product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Aurora B/AIM1 Antibody
catalog :
3094
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, other
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2a
Fang H, Niu K, Mo D, Zhu Y, Tan Q, Wei D, et al. RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity. Oncogenesis. 2018;7:68 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; fig 2
Helmke C, Raab M, Rodel F, Matthess Y, Oellerich T, Mandal R, et al. Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8. Cell Res. 2016;26:914-34 pubmed publisher
  • western blot; human; 1:500; fig 3
Iimori M, Watanabe S, Kiyonari S, Matsuoka K, Sakasai R, Saeki H, et al. Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability. Nat Commun. 2016;7:11117 pubmed publisher
  • western blot; human; fig 3
Dos Santos E, Carneiro Lobo T, Aoki M, Levantini E, Bassères D. Aurora kinase targeting in lung cancer reduces KRAS-induced transformation. Mol Cancer. 2016;15:12 pubmed publisher
  • immunocytochemistry; human
Martinez R, Blasina A, Hallin J, Hu W, Rymer I, Fan J, et al. Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility. PLoS ONE. 2015;10:e0138616 pubmed publisher
  • western blot; human
Choi M, Kim W, Cheon M, Lee C, Kim J. Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells. Cancer Lett. 2015;357:591-601 pubmed publisher
  • western blot; human; 1:1000
Althoff K, Lindner S, Odersky A, Mestdagh P, Beckers A, Karczewski S, et al. miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin. Int J Cancer. 2015;136:1308-20 pubmed publisher
Sufit A, Lee Sherick A, DeRyckere D, Rupji M, Dwivedi B, Varella Garcia M, et al. MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. PLoS ONE. 2016;11:e0165107 pubmed publisher
Rodgers L, O Hainmhire E, Young A, Burdette J. Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium. Oncotarget. 2016;7:32785-95 pubmed publisher
Haque M, Song J, Fino K, Wang Y, Sandhu P, Song X, et al. C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open Biol. 2016;6:150208 pubmed publisher
Thorenoor N, Faltejskova Vychytilova P, Hombach S, Mlcochova J, Kretz M, Svoboda M, et al. Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget. 2016;7:622-37 pubmed publisher
Deng X, von Keudell G, Suzuki T, Dohmae N, Nakakido M, Piao L, et al. PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP. Oncotarget. 2015;6:35173-82 pubmed publisher
Li H, Zhong X, Chau K, Santistevan N, Guo W, Kong G, et al. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nat Commun. 2014;5:5601 pubmed publisher
Halley Stott R, Jullien J, Pasque V, Gurdon J. Mitosis gives a brief window of opportunity for a change in gene transcription. PLoS Biol. 2014;12:e1001914 pubmed publisher
Yang H, Lawrence H, Kazi A, Gevariya H, Patel R, Luo Y, et al. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation. Oncotarget. 2014;5:2947-61 pubmed
Cholewa B, Pellitteri Hahn M, Scarlett C, Ahmad N. Large-scale label-free comparative proteomics analysis of polo-like kinase 1 inhibition via the small-molecule inhibitor BI 6727 (Volasertib) in BRAF(V600E) mutant melanoma cells. J Proteome Res. 2014;13:5041-50 pubmed publisher
McCloy R, Rogers S, Caldon C, Lorca T, Castro A, Burgess A. Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events. Cell Cycle. 2014;13:1400-12 pubmed publisher
Cho H, Shimazu T, Toyokawa G, Daigo Y, Maehara Y, Hayami S, et al. Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun. 2012;3:1072 pubmed publisher
Hartsink Segers S, Zwaan C, Exalto C, Luijendijk M, Calvert V, Petricoin E, et al. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target. Leukemia. 2013;27:560-8 pubmed publisher
Jacob N, Cooley J, Shirai K, Chakravarti A. Survivin splice variants are not essential for mitotic progression or inhibition of apoptosis induced by doxorubicin and radiation. Onco Targets Ther. 2012;5:7-20 pubmed publisher
Mackay D, Makise M, Ullman K. Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol. 2010;191:923-31 pubmed publisher
product information
SKU :
3094P
Product-Name :
Aurora B/AIM1 Antibody
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
40
Host :
Rabbit
Target :
Aurora B
Primary-Protein :
AurB
Alt-Names :
AIK2,AIM-1,AIM1,ARK-2,ARK2,AURKB,AurB,Aurora B,Aurora kinase B,Aurora- and IPL1-like midbody-associated protein 1,Aurora-related kinase 2,Aurora/IPL1-related kinase 2,IPL1,STK-1,STK12,STK5,Serine/threonine-protein kinase 12,Serine/threonine-protein kinase aurora-B,aurkb-sv1,aurkb-sv2,aurora kinase B-Sv1,aurora kinase B-Sv2,aurora-1,aurora-B,serine/threonine kinase 12
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.