product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PDGF Receptor α (D1E1E) XP® Rabbit mAb
catalog :
3174
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D1E1E
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, western blot knockout validation
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 3a
Lin C, Tsai M, Chen Y, Liu W, Lin C, Hsu K, et al. Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Biomol Ther (Seoul). 2021;29:551-561 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6h
Mangold K, Masek J, He J, Lendahl U, Fuchs E, Andersson E. Highly efficient manipulation of nervous system gene expression with NEPTUNE. Cell Rep Methods. 2021;1: pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2k
Minakawa T, Matoba T, Ishidate F, Fujiwara T, Takehana S, Tabata Y, et al. Extracellular vesicles synchronize cellular phenotypes of differentiating cells. J Extracell Vesicles. 2021;10:e12147 pubmed publisher
  • western blot; human; loading ...; fig 2a
Ostriker A, Xie Y, Chakraborty R, Sizer A, Bai Y, Ding M, et al. TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy. Circulation. 2021;144:455-470 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 7d
Li J, Sun Z, Luo G, Wang S, Cui H, Yao Z, et al. Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult. Front Immunol. 2021;12:649285 pubmed publisher
  • western blot; mouse; loading ...; fig s1a
Gangoso E, Southgate B, Bradley L, Rus S, Gálvez Cancino F, McGivern N, et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell. 2021;184:2454-2470.e26 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 6a
Lai Y, Chao H, Lai A, Lin S, Chang Y, Huang Y. CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis. J Biomed Sci. 2020;27:52 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5h
Chen M, Lu P, Ma Q, Cao Y, Chen N, Li W, et al. CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes. Sci Adv. 2020;6:eaax9605 pubmed publisher
  • flow cytometry; mouse; 1:500; loading ...; fig e10b
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4e
SEGEL M, Neumann B, Hill M, Weber I, Viscomi C, Zhao C, et al. Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature. 2019;573:130-134 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 3f
  • immunocytochemistry; mouse; 1:500; loading ...; fig 3e
Garcia Agudo L, Janova H, Sendler L, Arinrad S, Steixner A, Hassouna I, et al. Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion. FASEB J. 2019;33:8634-8647 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1s1a
Dimas P, Montani L, Pereira J, Moreno D, Trötzmüller M, Gerber J, et al. CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Stivala S, Codilupi T, Brkic S, Baerenwaldt A, Ghosh N, Hao Shen H, et al. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019;130:1596-1611 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:600; loading ...; fig 5d
Gerber D, Ghidinelli M, Tinelli E, Somandin C, Gerber J, Pereira J, et al. Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function. elife. 2019;8: pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig s7c
Li Q, Cheng Z, Zhou L, Darmanis S, Neff N, Okamoto J, et al. Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron. 2019;101:207-223.e10 pubmed publisher
  • western blot; human; 1:1000; fig s3c
Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018;115:E5746-E5755 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:10; loading ...; fig 3f
Rux D, Song J, Swinehart I, Pineault K, Schlientz A, Trulik K, et al. Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells. Dev Cell. 2016;39:653-666 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig e5
Mueller A, van Velthoven C, Fukumoto K, Cheung T, Rando T. Intronic polyadenylation of PDGFR? in resident stem cells attenuates muscle fibrosis. Nature. 2016;540:276-279 pubmed publisher
  • immunocytochemistry; human; fig 6
  • western blot; human; fig s6
Westcott J, Prechtl A, Maine E, Dang T, Esparza M, Sun H, et al. An epigenetically distinct breast cancer cell subpopulation promotes collective invasion. J Clin Invest. 2015;125:1927-43 pubmed publisher
  • western blot; human
Roh J, Huang J, Hu W, Yang X, Jennings N, Sehgal V, et al. Biologic effects of platelet-derived growth factor receptor ? blockade in uterine cancer. Clin Cancer Res. 2014;20:2740-50 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Gao Y, Bayless K, Li Q. TGFBR1 is required for mouse myometrial development. Mol Endocrinol. 2014;28:380-94 pubmed publisher
  • immunohistochemistry; human; 1:150
Knösel T, Werner M, Jung A, Kirchner T, Dürr H. Dedifferentiated chondrosarcoma mimicking a giant cell tumor. Is this low grade dedifferentiated chondrosarcoma?. Pathol Res Pract. 2014;210:194-7 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300
Helmy K, Halliday J, Fomchenko E, Setty M, Pitter K, Hafemeister C, et al. Identification of global alteration of translational regulation in glioma in vivo. PLoS ONE. 2012;7:e46965 pubmed publisher
  • immunohistochemistry; human; 1:200
  • western blot; human; 1:2000
Eckert M, Lwin T, Chang A, Kim J, Danis E, Ohno Machado L, et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell. 2011;19:372-86 pubmed publisher
Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, et al. Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest. 2018;128:734-745 pubmed publisher
Tugay K, Guay C, Marques A, Allagnat F, Locke J, Harries L, et al. Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia. 2016;59:161-169 pubmed publisher
Martins T, Sanglard L, Silva W, Chizzotti M, Rennó L, Serão N, et al. Molecular Factors Underlying the Deposition of Intramuscular Fat and Collagen in Skeletal Muscle of Nellore and Angus Cattle. PLoS ONE. 2015;10:e0139943 pubmed publisher
Ohsaka A, Hirota Komatsu S, Araki M, Komatsu N. Platelet-derived growth factor receptors form complexes with neuropilin-1 during megakaryocytic differentiation of thrombopoietin-dependent UT-7/TPO cells. Biochem Biophys Res Commun. 2015;459:443-9 pubmed publisher
Carrillo Sepúlveda M, Keen H, Davis D, Grobe J, Sigmund C. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. PLoS ONE. 2014;9:e103786 pubmed publisher
Schwickart M, Mehrzai F, Pearson J, Shaghasi N, Chavez C, Schneider A, et al. Identification and elimination of target-related matrix interference in a neutralizing anti-drug antibody assay. J Immunol Methods. 2014;403:52-61 pubmed publisher
Wiradjaja F, Cottle D, Jones L, Smyth I. Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice. Dis Model Mech. 2013;6:1426-33 pubmed publisher
Huang Y, Das A, Yang Q, Zhu M, Du M. Zfp423 promotes adipogenic differentiation of bovine stromal vascular cells. PLoS ONE. 2012;7:e47496 pubmed publisher
Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS ONE. 2009;4:e7752 pubmed publisher
Zheng H, Ying H, Yan H, Kimmelman A, Hiller D, Chen A, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008;455:1129-33 pubmed publisher
product information
SKU :
3174S
Product-Name :
PDGF Receptor α (D1E1E) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M
Applications :
Flow cytometry
Product-Category :
RTK
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
190
Host :
Rabbit
Target :
PDGFR-a
Primary-Protein :
PDGFRa
Alt-Names :
Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140A,CD140a antigen,MGC74795,PDGF-R-alpha,PDGFR2,PDGFRA,PGFRA,RHEPDGFRA,platelet-derived growth factor receptor, alpha polypeptide,rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.