| Published Application/Species/Dilution | Reference |
|---|
| Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;: pubmed |
- western blot; human; fig 3
| Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0147344 pubmed publisher |
| Perdigão-Henriques R, Petrocca F, Altschuler G, Thomas M, Le M, Tan S, et al. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes. Oncogene. 2016;35:158-72 pubmed publisher |
- immunocytochemistry; mouse; 1:100; fig 5f
| Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, et al. Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nat Commun. 2016;7:10305 pubmed publisher |
- western blot; human; fig 3
| Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res. 2016;17:107 pubmed publisher |
- western blot; mouse; fig 3
| Garrel G, Racine C, L'Hôte D, Denoyelle C, Guigon C, di Clemente N, et al. Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty. Sci Rep. 2016;6:23790 pubmed publisher |
- western blot; mouse; fig 6
| Illich D, Zhang M, Ursu A, Osorno R, Kim K, Yoon J, et al. Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs. Cell Rep. 2016;: pubmed publisher |
- western blot; mouse; 1:500; fig 6
| Thakur A, Nigri J, Lac S, Leca J, Bressy C, Berthezene P, et al. TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma. Cell Death Differ. 2016;: pubmed publisher |
- immunohistochemistry - frozen section; human; 1:100; fig 5
| Chen P, Qin L, Li G, Tellides G, Simons M. Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO Mol Med. 2016;8:712-28 pubmed publisher |
| Kim J, Shim M. Prostaglandin F2α receptor (FP) signaling regulates Bmp signaling and promotes chondrocyte differentiation. Biochim Biophys Acta. 2015;1853:500-12 pubmed publisher |
| Singh K, Lovren F, Pan Y, Quan A, Ramadan A, Matkar P, et al. The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem. 2015;290:2547-59 pubmed publisher |
- immunocytochemistry; mouse; 1:100; fig s4e
| Yang N, Li L, Eguether T, Sundberg J, Pazour G, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015;142:2194-202 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100
| Noda K, Mishina Y, Komatsu Y. Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2015;: pubmed publisher |
- western blot; human; fig 1
| Li L, Qi L, Liang Z, Song W, Liu Y, Wang Y, et al. Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells. Int J Mol Med. 2015;36:113-22 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500; fig s2
| Pickup M, Hover L, Guo Y, Gorska A, Chytil A, Novitskiy S, et al. Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. Oncotarget. 2015;6:22890-904 pubmed |
- western blot; human; fig 1
| Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y. Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. J Biol Chem. 2015;290:6086-105 pubmed publisher |
- western blot; mouse; fig 2.a,b
| Schachtrup C, Ryu J, Mammadzada K, Khan A, Carlton P, Perez A, et al. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci. 2015;18:1077-80 pubmed publisher |
- western blot; human; fig 1
| Rojas-Fernandez A, Herhaus L, MacArtney T, Lachaud C, Hay R, Sapkota G. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9. Sci Rep. 2015;5:9811 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 5 ug/ml; fig 4
| Bach F, Zhang Y, Miranda-Bedate A, Verdonschot L, Bergknut N, Creemers L, et al. Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Res Ther. 2015;18:59 pubmed publisher |
- western blot; mouse; 1:500; fig 6
| Tateossian H, Morse S, Simon M, Dean C, Brown S. Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015;8:1531-42 pubmed publisher |
| Cohen T, Kollias H, Liu N, Ward C, Wagner K. Genetic disruption of Smad7 impairs skeletal muscle growth and regeneration. J Physiol. 2015;593:2479-97 pubmed publisher |
| Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher |
- proximity ligation assay; mouse; fig s12
| Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher |
- western blot; human; 1:1000
| Karki S, Surolia R, Hock T, Guroji P, Zolak J, Duggal R, et al. Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. FASEB J. 2014;28:1122-31 pubmed publisher |
| Sengupta S, Jana S, Bhattacharyya A. TGF-β-Smad2 dependent activation of CDC 25A plays an important role in cell proliferation through NFAT activation in metastatic breast cancer cells. Cell Signal. 2014;26:240-52 pubmed publisher |
| Beaudoin M, Snook L, Arkell A, Stefanson A, Wan Z, Simpson J, et al. Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats. Obesity (Silver Spring). 2014;22:1632-42 pubmed publisher |
| Bar-Klein G, Cacheaux L, Kamintsky L, Prager O, Weissberg I, Schoknecht K, et al. Losartan prevents acquired epilepsy via TGF-β signaling suppression. Ann Neurol. 2014;75:864-75 pubmed publisher |
| Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G, et al. Hepatocyte growth factor regulates the TGF-β1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med. 2014;34:381-90 pubmed publisher |
- western blot; rat; 1:1000
| Borkham-Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher |
| Strand D, Liang Y, Yang F, Barron D, Ressler S, Schauer I, et al. TGF-β induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways. Am J Clin Exp Urol. 2014;2:239-48 pubmed |
- immunohistochemistry; zebrafish
| Zhu Z, Chen J, Xiong J, Peng J. Haploinsufficiency of Def activates p53-dependent TGFβ signalling and causes scar formation after partial hepatectomy. PLoS ONE. 2014;9:e96576 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:500; fig 3
| Xu L, Golshirazian I, Asbury B, Li Y. Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA. Histol Histopathol. 2014;29:609-18 pubmed |
- western blot; human; 1:1000
| Hou P, Chuang C, Kao C, Chou S, Stone L, Ho H, et al. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res. 2013;41:7753-70 pubmed publisher |
- western blot; Domestic guinea pig
| Eckhouse S, Akerman A, Logdon C, Oelsen J, O'Quinn E, Nadeau E, et al. Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: relationship to interstitial microRNA dynamics and myocardial function. J Thorac Cardiovasc Surg. 2013;145:267-275, 277.e1-4; discussion 275-7 pubmed publisher |
| Harazono Y, Muramatsu T, Endo H, Uzawa N, Kawano T, Harada K, et al. miR-655 Is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2. PLoS ONE. 2013;8:e62757 pubmed publisher |
| Reese C, Dyer S, Perry B, Bonner M, Oates J, Hofbauer A, et al. Differential regulation of cell functions by CSD peptide subdomains. Respir Res. 2013;14:90 pubmed publisher |
- immunocytochemistry; mouse; 1:300
- western blot; mouse; 1:1000
| Spiller C, Feng C, Jackson A, Gillis A, Rolland A, Looijenga L, et al. Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. Development. 2012;139:4123-32 pubmed publisher |
- western blot; human; 1:1,000
| Kaur J, Reinhardt D. Immobilized metal affinity chromatography co-purifies TGF-β1 with histidine-tagged recombinant extracellular proteins. PLoS ONE. 2012;7:e48629 pubmed publisher |
| Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, Li J, et al. Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. Nat Commun. 2016;7:11012 pubmed publisher |
| Nasrallah R, Knezevic K, Thai T, Thomas S, Gottgens B, Lacaud G, et al. Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis. Biol Open. 2015;4:819-29 pubmed publisher |
| Wang Y, Ho C, Bang E, Rejon C, Libasci V, Pertchenko P, et al. Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis. Endocrinology. 2014;155:1970-81 pubmed publisher |
| Chen H, Sun H, Tao D, Yang P, Bian S, Liu Y, et al. Znf45l affects primitive hematopoiesis by regulating transforming growth factor-β signaling. BMB Rep. 2014;47:21-6 pubmed |
| Rejon C, Ho C, Wang Y, Zhou X, Bernard D, Hebert T. Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells. Cell Signal. 2013;25:1403-12 pubmed publisher |
| Louafi F, Martinez-Nunez R, Sanchez-Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}. J Biol Chem. 2010;285:41328-36 pubmed publisher |
| Nagata M, Goto K, Ehata S, Kobayashi N, Saitoh M, Miyoshi H, et al. Nuclear and cytoplasmic c-Ski differently modulate cellular functions. Genes Cells. 2006;11:1267-80 pubmed |
| Ehata S, Hanyu A, Hayashi M, Aburatani H, Kato Y, Fujime M, et al. Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res. 2007;67:9694-703 pubmed |
| Kroening S, Neubauer E, Wullich B, Aten J, Goppelt-Struebe M. Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. Am J Physiol Renal Physiol. 2010;298:F796-806 pubmed publisher |
