product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
c-Kit (D13A2) XP® Rabbit mAb
catalog :
3074
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D13A2
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1c, 4e, s4a, s4b
Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, et al. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun. 2020;11:1304 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2c
Varuzhanyan G, Rojansky R, Sweredoski M, Graham R, Hess S, Ladinsky M, et al. Mitochondrial fusion is required for spermatogonial differentiation and meiosis. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4
HERRING B, Hoggatt A, Gupta A, Wo J. Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice. Neurogastroenterol Motil. 2019;31:e13528 pubmed publisher
  • western blot; human; 1:1000; fig 4e
Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018;115:E5746-E5755 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6e
Liao C, Booker R, Morrison S, Le L. Identification of hair shaft progenitors that create a niche for hair pigmentation. Genes Dev. 2017;31:744-756 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s3i
Guimarães Camboa N, Cattaneo P, Sun Y, Moore Morris T, Gu Y, Dalton N, et al. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017;20:345-359.e5 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:750; fig 4
  • western blot; mouse; 1:1000
Saatcioglu H, Cuevas I, Castrillon D. Control of Oocyte Reawakening by Kit. PLoS Genet. 2016;12:e1006215 pubmed publisher
  • western blot; human; fig 3e
Moore A, Ceraudo E, Sher J, Guan Y, Shoushtari A, Chang M, et al. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nat Genet. 2016;48:675-80 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 1a
Zhang C, Huang X, Lu H, Meng X, Liu D, Kim Y, et al. Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice. Mol Cell Endocrinol. 2016;423:77-86 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 8
Geister K, Brinkmeier M, Cheung L, Wendt J, Oatley M, Burgess D, et al. LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. PLoS Genet. 2015;11:e1005569 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 5
Gely Pernot A, Raverdeau M, Teletin M, Vernet N, Féret B, Klopfenstein M, et al. Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor. PLoS Genet. 2015;11:e1005501 pubmed publisher
  • western blot; mouse; fig 2
Mizuno S, Takami K, Daitoku Y, Tanimoto Y, Dinh T, Mizuno Iijima S, et al. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Sci Rep. 2015;5:13632 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; fig 3
  • western blot; mouse; 1:300; fig 4
Gao X, Ma W, Nie J, Zhang C, Zhang J, Yao G, et al. A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death Dis. 2015;6:e1610 pubmed publisher
  • immunoprecipitation; mouse
Rai S, Tanaka H, Suzuki M, Ogoh H, Taniguchi Y, Morita Y, et al. Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells. PLoS ONE. 2014;9:e109441 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50
Goldstein B, Goss G, Hatzistergos K, Rangel E, Seidler B, Saur D, et al. Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons. J Comp Neurol. 2015;523:15-31 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400
Zhang Y, Bitner D, Pontes Filho A, Li F, Liu S, Wang H, et al. Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system. Neurogastroenterol Motil. 2014;26:77-97 pubmed publisher
Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea Rodríguez I, et al. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Cell Rep. 2018;25:3674-3692.e10 pubmed publisher
SCHMITT M, Schewe M, Sacchetti A, Feijtel D, van de Geer W, Teeuwssen M, et al. Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. Cell Rep. 2018;24:2312-2328.e7 pubmed publisher
Ran L, Chen Y, Sher J, Wong E, Murphy D, Zhang J, et al. FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. Cancer Discov. 2018;8:234-251 pubmed publisher
McIver S, Katsumura K, Davids E, Liu P, Kang Y, Yang D, et al. Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis. elife. 2016;5: pubmed publisher
Bulatovic I, Ibarra C, Österholm C, Wang H, Beltrán Rodríguez A, Varas Godoy M, et al. Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells. PLoS ONE. 2015;10:e0120176 pubmed publisher
Huang Z, Ruan H, Zhang Z, Chen W, Lin Z, Zeng H, et al. Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. Am J Pathol. 2014;184:122-32 pubmed publisher
Jinesh G, Choi W, Shah J, Lee E, Willis D, Kamat A. Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis. Cell Death Differ. 2013;20:382-95 pubmed publisher
product information
SKU :
3074S
Product-Name :
c-Kit (D13A2) XP® Rabbit mAb
Size :
100 ul
Price-(USD) :
260 USD
Species-x-Reactivity :
H, M
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
RTK
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
120 and 145
Host :
Rabbit
Target :
Kit
Primary-Protein :
Kit
Alt-Names :
C-Kit,CD117,KIT,Mast/stem cell growth factor receptor,PBT,Proto-oncogene c-Kit,SCFR,Tyrosine-protein kinase Kit,proto-oncogene tyrosine-protein kinase Kit,soluble KIT variant 1,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.