product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-FAK (Tyr397) Antibody
catalog :
3283S
quantity :
100 ul
price :
274 USD
clonality :
polyclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 23
Published Application/Species/DilutionReference
  • western blot; human; 1:500; fig 5s1
Krusche B, Ottone C, Clements M, Johnstone E, Goetsch K, Lieven H, et al. EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells. elife. 2016;5: pubmed publisher
  • western blot; mouse; fig 1
Jadav R, Kumar D, Buwa N, Ganguli S, Thampatty S, Balasubramanian N, et al. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cell Signal. 2016;28:1124-36 pubmed publisher
  • western blot; human; fig 2
Luey B, May F. Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway. Mol Cancer. 2016;15:8 pubmed publisher
  • western blot; human; fig 5
Jeong A, Han S, Lee S, Su Park J, Lu Y, Yu S, et al. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway. Sci Rep. 2016;6:27391 pubmed publisher
  • western blot; human; fig 6
Scott D, Tolbert C, Burridge K. Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF. Mol Biol Cell. 2016;27:1420-30 pubmed publisher
  • immunocytochemistry; mouse; 1:50; fig 6
  • western blot; mouse; fig 7
Sugar T, Wassenhove-McCarthy D, Orr A, Green J, van Kuppevelt T, McCarthy K. N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions. Am J Physiol Renal Physiol. 2016;310:F1123-35 pubmed publisher
  • western blot; human; fig 4
Wang S, Cui H, Liu Y, Zhao P, Zhang Y, Fu Z, et al. CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget. 2015;6:243-57 pubmed
  • western blot; human
  • western blot; mouse
Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2015;: pubmed publisher
  • western blot; human; 1:1000
  • immunocytochemistry; human; 1:100
Zhang H, Chen Y, Wadham C, McCaughan G, Keane F, Gorrell M. Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochim Biophys Acta. 2015;1853:470-80 pubmed publisher
  • western blot; human; 1:1000
Wang C, Xiang R, Zhang X, Chen Y. Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinase. Mol Med Rep. 2015;12:3374-80 pubmed publisher
  • western blot; rat
Mills R, Mita M, Nakagawa J, Shoji M, Sutherland C, Walsh M. A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle. J Biol Chem. 2015;290:8677-92 pubmed publisher
  • western blot; human; 1:1000
Webber P, Park C, Qui M, Ramalingam S, Khuri F, Fu H, et al. Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015;2:765-76 pubmed
  • western blot; mouse
Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, et al. TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE. 2015;10:e0117908 pubmed publisher
  • western blot; human; 1:1000
Pelillo C, Bergamo A, Mollica H, Bestagno M, Sava G. Colorectal Cancer Metastases Settle in the Hepatic Microenvironment Through α5β1 Integrin. J Cell Biochem. 2015;116:2385-96 pubmed publisher
  • western blot; human
Xiong X, Wang Y, Liu C, Lu Q, Liu T, Chen G, et al. Heat shock protein 90β stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cells. Exp Cell Res. 2014;326:78-89 pubmed publisher
  • western blot; human
Czaplinska D, Turczyk L, Grudowska A, Mieszkowska M, Lipinska A, Skladanowski A, et al. Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration. Biochim Biophys Acta. 2014;1843:2461-70 pubmed publisher
  • western blot; human; 1:1000
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, et al. Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy. FASEB J. 2014;28:131-42 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Potthoff E, Franco D, D'Alessandro V, Starck C, Falk V, Zambelli T, et al. Toward a rational design of surface textures promoting endothelialization. Nano Lett. 2014;14:1069-79 pubmed publisher
  • immunocytochemistry; human
Deneubourg L, Elong Edimo W, Moreau C, Vanderwinden J, Erneux C. Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines. Cell Signal. 2014;26:1193-203 pubmed publisher
  • western blot; human
Costa P, Scales T, Ivaska J, Parsons M. Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion. PLoS ONE. 2013;8:e74659 pubmed publisher
  • immunohistochemistry - paraffin section; human
Sáinz-Jaspeado M, Huertas-Martinez J, Lagares-Tena L, Martín Liberal J, Mateo-Lozano S, de Alava E, et al. EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1. PLoS ONE. 2013;8:e71449 pubmed publisher
Fu X, Goglia L, Sanchez A, Flamini M, Giretti M, Tosi V, et al. Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. Endocr Relat Cancer. 2010;17:431-43 pubmed publisher
Zaytseva Y, Rychahou P, Gulhati P, Elliott V, Mustain W, O'Connor K, et al. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res. 2012;72:1504-17 pubmed publisher
product information
SKU :
3283S
Product-Name :
Phospho-FAK (Tyr397) Antibody
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Hm, Pg
Applications :
Western blot
Product-Category :
Adhesion/ECM
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
125
Host :
Rabbit
Target :
FAK (Tyr397) phosphate
Primary-Protein :
FAK
Alt-Names :
FADK,FADK 1,FAK,FAK-related non-kinase polypeptide,FAK1,FRNK,Focal adhesion kinase 1,PTK2,PTK2 protein tyrosine kinase 2,Protein-tyrosine kinase 2,pp125FAK
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.