Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb | Cell Signaling Technology 3108 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb

catalog :

3108

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

138D4

reactivity :

human, mouse, rat, dogs, chicken, bovine, pigs , zebrafish , fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 171

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; loading ...; fig 2c	Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed publisher
immunohistochemistry; pigs ; 1:1000; loading ...; fig 4a	Keppie S, Mansfield J, Tang X, Philp C, Graham H, Onnerfjord P, et al. Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis. Function (Oxf). 2021;2:zqab037 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 3b	Savorani C, Malinverno M, Seccia R, Maderna C, Giannotta M, Terreran L, et al. A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition. J Cell Sci. 2021;134: pubmed publisher
western blot; bovine; 1:500; loading ...; fig 3a	Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s5a	Arnold F, Mahaddalkar P, Kraus J, Zhong X, Bergmann W, Srinivasan D, et al. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration. Adv Sci (Weinh). 2021;8:2100626 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5f	Pang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, et al. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Front Cell Dev Biol. 2021;9:706143 pubmed publisher
western blot; human; 1:1000; fig 5e	Bruce J, To K, Lui V, Chung G, Chan Y, Tsang C, et al. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape. Nat Commun. 2021;12:4193 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6e	Niu B, Liu J, Lv B, Lin J, Li X, Wu C, et al. Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun. 2021;12:2809 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s6j	Nasu M, Esumi S, Hatakeyama J, Tamamaki N, Shimamura K. Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem Cells. Front Cell Dev Biol. 2021;9:632381 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7a	Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol. 2021;4:490 pubmed publisher
western blot; rat; 1:1000; fig 6e	Meng K, Cai H, Cai S, Hong Y, Zhang X. Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats. Front Cell Dev Biol. 2021;9:644160 pubmed publisher
western blot; human; 1:1000; loading ...; fig 2a	Gori I, George R, Purkiss A, Strohbuecker S, Randall R, Ogrodowicz R, et al. Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization. elife. 2021;10: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 6c	Kushioka J, Kaito T, Okada R, Ishiguro H, Bal Z, Kodama J, et al. A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone. Bone Res. 2020;8:41 pubmed publisher
immunohistochemistry; mouse; 1:100; loading ...; fig 4a	Hara H, Maemura S, Fujiwara T, Takeda N, Ishii S, Yagi H, et al. Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome. PLoS ONE. 2020;15:e0239908 pubmed publisher
flow cytometry; mouse; 1:200; fig 4b	Alonso Herranz L, Sahún Español Á, Paredes A, Gonzalo P, Gkontra P, Núñez V, et al. Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction. elife. 2020;9: pubmed publisher
western blot; fruit fly ; 1:1000; loading ...; fig 2s	Upadhyay A, Peterson A, Kim M, O Connor M. Muscle-derived Myoglianin regulates Drosophila imaginal disc growth. elife. 2020;9: pubmed publisher
western blot; human; loading ...; fig s2	Shoemaker L, McCormick A, Allen B, Chang S. Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations. Clin Transl Med. 2020;10:e99 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7a	Huang W, Yu D, Wang M, Han Y, Lin J, Wei D, et al. ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma. Cell Prolif. 2020;53:e12836 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1s1a western blot; human; 1:1000; loading ...; fig 1b	Aykul S, Corpina R, Goebel E, Cunanan C, Dimitriou A, Kim H, et al. Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop. elife. 2020;9: pubmed publisher
western blot; mouse; loading ...; fig 6a	Chakrabarti M, Al Sammarraie N, Gebere M, Bhattacharya A, Chopra S, Johnson J, et al. Transforming Growth Factor Beta3 is Required for Cardiovascular Development. J Cardiovasc Dev Dis. 2020;7: pubmed publisher
western blot; human; 1:100; loading ...; fig 5c	Wang X, Lu Q, Fei X, Zhao Y, Shi B, Li C, et al. Expression and Prognostic Value of Id-4 in Patients with Esophageal Squamous Cell Carcinoma. Onco Targets Ther. 2020;13:1225-1234 pubmed publisher
western blot; dogs; 1:2000; loading ...; fig 5c	Wu Q, Li G, Wen C, Zeng T, Fan Y, Liu C, et al. Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis. Sci Adv. 2020;6:eaay9819 pubmed publisher
western blot; human; 1:1000; loading ...; fig 1c	Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher
western blot; human; loading ...; fig 2c	Zhou S, da Silva S, Siegel P, Philip A. CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro. Sci Rep. 2019;9:16317 pubmed publisher
western blot; human; loading ...; fig 1d	He R, Wang M, Zhao C, Shen M, Yu Y, He L, et al. TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. J Exp Clin Cancer Res. 2019;38:340 pubmed publisher
western blot; human; 1:1000; loading ...; fig 1a, 1c immunohistochemistry; mouse; 1:300; loading ...; fig 7c	Morabito M, Larcher M, Cavalli F, Foray C, Forget A, Mirabal Ortega L, et al. An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma. EMBO Mol Med. 2019;11:e9830 pubmed publisher
immunohistochemistry; mouse; 1:50; loading ...; fig 2c western blot; mouse; 1:1000; loading ...; fig 2d	van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 3a	Wang W, Chun H, Baek J, Sadik J, Shirazyan A, Razavi P, et al. The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. Proc Natl Acad Sci U S A. 2019;116:15570-15579 pubmed publisher
western blot; mouse; 1:500; fig 6a	Cibi D, Mia M, Guna Shekeran S, Yun L, Sandireddy R, Gupta P, et al. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. elife. 2019;8: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 1b	Miller D, Schmierer B, Hill C. TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation. J Cell Sci. 2019;: pubmed publisher
western blot; human; 1:1000; loading ...; fig 3b	Tsai C, Tsai C, Yi J, Kao H, Huang Y, Wang C, et al. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells. Sci Rep. 2019;9:5197 pubmed publisher
western blot; mouse; loading ...; fig 4c	Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y, et al. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. EBioMedicine. 2019;40:43-55 pubmed publisher
western blot; human; 1:1000; loading ...; fig 5d	Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed publisher
western blot; mouse; loading ...; fig 5d	Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
western blot; mouse; fig 3a	Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk U, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018;9:1352 pubmed publisher
western blot; zebrafish ; 1:200; loading ...; fig 2b	Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doğanlı C, et al. CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium. Cell Rep. 2018;22:2584-2592 pubmed publisher
western blot; human; loading ...; fig 4a	Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 5a	Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed publisher
immunohistochemistry; human; 1:250; loading ...; fig 3c	Browne A, Charmsaz S, Varešlija D, Fagan A, Cosgrove N, Cocchiglia S, et al. Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer. Oncogene. 2018;37:2008-2021 pubmed publisher
western blot; human; loading ...; fig s5s	Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
western blot; human; loading ...; fig 1e	Ventura E, Weller M, Burghardt I. Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells. J Immunol. 2017;198:4569-4574 pubmed publisher
western blot; mouse; fig s16	Wassermann Dozorets R, Rubinstein M. C/EBPÎ² LIP augments cell death by inducing osteoglycin. Cell Death Dis. 2017;8:e2733 pubmed publisher
western blot; mouse; loading ...; fig 1c	Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6b	Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, et al. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017;8:14105 pubmed publisher
western blot; mouse; loading ...; fig 4e	Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 2i	Oller J, Méndez Barbero N, Ruiz E, Villahoz S, Renard M, Canelas L, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017;23:200-212 pubmed publisher
western blot; mouse; loading ...; fig 7b	Bugyei Twum A, Abadeh A, Thai K, Zhang Y, Mitchell M, Kabir G, et al. Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction. Sci Rep. 2016;6:39551 pubmed publisher
western blot; mouse; loading ...; fig 5b	Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher
western blot; human; 1:1000; loading ...; fig 6a	Yang J, Savvatis K, Kang J, Fan P, Zhong H, Schwartz K, et al. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. Nat Commun. 2016;7:13710 pubmed publisher
western blot; human; loading ...; fig 1a	Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed publisher
western blot; human; 1:1000; loading ...; fig 7d	Zhu L, Gómez Durán A, Saretzki G, Jin S, Tilgner K, Melguizo Sanchís D, et al. The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J Cell Biol. 2016;215:187-202 pubmed
immunohistochemistry - paraffin section; mouse; loading ...; fig s1e	Wang W, Song B, Anbarchian T, Shirazyan A, Sadik J, Lyons K. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016;12:e1006352 pubmed publisher
western blot; human; 1:200; fig st1	Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
western blot; human; 1:1000; fig 1 western blot; mouse; 1:1000; fig s1	Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed publisher
western blot; human; 1:500; loading ...; fig 5b	Xiao X, Senavirathna L, Gou X, Huang C, Liang Y, Liu L. EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis. Physiol Rep. 2016;4: pubmed publisher
western blot; human; fig 1	Languino L, Singh A, Prisco M, Inman G, Luginbuhl A, Curry J, et al. Exosome-mediated transfer from the tumor microenvironment increases TGF? signaling in squamous cell carcinoma. Am J Transl Res. 2016;8:2432-7 pubmed
western blot; rat; loading ...; fig 3d	Kang L, Zhang D, Ma C, Zhang J, Jia K, Liu J, et al. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Sci Rep. 2016;6:27460 pubmed publisher
western blot; human; 1:2000; fig s1	Fessler E, Drost J, van Hooff S, Linnekamp J, Wang X, Jansen M, et al. TGFÎ² signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol Med. 2016;8:745-60 pubmed publisher
western blot; human; 1:1000; fig 1	Chen P, Qin L, Li G, Tellides G, Simons M. Smooth muscle FGF/TGFÎ² cross talk regulates atherosclerosis progression. EMBO Mol Med. 2016;8:712-28 pubmed publisher
western blot; human; fig 2	Lin S, Wang B, Lin C, Chien P, Wu Y, Ko J, et al. Chidamide alleviates TGF-?-induced epithelial-mesenchymal transition in lung cancer cell lines. Mol Biol Rep. 2016;43:687-95 pubmed publisher
western blot; mouse; 1:1000; fig s2	Bianchi E, Boekelheide K, Sigman M, Lamb D, Hall S, Hwang K. Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-β Signaling Pathway. PLoS ONE. 2016;11:e0153968 pubmed publisher
western blot; human; 1:1000; fig 4	Xu X, Tan X, Hulshoff M, Wilhelmi T, Zeisberg M, Zeisberg E. Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells. FEBS Lett. 2016;590:1222-33 pubmed publisher
western blot; human; 1:2000; fig 4	Ding Z, Jin G, Wang W, Sun Y, Chen W, Chen L, et al. Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells. Int J Mol Sci. 2016;17:408 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50-1:200; fig 4	Bassey Archibong B, Kwiecien J, Milosavljevic S, Hallett R, Rayner L, Erb M, et al. Kaiso depletion attenuates transforming growth factor-? signaling and metastatic activity of triple-negative breast cancer cells. Oncogenesis. 2016;5:e208 pubmed publisher
western blot; human; fig 3e	Becker M, Ibrahim Y, Oh A, Fagan D, Byron S, Sarver A, et al. Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer. PLoS ONE. 2016;11:e0150564 pubmed publisher
western blot; human; 1:1000; fig s1a	Rafehi S, Ramos Valdes Y, Bertrand M, McGee J, PrÃ©fontaine M, Sugimoto A, et al. TGFβ signaling regulates epithelial-mesenchymal plasticity in ovarian cancer ascites-derived spheroids. Endocr Relat Cancer. 2016;23:147-59 pubmed publisher
western blot; human; fig 5	Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-Î² signalling. Oncogene. 2016;35:4388-98 pubmed publisher
western blot; mouse; 1:1000; fig 1	Das R, Xu S, Nguyen T, Quan X, Choi S, Kim S, et al. Transforming Growth Factor Î²1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis. J Biol Chem. 2015;290:30830-42 pubmed publisher
western blot; mouse; 1:500; fig 7	Quigley H, Pitha I, Welsbie D, Nguyen C, Steinhart M, Nguyen T, et al. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS ONE. 2015;10:e0141137 pubmed publisher
western blot; human; fig s2d	Pelish H, Liau B, Nitulescu I, Tangpeerachaikul A, Poss Z, Da Silva D, et al. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 2015;526:273-276 pubmed publisher
western blot; mouse; 1:1000; fig 2	Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266 pubmed publisher
western blot; mouse; 1:1000; fig 1	Zhao Y, Londono P, Cao Y, Sharpe E, Proenza C, O Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015;6:8243 pubmed publisher
western blot; human; fig 4c	Marchiq I, Albrengues J, Granja S, Gaggioli C, PouyssÃ©gur J, Simon M. Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction. Oncotarget. 2015;6:24636-48 pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 8 immunocytochemistry; mouse; fig 8 western blot; mouse	Thomas A, Eijgelaar W, Daemen M, Newby A. Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. PLoS ONE. 2015;10:e0128163 pubmed publisher
immunocytochemistry; mouse; 1:100; fig 6b western blot; mouse; fig 6c	Carthy J, Meredith A, Boroomand S, Abraham T, Luo Z, Knight D, et al. Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts. PLoS ONE. 2015;10:e0133056 pubmed publisher
western blot; mouse; fig 1 immunohistochemistry; human; 1:25	Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, et al. JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J. 2015;34:2162-81 pubmed publisher
western blot; human; fig 1	Cui W, Zhou J, Dehne N, BrÃ¼ne B. Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFÎ² signaling in macrophages. Cell Biosci. 2015;5:36 pubmed publisher
western blot; human; fig 5	Zhao L, Liu S, Che X, Hou K, Ma Y, Li C, et al. Bufalin inhibits TGF-Î²-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-Î² receptors. Int J Mol Med. 2015;36:645-52 pubmed publisher
western blot; human; fig 7	Huygens C, LiÃ©nart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie P, et al. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor Î²1 (TGF-Î²1) Production in Human Regulatory T Cells. J Biol Chem. 2015;290:20105-16 pubmed publisher
western blot; human; 1:1000; fig 6	Krishnan S, Szabo E, Burghardt I, Frei K, Tabatabai G, Weller M. Modulation of cerebral endothelial cell function by TGF-Î² in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition. Oncotarget. 2015;6:22480-95 pubmed
western blot; human; fig 5	Min K, Liggett J, Silva G, Wu W, Wang R, Shen R, et al. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Oncogene. 2016;35:377-88 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:100; fig 2 western blot; mouse; fig 2	Kuroki H, Hayashi H, Nakagawa S, Sakamoto K, Higashi T, Nitta H, et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor Î² signal activation and liver regeneration after hepatectomy in an experimental model. Br J Surg. 2015;102:813-25 pubmed publisher
western blot; human; fig 4c	Li Y, Drabsch Y, Pujuguet P, Ren J, van Laar T, Zhang L, et al. Genetic depletion and pharmacological targeting of Î±v integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res. 2015;17:28 pubmed publisher
western blot; mouse; loading ...; fig S4a	Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE. 2015;10:e0121939 pubmed publisher
western blot; mouse; 1:500	Tapia O, Fong L, Huber M, Young S, Gerace L. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS ONE. 2015;10:e0116196 pubmed publisher
western blot; mouse; 1:500; fig 5	Tassinari V, Campolo F, Cesarini V, Todaro F, Dolci S, Rossi P. Fgf9 inhibition of meiotic differentiation in spermatogonia is mediated by Erk-dependent activation of Nodal-Smad2/3 signaling and is antagonized by Kit Ligand. Cell Death Dis. 2015;6:e1688 pubmed publisher
western blot; human	Perna F, Vu L, Themeli M, Kriks S, Hoya Arias R, Khanin R, et al. The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. Stem Cell Reports. 2015;4:658-69 pubmed publisher
western blot; human; fig 3	Rao R, Dhele N, Cheemadan S, Ketkar A, Jayandharan G, Palakodeti D, et al. Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming. Sci Rep. 2015;5:8229 pubmed publisher
western blot; mouse; 1:1000; fig 7	Tontonoz P, Cortez Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, et al. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015;35:1125-38 pubmed publisher
western blot; human; 1:1000	Aykul S, Ni W, Mutatu W, Martinez Hackert E. Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes. PLoS ONE. 2015;10:e0114954 pubmed publisher
western blot; rat; 1:1000	Scholze A, Foo L, Mulinyawe S, Barres B. BMP signaling in astrocytes downregulates EGFR to modulate survival and maturation. PLoS ONE. 2014;9:e110668 pubmed publisher
immunohistochemistry - paraffin section; human western blot; human; 1:1000	Joseph J, Conroy S, Tomar T, Eggens Meijer E, Bhat K, Copray S, et al. TGF-Î² is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion. Cell Death Dis. 2014;5:e1443 pubmed publisher
western blot; human; fig 3	Gray A, Stephens C, Bigelow R, Coleman D, Cardelli J. The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-Î²-induced myofibroblast phenotypes through RhoA and ERK inhibition. PLoS ONE. 2014;9:e109208 pubmed publisher
western blot; mouse; 1:100; fig 5a	Ramnath N, van de Luijtgaarden K, van der Pluijm I, van Nimwegen M, van Heijningen P, Swagemakers S, et al. Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema. PLoS ONE. 2014;9:e106054 pubmed publisher
western blot; mouse; fig 2,3	Flanders K, Heger C, Conway C, Tang B, Sato M, Dengler S, et al. Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-Î²/bone morphogenetic protein Smad signaling complexes in tissue sections. J Histochem Cytochem. 2014;62:846-63 pubmed publisher
western blot; pigs	Wang H, Leinwand L, Anseth K. Roles of transforming growth factor-?1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation. FASEB J. 2014;28:4551-62 pubmed publisher
western blot; human	Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed publisher
western blot; mouse; loading ...; fig 3,4	Li W, Li Q, Jiao Y, Qin L, Ali R, Zhou J, et al. Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest. 2014;124:755-67 pubmed publisher
immunoprecipitation; human western blot; human	Feng Y, Wu H, Xu Y, Zhang Z, Liu T, Lin X, et al. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-? signaling. J Biol Chem. 2014;289:2072-83 pubmed publisher
western blot; human	Kondo M, Yamaoka K, Sonomoto K, Fukuyo S, Oshita K, Okada Y, et al. IL-17 inhibits chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE. 2013;8:e79463 pubmed publisher
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product information

SKU :

3108S

Product-Name :

Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb

Size :

100 ul

Price-(USD) :

274 USD

Species-x-Reactivity :

H, M, R, Mi

Applications :

Western blot

Product-Category :

Developmental Biology

Shipping-Temp :

COLD

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

Host :

Rabbit

Target :

Smad2 (Ser465/Ser467) phosphate

Primary-Protein :

Smad2

Alt-Names :

JV18,JV18-1,MAD homolog 2,MAD, mothers against decapentaplegic homolog 2,MADH2,MADR2,MGC22139,MGC34440,Mad protein homolog,Mad-related protein 2,Mothers against DPP homolog 2,Mothers against decapentaplegic homolog 2,SMAD 2,SMAD family member 2,SMAD, mothers against DPP homolog 2,SMAD2,Sma- and Mad-related protein 2,hMAD-2,hSMAD2,mother against DPP homolog 2

more info or order :

Cell Signaling Technology product webpage