product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PERK (C33E10) Rabbit mAb
catalog :
3192
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C33E10
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other, western blot knockout validation
citations: 91
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 2b
Lu Y, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, et al. MARK2 phosphorylates eIF2α in response to proteotoxic stress. PLoS Biol. 2021;19:e3001096 pubmed publisher
  • western blot knockout validation; mouse; 1:500; fig 6d
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed publisher
  • western blot knockout validation; mouse; loading ...; fig 2b
Saveljeva S, Cleary P, Mnich K, Ayo A, Pakos Zebrucka K, Patterson J, et al. Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival. Oncotarget. 2016;7:12254-66 pubmed publisher
  • western blot knockout validation; mouse; fig 5
Ma T, Trinh M, Wexler A, Bourbon C, Gatti E, Pierre P, et al. Suppression of eIF2? kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013;16:1299-305 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, et al. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021;24:102758 pubmed publisher
  • western blot; mouse; loading ...; fig 6f
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1b
Cho J, Lee J, Kim H, Lee H, Fang Z, Kwon H, et al. Ethyl Acetate Fraction of Amomum villosum var. xanthioides Attenuates Hepatic Endoplasmic Reticulum Stress-Induced Non-Alcoholic Steatohepatitis via Improvement of Antioxidant Capacities. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6h
  • western blot; mouse; 1:1000; loading ...; fig 5c
Zhou Y, Ye X, Zhang C, Wang J, Guan Z, Yan J, et al. Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis. J Genet Genomics. 2021;48:403-410 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 3d
Torres A, Rodríguez Escribà M, Marcet Houben M, Santos Vieira H, Camacho N, Catena H, et al. Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins. Nucleic Acids Res. 2021;49:7011-7034 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Li Y, Chen L, Li L, Sottas C, Petrillo S, Lazaris A, et al. Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021;24:102457 pubmed publisher
  • western blot; mouse; loading ...; fig 7c
Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, et al. Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cell Mol Gastroenterol Hepatol. 2021;12:633-651 pubmed publisher
  • western blot; mouse; fig 1a
Lim Y, Kim S, Kim E. Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Mol Brain. 2021;14:65 pubmed publisher
  • western blot; human; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 6d
Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, et al. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021;296:100624 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher
  • western blot; human; loading ...; fig 3d
Clementi E, Inglin L, Beebe E, Gsell C, Garajova Z, Markkanen E. Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction. BMC Biol. 2020;18:36 pubmed publisher
  • western blot; mouse; loading ...; fig s2a
Smith H, Freeman O, Butcher A, Holmqvist S, Humoud I, Schätzl T, et al. Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Neuron. 2020;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4c
Zhu P, Khatiwada S, Cui Y, Reineke L, Dooling S, Kim J, et al. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019;366:843-849 pubmed publisher
  • western blot; mouse; loading ...; fig 5f
Wang Y, Chiang I, Ohara T, Fujii S, Cheng J, Muegge B, et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 2019;179:1144-1159.e15 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Mogilenko D, Haas J, L homme L, Fleury S, Quemener S, Levavasseur M, et al. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell. 2019;177:1201-1216.e19 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 5a
Brody M, Vanhoutte D, Bakshi C, Liu R, Correll R, Sargent M, et al. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. J Biol Chem. 2019;294:8918-8929 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Schiattarella G, Altamirano F, Tong D, French K, Villalobos E, Kim S, et al. Nitrosative stress drives heart failure with preserved ejection fraction. Nature. 2019;568:351-356 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2c
Cao Y, Trillo Tinoco J, Sierra R, Anadon C, Dai W, Mohamed E, et al. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun. 2019;10:1280 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5f
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher
  • western blot; mouse; loading ...; fig 3h
Gallot Y, Bohnert K, Straughn A, Xiong G, Hindi S, Kumar A. PERK regulates skeletal muscle mass and contractile function in adult mice. FASEB J. 2019;33:1946-1962 pubmed publisher
  • western blot; human; fig 3b
Green K, Glineburg M, Kearse M, Flores B, Linsalata A, Fedak S, et al. RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response. Nat Commun. 2017;8:2005 pubmed publisher
  • western blot; mouse; fig 2d
Ersoy B, Maner Smith K, Li Y, Alpertunga I, Cohen D. Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress. J Clin Invest. 2018;128:141-156 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Xiao N, Yang L, Yang Y, Liu L, Li J, Liu B, et al. Ginsenoside Rg5 Inhibits Succinate-Associated Lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance. Front Pharmacol. 2017;8:43 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability. Nat Commun. 2017;8:14186 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2
  • western blot; mouse; 1:500; loading ...; fig 1b
Yoon J, Park K, Hwang D, Rhee K. Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells. Mol Reprod Dev. 2017;84:265-274 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 7c
Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Yang Z, Tsuchiya H, Zhang Y, Lee S, Liu C, Huang Y, et al. REV-ERB? Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. Am J Pathol. 2016;186:2909-2920 pubmed publisher
  • western blot; human; 1:1000; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; mouse; fig 5
Taniuchi S, Miyake M, Tsugawa K, Oyadomari M, Oyadomari S. Integrated stress response of vertebrates is regulated by four eIF2? kinases. Sci Rep. 2016;6:32886 pubmed publisher
  • other; mouse; 1:500; fig 1
  • western blot; mouse; 1:500; fig 1
Zhu S, Henninger K, McGrath B, Cavener D. PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility. PLoS ONE. 2016;11:e0162766 pubmed publisher
  • western blot; rat; fig 3a
Krawczyk K, Ekman M, Rippe C, Grossi M, Nilsson B, Albinsson S, et al. Assessing the contribution of thrombospondin-4 induction and ATF6? activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep. 2016;6:32449 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Liu J, Ma Y, Sun C, Li S, Wang J. High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A. Biomed Res Int. 2016;2016:4130834 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 1a
  • western blot; human; 1:500; loading ...; fig 1a
Marwarha G, Claycombe K, Schommer J, Collins D, Ghribi O. Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBP? Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain. Cell Signal. 2016;28:1789-805 pubmed publisher
  • western blot; human; 1:500; fig 3
Gallagher C, Garri C, Cain E, Ang K, Wilson C, Chen S, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. elife. 2016;5: pubmed publisher
  • western blot; mouse; fig 4
Hamlin A, Basford J, Jaeschke A, Hui D. LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes. J Biol Chem. 2016;291:16610-9 pubmed publisher
  • western blot; human; fig 1a
Chaveroux C, Sarcinelli C, Barbet V, Belfeki S, Barthelaix A, Ferraro Peyret C, et al. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. Sci Rep. 2016;6:27278 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 2
Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed publisher
  • western blot; human; fig 2
Gupta A, Hossain M, Miller N, Kerin M, Callagy G, Gupta S. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer. Oncogene. 2016;35:5860-5871 pubmed publisher
  • western blot; mouse; fig s3
Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher
  • western blot; mouse; loading ...; fig s5g
Llambi F, Wang Y, Victor B, Yang M, Schneider D, Gingras S, et al. BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell. 2016;165:421-33 pubmed publisher
  • western blot; human; fig 5
Gupta A, Hossain M, Read D, Hetz C, Samali A, Gupta S. PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Sci Rep. 2015;5:18304 pubmed publisher
  • western blot; mouse; fig 1
Gao X, Krokowski D, Guan B, Bederman I, Majumder M, Parisien M, et al. Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response. elife. 2015;4:e10067 pubmed publisher
  • western blot; mouse; 1:2000; fig 1
Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015;17:1546-55 pubmed publisher
  • western blot; human; 1:1000; fig 3
Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, et al. Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget. 2015;6:33165-77 pubmed publisher
  • immunocytochemistry; human; 1:500; tbl 4
Nath A, Li I, Roberts L, Chan C. Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. Sci Rep. 2015;5:14752 pubmed publisher
  • western blot; human; fig 6
Artero Castro A, Perez Alea M, Feliciano A, Leal J, Genestar M, Castellvi J, et al. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 2015;11:1499-519 pubmed publisher
  • western blot; human
D Osualdo A, Anania V, Yu K, Lill J, Kaufman R, Matsuzawa S, et al. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. PLoS ONE. 2015;10:e0130635 pubmed publisher
  • western blot; mouse; fig 4,8
  • western blot; human; fig 4,8
So J, Cho S, Min S, Kimball S, Lee A. IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol. 2015;35:2761-70 pubmed publisher
  • immunoprecipitation; human; fig 4
Plumb R, Zhang Z, Appathurai S, Mariappan M. A functional link between the co-translational protein translocation pathway and the UPR. elife. 2015;4: pubmed publisher
  • western blot; human; fig 2
Sheng X, Arnoldussen Y, Storm M, Tesikova M, Nenseth H, Zhao S, et al. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015;7:788-801 pubmed publisher
  • western blot; mouse; 1:1000; fig 6a
Dametto P, Lakkaraju A, Bridel C, Villiger L, O CONNOR T, Herrmann U, et al. Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP. PLoS ONE. 2015;10:e0117412 pubmed publisher
  • western blot; human
Deegan S, Koryga I, Glynn S, Gupta S, Gorman A, Samali A. A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. Biochem Biophys Res Commun. 2015;456:305-11 pubmed publisher
  • western blot; human; 1:1000
Le Pape S, Dimitrova E, Hannaert P, Konovalov A, Volmer R, Ron D, et al. Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury. FEBS Lett. 2014;588:3062-7 pubmed publisher
  • western blot; mouse
Maas N, Singh N, Diehl J. Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther. 2014;15:1106-11 pubmed publisher
  • western blot; human
Sisinni L, Maddalena F, Lettini G, Condelli V, Matassa D, Esposito F, et al. TRAP1 role in endoplasmic reticulum stress protection favors resistance to anthracyclins in breast carcinoma cells. Int J Oncol. 2014;44:573-82 pubmed publisher
  • western blot; mouse
Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2? phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher
  • western blot; mouse; 1:1000
Devi L, Ohno M. Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher
Santofimia Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, et al. Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. Sci Rep. 2018;8:16999 pubmed publisher
Siddiquey M, Zhang H, Nguyen C, Domma A, Kamil J. The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response. J Virol. 2018;92: pubmed publisher
Kefalas G, Jouvet N, Baldwin C, Estall J, Larose L. Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses. J Biol Chem. 2018;293:12516-12524 pubmed publisher
Hossain M, Barua D, Arabkari V, Islam N, Gupta A, Gupta S. Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death. Oncotarget. 2018;9:11707-11721 pubmed publisher
Ko C, Counihan D, Wu J, Hatzoglou M, Puchowicz M, Croniger C. Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype. J Biol Chem. 2018;293:3399-3409 pubmed publisher
Bu Y, Yoshida A, Chitnis N, Altman B, Tameire F, Oran A, et al. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018;20:104-115 pubmed publisher
Kim H, Joe Y, Kim S, Park S, Park J, Chen Y, et al. Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2?-ATF4 pathway. Free Radic Biol Med. 2017;110:81-91 pubmed publisher
Erzurumlu Y, Ballar P. Androgen Mediated Regulation of Endoplasmic Reticulum-Associated Degradation and its Effects on Prostate Cancer. Sci Rep. 2017;7:40719 pubmed publisher
Chen Y, Holstein D, Aime S, Bollo M, Lechleiter J. Calcineurin β protects brain after injury by activating the unfolded protein response. Neurobiol Dis. 2016;94:139-56 pubmed publisher
Soeda J, Mouralidarane A, Cordero P, Li J, Nguyen V, Carter R, et al. Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas. J Physiol Biochem. 2016;72:281-91 pubmed publisher
He J, Wang C, Sun Y, Lu B, Cui J, Dong N, et al. Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress. Int J Mol Med. 2016;37:889-900 pubmed publisher
Radford H, Moreno J, Verity N, Halliday M, Mallucci G. PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol. 2015;130:633-42 pubmed publisher
Koyama S, Omura T, Yonezawa A, Imai S, Nakagawa S, Nakagawa T, et al. Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. PLoS ONE. 2015;10:e0136176 pubmed publisher
Mendez A, Alfaro J, Morales Soto M, Dar A, McCullagh E, Gotthardt K, et al. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. elife. 2015;4: pubmed publisher
Herrmann U, Sonati T, Falsig J, Reimann R, Dametto P, O CONNOR T, et al. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathog. 2015;11:e1004662 pubmed publisher
Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed publisher
Deegan S, Saveljeva S, Logue S, Pakos Zebrucka K, Gupta S, Vandenabeele P, et al. Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Autophagy. 2014;10:1921-36 pubmed publisher
Raina K, Noblin D, Serebrenik Y, Adams A, Zhao C, Crews C. Targeted protein destabilization reveals an estrogen-mediated ER stress response. Nat Chem Biol. 2014;10:957-62 pubmed publisher
Trinh M, Ma T, Kaphzan H, Bhattacharya A, Antion M, Cavener D, et al. The eIF2? kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014;21:298-304 pubmed publisher
Johnson J, Koetsier J, Sirico A, Agidi A, Antonini D, Missero C, et al. The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. J Invest Dermatol. 2014;134:2154-2162 pubmed publisher
Colin Cassin C, Yao X, Cerella C, Chbicheb S, Kuntz S, Mazerbourg S, et al. PPAR?-inactive ?2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells. Mol Carcinog. 2015;54:393-404 pubmed publisher
Devi L, Ohno M. Deletion of the eIF2? Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease. PLoS ONE. 2013;8:e77335 pubmed publisher
Matassa D, Amoroso M, Agliarulo I, Maddalena F, Sisinni L, Paladino S, et al. Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. Cell Death Dis. 2013;4:e851 pubmed publisher
He C, Stroink A, Vogel L, Wang C. Temperature increase exacerbates apoptotic neuronal death in chemically-induced ischemia. PLoS ONE. 2013;8:e68796 pubmed publisher
Arribas González E, Alonso Torres P, Aragón C, López Corcuera B. Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2). PLoS ONE. 2013;8:e63230 pubmed publisher
Perry J, Ahmed M, Chang K, Donato N, Showalter H, Wobus C. Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. PLoS Pathog. 2012;8:e1002783 pubmed publisher
Morotomi Yano K, Oyadomari S, Akiyama H, Yano K. Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2? phosphorylation and 4E-BP1 dephosphorylation. Exp Cell Res. 2012;318:1733-44 pubmed publisher
De Raedt T, Walton Z, Yecies J, Li D, Chen Y, Malone C, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011;20:400-13 pubmed publisher
Chen C, Shaikenov T, Peterson T, Aimbetov R, Bissenbaev A, Lee S, et al. ER stress inhibits mTORC2 and Akt signaling through GSK-3?-mediated phosphorylation of rictor. Sci Signal. 2011;4:ra10 pubmed publisher
product information
SKU :
3192S
Product-Name :
PERK (C33E10) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Western blot
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
140
Host :
Rabbit
Target :
PERK
Primary-Protein :
PERK
Alt-Names :
DKFZp781H1925,E2AK3,EIF2AK3,Eukaryotic translation initiation factor 2-alpha kinase 3,HRI,HsPEK,PEK,PERK,PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,WRS,eukaryotic translation initiation factor 2 alpha kinase 3,heme-regulated EIF2-alpha kinase
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.