product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb
catalog :
3033
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
93H1
reactivity :
human, mouse, rat, dogs, bovine, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, reverse phase protein lysate microarray, other, western blot knockout validation
more info or order :
Cell Signaling Technology product webpage
citations: 440
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2b
  • western blot knockout validation; human; loading ...; fig e5b
Liu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisher
  • western blot; mouse; fig 5i
Ma S, Xu H, Huang W, Gao Y, Zhou H, Li X, et al. Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation. Front Physiol. 2021;12:706359 pubmed publisher
  • western blot; human; loading ...; fig 4b
Zheng J, Yao L, Zhou Y, Gu X, Wang C, Bao K, et al. A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. Cell Death Dis. 2021;12:871 pubmed publisher
  • western blot; mouse; 1:1000; fig 4d, 4g
Wu K, Feng J, Lyu F, Xing F, Sharma S, Liu Y, et al. Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer. Nat Commun. 2021;12:5196 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 7a
  • western blot; mouse; 1:1000; loading ...; fig 6a
Ho T, Yeh S, Chen S, Tsao Y. Integrin αv and Vitronectin Prime Macrophage-Related Inflammation and Contribute the Development of Dry Eye Disease. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; loading ...; fig s4b
Du Y, Zhang M, Liu X, Li Z, Hu M, Tian Y, et al. CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65. EMBO Rep. 2021;22:e52576 pubmed publisher
  • western blot; human; loading ...; fig 1e
  • western blot; mouse; loading ...; fig 3c
Xu X, Lei Y, Chen L, Zhou H, Liu H, Jiang J, et al. Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J Exp Clin Cancer Res. 2021;40:253 pubmed publisher
  • flow cytometry; mouse
Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Honda S, Ikeda K, Urata R, Yamazaki E, Emoto N, Matoba S. Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis. Sci Rep. 2021;11:14608 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Yang W, Lu X, Zhang T, Han W, Li J, He W, et al. TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling. Bone Res. 2021;9:33 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Lu J, Wang W, Li P, Wang X, Gao C, Zhang B, et al. MiR-146a regulates regulatory T cells to suppress heart transplant rejection in mice. Cell Death Discov. 2021;7:165 pubmed publisher
  • western blot; human; fig s3-1n
Jeong D, Kim H, Kim H, Kang M, Jung H, Oh Y, et al. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. elife. 2021;10: pubmed publisher
  • western blot; rat; loading ...; fig 3c
Wu Y, Zhang J, Li C, Hu H, Qin B, Wang T, et al. The Activation of ROS/NF-κB/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition. Oxid Med Cell Longev. 2021;2021:8836355 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 11c
Lee B, Hong S, Kim M, Kim E, Park H, Jung H, et al. Lycii radicis cortex inhibits glucocorticoid‑induced bone loss by downregulating Runx2 and BMP‑2 expression. Int J Mol Med. 2021;48: pubmed publisher
  • western blot; mouse; loading ...; fig 2g
Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, et al. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep. 2021;35:109272 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4c
Frottin F, Pérez Berlanga M, Hartl F, Hipp M. Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model. elife. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 7g
Zhang X, Song L, Li L, Zhu B, Huo L, Hu Z, et al. Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy. Signal Transduct Target Ther. 2021;6:235 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3e
Xu X, Huang X, Zhang L, Huang X, Qin Z, Hua F. Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway. BMC Nephrol. 2021;22:218 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 1e
  • western blot; human; loading ...; fig 2a
Zhang Z, Zhang L, Zhang Q, Liu B, Li F, Xin Y, et al. HO-1/CO Maintains Intestinal Barrier Integrity through NF-κB/MLCK Pathway in Intestinal HO-1-/- Mice. Oxid Med Cell Longev. 2021;2021:6620873 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Jiang D, Zhang J, Lin S, Wang Y, Chen Y, Fan J. Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet. Front Cell Dev Biol. 2021;9:628143 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1g
Parodi B, Sanna A, Cedola A, Uccelli A, Kerlero de Rosbo N. Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response. Front Immunol. 2021;12:655212 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1d
Atcha H, Jairaman A, Holt J, Meli V, Nagalla R, Veerasubramanian P, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021;12:3256 pubmed publisher
  • western blot; human; loading ...; fig 1a, 4g, 7f
  • western blot; mouse; fig 6a
Chen S, Liu H, Li Z, Tang J, Huang B, Zhi F, et al. Epithelial PBLD attenuates intestinal inflammatory response and improves intestinal barrier function by inhibiting NF-κB signaling. Cell Death Dis. 2021;12:563 pubmed publisher
  • western blot; human; loading ...; fig 7h
Ma X, Zhao T, Yan H, Guo K, Liu Z, Wei L, et al. Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma. Cell Death Dis. 2021;12:544 pubmed publisher
  • western blot; human; loading ...; fig 3c
Leon K, Buj R, Lesko E, Dahl E, Chen C, Tangudu N, et al. DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A. J Cell Biol. 2021;220: pubmed publisher
  • immunohistochemistry; mouse; 1:20; loading ...; fig 8g
Grol M, Haelterman N, Lim J, Munivez E, Archer M, Hudson D, et al. Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta. elife. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 3a
Lagosz Cwik K, Wielento A, Lipska W, Kantorowicz M, Darczuk D, Kaczmarzyk T, et al. hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis. Sci Rep. 2021;11:10770 pubmed publisher
  • western blot; pigs ; loading ...; fig 3h
Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, et al. The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response. Nucleic Acids Res. 2021;49:5537-5552 pubmed publisher
  • western blot; mouse; loading ...; fig 5h
Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, et al. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. J Nutr Biochem. 2021;95:108761 pubmed publisher
  • western blot; mouse; loading ...; fig ev2c
Pei G, Zyla J, He L, Moura Alves P, Steinle H, Saikali P, et al. Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate. EMBO J. 2021;40:e106272 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Lu H, Hsu H, Li C, Li S, Lin S, Shih C, et al. Hydrogen Sulfide Attenuates Aortic Remodeling in Aortic Dissection Associating with Moderated Inflammation and Oxidative Stress through a NO-Dependent Pathway. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7p
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, et al. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biol. 2021;43:101979 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5a
Huo Y, Selenica P, Mahdi A, Pareja F, Kyker Snowman K, Chen Y, et al. Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development. NPJ Breast Cancer. 2021;7:45 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Qin W, Brands X, Van T Veer C, F de Vos A, Sirard J, J T H Roelofs J, et al. Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection. PLoS Pathog. 2021;17:e1009491 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6g
Yin S, Li L, Tao Y, Yu J, Wei S, Liu M, et al. The Inhibitory Effect of Artesunate on Excessive Endoplasmic Reticulum Stress Alleviates Experimental Colitis in Mice. Front Pharmacol. 2021;12:629798 pubmed publisher
  • western blot; mouse; loading ...
Liu X, Jiang J, Liao Y, Tang I, Zheng E, Qiu W, et al. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. Adv Sci (Weinh). 2021;8:2002147 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zhang Y, Liu J, Wang X, Zhang J, Xie C. Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury. Aging (Albany NY). 2021;13:6752-6764 pubmed publisher
  • western blot; rat; 1:1000; fig 8a
Huang Y, Xiao X, Xiao H, Hu Z, Tan F. CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult. Aging (Albany NY). 2021;13:4335-4356 pubmed publisher
  • western blot; mouse; loading ...; fig 3i
Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, et al. ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth. Cancer Res. 2021;81:174-186 pubmed publisher
  • western blot; pigs ; loading ...; fig 4a
Tian M, Chen J, Wu Z, Song H, Yang F, Cui C, et al. Fat Encapsulation Reduces Diarrhea in Piglets Partially by Repairing the Intestinal Barrier and Improving Fatty Acid Transport. Animals (Basel). 2020;11: pubmed publisher
  • western blot; mouse; loading ...; fig 4f
Zhang D, Liu C, Li H, Jiao J. Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors. Adv Sci (Weinh). 2020;7:2002117 pubmed publisher
  • western blot; human; fig 2a
Nakayama A, Albarrán Juárez J, Liang G, Roquid K, Iring A, Tonack S, et al. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. JCI Insight. 2020;5: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Hu Q, Lu Y, Hu F, He S, Xu X, Niu Y, et al. Resistant dextrin reduces obesity and attenuates adipose tissue inflammation in high-fat diet-fed mice. Int J Med Sci. 2020;17:2611-2621 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 6c
Wang T, Gao Y, Yue R, Wang X, Shi Y, Xu J, et al. Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF-κB/NLRP3 Axis. Evid Based Complement Alternat Med. 2020;2020:2735714 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 3a
  • western blot; human; 1:1000; loading ...; fig 1a
Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, et al. HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma. Theranostics. 2020;10:10434-10447 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, et al. Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis. Front Immunol. 2020;11:1598 pubmed publisher
  • western blot; mouse; loading ...; fig s6c
Han C, Kang I, Harten I, Gebe J, Chan C, Omer M, et al. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020;31:107818 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Hastings J, González Rajal A, Latham S, Han J, McCloy R, O Donnell Y, et al. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s10a
Lechertier T, Reynolds L, Kim H, Pedrosa A, Gómez Escudero J, Muñoz Félix J, et al. Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nat Commun. 2020;11:2810 pubmed publisher
  • western blot; human; loading ...; fig 5g
Zhao Z, Xiang S, Qi J, Wei Y, Zhang M, Yao J, et al. Correction of the tumor suppressor Salvador homolog-1 deficiency in tumors by lycorine as a new strategy in lung cancer therapy. Cell Death Dis. 2020;11:387 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Du T, Yan Z, Zhu S, Chen G, Wang L, Ye Z, et al. QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism. Cell Death Dis. 2020;11:330 pubmed publisher
  • flow cytometry; human; 1:100; loading ...; fig 2a
Wong S, Lenzini S, Cooper M, Mooney D, Shin J. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Sci Adv. 2020;6:eaaw0158 pubmed publisher
  • flow cytometry; human; loading ...; fig 3a
Einhaus J, Pecher A, Asteriti E, Schmid H, Secker K, Duerr Stoerzer S, et al. Inhibition of effector B cells by ibrutinib in systemic sclerosis. Arthritis Res Ther. 2020;22:66 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2c
  • western blot; human; 1:1000; loading ...; fig 1g, 1h, 2e
Szymura S, Bernal G, Wu L, Zhang Z, Crawley C, Voce D, et al. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy. BMC Biol. 2020;18:32 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b, s12b
von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Farabaugh K, Krokowski D, Guan B, Gao Z, Gao X, Wu J, et al. PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation. elife. 2020;9: pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 5c
Yan S, Ding H, Peng J, Wang X, Pang C, Wei J, et al. Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro. Biosci Rep. 2020;40: pubmed publisher
  • western blot; mouse; loading ...; fig 4g
Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 8a
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 8c
  • immunocytochemistry; rat; 1:200; loading ...; fig s1c
  • western blot; rat; 1:1000; loading ...; fig s1a
Chen F, Jiang G, Liu H, Li Z, Pei Y, Wang H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. Bone Res. 2020;8:10 pubmed publisher
  • western blot; human; loading ...; fig 5e
Wang S, Qi Y, Gao X, Qiu W, Liu Q, Guo X, et al. Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma. Cell Death Dis. 2020;11:168 pubmed publisher
  • immunohistochemistry; rat; 1:1200; loading ...; fig 10
Merlo S, Luaces J, Spampinato S, Toro Urrego N, Caruso G, D Amico F, et al. SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence. Biomolecules. 2020;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5e
Wan G, An Y, Tao J, Wang Y, Zhou Q, Yang R, et al. MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway. Biosci Rep. 2020;40: pubmed publisher
  • western blot; mouse; loading ...; fig 3f
Guo X, Kolpakov M, Hooshdaran B, Schappell W, Wang T, Eguchi S, et al. Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload. JACC Basic Transl Sci. 2020;5:69-83 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
  • western blot; human; loading ...; fig 6c
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6l
Pakarinen E, Danilova T, Voikar V, Chmielarz P, Piepponen P, Airavaara M, et al. MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. Eneuro. 2020;7: pubmed publisher
  • western blot; human; loading ...; fig 4a
Lin L, Li Y, Liu M, Li Q, Liu Q, Li R. The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation. Aging (Albany NY). 2020;12:1685-1703 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4
Meng X, Zhao Y, Han B, Zha C, Zhang Y, Li Z, et al. Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways. Nat Commun. 2020;11:594 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4a
Cheung E, DeNicola G, Nixon C, Blyth K, Labuschagne C, Tuveson D, et al. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020;37:168-182.e4 pubmed publisher
  • western blot; rat; loading ...; fig 7a
  • western blot; human; loading ...; fig 10a
Zhang Y, Mao X, Chen W, Guo X, Yu L, Jiang F, et al. A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation. Mol Ther Nucleic Acids. 2020;19:890-904 pubmed publisher
  • western blot; human; fig 7g
Nixon C, Mavigner M, Sampey G, Brooks A, Spagnuolo R, Irlbeck D, et al. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020;578:160-165 pubmed publisher
  • western blot; human; loading ...; fig 1a
Lohard S, Bourgeois N, Maillet L, Gautier F, Fétiveau A, Lasla H, et al. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nat Commun. 2020;11:259 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2b
Li Y, Xu S, Xu Q, Chen Y. Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-κB signalling pathway. Artif Cells Nanomed Biotechnol. 2020;48:452-462 pubmed publisher
  • western blot; human; loading ...; fig 4a
Cai H, Yan L, Liu N, Xu M, Cai H. IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway. Biomed Pharmacother. 2020;123:109790 pubmed publisher
  • western blot; human; loading ...; fig 4g
Wang H, Chen Z, Wang S, Gao X, Qian M, Qiu W, et al. TGFβ1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-κB signalling pathway in human gliomas. Mol Oncol. 2020;14:407-425 pubmed publisher
  • western blot; human; loading ...; fig 2a
Jobin P, Solis N, Machado Y, Bell P, Rai S, Kwon N, et al. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage. J Biol Chem. 2020;295:2186-2202 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1e, 2c
Li Z, Wang H, Zeng Q, Yan J, Hu Y, Li H, et al. p65/miR-23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma. Cancer Med. 2020;9:711-723 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Zhang R, Liu Y, Chen Y, Li Q, Marshall C, Wu T, et al. Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption. CNS Neurosci Ther. 2020;26:228-239 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Zhang Q, Xiang L, Zaman M, Dong W, He G, Deng G. Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus. Front Immunol. 2019;10:3020 pubmed publisher
  • western blot; human; fig 2a
Jia Z, Huang Y, Ji X, Sun J, Fu G. Ticagrelor and clopidogrel suppress NF-κB signaling pathway to alleviate LPS-induced dysfunction in vein endothelial cells. BMC Cardiovasc Disord. 2019;19:318 pubmed publisher
  • western blot; rat; loading ...; fig 6i
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H. Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis. Aging (Albany NY). 2019;11:12532-12545 pubmed publisher
  • western blot; human; loading ...; fig 4a
Zoi I, Karamouzis M, Xingi E, Sarantis P, Thomaidou D, Lembessis P, et al. Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas. Breast Cancer Res. 2019;21:132 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
  • immunocytochemistry; mouse; 1:100; loading ...; fig 6e
  • western blot; mouse; loading ...; fig 2a, 2e
Thirugnanam K, Cossette S, Lu Q, Chowdhury S, Harmann L, Gupta A, et al. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. J Am Heart Assoc. 2019;8:e012792 pubmed publisher
  • western blot; human; loading ...; fig ev4b
Weiterer S, Meier Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, et al. Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J. 2019;:e101533 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 7c
  • western blot; rat; 1:400; loading ...; fig 7a
Xia Y, Xue M, Wang Y, Huang Z, Huang C. Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord. J Pain Res. 2019;12:2851-2863 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1n, 3g
Lu Y, Zheng Y, Coyaud E, Zhang C, Selvabaskaran A, Yu Y, et al. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. Science. 2019;366:460-467 pubmed publisher
  • western blot; mouse; loading ...; fig e6j
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, et al. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. Sci Adv. 2019;5:eaau7802 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Wang P, Qi X, Xu G, Liu J, Guo J, Li X, et al. CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. Aging (Albany NY). 2019;11:7402-7415 pubmed publisher
  • western blot; human; loading ...; fig 5a
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, et al. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochem Pharmacol. 2019;170:113642 pubmed publisher
  • western blot; human; loading ...; fig 2d
Managò A, Audrito V, Mazzola F, Sorci L, Gaudino F, Gizzi K, et al. Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation. Nat Commun. 2019;10:4116 pubmed publisher
  • western blot; mouse; loading ...; fig 10b
Zhou C, Sun X, Hu Y, Song J, Dong S, Kong D, et al. Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease. Aging (Albany NY). 2019;11:7257-7273 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Ng A, Li Z, Jones M, Yang S, Li C, Fu C, et al. Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4a
Shang S, Ji X, Zhang L, Chen J, Li C, Shi R, et al. Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis. Cancer Res. 2019;79:5513-5526 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4g
Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed publisher
  • western blot; human; loading ...; fig 2a
Jobin P, Solis N, Machado Y, Bell P, Kwon N, Kim S, et al. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. J Biol Chem. 2019;294:12866-12879 pubmed publisher
  • western blot; human; loading ...; fig 6a, 6b
Xu Y, Zhang Q, Zhou J, Li Z, Guo J, Wang W, et al. Down-regulation of SOX18 inhibits laryngeal carcinoma cell proliferation, migration, and invasion through JAK2/STAT3 signaling. Biosci Rep. 2019;: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 3a
Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, et al. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019;10:2352 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5g, 5h
  • western blot; human; loading ...; fig 5a, 5b
Kong L, Wu Z, Zhao Y, Lu X, Shi H, Liu S, et al. Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression. Biosci Rep. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 3d
  • western blot; pigs ; fig 1h
Liu Y, Li R, Chen X, Zhi Y, Deng R, Zhou E, et al. Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses To Suppress Proinflammatory Responses via the DAP12-Syk Pathway. MBio. 2019;10: pubmed publisher
  • western blot; human; loading ...; fig 5b
Zhang H, Wang J, Wang Y, Gao C, Gu Y, Huang J, et al. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats. Oxid Med Cell Longev. 2019;2019:2853534 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig s8a
  • western blot; mouse; 1:1000; loading ...; fig 6c
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, et al. Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. Nat Commun. 2019;10:1801 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 4d
Udden S, Kwak Y, Godfrey V, Khan M, Khan S, Loof N, et al. NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f
Walens A, DiMarco A, Lupo R, Kroger B, Damrauer J, Alvarez J. CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5h
Liu X, Chen H, Hou Y, Ma X, Ye M, Huang R, et al. Adaptive EGF expression sensitizes pancreatic cancer cells to ionizing radiation through activation of the cyclin D1/P53/PARP pathway. Int J Oncol. 2019;54:1466-1480 pubmed publisher
  • western blot; mouse; loading ...; fig s2d
Wu J, Ma S, Sandhoff R, Ming Y, Hotz Wagenblatt A, Timmerman V, et al. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019;50:1218-1231.e5 pubmed publisher
  • western blot; mouse; loading ...; fig 1i
Tan Y, Kagan J. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 6f
  • western blot; mouse; loading ...; fig 6b
Mentrup T, Theodorou K, Cabrera Cabrera F, Helbig A, Happ K, Gijbels M, et al. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. J Exp Med. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Losier T, Akuma M, McKee Muir O, LeBlond N, Suk Y, Alsaadi R, et al. AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Rep. 2019;26:2150-2165.e5 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a, 3c, s3d
Liu Z, Wu C, Pan Y, Liu H, Wang X, Yang Y, et al. NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages. Sci Adv. 2019;5:eaav0163 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6d
Wu W, Zhang W, Choi M, Zhao J, Gao P, Xue M, et al. Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation. Redox Biol. 2019;22:101137 pubmed publisher
  • western blot; mouse; loading ...; fig 2c
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Fan Y, Yang L, Wei Q, Ding Y, Tang Z, Tan P, et al. Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells. Asian J Androl. 2019;21:393-399 pubmed publisher
  • western blot; human; loading ...; fig 3b
Zhang J, Wang D, Wang L, Wang S, Roden A, Zhao H, et al. Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2019;316:L487-L497 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
  • western blot; human; loading ...; fig 3a, 3b
Lou C, Lu H, Ma Z, Liu C, Zhang Y. Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway. Biomed Pharmacother. 2019;109:563-572 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  • western blot; human; fig 7c
Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
  • flow cytometry; human; loading ...; fig 2d
Richardson J, Armbruster N, Günter M, Henes J, Autenrieth S. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018;9:2603 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Mouhadeb O, Ben Shlomo S, Cohen K, Farkash I, Gruber S, Maharshak N, et al. Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function. Front Immunol. 2018;9:2623 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6d
  • western blot; mouse; loading ...; fig 3e
Hakuno D, Kimura M, Ito S, Satoh J, Nakashima Y, Horie T, et al. Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction. Sci Rep. 2018;8:16749 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8d
Zhu H, Zhang L, Wu Y, Dong B, Guo W, Wang M, et al. T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. elife. 2018;7: pubmed publisher
  • western blot; human; loading ...; fig 3a
Luong P, Hedl M, Yan J, Zuo T, Fu T, Jiang X, et al. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. elife. 2018;7: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3g, 4c
Zhang X, Zhang M, Wang C. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Biochem Biophys Res Commun. 2018;506:137-144 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Yin J, Wang Y, Chang J, Li B, Zhang J, Liu Y, et al. Apelin inhibited epithelial-mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i. Cell Death Dis. 2018;9:1031 pubmed publisher
  • western blot; mouse; loading ...; fig 8a
Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, et al. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med. 2018;215:2850-2867 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Chorzalska A, Morgan J, Ahsan N, Treaba D, Olszewski A, Petersen M, et al. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Cao Y, Xu Y, Auchoybur M, Chen W, He S, Qin W, et al. Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages. J Mol Cell Cardiol. 2018;123:1-12 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 6c
Kang L, Kwon E, Lee K, Cho C, Lee J, Ryu Y, et al. 3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Br J Pharmacol. 2018;175:4295-4309 pubmed publisher
  • western blot; human; loading ...; fig 6d
Lee S, North K, Kim E, Jang E, Obeng E, Lu S, et al. Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations. Cancer Cell. 2018;34:225-241.e8 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s6a
Cuchet Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, CURTIS J, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018;361:810-813 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s4a
Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, et al. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. Nat Commun. 2018;9:2789 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Tan B, Shi X, Zhang J, Qin J, Zhang N, Ren H, et al. Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization. Cancer Res. 2018;78:4929-4942 pubmed publisher
  • western blot; human; loading ...; fig 2b
Dai L, Del Valle L, Miley W, Whitby D, Ochoa A, Flemington E, et al. Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene. 2018;37:4534-4545 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Song H, Li X, Liu Y, Lu W, Cui Z, Zhou L, et al. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS. Int J Mol Med. 2018;42:193-207 pubmed publisher
  • western blot; mouse; loading ...; fig 6h
Xi J, Huang Q, Wang L, Ma X, Deng Q, Kumar M, et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018;37:3151-3165 pubmed publisher
  • other; human; loading ...; fig 4c
Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  • western blot; mouse; 1:2000
Sun J, Wang Z, Wang X. Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice. Organogenesis. 2018;14:13-24 pubmed publisher
  • western blot; mouse; fig 5f
  • western blot; human; loading ...; fig 4j
Zhang H, Song Y, Yang H, Liu Z, Gao L, Liang X, et al. Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018;37:2456-2468 pubmed publisher
  • western blot; human; loading ...; fig 7c
Bogdan D, Falcone J, Kanjiya M, Park S, Carbonetti G, Studholme K, et al. Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. J Biol Chem. 2018;293:5295-5306 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5m
Jung Y, Cackowski F, Yumoto K, Decker A, Wang J, Kim J, et al. CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes. Cancer Res. 2018;78:2026-2039 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6c
Liu F, Dai M, Xu Q, Zhu X, Zhou Y, Jiang S, et al. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis. Oncogene. 2018;37:2394-2409 pubmed publisher
  • western blot; human; fig 5h
Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 11h
Sui Y, Liu Z, Park S, Thatcher S, Zhu B, Fernandez J, et al. IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight. 2018;3: pubmed publisher
  • western blot; human; 1:1000; fig 3h
Xu S, Zhou Z, Li H, Liu Z, Pan X, Wang F, et al. BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis. J Cell Sci. 2018;131: pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
Yang L, Shen L, Gao P, Li G, He Y, Wang M, et al. Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms. Oncotarget. 2017;8:92827-92840 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2c
Padilla J, Carpenter A, Das N, Kandikattu H, López Ongil S, Martinez Lemus L, et al. TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells. Am J Physiol Heart Circ Physiol. 2018;314:H52-H64 pubmed publisher
  • western blot; human; fig 1c
Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Yang Y, Yang S, Guo J, Cui Y, Tang B, Li X, et al. Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17. J Neurosci. 2017;37:9101-9115 pubmed publisher
  • western blot; human; loading ...; fig 3c
Franz S, Rennert P, Woznik M, Grützke J, Lüdde A, Arriero Pais E, et al. Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes. J Virol. 2017;91: pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Huh H, Lee E, Shin J, Park B, Lee S. STRAP positively regulates TLR3-triggered signaling pathway. Cell Immunol. 2017;318:55-60 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s13a
Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, et al. The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nat Commun. 2017;8:15426 pubmed publisher
  • flow cytometry; human; loading ...; fig 8c
Domae E, Hirai Y, Ikeo T, Goda S, Shimizu Y. Cytokine-mediated activation of human ex vivo-expanded V?9V?2 T cells. Oncotarget. 2017;8:45928-45942 pubmed publisher
  • western blot; human; loading ...; fig 4f
van Wijk S, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, et al. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-?B and restricts bacterial proliferation. Nat Microbiol. 2017;2:17066 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; loading ...; fig 2a, 2c, 2d
Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
  • western blot; mouse; 1:500; fig 7b
Xiong G, Hindi S, Mann A, Gallot Y, Bohnert K, Cavener D, et al. The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. elife. 2017;6: pubmed publisher
  • western blot; human; loading ...; fig 1b
Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • immunocytochemistry; rat; 1:100; loading ...; fig 6d
  • western blot; rat; 1:1000; loading ...; fig 6a
Zeng W, Han Y, Zhu G, Huang L, Deng Y, Wang Q, et al. Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia. BMC Neurosci. 2017;18:32 pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig 3a
Song Y, Lai L, Chong Z, He J, Zhang Y, Xue Y, et al. E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses. Nat Commun. 2017;8:14654 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s1
Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200; loading ...; fig 3
Zinni M, Zuena A, Marconi V, Petrella C, Fusco I, Giuli C, et al. Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis: A study on GR-mediated anti-inflammatory effect and prokineticin system. PLoS ONE. 2017;12:e0173484 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
  • western blot; human; loading ...; fig 5a
Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
  • western blot; mouse; loading ...; fig 2a, 3a
  • western blot; human; loading ...; fig 2b
Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
  • western blot; mouse; loading ...; fig 7c
Xiong X, Liu Y, Mei Y, Peng J, Wang Z, Kong B, et al. Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling. Sci Rep. 2017;7:41857 pubmed publisher
  • western blot; human; loading ...; fig 5a
Zeng Q, Song R, Fullerton D, Ao L, Zhai Y, Li S, et al. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Natl Acad Sci U S A. 2017;114:1631-1636 pubmed publisher
  • western blot; human; loading ...; fig 4b
Lin Y, Lin Y, Huang M, Kuo P, Wu C, Lee M, et al. Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification. Mol Immunol. 2017;83:82-91 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  • western blot; human; 1:1000; fig 7a
Schober T, Magg T, Laschinger M, Rohlfs M, Linhares N, Puchalka J, et al. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017;8:14209 pubmed publisher
  • western blot; human; fig 4e
Indrakusuma I, Romacho T, Eckel J. Protease-Activated Receptor 2 Promotes Pro-Atherogenic Effects through Transactivation of the VEGF Receptor 2 in Human Vascular Smooth Muscle Cells. Front Pharmacol. 2016;7:497 pubmed publisher
  • western blot; human; loading ...; fig 7g
Cianciola N, Chung S, Manor D, Carlin C. Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. J Virol. 2017;91: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5h
Oller J, Méndez Barbero N, Ruiz E, Villahoz S, Renard M, Canelas L, et al. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome. Nat Med. 2017;23:200-212 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017;292:2411-2421 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Hammers D, Sleeper M, Forbes S, Coker C, Jirousek M, Zimmer M, et al. Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle. JCI Insight. 2016;1:e90341 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, et al. Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice. J Am Heart Assoc. 2016;5: pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 7a
Liu W, Sun Y, He Y, Zhang H, Zheng Y, Yao Y, et al. IL-1? impedes the chondrogenic differentiation of synovial fluid mesenchymal stem cells in the human temporomandibular joint. Int J Mol Med. 2017;39:317-326 pubmed publisher
  • western blot; human; loading ...; fig 7a
Zhang W, Kang M, Zhang T, Li B, Liao X, Wang R. Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Shahriari K, Shen F, Worrede Mahdi A, Liu Q, Gong Y, Garcia F, et al. Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Oncogene. 2017;36:2846-2856 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Huh H, Ra E, Lee T, Kang S, Park A, Lee E, et al. STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway. Sci Rep. 2016;6:38849 pubmed publisher
  • western blot; human; loading ...; fig 2d
Tsai C, Lin Y, Huang C, Shih C, Tsai Y, Tsao N, et al. Thrombomodulin regulates monocye differentiation via PKC? and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7b
Schliesser M, Claus R, Hielscher T, Grimm C, Weichenhan D, Blaes J, et al. Prognostic relevance of miRNA-155 methylation in anaplastic glioma. Oncotarget. 2016;7:82028-82045 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed publisher
  • western blot; human; loading ...; fig 2a
Lin T, Cheng C, Su H, Huang N, Chen J, Kang H, et al. Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus. Front Immunol. 2016;7:440 pubmed
  • western blot; mouse; loading ...; fig s3h
Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed publisher
  • western blot; mouse; fig 3
Lin J, Kumari S, Kim C, Van T, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124-128 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s5e
Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, et al. Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. Am J Physiol Heart Circ Physiol. 2016;311:H1485-H1497 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 2i
  • western blot; human; 1:1000; loading ...; fig 2g
Jiang Y, Zeng Y, Huang X, Qin Y, Luo W, Xiang S, et al. Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1023-L1035 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
Zhou Z, Tang Y, Jin X, Chen C, Lu Y, Liu L, et al. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression. J Diabetes Res. 2016;2016:4847812 pubmed
  • western blot; mouse; loading ...; fig 6d
Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 9a
He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  • western blot; mouse; loading ...; fig 4
Figueroa González G, García Castillo V, Coronel Hernández J, López Urrutia E, León Cabrera S, Arias Romero L, et al. Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer. J Cancer. 2016;7:1632-1644 pubmed
  • western blot; human; loading ...; fig 4a
Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed
  • western blot; human; 1:1000; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; loading ...; fig 5b
Sikora M, Jacobsen B, Levine K, Chen J, Davidson N, Lee A, et al. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016;18:92 pubmed publisher
  • western blot; mouse; loading ...; fig 2f
Kaneda M, Messer K, Ralainirina N, Li H, Leem C, Gorjestani S, et al. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016;539:437-442 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s8d
Hirai Yuki A, Hensley L, McGivern D, Gonzalez Lopez O, Das A, Feng H, et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016;353:1541-1545 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 2a
Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Ando Y, Oku T, Tsuji T. Platelet Supernatant Suppresses LPS-Induced Nitric Oxide Production from Macrophages Accompanied by Inhibition of NF-?B Signaling and Increased Arginase-1 Expression. PLoS ONE. 2016;11:e0162208 pubmed publisher
  • western blot; human; loading ...; tbl 1
Scott D, Rhee D, Duda D, Kelsall I, Olszewski J, Paulo J, et al. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Cell. 2016;166:1198-1214.e24 pubmed publisher
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; mouse; fig 6
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Saggu R, Schumacher T, Gerich F, Rakers C, Tai K, Delekate A, et al. Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia. Acta Neuropathol Commun. 2016;4:76 pubmed publisher
  • western blot; mouse; fig 9
Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, et al. Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. Oncotarget. 2016;7:56030-56044 pubmed publisher
  • western blot; mouse; loading ...; fig s2b
Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, et al. IRF3 promotes adipose inflammation and insulin resistance and represses browning. J Clin Invest. 2016;126:2839-54 pubmed publisher
  • western blot; human; loading ...; fig 3b
Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-?B pathway in a transcription-independent manner. Nucleic Acids Res. 2016;44:7331-49 pubmed publisher
  • western blot; human; fig 6
Kim H, Choi M, Inn K, Kim B. Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner. Sci Rep. 2016;6:28896 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8a
Xiang N, Liu J, Liao Y, Huang Y, Wu Z, Bai Z, et al. Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway. Sci Rep. 2016;6:27583 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, et al. Activation of STING requires palmitoylation at the Golgi. Nat Commun. 2016;7:11932 pubmed publisher
  • western blot; human; loading ...; fig s5
Li Y, Liu C, Su T, Cheng H, Jeng Y, Lin H, et al. Characterization of metastatic tumor antigen 1 and its interaction with hepatitis B virus X protein in NF-κB signaling and tumor progression in a woodchuck hepatocellular carcinoma model. Oncotarget. 2016;7:47173-47185 pubmed publisher
  • western blot; mouse; fig 4
Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher
  • western blot; human; fig 5
Wagner S, Satpathy S, Beli P, Choudhary C. SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016;35:1868-84 pubmed publisher
  • western blot; human; fig 5
Li Q, Karim A, Ding X, Das B, Dobrowolski C, Gibson R, et al. Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis. Sci Rep. 2016;6:27566 pubmed publisher
  • western blot; human; fig 3
Duran C, Lee D, Jung J, Ravi S, Pogue C, Toussaint L, et al. NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-?B pathway. Oncogenesis. 2016;5:e231 pubmed publisher
  • western blot; mouse; loading ...; fig 2h
Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher
  • immunocytochemistry; human; 1:20; fig 5
Han B, Poppinga W, Zuo H, Zuidhof A, Bos I, Smit M, et al. The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. Sci Rep. 2016;6:26928 pubmed publisher
  • western blot; mouse; fig 2
Yu H. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. PLoS ONE. 2016;11:e0156303 pubmed publisher
  • flow cytometry; human
  • western blot; human; loading ...; fig 7a
Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Song X, Yao Z, Yang J, Zhang Z, Deng Y, Li M, et al. HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways. Oncotarget. 2016;7:33796-808 pubmed publisher
  • western blot; mouse; fig 4
Wang X, Wan H, Wei X, Zhang Y, Qu P. CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice. Mol Med Rep. 2016;14:49-56 pubmed publisher
  • western blot; mouse; fig 1
Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 4
Roth S, Spalinger M, Gottier C, Biedermann L, Zeitz J, Lang S, et al. Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. PLoS ONE. 2016;11:e0154817 pubmed publisher
  • western blot; bovine; loading ...; fig 9f
  • western blot; human; fig 9e
Ishizuka S, Askew E, Ishizuka N, Knudson C, Knudson W. 4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition. J Biol Chem. 2016;291:12087-104 pubmed publisher
  • western blot; rat; 1:500; fig 6
Tang S, Su H, Zhang Q, Tang H, Wang C, Zhou Q, et al. Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-?B/I?B? system through the activation of AMP-activated protein kinase. Int J Mol Med. 2016;37:1558-66 pubmed publisher
  • western blot; human; loading ...; fig 5a
Wang X, Wang N, Li H, Liu M, Cao F, Yu X, et al. Up-Regulation of PAI-1 and Down-Regulation of uPA Are Involved in Suppression of Invasiveness and Motility of Hepatocellular Carcinoma Cells by a Natural Compound Berberine. Int J Mol Sci. 2016;17:577 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
  • western blot; human; loading ...; fig 1c
Lin A, Wang G, Zhao H, Zhang Y, Han Q, Zhang C, et al. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. Oncoimmunology. 2016;5:e1074376 pubmed
  • western blot; human; 1:500; fig 8
Canton J, Schlam D, Breuer C, Gutschow M, Glogauer M, Grinstein S. Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages. Nat Commun. 2016;7:11284 pubmed publisher
  • western blot; mouse; loading ...; fig 5e
Damle S, Martin R, Cross J, Conrad D. Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis. Mucosal Immunol. 2017;10:205-214 pubmed publisher
  • western blot; human; fig 1
  • western blot; mouse; fig 1
West A, Martin B, Andrews D, Hogg S, Banerjee A, Grigoriadis G, et al. The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock. Oncogenesis. 2016;5:e216 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Chen S, Wang C, Yeo S, Liang C, Okamoto T, Sun S, et al. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes Dev. 2016;30:856-69 pubmed publisher
  • western blot; mouse; loading ...; fig s1e
Wang G, Liu X, Gaertig M, Li S, Li X. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proc Natl Acad Sci U S A. 2016;113:3359-64 pubmed publisher
  • western blot; mouse; fig 3
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  • western blot; mouse; 1:1000; tbl 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher
  • western blot; mouse; 1:2000; fig 4a
Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, et al. The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. Nat Commun. 2016;7:10761 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Xiao J, Shao L, Shen J, Jiang W, Feng Y, Zheng P, et al. Effects of ketanserin on experimental colitis in mice and macrophage function. Int J Mol Med. 2016;37:659-68 pubmed publisher
  • western blot; human; loading ...; fig s1a
Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, et al. Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation. Biochim Biophys Acta. 2016;1863:1106-18 pubmed publisher
  • western blot; mouse
Däbritz J, Judd L, Chalinor H, Menheniott T, Giraud A. Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells. Sci Rep. 2016;6:20584 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7
  • western blot; mouse; fig 8
Jean Charles P, Zhang L, Wu J, Han S, Brian L, Freedman N, et al. Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation. J Biol Chem. 2016;291:7450-64 pubmed publisher
  • western blot; human; fig 5h
Capell B, Drake A, Zhu J, Shah P, Dou Z, Dorsey J, et al. MLL1 is essential for the senescence-associated secretory phenotype. Genes Dev. 2016;30:321-36 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Kishi N, MacDonald J, Ye J, Molyneaux B, Azim E, Macklis J. Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice. Nat Commun. 2016;7:10520 pubmed publisher
  • western blot; human; loading ...; fig 2b
Lu S, Natarajan S, Mott J, Kharbanda K, Harrison Findik D. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway. PLoS ONE. 2016;11:e0147474 pubmed publisher
  • western blot; mouse; fig 5
Ding X, Pan L, Wang Y, Xu Q. Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice. Int J Mol Med. 2016;37:703-15 pubmed publisher
  • western blot; mouse; fig 2b
Liu H, Shi H, Huang F, Peterson K, Wu H, Lan Y, et al. Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway. Sci Rep. 2016;6:19137 pubmed publisher
  • western blot; human; fig 3
Ai L, Xu Q, Wu C, Wang X, Chen Z, Su D, et al. A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis. Int J Biol Sci. 2015;11:1436-46 pubmed publisher
  • western blot; mouse; fig 4C
Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci Rep. 2015;5:17192 pubmed publisher
  • western blot; human; fig 7
Yen Y, Hsiao J, Jiang S, Chang J, Wang S, Shen Y, et al. Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1. Oncotarget. 2015;6:41837-55 pubmed publisher
  • western blot; human; 1:100; fig s7
Hoshino A, Costa Silva B, Shen T, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329-35 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Lee D, Goldberg A. Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5. J Biol Chem. 2015;290:30269-79 pubmed publisher
  • western blot; human; fig 1
Dumas A, Lê Bury G, Marie Anaïs F, Herit F, Mazzolini J, Guilbert T, et al. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J Cell Biol. 2015;211:359-72 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig s4a
Gruosso T, Garnier C, Abélanet S, Kieffer Y, Lemesre V, Bellanger D, et al. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nat Commun. 2015;6:8583 pubmed publisher
  • western blot; mouse; fig 6
Yao X, Carlson D, Sun Y, Ma L, Wolf S, Minei J, et al. Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS ONE. 2015;10:e0139416 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 3b
Singh S, Chand H, Gundavarapu S, Saeed A, Langley R, Tesfaigzi Y, et al. HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS ONE. 2015;10:e0137757 pubmed publisher
  • western blot; human; 1:1000; fig 4a
Wang J, Hua W, Huang S, Fan K, Takeshima L, Mao Y, et al. RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb. Oncotarget. 2015;6:30165-77 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Nakamura R, Sene A, Santeford A, Gdoura A, Kubota S, Zapata N, et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun. 2015;6:7847 pubmed publisher
  • western blot; mouse; 1:500
He J, Quintana M, Sullivan J, L Parry T, J Grevengoed T, Schisler J, et al. MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. Cardiovasc Diabetol. 2015;14:97 pubmed publisher
  • western blot; human; fig 3d
Oteiza A, Mechti N. Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis. J Interferon Cytokine Res. 2015;35:859-74 pubmed publisher
  • flow cytometry; human; loading ...; fig 6c
Trinh B, Barengo N, Kim S, Lee J, Zweidler McKay P, Naora H. The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling. J Cell Sci. 2015;128:3055-67 pubmed publisher
  • flow cytometry; mouse; fig s2
Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, et al. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015;6:7652 pubmed publisher
  • western blot; mouse; fig 1
Wang Y, Lian Q, Yang B, Yan S, Zhou H, He L, et al. TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLoS Pathog. 2015;11:e1005012 pubmed publisher
  • flow cytometry; mouse; fig 6
Jin X, Yao T, Zhou Z, Zhu J, Zhang S, Hu W, et al. Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway. Biomed Res Int. 2015;2015:732450 pubmed publisher
  • western blot; mouse; fig 3
Yi M, Zhang E, Baek H, Kim S, Shin N, Kang J, et al. Growth Differentiation Factor 15 Expression in Astrocytes After Excitotoxic Lesion in the Mouse Hippocampus. Exp Neurobiol. 2015;24:133-8 pubmed publisher
  • western blot; mouse
Krokowski D, Jobava R, Guan B, Farabaugh K, Wu J, Majumder M, et al. Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity. J Biol Chem. 2015;290:17822-37 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 8
Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J. Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection. J Biol Chem. 2015;290:17306-20 pubmed publisher
  • western blot; human; 1:1000; fig s1
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher
  • western blot; human
Greenfeld H, Takasaki K, Walsh M, Ersing I, Bernhardt K, Ma Y, et al. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015;11:e1004890 pubmed publisher
  • western blot; human; fig 9
Wang Z, Cao C, Huang L, Ke Z, Luo C, Lin Z, et al. EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway. Oncotarget. 2015;6:14191-208 pubmed
  • western blot; human; fig 3
Sahu G, Farley K, El Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, et al. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015;483:185-202 pubmed publisher
  • western blot; human
Katanov C, Lerrer S, Liubomirski Y, Leider Trejo L, Meshel T, Bar J, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-? and the NF-?B pathway. Stem Cell Res Ther. 2015;6:87 pubmed publisher
  • western blot; mouse; fig s2
Lin A, Beasley F, Olson J, Keller N, Shalwitz R, Hannan T, et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015;11:e1004818 pubmed publisher
  • western blot; human
Willy J, Young S, Stevens J, Masuoka H, Wek R. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell. 2015;26:2190-204 pubmed publisher
  • western blot; human; 1:2500; fig 5a
Koizume S, Ito S, Nakamura Y, Yoshihara M, Furuya M, Yamada R, et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol Cancer. 2015;14:77 pubmed publisher
  • western blot; human; fig 1c
Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Ailenberg M, Di Ciano Oliveira C, Szaszi K, Dan Q, Rozycki M, Kapus A, et al. Dynasore enhances the formation of mitochondrial antiviral signalling aggregates and endocytosis-independent NF-κB activation. Br J Pharmacol. 2015;172:3748-63 pubmed publisher
  • western blot; human
Liu Z, Jiang C, Zhang J, Liu B, Du Q. Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities. J Diabetes. 2016;8:324-35 pubmed publisher
  • western blot; mouse
Bao M, Cai Z, Zhang X, Li L, Liu X, Wan N, et al. Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction. Basic Res Cardiol. 2015;110:25 pubmed publisher
  • reverse phase protein lysate microarray; human; tbl s2
Fallahi Sichani M, Moerke N, Niepel M, Zhang T, Gray N, Sorger P. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol. 2015;11:797 pubmed publisher
  • western blot; human; 1:500
Lavoz C, Alique M, Rodrígues Díez R, Pato J, Keri G, Mezzano S, et al. Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway. J Pathol. 2015;236:407-20 pubmed publisher
  • western blot; human
Coon B, Baeyens N, Han J, Budatha M, Ross T, Fang J, et al. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex. J Cell Biol. 2015;208:975-86 pubmed publisher
  • flow cytometry; mouse; fig 2
Woods S, Waite A, O Dea K, Halford P, Takata M, Wilson M. Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation. Am J Physiol Lung Cell Mol Physiol. 2015;308:L912-21 pubmed publisher
  • western blot; human; 1:1000; fig s5
  • western blot; mouse; 1:1000; fig s4
Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, et al. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol. 2015;17:434-44 pubmed publisher
  • western blot; mouse; fig 10A
Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher
  • flow cytometry; mouse; fig 5
Pannu J, Belle J, Forster M, Duerr C, Shen S, Kane L, et al. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS ONE. 2015;10:e0117304 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
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product information
SKU :
3033S
Product-Name :
Phospho-NF-κB p65 (Ser536) (93H1) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Hm, Mk, Pg, (Dg)
Applications :
Flow cytometry
Product-Category :
Immunology and Inflammation
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
65
Host :
Rabbit
Target :
NFkB-p65 (Ser536) phosphate
Primary-Protein :
NFkB-p65
Alt-Names :
MGC131774,NFKB3,Nuclear factor NF-kappa-B p65 subunit,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3,RELA,TF65,Transcription factor p65,p65,v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)),v-rel reticuloendotheliosis viral oncogene homolog A (avian),v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.