E8228-E8237 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Tripathi M, Zhang C, Singh B, Sinha R, Moe K, DeSilva D, et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016;7:e2513 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2c
| Strietz J, Stepputtis S, Preca B, Vannier C, Kim M, Castro D, et al. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget. 2016;7:83278-83293 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Yang Z, Tsuchiya H, Zhang Y, Lee S, Liu C, Huang Y, et al. REV-ERB? Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. Am J Pathol. 2016;186:2909-2920 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Liu J, Ma Y, Sun C, Li S, Wang J. High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A. Biomed Res Int. 2016;2016:4130834 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 1a
- western blot; mouse; 1:500; loading ...; fig 1a
| Marwarha G, Claycombe K, Schommer J, Collins D, Ghribi O. Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBP? Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain. Cell Signal. 2016;28:1789-805 pubmed publisher |
- western blot; human; loading ...; fig 3c
| Trousil S, Kaliszczak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. 2016;7:37103-37120 pubmed publisher |
- western blot; mouse; 1:1000; fig 4b
| Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs S, Diehl J. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Tamura Y, Matsunaga Y, Kitaoka Y, Hatta H. Effects of Heat Stress Treatment on Age-dependent Unfolded Protein Response in Different Types of Skeletal Muscle. J Gerontol A Biol Sci Med Sci. 2017;72:299-308 pubmed publisher |
- western blot; mouse; 1:1500; loading ...; fig 3b
| Soeda J, Mouralidarane A, Cordero P, Li J, Nguyen V, Carter R, et al. Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas. J Physiol Biochem. 2016;72:281-91 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2a
| Tibullo D, Barbagallo I, Giallongo C, Vanella L, Conticello C, Romano A, et al. Heme oxygenase-1 nuclear translocation regulates bortezomibinduced cytotoxicity and mediates genomic instability in myeloma cells. Oncotarget. 2016;7:28868-80 pubmed publisher |
- western blot; human; fig 4
| Chusri P, Kumthip K, Hong J, Zhu C, Duan X, Jilg N, et al. HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response. Sci Rep. 2016;6:22487 pubmed publisher |
- western blot; mouse; fig 2A
| Wang Z, Liu N, Liu K, Zhou G, Gan J, Wang Z, et al. Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis. Autophagy. 2015;11:2358-69 pubmed publisher |
- immunoprecipitation; human; fig 3
- immunocytochemistry; human; fig s2
- western blot; human; 1:2000; fig 1
- immunohistochemistry - paraffin section; mouse; fig 5
- western blot; mouse; 1:2000; fig 1
| Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher |
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- western blot; human
- western blot; mouse; fig 1,2,4,7
| So J, Cho S, Min S, Kimball S, Lee A. IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol. 2015;35:2761-70 pubmed publisher |
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| Plumb R, Zhang Z, Appathurai S, Mariappan M. A functional link between the co-translational protein translocation pathway and the UPR. elife. 2015;4: pubmed publisher |
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| Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses. Cell Death Dis. 2015;6:e1719 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Bright M, Itzhak D, Wardell C, Morgan G, Davies F. Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress. Mol Cell Biol. 2015;35:2186-202 pubmed publisher |
- western blot; human; fig 2
| Sheng X, Arnoldussen Y, Storm M, Tesikova M, Nenseth H, Zhao S, et al. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015;7:788-801 pubmed publisher |
- western blot; human; fig 5
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| Khan E, Sankaran S, Llontop L, del Campo A. Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro. BMC Mol Cell Biol. 2020;21:22 pubmed publisher |
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