product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
BiP (C50B12) Rabbit mAb
catalog :
3177S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
hamsters, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 25
Published Application/Species/DilutionReference
  • immunocytochemistry; human; 1:400; fig 5C
  • western blot; human; 1:1000; fig 5A
Zhou X, Wei Y, Qiu S, Xu Y, Zhang T, Zhang S. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0157590 pubmed publisher
  • western blot; human; fig 5
Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016;7:15868-84 pubmed publisher
  • western blot; mouse; fig 5
Park W, Kim S, Kim Y, Park J. Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription. Int J Mol Med. 2016;: pubmed publisher
  • western blot; rat; 1:500; fig 4
Jia W, Jian Z, Li J, Luo L, Zhao L, Zhou Y, et al. Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury. Int J Mol Med. 2016;37:1199-208 pubmed publisher
  • immunocytochemistry; human; 1:800
  • immunocytochemistry; mouse; 1:800
Sasaki M, Yoshimura-Miyakoshi M, Sato Y, Nakanuma Y. A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis. J Gastroenterol. 2015;50:984-95 pubmed publisher
  • immunohistochemistry; mouse
Bueno M, Lai Y, Romero Y, Brands J, St Croix C, Kamga C, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015;125:521-38 pubmed publisher
  • western blot; mouse; 1:1000
  • immunohistochemistry; mouse; 1:100
Maeda Y, Fukushima K, Kariya S, Orita Y, Nishizaki K. Dexamethasone Regulates Cochlear Expression of Deafness-associated Proteins Myelin Protein Zero and Heat Shock Protein 70, as Revealed by iTRAQ Proteomics. Otol Neurotol. 2015;36:1255-65 pubmed publisher
  • western blot; rat; 1:500
Liu S, Sarkar C, Dinizo M, Faden A, Koh E, Lipinski M, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis. 2015;6:e1582 pubmed publisher
  • western blot; mouse; 1:1000
Gomez-Cavazos J, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J Cell Biol. 2015;208:671-81 pubmed publisher
  • immunohistochemistry; mouse; fig 7
Linz A, Knieper Y, Gronau T, Hansen U, Aszodi A, Garbi N, et al. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. J Bone Miner Res. 2015;30:1481-93 pubmed publisher
  • western blot; human; 1:1000; fig 2
  • immunocytochemistry; human; fig 3
Cha-Molstad H, Sung K, Hwang J, Kim K, Yu J, Yoo Y, et al. Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol. 2015;17:917-29 pubmed publisher
  • western blot; mouse; fig 2c
Zhang Y, Seo S, Bhattarai S, Bugge K, Searby C, Zhang Q, et al. BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Hum Mol Genet. 2014;23:40-51 pubmed publisher
  • western blot; hamsters
Ding Y, Dellisanti C, Ko M, Czajkowski C, Puglielli L. The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides. J Biol Chem. 2014;289:32044-55 pubmed publisher
  • western blot; mouse
Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher
  • western blot; human
Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K. Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. Cell Stress Chaperones. 2013;18:11-23 pubmed publisher
  • western blot; rat
Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, et al. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013;18:800-10 pubmed publisher
  • immunohistochemistry; human; 1:200
Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino A. Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer. 2008;8:229 pubmed publisher
Law C, Ashcroft H, Zheng W, Sexton J. Assay development and multivariate scoring for high-content discovery of chemoprotectants of endoplasmic-reticulum-stress-mediated amylin-induced cytotoxicity in pancreatic beta cells. Assay Drug Dev Technol. 2014;12:375-84 pubmed publisher
Kuo D, Labelle-Dumais C, Mao M, Jeanne M, Kauffman W, Allen J, et al. Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations. Hum Mol Genet. 2014;23:1709-22 pubmed publisher
Xu X, Bucala R, Ren J. Macrophage migration inhibitory factor deficiency augments doxorubicin-induced cardiomyopathy. J Am Heart Assoc. 2013;2:e000439 pubmed publisher
Balakrishnan B, Sen D, Hareendran S, Roshini V, David S, Srivastava A, et al. Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS ONE. 2013;8:e53845 pubmed publisher
Guo L, Chen Z, Cox B, Amarnath V, Epand R, Epand R, et al. Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation. J Biol Chem. 2011;286:18170-80 pubmed publisher
Moumen A, Virard I, Raoul C. Accumulation of wildtype and ALS-linked mutated VAPB impairs activity of the proteasome. PLoS ONE. 2011;6:e26066 pubmed publisher
Venkataramani V, Thiele K, Behnes C, Wulf G, Thelen P, Opitz L, et al. Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells. Am J Pathol. 2012;180:1636-52 pubmed publisher
Ling S, Lau E, Al-Shabeeb A, Nikolic A, Catalano A, Iland H, et al. Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1. Haematologica. 2012;97:64-72 pubmed publisher
product information
SKU :
3177S
Product-Name :
BiP (C50B12) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Immunohistochemistry (Frozen)
Product-Category :
Protein Folding and Trafficking
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
78
Host :
Rabbit
Target :
BiP
Primary-Protein :
GRP78
Alt-Names :
78 kDa glucose-regulated protein,BiP,Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78,FLJ26106,GRP-78,GRP78,HSPA5,Heat shock 70 kDa protein 5,Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD),Immunoglobulin heavy chain-binding protein,MIF2,heat shock 70kD protein 5 (glucose-regulated protein, 78kD),heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.