product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Aurora A (Thr288) (C39D8) Rabbit mAb
catalog :
3079S
quantity :
100 ul
price :
274 USD
clonality :
monoclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, common platanna
application :
western blot, immunocytochemistry
more info or order :
Cell Signaling Technology product webpage
citations: 13
Published Application/Species/DilutionReference
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • immunocytochemistry; human; 1:500; fig s5
Barretta M, Spano D, D'Ambrosio C, Cervigni R, Scaloni A, Corda D, et al. Aurora-A recruitment and centrosomal maturation are regulated by a Golgi-activated pool of Src during G2. Nat Commun. 2016;7:11727 pubmed publisher
  • immunocytochemistry; human; fig 3s
Wike C, Graves H, Hawkins R, Gibson M, Ferdinand M, Zhang T, et al. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. elife. 2016;5: pubmed publisher
  • western blot; human; fig 2
Kobayashi A, Hashizume C, Dowaki T, Wong R. Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A. Cell Cycle. 2015;14:1447-58 pubmed publisher
  • western blot; mouse; 1:100
Bangs F, Schrode N, Hadjantonakis A, Anderson K. Lineage specificity of primary cilia in the mouse embryo. Nat Cell Biol. 2015;17:113-22 pubmed publisher
  • western blot; human
Xu L, Long Z, Peng F, Liu Y, Xu J, Wang C, et al. Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells. Oncotarget. 2014;5:7498-511 pubmed
  • immunocytochemistry; human
Mannino M, Gomez-Roman N, Hochegger H, Chalmers A. Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics. Stem Cell Res. 2014;13:135-43 pubmed publisher
  • western blot; common platanna; 1:5,000
Kang Q, Srividhya J, Ipe J, Pomerening J. Evidence toward a dual phosphatase mechanism that restricts Aurora A (Thr-295) phosphorylation during the early embryonic cell cycle. J Biol Chem. 2014;289:17480-96 pubmed publisher
  • western blot; human; 1:1000
  • immunocytochemistry; human; 1:200
Tan E, Caro S, Potnis A, Lanza C, Slawson C. O-linked N-acetylglucosamine cycling regulates mitotic spindle organization. J Biol Chem. 2013;288:27085-99 pubmed publisher
  • western blot; mouse
Qi W, Spier C, Liu X, Agarwal A, Cooke L, Persky D, et al. Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment. Leuk Res. 2013;37:434-9 pubmed publisher
  • immunocytochemistry; human
Lin Y, Richards F, Krippendorff B, Bramhall J, Harrington J, Bapiro T, et al. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer. 2012;107:1692-701 pubmed publisher
Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, et al. Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways. PLoS ONE. 2013;8:e65264 pubmed publisher
Qi W, Liu X, Cooke L, Persky D, Miller T, Squires M, et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012;130:2997-3005 pubmed publisher
product information
SKU :
3079S
Product-Name :
Phospho-Aurora A (Thr288) (C39D8) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
48
Host :
Rabbit
Target :
Aurora A (Thr288) phosphate
Primary-Protein :
AurA
Alt-Names :
AIK,ARK-1,ARK1,AURA,AURKA,AURORA2,Aurora A,Aurora kinase A,Aurora-related kinase 1,Aurora/IPL1-related kinase 1,BTAK,Breast tumor-amplified kinase,IPL1-related kinase,MGC34538,STK15,STK6,STK7,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A,aurora/IPL1-like kinase,breast-tumor-amplified kinase,hARK1,serine/threonine kinase 6,serine/threonine protein kinase 15
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.