| Published Application/Species/Sample/Dilution | Reference |
|---|
- chromatin immunoprecipitation; human; loading ...; fig 2g
- immunoprecipitation; mouse; loading ...; fig 1c
| Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed publisher |
- western blot; human; loading ...; fig s10f
| Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; mouse; fig 7a
| Cai W, Sakaguchi M, Kleinridders A, Gonzalez Del Pino G, Dreyfuss J, O Neill B, et al. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017;8:14892 pubmed publisher |
- western blot; human; loading ...; fig 3b
| Yong K, Li A, Ou W, Hong C, Zhao W, Wang F, et al. Targeting SALL4 by entinostat in lung cancer. Oncotarget. 2016;7:75425-75440 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...
- western blot; human; 1:1000; loading ...; fig 5a
| Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig st1
| Huber M, Falkenberg N, Hauck S, Priller M, Braselmann H, Feuchtinger A, et al. Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer. Oncotarget. 2016;7:44062-44075 pubmed publisher |
- western blot; human; fig 4c
| Svalina M, Kikuchi K, Abraham J, Lal S, Davare M, Settelmeyer T, et al. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. Sci Rep. 2016;6:27012 pubmed publisher |
- immunocytochemistry; mouse
| Boothe T, Lim G, Cen H, Skovsø S, Piske M, Li S, et al. Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells. Mol Metab. 2016;5:366-378 pubmed publisher |
- immunohistochemistry; mouse; fig 1
| Gazit N, Vertkin I, Shapira I, Helm M, Slomowitz E, Sheiba M, et al. IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses. Neuron. 2016;89:583-97 pubmed publisher |
- western blot; human; fig 4
| Luey B, May F. Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway. Mol Cancer. 2016;15:8 pubmed publisher |
- western blot; human; fig 5
| Heynen G, Nevedomskaya E, Palit S, Jagalur Basheer N, Lieftink C, Schlicker A, et al. Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma. Mol Cancer Res. 2016;14:411-22 pubmed publisher |
- western blot; human; 1:50; loading ...; fig 1b
| Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed publisher |
- western blot; dog; 1:500; fig 5
| Clemente Vicario F, Alvarez C, ROWELL J, Roy S, London C, Kisseberth W, et al. Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines. PLoS ONE. 2015;10:e0142007 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Ramcharan R, Aleksic T, Kamdoum W, Gao S, Pfister S, Tanner J, et al. IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. Oncotarget. 2015;6:39877-90 pubmed publisher |
- western blot; human; fig 4b
| Seashore Ludlow B, Rees M, Cheah J, Cokol M, Price E, Coletti M, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discov. 2015;5:1210-23 pubmed publisher |
- western blot; human; fig 6
| Huygens C, Liénart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie P, et al. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells. J Biol Chem. 2015;290:20105-16 pubmed publisher |
- western blot; human; loading ...; fig 1c,2a,2b,2c,2d,2e,2f,2h,2i,2j,2k,3a,3b,3c,3d,3e,3f,
| Min H, Yun H, Lee J, Lee H, Cho J, Jang H, et al. Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. Mol Cancer. 2015;14:113 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Jang D, Kwon H, Jeong K, Lee J, Pak Y. Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor. J Cell Sci. 2015;128:2179-90 pubmed publisher |
- immunohistochemistry - paraffin section; human; tbl 3
| Heskamp S, Boerman O, Molkenboer Kuenen J, Wauters C, Strobbe L, Mandigers C, et al. Upregulation of IGF-1R expression during neoadjuvant therapy predicts poor outcome in breast cancer patients. PLoS ONE. 2015;10:e0117745 pubmed publisher |
- western blot; human; fig 1
| Rohatgi R, Janusis J, Leonard D, Bellvé K, Fogarty K, Baehrecke E, et al. Beclin 1 regulates growth factor receptor signaling in breast cancer. Oncogene. 2015;34:5352-62 pubmed publisher |
- immunohistochemistry - paraffin section; human
- western blot; human
| Subramani R, Lopez Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher |
- immunohistochemistry; human; 1:20
| Chen W, Ho C, Chang Y, Chen H, Lin C, Ling T, et al. Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. Nat Commun. 2014;5:3472 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:600
| Zhang G, Yang S, Li X, Zhou D. Expression and possible role of IGF-IR in the mouse gastric myenteric plexus and smooth muscles. Acta Histochem. 2014;116:788-94 pubmed publisher |
- western blot; mouse; 1:1000
| Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher |
| Zhu S, Ward B, Yu J, Matthew Onabanjo A, Janusis J, Hsieh C, et al. IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 2018;3: pubmed publisher |
| Titone R, Zhu M, Robertson D. Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells. Sci Rep. 2018;8:4378 pubmed publisher |
| Burrell L, Gayed D, Griggs K, Patel S, Velkoska E. Adverse cardiac effects of exogenous angiotensin 1-7 in rats with subtotal nephrectomy are prevented by ACE inhibition. PLoS ONE. 2017;12:e0171975 pubmed publisher |
| Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;36:3274-3286 pubmed publisher |
| Decourtye L, Mire E, Clemessy M, Heurtier V, Ledent T, Robinson I, et al. IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice. PLoS ONE. 2017;12:e0170083 pubmed publisher |
| Peterse E, Cleven A, de Jong Y, Briaire de Bruijn I, Fletcher J, Danen E, et al. No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone. BMC Cancer. 2016;16:475 pubmed publisher |
| Khan I, Pant I, Narra S, Radhesh R, Ranganathan K, Rao S, et al. Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut. J Cell Mol Med. 2015;19:2397-412 pubmed publisher |
| Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, et al. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Mol Med. 2015;7:996-1003 pubmed publisher |
| Lv L, Liu B. Role of non-classical renin-angiotensin system axis in renal fibrosis. Front Physiol. 2015;6:117 pubmed publisher |
| Aaltonen K, Rosendahl A, Olsson H, Malmström P, Hartman L, Fernö M. Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer. BMC Cancer. 2014;14:794 pubmed publisher |
| Andrieu T, Fustier P, Alikhani Koupaei R, Ignatova I, Guettinger A, Frey F, et al. Insulin, CCAAT/enhancer-binding proteins and lactate regulate the human 11?-hydroxysteroid dehydrogenase type 2 gene expression in colon cancer cell lines. PLoS ONE. 2014;9:e105354 pubmed publisher |
| Mattes C, Laube M, Thome U. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells. Physiol Rep. 2014;2:e00269 pubmed publisher |
| Chatterjee S, Bacopulos S, Yang W, Amemiya Y, SPYROPOULOS D, Raouf A, et al. Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland. PLoS ONE. 2014;9:e87858 pubmed publisher |
| Bronner D, O Riordan M, He Y. Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis. Front Cell Infect Microbiol. 2013;3:83 pubmed publisher |
| Huang L, Chen T, Chen C, Chen S, Liu Y, Wu J, et al. Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy. World J Surg Oncol. 2013;11:307 pubmed publisher |
| Chitnis M, Lodhia K, Aleksic T, Gao S, Protheroe A, Macaulay V. IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination. Oncogene. 2014;33:5262-73 pubmed publisher |
| Sanchez N, Gallagher M, Lao N, Gallagher C, Clarke C, Doolan P, et al. MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3. PLoS ONE. 2013;8:e65671 pubmed publisher |
| Itkonen H, Mills I. N-linked glycosylation supports cross-talk between receptor tyrosine kinases and androgen receptor. PLoS ONE. 2013;8:e65016 pubmed publisher |
| Epaud R, Aubey F, Xu J, Chaker Z, Clemessy M, Dautin A, et al. Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. PLoS ONE. 2012;7:e48071 pubmed publisher |
| Yao J, Gao X, Chow C, Zhan X, Hu C, Mei Y. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons. J Biol Chem. 2012;287:41534-45 pubmed publisher |
| Kang H, Yi Y, Kim H, Hong Y, Seong Y, Bae I. BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site. Cell Death Dis. 2012;3:e336 pubmed publisher |
| Marshall J, Holmberg J, Chou E, Ocampo A, Oh J, Lee J, et al. Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration. J Cell Biol. 2012;197:1009-27 pubmed publisher |
| Leang R, Wu T, Hwang S, Liang L, Tong L, Truong J, et al. The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. PLoS Pathog. 2011;7:e1002292 pubmed publisher |
| Sarfstein R, Bruchim I, Fishman A, Werner H. The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway. PLoS ONE. 2011;6:e24468 pubmed publisher |
| Vinciguerra M, Santini M, Claycomb W, Ladurner A, Rosenthal N. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY). 2009;2:43-62 pubmed |
| Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed publisher |
