| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig 2
| Li Z, Frey J, Wong G, Faugere M, Wolfgang M, Kim J, et al. Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts. Endocrinology. 2016;157:4094-4103 pubmed |
- western blot; mouse; 1:1000; loading ...; fig 5e, 5f, 5g
| Helsley R, Varadharajan V, Brown A, Gromovsky A, Schugar R, Ramachandiran I, et al. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. elife. 2019;8: pubmed publisher |
- immunoprecipitation; mouse; loading ...; fig s2b
| Hancock M, Meyer R, Mistry M, Khetani R, Wagschal A, Shin T, et al. Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019;177:722-736.e22 pubmed publisher |
- western blot; brown rat; 1:1000; loading ...; fig 4f, 5f
| Zhou X, Zhang R, Zou Z, Shen X, Xie T, Xu C, et al. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. Br J Pharmacol. 2019;176:478-490 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Wei X, Guo L, Liu Y, Zhou S, Liu Y, Dou X, et al. Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. Biochem Biophys Res Commun. 2017;491:814-820 pubmed publisher |
- western blot; swine; loading ...; fig 5b
| Cai C, Qian L, Jiang S, Sun Y, Wang Q, Ma D, et al. Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs. Oncotarget. 2017;8:34911-34922 pubmed publisher |
- western blot; mouse; fig s3d
- western blot; human; fig 1a
| Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher |
- flow cytometry; mouse; loading ...; fig 5b
| Dror E, Dalmas E, Meier D, Wueest S, Thévenet J, Thienel C, et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol. 2017;18:283-292 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, et al. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2017;13:41-56 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher |
- western blot; brown rat; fig 6
| de Castro Barbosa T, Ingerslev L, Alm P, Versteyhe S, Massart J, Rasmussen M, et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab. 2016;5:184-197 pubmed publisher |
- western blot; mouse; fig 3
| Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, et al. Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice. Drug Des Devel Ther. 2015;9:6327-42 pubmed publisher |
- western blot; mouse; fig 3E
| Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci Rep. 2015;5:17192 pubmed publisher |
- western blot; human; 1:1000
| Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez Villaseñor I, et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain. 2015;8:51 pubmed publisher |
- immunohistochemistry; mouse
- western blot; mouse
| Tan X, Xue Y, Ma T, Wang X, Li J, Lan L, et al. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015;10:24 pubmed publisher |
- western blot; human; fig 5
| Meyer K, Albaugh B, Schoenike B, Roopra A. Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST. Mol Cell Biol. 2015;35:2991-3004 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Min H, Yun H, Lee J, Lee H, Cho J, Jang H, et al. Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. Mol Cancer. 2015;14:113 pubmed publisher |
- western blot; mouse; fig 2
| Kim J, Toda C, D Agostino G, Zeiss C, DiLeone R, Elsworth J, et al. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A. 2014;111:11876-81 pubmed publisher |
| Kim K, Lee S, Ryu S, Han D. Efficient isolation and elution of cellular proteins using aptamer-mediated protein precipitation assay. Biochem Biophys Res Commun. 2014;448:114-9 pubmed publisher |
| Kang L, Mokshagundam S, Reuter B, Lark D, Sneddon C, Hennayake C, et al. Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice. Diabetes. 2016;65:1590-600 pubmed publisher |
| Wu L, Nguyen L, Zhou K, de Soysa T, Li L, Miller J, et al. Precise let-7 expression levels balance organ regeneration against tumor suppression. elife. 2015;4:e09431 pubmed publisher |
| Wang I, Ramrattan G, Cheung V. Genetic variation in insulin-induced kinase signaling. Mol Syst Biol. 2015;11:820 pubmed publisher |
| Sun J, Wang Y, Fu X, Chen Y, Wang D, Li W, et al. Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice. Biomed Res Int. 2015;2015:139451 pubmed publisher |
| Krüger J, Brachs S, Trappiel M, Kintscher U, Meyborg H, Wellnhofer E, et al. Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice. Mol Metab. 2015;4:325-36 pubmed publisher |
| Andrieu T, Fustier P, Alikhani Koupaei R, Ignatova I, Guettinger A, Frey F, et al. Insulin, CCAAT/enhancer-binding proteins and lactate regulate the human 11?-hydroxysteroid dehydrogenase type 2 gene expression in colon cancer cell lines. PLoS ONE. 2014;9:e105354 pubmed publisher |
| Wang X, Wahl R. Responses of the insulin signaling pathways in the brown adipose tissue of rats following cold exposure. PLoS ONE. 2014;9:e99772 pubmed publisher |
| Cheung V, Nayak R, Wang I, Elwyn S, Cousins S, Morley M, et al. Polymorphic cis- and trans-regulation of human gene expression. PLoS Biol. 2010;8: pubmed publisher |
