product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Caveolin-1 (D46G3) XP® Rabbit mAb
catalog :
3267
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D46G3
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
citations: 46
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:2000; loading ...; fig 2d
Jozic I, Abujamra B, Elliott M, Wikramanayake T, Marjanovic J, Stone R, et al. Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds. Commun Biol. 2021;4:757 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig 3f
Shi X, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y. Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration. Front Cell Dev Biol. 2021;9:665919 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2
  • western blot; mouse; 1:1000; loading ...; fig 1b
Gurley J, Gmyrek G, McClellan M, Hargis E, Hauck S, Dozmorov M, et al. Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina. Invest Ophthalmol Vis Sci. 2020;61:19 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 3b
Zhang Z, Le K, La Placa D, Armstrong B, Miller M, Shively J. CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils. Bone Rep. 2020;12:100237 pubmed publisher
  • western blot; human; loading ...; fig 1a
Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al. WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed publisher
  • immunocytochemistry; human; fig 4b
  • western blot; human; fig s12
Wang C, Puerta Guardo H, Biering S, Glasner D, Tran E, Patana M, et al. Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation. PLoS Pathog. 2019;15:e1007938 pubmed publisher
  • western blot; mouse; 1:1000; fig 1s1a
  • western blot; human; 1:1000; loading ...; fig 1s1a
Li Y, Li K, Hu W, Ojcius D, Fang J, Li S, et al. Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer. elife. 2019;8: pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1a
  • immunocytochemistry; human; 1:100; loading ...; fig 1b
  • western blot; human; 1:100; loading ...; fig 1a
Jiu Y. Vimentin intermediate filaments function as a physical barrier during intracellular trafficking of caveolin-1. Biochem Biophys Res Commun. 2018;507:161-167 pubmed publisher
  • western blot; mouse; loading ...; fig s6a
Clemente C, Rius C, Alonso Herranz L, Martín Alonso M, Pollán A, Camafeita E, et al. MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Nat Commun. 2018;9:910 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, et al. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proc Natl Acad Sci U S A. 2017;114:10737-10742 pubmed publisher
  • western blot; rat; fig 4g
Rippe C, Zhu B, Krawczyk K, Bavel E, Albinsson S, Sjölund J, et al. Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway. Sci Rep. 2017;7:1334 pubmed publisher
  • western blot; human; loading ...; fig 6a
Shi D, Liu Y, Xi R, Zou W, Wu L, Zhang Z, et al. Caveolin-1 contributes to realgar nanoparticle therapy in human chronic myelogenous leukemia K562 cells. Int J Nanomedicine. 2016;11:5823-5835 pubmed
  • western blot; dogs; 1:1000; fig 3a
Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:1000; fig 4
  • western blot; rat; 1:1000; fig 3
Zhao Y, Song J, Ma X, Zhang B, Li D, Pang H. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res. 2016;11:944-50 pubmed publisher
  • immunocytochemistry; mouse; fig 3
  • western blot; mouse; fig 3
Boothe T, Lim G, Cen H, Skovsø S, Piske M, Li S, et al. Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab. 2016;5:366-378 pubmed publisher
  • western blot; human; fig 1
  • immunohistochemistry; mouse; 1:100; fig 7
Krawczyk K, Yao Mattisson I, Ekman M, Oskolkov N, Grantinge R, Kotowska D, et al. Myocardin Family Members Drive Formation of Caveolae. PLoS ONE. 2015;10:e0133931 pubmed publisher
  • western blot; human; fig 3b
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher
  • western blot; human; fig 5
Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, et al. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep. 2015;5:8428 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
  • western blot; mouse; 1:2000; fig 7
Zeng J, Ekman M, Grossi M, Svensson D, Nilsson B, Jiang C, et al. Vasopressin-induced mouse urethral contraction is modulated by caveolin-1. Eur J Pharmacol. 2015;750:59-65 pubmed publisher
  • western blot; rat; fig 5
Sadegh M, Ekman M, Krawczyk K, Svensson D, Göransson O, Dahan D, et al. Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. PLoS ONE. 2015;10:e0116784 pubmed publisher
  • western blot; rat; 1:5000
Yang N, Liu Y, Pan C, Sun K, Wei X, Mao X, et al. Pretreatment with andrographolide pills(®) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Microcirculation. 2014;21:703-16 pubmed publisher
  • western blot; mouse
Niesman I, Schilling J, Shapiro L, Kellerhals S, Bonds J, Kleschevnikov A, et al. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014;11:39 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:1200
  • western blot; rat; 1:1000
Ekman M, Uvelius B, Albinsson S, Swärd K. HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Lab Invest. 2014;94:557-68 pubmed publisher
  • western blot; human; 1:200; fig 4
Clarysse L, Gueguinou M, Potier Cartereau M, Vandecasteele G, Bougnoux P, Chevalier S, et al. cAMP-PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3-Orai1 complex. Pflugers Arch. 2014;466:1921-32 pubmed publisher
  • western blot; mouse
Ekman M, Bhattachariya A, Dahan D, Uvelius B, Albinsson S, Swärd K. Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. PLoS ONE. 2013;8:e82308 pubmed publisher
Brandel A, Aigal S, Lagies S, Schlimpert M, Meléndez A, Xu M, et al. The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa. Cell Mol Life Sci. 2021;78:3637-3656 pubmed publisher
Shi X, Fan C, Jiu Y. Unidirectional Regulation of Vimentin Intermediate Filaments to Caveolin-1. Int J Mol Sci. 2020;21: pubmed publisher
Toh H, Lin C, Nakajima S, Aikawa C, Nozawa T, Nakagawa I. Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Front Cell Infect Microbiol. 2019;9:398 pubmed publisher
Xu S, Bala S, Bendeck M. Discoidin domain receptor 1 deficiency in vascular smooth muscle cells leads to mislocalisation of N-cadherin contacts. Biol Open. 2019;8: pubmed publisher
Krawczyk K, Hansson J, Nilsson H, Krawczyk K, Swärd K, Johansson M. Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1. BMC Nephrol. 2017;18:320 pubmed publisher
Caino M, Seo J, Wang Y, Rivadeneira D, Gabrilovich D, Kim E, et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017;127:3755-3769 pubmed publisher
Minguet S, Kläsener K, Schaffer A, Fiala G, Osteso Ibanez T, Raute K, et al. Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nat Immunol. 2017;18:1150-1159 pubmed publisher
Feng J, Yang H, Zhang Y, Wei H, Zhu Z, Zhu B, et al. Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Oncogene. 2017;36:5829-5839 pubmed publisher
Zhang Y, Xie L, Gunasekar S, Tong D, Mishra A, Gibson W, et al. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017;19:504-517 pubmed publisher
Zamarron B, Mergian T, Cho K, Martinez Santibañez G, Luan D, Singer K, et al. Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice. Diabetes. 2017;66:392-406 pubmed publisher
Lu J, Chiang Y, Lin Y, Chang Y, Lu C, Chen T, et al. Disruption of Lipid Raft Function Increases Expression and Secretion of Monocyte Chemoattractant Protein-1 in 3T3-L1 Adipocytes. PLoS ONE. 2016;11:e0169005 pubmed publisher
Gueguinou M, Harnois T, Crottès D, Uguen A, Déliot N, Gambade A, et al. SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline. Oncotarget. 2016;7:36168-36184 pubmed publisher
Lichtenberger B, Mastrogiannaki M, Watt F. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages. Nat Commun. 2016;7:10537 pubmed publisher
Grossi M, Rippe C, Sathanoori R, Swärd K, Forte A, Erlinge D, et al. Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake. Biosci Rep. 2014;34:e00153 pubmed publisher
Bangphoomi N, Takenaka Uema A, Sugi T, Kato K, Akashi H, Horimoto T. Akabane virus utilizes alternative endocytic pathways to entry into mammalian cell lines. J Vet Med Sci. 2014;76:1471-8 pubmed
Konkel M, Samuelson D, Eucker T, Shelden E, O Loughlin J. Invasion of epithelial cells by Campylobacter jejuni is independent of caveolae. Cell Commun Signal. 2013;11:100 pubmed publisher
Azegrouz H, Karemore G, Torres A, Alaíz C, Gonzalez A, Nevado P, et al. Cell-based fuzzy metrics enhance high-content screening (HCS) assay robustness. J Biomol Screen. 2013;18:1270-83 pubmed publisher
Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, et al. The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. Sci Rep. 2013;3:2553 pubmed publisher
Minami T, Kijima T, Otani Y, Kohmo S, Takahashi R, Nagatomo I, et al. HER2 as therapeutic target for overcoming ATP-binding cassette transporter-mediated chemoresistance in small cell lung cancer. Mol Cancer Ther. 2012;11:830-41 pubmed publisher
Deng J, Huang Q, Wang F, Liu Y, Wang Z, Wang Z, et al. The role of caveolin-1 in blood-brain barrier disruption induced by focused ultrasound combined with microbubbles. J Mol Neurosci. 2012;46:677-87 pubmed publisher
Béliveau F, Brulé C, Desilets A, Zimmerman B, Laporte S, Lavoie C, et al. Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality. J Biol Chem. 2011;286:29035-43 pubmed publisher
product information
SKU :
3267S
Product-Name :
Caveolin-1 (D46G3) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, B, Dg
Applications :
Flow cytometry
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
21, 24
Host :
Rabbit
Target :
caveolin-1
Primary-Protein :
caveolin-1
Alt-Names :
BSCL3,CAV,CAV1,CGL3,Caveolin-1,MSTP085,VIP21,caveolin 1, caveolae protein, 22kDa,cell growth-inhibiting protein 32
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.