product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Smad2 (L16D3) Mouse mAb
catalog :
3103
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
L16D3
reactivity :
human, mouse, rat
application :
western blot
citations: 47
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig s9c
Lin F, Meng X, Guo Y, Cao W, Liu W, Xia Q, et al. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. Sci Adv. 2019;5:eaax1608 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
MacFarlane E, Parker S, Shin J, Kang B, Ziegler S, Creamer T, et al. Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome. J Clin Invest. 2019;129:659-675 pubmed publisher
  • western blot; human; loading ...; fig 4a
Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher
  • western blot; human; 1:1000; fig 2c
Bajikar S, Wang C, Borten M, Pereira E, Atkins K, Janes K. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Dev Cell. 2017;43:418-435.e13 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, et al. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017;214:1453-1469 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Kusumoto H, Shintani Y, Kanzaki R, Kawamura T, Funaki S, Minami M, et al. Podocalyxin influences malignant potential by controlling epithelial-mesenchymal transition in lung adenocarcinoma. Cancer Sci. 2017;108:528-535 pubmed publisher
  • western blot; rat; fig 5
Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed publisher
  • western blot; human; 1:2000; fig s1
Fessler E, Drost J, van Hooff S, Linnekamp J, Wang X, Jansen M, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol Med. 2016;8:745-60 pubmed publisher
  • western blot; human; fig 3
Yin K, Yin W, Wang Y, Zhou L, Liu Y, Yang G, et al. MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-? signaling in estrogen receptor positive breast cancer cells. Oncotarget. 2016;7:24537-48 pubmed publisher
  • western blot; human; loading ...; fig 1e
  • western blot; mouse; loading ...; fig 1g
Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, Li J, et al. Differential TGF? pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. Nat Commun. 2016;7:11012 pubmed publisher
  • western blot; rat; 1:1000
Jeong M, Kim S, Kang H, Park K, Park W, Yang S, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS ONE. 2015;10:e0136236 pubmed publisher
  • western blot; mouse; fig 2.a,b
Schachtrup C, Ryu J, Mammadzada K, Khan A, Carlton P, Perez A, et al. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci. 2015;18:1077-80 pubmed publisher
  • western blot; human; 1:2000; fig 6a
Janes K. An analysis of critical factors for quantitative immunoblotting. Sci Signal. 2015;8:rs2 pubmed publisher
  • western blot; mouse
Kim J, Shim M. Prostaglandin F2α receptor (FP) signaling regulates Bmp signaling and promotes chondrocyte differentiation. Biochim Biophys Acta. 2015;1853:500-12 pubmed publisher
  • western blot; mouse; loading ...; fig 3,4
Li W, Li Q, Jiao Y, Qin L, Ali R, Zhou J, et al. Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest. 2014;124:755-67 pubmed publisher
  • western blot; human; fig 1
Holtzhausen A, Golzio C, How T, Lee Y, Schiemann W, Katsanis N, et al. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014;28:1248-67 pubmed publisher
  • western blot; human; 1:2000; fig 1
de Seny D, Cobraiville G, Charlier E, Neuville S, Esser N, Malaise D, et al. Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties. PLoS ONE. 2013;8:e66769 pubmed publisher
  • western blot; mouse; fig 4a
Turco M, Furia L, Dietze A, Fernandez Diaz L, Ronzoni S, Sciullo A, et al. Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein. Stem Cells. 2012;30:2423-36 pubmed publisher
Li S, Tu C, Wan L, Chen R, Duan Z, Ren X, et al. FGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-β/β-catenin pathway. Cell Div. 2019;14:13 pubmed publisher
Wang S, Lu Y, Hong Q, Geng X, Wang X, Zheng W, et al. Protein Array-Based Detection of Proteins in Kidney Tissues from Patients with Membranous Nephropathy. Biomed Res Int. 2017;2017:7843584 pubmed publisher
Jarad M, Kuczynski E, Morrison J, Viloria Petit A, Coomber B. Release of endothelial cell associated VEGFR2 during TGF-β modulated angiogenesis in vitro. BMC Cell Biol. 2017;18:10 pubmed publisher
Okamoto A, Nojiri T, Konishi K, Tokudome T, Miura K, Hosoda H, et al. Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice : ANP for pulmonary fibrosis. Respir Res. 2017;18:1 pubmed publisher
Davaapil H, Brockes J, Yun M. Conserved and novel functions of programmed cellular senescence during vertebrate development. Development. 2017;144:106-114 pubmed publisher
Sun W, Gui L, Zuo X, Zhang L, Zhou D, Duan X, et al. Human epithelial-type ovarian tumour marker beta-2-microglobulin is regulated by the TGF-β signaling pathway. J Transl Med. 2016;14:75 pubmed publisher
Choi H, Jain V, Krueger B, Marshall V, Kim C, Shisler J, et al. Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-β Signaling. PLoS Pathog. 2015;11:e1005255 pubmed publisher
Iyengar P, Jaynes P, Rodón L, Lama D, Law K, Lim Y, et al. USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination. Sci Rep. 2015;5:14733 pubmed publisher
Xiong S, Klausen C, Cheng J, Zhu H, Leung P. Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling. Oncotarget. 2015;6:31659-73 pubmed publisher
Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström S. Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 2015;6:8198 pubmed publisher
Ischenko I, Petrenko O, Hayman M. A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells. Oncotarget. 2015;6:15814-27 pubmed
Kee H, Kim G, Cho S, Kwon J, Ahn Y, Kook H, et al. miR-18a-5p MicroRNA Increases Vascular Smooth Muscle Cell Differentiation by Downregulating Syndecan4. Korean Circ J. 2014;44:255-63 pubmed publisher
Yeung C, Gossan N, Lu Y, Hughes A, Hensman J, Bayer M, et al. Gremlin-2 is a BMP antagonist that is regulated by the circadian clock. Sci Rep. 2014;4:5183 pubmed publisher
Wachowicz K, Hermann Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G. Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells. PLoS ONE. 2014;9:e96401 pubmed publisher
Wang C, Bajikar S, Jamal L, Atkins K, Janes K. A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nat Cell Biol. 2014;16:345-56 pubmed publisher
Ardelean D, Yin M, Jerkic M, Peter M, Ngan B, Kerbel R, et al. Anti-VEGF therapy reduces intestinal inflammation in Endoglin heterozygous mice subjected to experimental colitis. Angiogenesis. 2014;17:641-59 pubmed publisher
Ruiz E, Oeztuerk Winder F, Ventura J. A paracrine network regulates the cross-talk between human lung stem cells and the stroma. Nat Commun. 2014;5:3175 pubmed publisher
Ardelean D, Jerkic M, Yin M, Peter M, Ngan B, Kerbel R, et al. Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment. Angiogenesis. 2014;17:129-46 pubmed publisher
Judson R, Greve T, Parchem R, Blelloch R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol. 2013;20:1227-35 pubmed publisher
Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, et al. PARP-1 regulates expression of TGF-? receptors in T cells. Blood. 2013;122:2224-32 pubmed publisher
Do J, Bonni A, Tuszynski M. SnoN facilitates axonal regeneration after spinal cord injury. PLoS ONE. 2013;8:e71906 pubmed publisher
Nagaoka T, Karasawa H, Turbyville T, Rangel M, Castro N, Gonzales M, et al. Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal. 2013;25:178-89 pubmed publisher
Sarközi R, Flucher K, Haller V, Pirklbauer M, Mayer G, Schramek H. Oncostatin M inhibits TGF-?1-induced CTGF expression via STAT3 in human proximal tubular cells. Biochem Biophys Res Commun. 2012;424:801-6 pubmed publisher
Preobrazhenska O, Wright J, Churg A. Regional heterogeneity in murine lung fibroblasts from normal mice or mice exposed once to cigarette smoke. PLoS ONE. 2012;7:e39761 pubmed publisher
Nelson E, Huang C, Ewel J, Chang A, Yuan C. Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts. Mol Vis. 2012;18:479-87 pubmed
Schoenherr C, Weiskirchen R, Haan S. Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses. Cell Commun Signal. 2010;8:19 pubmed publisher
Wang Q, Tao Y, Yuan J, Shen L, Liu C. Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro. BMC Cell Biol. 2010;11:31 pubmed publisher
Kleiter I, Song J, Lukas D, Hasan M, Neumann B, Croxford A, et al. Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain. 2010;133:1067-81 pubmed publisher
Li Q, Pangas S, Jorgez C, Graff J, Weinstein M, Matzuk M. Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol. 2008;28:7001-11 pubmed publisher
product information
SKU :
3103S
Product-Name :
Smad2 (L16D3) Mouse mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Western blot
Product-Category :
Developmental Biology
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
60
Host :
Mouse
Target :
Smad2
Primary-Protein :
Smad2
Alt-Names :
JV18,JV18-1,MAD homolog 2,MAD, mothers against decapentaplegic homolog 2,MADH2,MADR2,MGC22139,MGC34440,Mad protein homolog,Mad-related protein 2,Mothers against DPP homolog 2,Mothers against decapentaplegic homolog 2,SMAD 2,SMAD family member 2,SMAD, mothers against DPP homolog 2,SMAD2,Sma- and Mad-related protein 2,hMAD-2,hSMAD2,mother against DPP homolog 2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.