BiP (C50B12) Rabbit mAb | Cell Signaling Technology 3177 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

BiP (C50B12) Rabbit mAb

catalog :

3177

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

C50B12

reactivity :

hamsters, human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Cell Signaling Technology product webpage

citations: 122

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; bovine; 1:300; loading ...; fig 3d western blot; bovine; 1:1000; loading ...; fig 3c	Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
western blot; mouse; loading ...; fig s1a	Wei Y, Chen J, Xu X, Li F, Wu K, Jiang Y, et al. Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity-Related Properties. Adv Sci (Weinh). 2021;8:2004319 pubmed publisher
western blot; human; loading ...; fig 2f	Ko P, Choi J, Song S, Keum S, Jeong J, Hwang Y, et al. Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Int J Mol Sci. 2021;22: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5b	Zhou Y, Ye X, Zhang C, Wang J, Guan Z, Yan J, et al. Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis. J Genet Genomics. 2021;48:403-410 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3d	Torres A, Rodríguez Escribà M, Marcet Houben M, Santos Vieira H, Camacho N, Catena H, et al. Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins. Nucleic Acids Res. 2021;49:7011-7034 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4b	Xiao J, Tu B, Zhou X, Jiang X, Xu G, Zhang J, et al. Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles. J Nanobiotechnology. 2021;19:162 pubmed publisher
western blot; human; 1:500; loading ...; fig 5b	Prokakis E, Dyas A, Grün R, Fritzsche S, Bedi U, Kazerouni Z, et al. USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response. Oncogene. 2021;40:4004-4018 pubmed publisher
western blot; human; 1:500; loading ...; fig 5a	Martínez Gutiérrez A, Fernández Duran I, Marazuela Duque A, Simonet N, Yousef I, Martínez Rovira I, et al. Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1. Aging (Albany NY). 2021;13:12308-12333 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 1b western blot; mouse; 1:1000; loading ...; fig 1a	Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher
western blot; mouse; loading ...; fig 4a	Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2f western blot; human; 1:1000; loading ...; fig s6	von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 3a	Sozen E, Yazgan B, Tok O, Demirel T, Ercan F, Proto J, et al. Cholesterol induced autophagy via IRE1/JNK pathway promotes autophagic cell death in heart tissue. Metabolism. 2020;106:154205 pubmed publisher
western blot; human; loading ...; fig s1c	Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1a western blot; rat; 1:1000; loading ...; fig 1d	Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
western blot; hamsters; 1:1000; loading ...; fig 4a	Yong J, Bischof H, Burgstaller S, Siirin M, Murphy A, Malli R, et al. Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2. elife. 2019;8: pubmed publisher
western blot; human; 1:1000; loading ...; fig 4s1b	Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
western blot; human; 1:1000; loading ...; fig 7a	Wang X, Peng P, Pan Z, Fang Z, Lu W, Liu X. Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells. Biol Res. 2019;52:34 pubmed publisher
western blot; mouse; loading ...; fig 2a	Hernández Alvarez M, Sebastian D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, et al. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell. 2019;177:881-895.e17 pubmed publisher
western blot; mouse; loading ...; fig e5h	Schiattarella G, Altamirano F, Tong D, French K, Villalobos E, Kim S, et al. Nitrosative stress drives heart failure with preserved ejection fraction. Nature. 2019;568:351-356 pubmed publisher
western blot; mouse; loading ...; fig 4d	Wu J, Ma S, Sandhoff R, Ming Y, Hotz Wagenblatt A, Timmerman V, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019;50:1218-1231.e5 pubmed publisher
western blot; mouse; loading ...; fig 1h	Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 6b	Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole C, et al. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3d	Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 3f	Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
western blot; human; loading ...; fig 6e	Liang H, Xiao J, Zhou Z, Wu J, Ge F, Li Z, et al. Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis. Oncogene. 2018;37:1961-1975 pubmed publisher
western blot; mouse; fig 1k	Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, et al. Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. J Cell Biol. 2018;217:975-995 pubmed publisher
western blot; mouse; loading ...; fig 6e	Smith M, Harley M, Kemp A, Wills J, Lee M, Arends M, et al. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 2018;44:217-232.e11 pubmed publisher
western blot; human; 1:1000; fig 3b	Green K, Glineburg M, Kearse M, Flores B, Linsalata A, Fedak S, et al. RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response. Nat Commun. 2017;8:2005 pubmed publisher
western blot; mouse; 1:2000; fig 9c	Lüningschrör P, Binotti B, Dombert B, Heimann P, Pérez Lara A, Slotta C, et al. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017;8:678 pubmed publisher
western blot; mouse; 1:500; loading ...; fig 2a	Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5a	Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
western blot; rat; loading ...; fig 6	Chambers T, Santiesteban L, Gomez D, Chambers J. Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity. Toxicology. 2017;382:24-35 pubmed publisher
western blot; mouse; fig 1a	Samuel S, Ghosh S, Majeed Y, Arunachalam G, Emara M, Ding H, et al. Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochem Pharmacol. 2017;132:118-132 pubmed publisher
western blot; human; loading ...; fig 3d	Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
western blot; human; 1:5000; loading ...; fig 1e	Déry M, LeBlanc A. Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element. Sci Rep. 2017;7:42285 pubmed publisher
western blot; human; 1:1000; loading ...; fig s4b	Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, et al. A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability. Nat Commun. 2017;8:14186 pubmed publisher
western blot; human; loading ...; fig 5a	Dufour F, Rattier T, Constantinescu A, Zischler L, MorlÃ© A, Ben Mabrouk H, et al. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress. Oncotarget. 2017;8:9974-9985 pubmed publisher
western blot; mouse; loading ...; fig 3a	Tripathi M, Zhang C, Singh B, Sinha R, Moe K, DeSilva D, et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016;7:e2513 pubmed publisher
immunohistochemistry; human; fig 5e western blot; human; loading ...; fig 4a	Sareddy G, Viswanadhapalli S, Surapaneni P, Suzuki T, Brenner A, Vadlamudi R. Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway. Oncogene. 2017;36:2423-2434 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1b western blot; mouse; 1:1000; loading ...; fig 8c	Hu J, Li B, Apisa L, Yu H, Entenman S, Xu M, et al. ER stress inhibitor attenuates hearing loss and hair cell death in Cdh23erl/erl mutant mice. Cell Death Dis. 2016;7:e2485 pubmed publisher
western blot; mouse; loading ...; fig 1e	Fernández Verdejo R, Vanwynsberghe A, Essaghir A, Demoulin J, Hai T, Deldicque L, et al. Activating transcription factor 3 attenuates chemokine and cytokine expression in mouse skeletal muscle after exercise and facilitates molecular adaptation to endurance training. FASEB J. 2017;31:840-851 pubmed publisher
flow cytometry; mouse; loading ...; fig 6a	Jones D, Gaudette B, Wilmore J, Chernova I, Bortnick A, Weiss B, et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J Clin Invest. 2016;126:4250-4261 pubmed publisher
western blot; rat; loading ...; fig 4a western blot; human; loading ...; fig 8a western blot; mouse; loading ...; fig 3b	Beauvais G, Bode N, Watson J, Wen H, Glenn K, Kawano H, et al. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. J Neurosci. 2016;36:10245-10256 pubmed
western blot; mouse; 1:1000; fig 1	Vanhoutte D, Schips T, Kwong J, Davis J, Tjondrokoesoemo A, Brody M, et al. Thrombospondin expression in myofibers stabilizes muscle membranes. elife. 2016;5: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4b	Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
blocking or activating experiments; human; fig 3 western blot; human; fig 1	Kaliberov S, Kaliberova L, Yan H, Kapoor V, Hallahan D. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther. 2016;23:303-14 pubmed publisher
western blot; human; fig 6	Wong M, Chen S. Human Choline Kinase-? Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation. J Virol. 2016;90:9075-95 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2b	Zhang L, Ren F, Zhang X, Wang X, Shi H, Zhou L, et al. Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. Dis Model Mech. 2016;9:799-809 pubmed publisher
immunocytochemistry; human; 1:400; fig 5C western blot; human; 1:1000; fig 5A	Zhou X, Wei Y, Qiu S, Xu Y, Zhang T, Zhang S. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0157590 pubmed publisher
western blot; human; fig 3	Ansari M, Haqqi T. Interleukin-1Î² induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes. Sci Rep. 2016;6:27611 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1	Piton N, Wason J, Colasse É, Cornic M, Lemoine F, Le Pessot F, et al. Endoplasmic reticulum stress, unfolded protein response and development of colon adenocarcinoma. Virchows Arch. 2016;469:145-54 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 5h western blot; human; 1:1000; loading ...; fig 5h	Zanotto Filho A, Dashnamoorthy R, Loranc E, de Souza L, Moreira J, Suresh U, et al. Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human. PLoS ONE. 2016;11:e0153970 pubmed publisher
western blot; rat; 1:500; fig 4	Jia W, Jian Z, Li J, Luo L, Zhao L, Zhou Y, et al. Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury. Int J Mol Med. 2016;37:1199-208 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6a	Soeda J, Mouralidarane A, Cordero P, Li J, Nguyen V, Carter R, et al. Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas. J Physiol Biochem. 2016;72:281-91 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2a	Tibullo D, Barbagallo I, Giallongo C, Vanella L, Conticello C, Romano A, et al. Heme oxygenase-1 nuclear translocation regulates bortezomibinduced cytotoxicity and mediates genomic instability in myeloma cells. Oncotarget. 2016;7:28868-80 pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 2g western blot; mouse; fig 2e	Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed publisher
western blot; human; fig 5	Talarico C, Dattilo V, D Antona L, Barone A, Amodio N, Belviso S, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016;7:15868-84 pubmed publisher
western blot; human; fig 1	Sieber J, Hauer C, Bhuvanagiri M, Leicht S, Krijgsveld J, Neu Yilik G, et al. Proteomic Analysis Reveals Branch-specific Regulation of the Unfolded Protein Response by Nonsense-mediated mRNA Decay. Mol Cell Proteomics. 2016;15:1584-97 pubmed publisher
western blot; mouse; fig 5	Park W, Kim S, Kim Y, Park J. Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription. Int J Mol Med. 2016;37:613-22 pubmed publisher
western blot; mouse; 1:1000; fig 3 western blot; human; 1:1000; fig 1	Kyathanahalli C, Organ K, Moreci R, Anamthathmakula P, Hassan S, Caritis S, et al. Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent. Proc Natl Acad Sci U S A. 2015;112:14090-5 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3a	Zhu X, Zelmer A, Kapfhammer J, Wellmann S. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. FASEB J. 2016;30:624-34 pubmed publisher
western blot; mouse; loading ...; fig s3a	Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, et al. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016;23:358-68 pubmed publisher
western blot; human; 1:1000; fig 3	Patel M, Jacobson B, Ji Y, Drees J, Tang S, Xiong K, et al. Vesicular stomatitis virus expressing interferon-Î² is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget. 2015;6:33165-77 pubmed publisher
immunocytochemistry; human; fig 3 western blot; human; 1:1000; fig 2	Cha Molstad H, Sung K, Hwang J, Kim K, Yu J, Yoo Y, et al. Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol. 2015;17:917-29 pubmed publisher
western blot; human; loading ...; fig 4	Kuballa P, Baumann A, Mayer K, BÃ¤r U, Burtscher H, Brinkmann U. Induction of heat shock protein HSPA6 (HSP70B') upon HSP90 inhibition in cancer cell lines. FEBS Lett. 2015;589:1450-8 pubmed publisher
western blot; human; 1:1000; fig 3	Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
immunohistochemistry; mouse; 1:100 western blot; mouse; 1:1000	Maeda Y, Fukushima K, Kariya S, Orita Y, Nishizaki K. Dexamethasone Regulates Cochlear Expression of Deafness-associated Proteins Myelin Protein Zero and Heat Shock Protein 70, as Revealed by iTRAQ Proteomics. Otol Neurotol. 2015;36:1255-65 pubmed publisher
western blot; mouse; 1:1000	Gomez Cavazos J, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J Cell Biol. 2015;208:671-81 pubmed publisher
immunohistochemistry; mouse; fig 7	Linz A, Knieper Y, Gronau T, Hansen U, Aszodi A, Garbi N, et al. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. J Bone Miner Res. 2015;30:1481-93 pubmed publisher
western blot; rat; 1:500	Liu S, Sarkar C, Dinizo M, Faden A, Koh E, Lipinski M, et al. Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death. Cell Death Dis. 2015;6:e1582 pubmed publisher
immunohistochemistry; mouse	Bueno M, Lai Y, Romero Y, Brands J, St Croix C, Kamga C, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015;125:521-38 pubmed publisher
immunocytochemistry; human; 1:800 immunocytochemistry; mouse; 1:800	Sasaki M, Yoshimura Miyakoshi M, Sato Y, Nakanuma Y. A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis. J Gastroenterol. 2015;50:984-95 pubmed publisher
western blot; hamsters	Ding Y, Dellisanti C, Ko M, Czajkowski C, Puglielli L. The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides. J Biol Chem. 2014;289:32044-55 pubmed publisher
western blot; human; fig 2	Lin Y, Zhang H, Liang J, Li K, Zhu W, Fu L, et al. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-12 pubmed publisher
western blot; mouse; fig 2c	Zhang Y, Seo S, Bhattarai S, Bugge K, Searby C, Zhang Q, et al. BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Hum Mol Genet. 2014;23:40-51 pubmed publisher
western blot; mouse	Huang M, Sivagurunathan S, Ting S, Jansson P, Austin C, Kelly M, et al. Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2? phosphorylation, and the induction of downstream targets. Am J Pathol. 2013;183:745-57 pubmed publisher
western blot; rat	Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, et al. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013;18:800-10 pubmed publisher
western blot; human	Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K. Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress. Cell Stress Chaperones. 2013;18:11-23 pubmed publisher
immunohistochemistry; human; 1:200	Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino A. Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer. 2008;8:229 pubmed publisher
	Tabbarah S, Tavares E, Charish J, Vincent A, Paterson A, Di Scipio M, et al. COG5 variants lead to complex early onset retinal degeneration, upregulation of PERK and DNA damage. Sci Rep. 2020;10:21269 pubmed publisher
	Andersen J, Zhang J, Sun H, Liu X, Liu J, Nie J, et al. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport. Mol Metab. 2020;42:101055 pubmed publisher
	Elmallah M, Cogo S, Constantinescu A, Elifio Esposito S, Abdelfattah M, Micheau O. Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP. Cells. 2020;9: pubmed publisher
	Moore P, Qi J, Thamsen M, Ghosh R, Peng J, Gliedt M, et al. Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019;79:6190-6203 pubmed publisher
	Tian S, Wu Q, Zhou B, Choi M, Ding B, Yang W, et al. Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Cell Rep. 2019;28:2517-2526.e5 pubmed publisher
	Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, et al. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019;10:1492 pubmed publisher
	Wu J, Chen Y, Dobbs N, Sakai T, Liou J, Miner J, et al. STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med. 2019;: pubmed publisher
	Cassimeris L, Engiles J, Galantino Homer H. Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis. BMC Vet Res. 2019;15:24 pubmed publisher
	Ohui K, Afanasenko E, Bacher F, Ting R, Zafar A, Blanco Cabra N, et al. New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. J Med Chem. 2018;: pubmed publisher
	Santofimia Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, et al. Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. Sci Rep. 2018;8:16999 pubmed publisher
	Shiozaki Y, Okamura K, Kohno S, Keenan A, Williams K, Zhao X, et al. The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP. J Biol Chem. 2018;293:17008-17020 pubmed publisher
	Vagner T, Spinelli C, Minciacchi V, Balaj L, Zandian M, Conley A, et al. Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J Extracell Vesicles. 2018;7:1505403 pubmed publisher
	Simandi Z, Pajer K, Károlyi K, Sieler T, Jiang L, Kolostyak Z, et al. Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. J Neurosci. 2018;38:7683-7700 pubmed publisher
	Geng J, Zaitouna A, Raghavan M. Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP). PLoS Pathog. 2018;14:e1007171 pubmed publisher
	Hossain Z, Valicherla G, Gupta A, Syed A, Riyazuddin M, Chandra S, et al. Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus. Sci Rep. 2018;8:8715 pubmed publisher
	Garner K, Betin V, Pinto V, Graham M, Abgueguen E, Barnes M, et al. Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Sci Rep. 2018;8:3902 pubmed publisher
	Shumilov E, Bacher U, Perske C, Mohr A, Eiffert H, Hasenkamp J, et al. In-situ validation of the endothelial cell receptor GRP78 in a case of rhinocerebral mucormycosis -Letter to the Editor- (New-Data Letter). Antimicrob Agents Chemother. 2018;: pubmed publisher
	Miyagawa Hayashino A, Yoshifuji H, Kitagori K, Ito S, Oku T, Hirayama Y, et al. Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes. Arthritis Res Ther. 2018;20:13 pubmed publisher
	Elenbaas J, Bragazzi Cunha J, Azuero Dajud R, Nelson B, Oral E, Williams J, et al. Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F. Gastroenterology. 2018;154:1625-1629.e8 pubmed publisher
	Ko C, Counihan D, Wu J, Hatzoglou M, Puchowicz M, Croniger C. Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype. J Biol Chem. 2018;293:3399-3409 pubmed publisher
	Zhang Z, Chu S, Wang S, Jiang Y, Gao Y, Yang P, et al. RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. Br J Pharmacol. 2018;175:590-605 pubmed publisher
	Kim S, Kim H, Park M, Cho S, Goughnour P, Han D, et al. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. J Cell Biol. 2017;216:2201-2216 pubmed publisher
	ÃœnlÃ¼ B, Bogdanov V, Versteeg H. Interplay between alternatively spliced Tissue Factor and full length Tissue Factor in modulating coagulant activity of endothelial cells. Thromb Res. 2017;156:1-7 pubmed publisher
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product information

SKU :

3177S

Product-Name :

BiP (C50B12) Rabbit mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M

Applications :

Immunohistochemistry (Frozen)

Product-Category :

Protein Folding and Trafficking

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

BiP

Primary-Protein :

GRP78

Alt-Names :

78 kDa glucose-regulated protein,BiP,Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78,FLJ26106,GRP-78,GRP78,HSPA5,Heat shock 70 kDa protein 5,Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD),Immunoglobulin heavy chain-binding protein,MIF2,heat shock 70kD protein 5 (glucose-regulated protein, 78kD),heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

more info or order :

Cell Signaling Technology product webpage