product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Pyruvate Dehydrogenase (C54G1) Rabbit mAb
catalog :
3205
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C54G1
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 2c
  • immunohistochemistry - paraffin section; human; loading ...; fig 6a
Zhong Y, Li X, Ji Y, Li X, Li Y, Yu D, et al. Pyruvate dehydrogenase expression is negatively associated with cell stemness and worse clinical outcome in prostate cancers. Oncotarget. 2017;8:13344-13356 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 3a
Li Y, Li X, Li X, Zhong Y, Ji Y, Yu D, et al. PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence. Oncotarget. 2016;7:53837-53852 pubmed publisher
  • western blot; human; loading ...; fig 3f
Zhang W, Wang G, Xu Z, Tu H, Hu F, Dai J, et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019;: pubmed publisher
  • western blot; human; fig 5f
Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, et al. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017;7:46344 pubmed publisher
  • western blot; human; loading ...; fig 5e
Møller A, Kampmann U, Hedegaard J, Thorsen K, Nordentoft I, Vendelbo M, et al. Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes. Sci Rep. 2017;7:43775 pubmed publisher
  • western blot; mouse; loading ...; fig 3g
Zeng Q, Chen J, Li Y, Werle K, Zhao R, Quan C, et al. LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism. Oncogene. 2017;36:1245-1255 pubmed publisher
  • western blot; human; fig 7
Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
  • western blot; human; fig 3
Ma T, Fan B, Zhang C, Zhao H, Han C, Gao C, et al. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Sci Rep. 2016;6:29926 pubmed publisher
  • western blot; human; 1:1000; loading ...; tbl 1
Martins A, Sá R, Monteiro M, Barros A, Sousa M, Carvalho R, et al. Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics. Mol Cell Endocrinol. 2016;434:199-209 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Gray L, Rauckhorst A, Taylor E. A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity. J Biol Chem. 2016;291:7409-17 pubmed publisher
  • western blot; rat; 1:1000; fig 8
Lesmana R, Sinha R, Singh B, Zhou J, Ohba K, Wu Y, et al. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology. 2016;157:23-38 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Loureiro R, Magalhães Novais S, Mesquita K, Baldeiras I, Sousa I, Tavares L, et al. Melatonin antiproliferative effects require active mitochondrial function in embryonal carcinoma cells. Oncotarget. 2015;6:17081-96 pubmed
  • western blot; rat; 1:10000
Wang W, Visavadiya N, Pandya J, Nelson P, Sullivan P, Springer J. Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury. Exp Neurol. 2015;265:84-93 pubmed publisher
  • western blot; mouse; fig 2
Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher
Puleston D, Buck M, Klein Geltink R, Kyle R, Caputa G, O Sullivan D, et al. Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metab. 2019;: pubmed publisher
Pak H, Nam B, Lee Y, Kim Y, Roh J, Son J, et al. Human Plasmablast Migration Toward CXCL12 Requires Glucose Oxidation by Enhanced Pyruvate Dehydrogenase Activity via AKT. Front Immunol. 2018;9:1742 pubmed publisher
Stein C, Jadiya P, Zhang X, McLendon J, Abouassaly G, Witmer N, et al. Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Cell Rep. 2018;23:3710-3720.e8 pubmed publisher
Tang M, Vranas M, Krahn A, Pundlik S, Trempe J, Fon E. Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation. Nat Commun. 2017;8:14697 pubmed publisher
Zhang C, Lin M, Wu R, Wang X, Yang B, Levine A, et al. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A. 2011;108:16259-64 pubmed publisher
product information
SKU :
3205S
Product-Name :
Pyruvate Dehydrogenase (C54G1) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
43
Host :
Rabbit
Target :
PDHA1
Primary-Protein :
PDHA1
Alt-Names :
ODPA,PDHA,PDHA1,PDHCE1A,PDHE1-A type I,PHE1A,Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial,pyruvate dehydrogenase (lipoamide) alpha 1,pyruvate dehydrogenase E1 alpha 1,pyruvate dehydrogenase complex, E1-alpha polypeptide 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.