| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockout validation); mouse; fig 5
| Ma T, Trinh M, Wexler A, Bourbon C, Gatti E, Pierre P, et al. Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013;16:1299-305 pubmed publisher |
- other; mouse; 1:500; fig 1
- western blot (knockdown validation); mouse; 1:500; fig 1
| Zhu S, Henninger K, McGrath B, Cavener D. PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility. PLoS ONE. 2016;11:e0162766 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Liu J, Ma Y, Sun C, Li S, Wang J. High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A. Biomed Res Int. 2016;2016:4130834 pubmed publisher |
- western blot; rat; fig 3a
| Krawczyk K, Ekman M, Rippe C, Grossi M, Nilsson B, Albinsson S, et al. Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep. 2016;6:32449 pubmed publisher |
- western blot; human; 1:500; fig 3
| Gallagher C, Garri C, Cain E, Ang K, Wilson C, Chen S, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. elife. 2016;5: pubmed publisher |
- western blot; human; 1:1000; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; mouse; fig 5
| Taniuchi S, Miyake M, Tsugawa K, Oyadomari M, Oyadomari S. Integrated stress response of vertebrates is regulated by four eIF2α kinases. Sci Rep. 2016;6:32886 pubmed publisher |
- immunohistochemistry; mouse; 1:1000; fig 2
| Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed publisher |
- western blot; human; fig 2
| Gupta A, Hossain M, Miller N, Kerin M, Callagy G, Gupta S. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer. Oncogene. 2016;: pubmed publisher |
- western blot; mouse; fig 4
| Hamlin A, Basford J, Jaeschke A, Hui D. Low density lipoprotein receptor-related protein-1 deficiency exacerbates palmitate-induced steatosis and toxicity in hepatocytes. J Biol Chem. 2016;: pubmed |
- western blot; mouse; fig s3
| Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher |
| Deegan S, Koryga I, Glynn S, Gupta S, Gorman A, Samali A. A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. Biochem Biophys Res Commun. 2015;456:305-11 pubmed publisher |
- western blot; human; fig 2
| Sheng X, Arnoldussen Y, Storm M, Tesikova M, Nenseth H, Zhao S, et al. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015;7:788-801 pubmed publisher |
- western blot; human; fig 5
| Gupta A, Hossain M, Read D, Hetz C, Samali A, Gupta S. PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Sci Rep. 2015;5:18304 pubmed publisher |
- western blot; mouse; fig 1
| Gao X, Krokowski D, Guan B, Bederman I, Majumder M, Parisien M, et al. Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response. elife. 2015;4:e10067 pubmed publisher |
- western blot; human; fig 6
| Artero-Castro A, Pérez-Alea M, Feliciano A, Leal J, Genestar M, Castellvi J, et al. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 2015;11:1499-519 pubmed publisher |
- immunoprecipitation; human; fig 4
| Plumb R, Zhang Z, Appathurai S, Mariappan M. A functional link between the co-translational protein translocation pathway and the UPR. elife. 2015;4: pubmed publisher |
| D'Osualdo A, Anania V, Yu K, Lill J, Kaufman R, Matsuzawa S, et al. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0130635 pubmed publisher |
- western blot; human; fig 4,8
- western blot; mouse; fig 4,8
| So J, Cho S, Min S, Kimball S, Lee A. IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol. 2015;35:2761-70 pubmed publisher |
- western blot; mouse; 1:2000; fig 1
| Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher |
- western blot; human; 1:1000
| Le Pape S, Dimitrova E, Hannaert P, Konovalov A, Volmer R, Ron D, et al. Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury. FEBS Lett. 2014;588:3062-7 pubmed publisher |
| Sisinni L, Maddalena F, Lettini G, Condelli V, Matassa D, Esposito F, et al. TRAP1 role in endoplasmic reticulum stress protection favors resistance to anthracyclins in breast carcinoma cells. Int J Oncol. 2014;44:573-82 pubmed publisher |
| Maas N, Singh N, Diehl J. Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther. 2014;15:1106-11 pubmed publisher |
| Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher |
- western blot; mouse; 1:1000
| Devi L, Ohno M. Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher |
| Colin-Cassin C, Yao X, Cerella C, Chbicheb S, Kuntz S, Mazerbourg S, et al. PPARγ-inactive Δ2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells. Mol Carcinog. 2015;54:393-404 pubmed publisher |
| Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed publisher |
| Herrmann U, Sonati T, Falsig J, Reimann R, Dametto P, O'Connor T, et al. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathog. 2015;11:e1004662 pubmed publisher |
| Trinh M, Ma T, Kaphzan H, Bhattacharya A, Antion M, Cavener D, et al. The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014;21:298-304 pubmed publisher |
| Johnson J, Koetsier J, Sirico A, Agidi A, Antonini D, Missero C, et al. The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. J Invest Dermatol. 2014;134:2154-62 pubmed publisher |
| Arribas-González E, Alonso-Torres P, Aragón C, López-Corcuera B. Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2). PLoS ONE. 2013;8:e63230 pubmed publisher |
| De Raedt T, Walton Z, Yecies J, Li D, Chen Y, Malone C, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011;20:400-13 pubmed publisher |
| Chen C, Shaikenov T, Peterson T, Aimbetov R, Bissenbaev A, Lee S, et al. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor. Sci Signal. 2011;4:ra10 pubmed publisher |
| Perry J, Ahmed M, Chang K, Donato N, Showalter H, Wobus C. Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. PLoS Pathog. 2012;8:e1002783 pubmed publisher |
| Morotomi-Yano K, Oyadomari S, Akiyama H, Yano K. Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2α phosphorylation and 4E-BP1 dephosphorylation. Exp Cell Res. 2012;318:1733-44 pubmed publisher |
