product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Pyk2 (Tyr402) Antibody
catalog :
3291
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4a
Iampietro M, Younan P, Nishida A, Dutta M, Lubaki N, Santos R, et al. Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection. PLoS Pathog. 2017;13:e1006397 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 7a
  • western blot; human; loading ...; fig 7b
Eppler F, Quast T, Kolanus W. Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS ONE. 2017;12:e0172443 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Haas L, Salazar S, Kostylev M, Um J, Kaufman A, Strittmatter S. Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain. 2016;139:526-46 pubmed publisher
  • western blot; human; fig 5a
Wu X, Zahari M, Renuse S, Nirujogi R, Kim M, Manda S, et al. Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer. Mol Cell Proteomics. 2015;14:2887-900 pubmed publisher
  • western blot; mouse; 1:1000; fig  1
Revuelta López E, Cal R, Herraiz Martínez A, De Gonzalo Calvo D, Nasarre L, Roura S, et al. Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes. J Mol Cell Cardiol. 2015;85:25-36 pubmed publisher
  • western blot; human
Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  • western blot; human
Chattopadhyay R, Tinnikov A, Dyukova E, Singh N, Kotla S, Mobley J, et al. 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction. J Lipid Res. 2015;56:562-77 pubmed publisher
  • western blot; human
Yoon H, Choi Y, Song J, Do I, Kang S, Ko Y, et al. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PLoS ONE. 2014;9:e88587 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
  • immunocytochemistry; mouse
  • western blot; mouse
Aguilera K, Rivera L, Hur H, Carbon J, Toombs J, Goldstein C, et al. Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res. 2014;74:1032-44 pubmed publisher
  • western blot; mouse; fig s7a
Jabara H, McDonald D, Janssen E, Massaad M, Ramesh N, Borzutzky A, et al. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012;13:612-20 pubmed publisher
Hur H, Ham I, Lee D, Jin H, Aguilera K, Oh H, et al. Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma. BMC Cancer. 2017;17:87 pubmed publisher
Kamihara Y, Takada K, Sato T, Kawano Y, Murase K, Arihara Y, et al. The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/?-catenin signaling in human multiple myeloma. Oncotarget. 2016;7:64330-64341 pubmed publisher
Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem. 2013;288:30815-31 pubmed publisher
Kostourou V, Lechertier T, Reynolds L, Lees D, Baker M, Jones D, et al. FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun. 2013;4:2020 pubmed publisher
Kundumani Sridharan V, Dyukova E, Hansen D, Rao G. 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J Biol Chem. 2013;288:15830-42 pubmed publisher
product information
SKU :
3291S
Product-Name :
Phospho-Pyk2 (Tyr402) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, (R)
Applications :
Immunoprecipitation
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
116
Host :
Rabbit
Target :
Pyk2 (Tyr402) phosphate
Primary-Protein :
Pyk2
Alt-Names :
CADTK,CAK beta,CAK-beta,CAKB,Calcium-dependent tyrosine kinase,Cell adhesion kinase beta,FADK 2,FADK2,FAK2,Focal adhesion kinase 2,PKB,PTK,PTK2B,PTK2B protein tyrosine kinase 2 beta,PYK2,Proline-rich tyrosine kinase 2,Protein-tyrosine kinase 2-beta,RAFTK,Related adhesion focal tyrosine kinase,protein kinase B,protein tyrosine kinase 2 beta
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.