product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Insulin (C27C9) Rabbit mAb
catalog :
3014
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C27C9
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 22
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 4b
  • immunohistochemistry; human; 1:400; loading ...; fig 1c
Zhang X, Tao J, Yu J, Hu N, Zhang X, Wang G, et al. Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis. Cell Death Dis. 2021;12:867 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4a
Yang S, Qu Y, Chen J, Chen S, Sun L, Zhou Y, et al. Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion. Front Pharmacol. 2021;12:688073 pubmed publisher
  • western blot; rat; loading ...; fig 4b
Tokuo H, Komaba S, Coluccio L. In pancreatic β-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi. Mol Biol Cell. 2021;32:1210-1220 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1j
Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, et al. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021;296:100624 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Viloria K, Nasteska D, Briant L, Heising S, Larner D, Fine N, et al. Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Cell Rep. 2020;31:107761 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4i
Hamada S, Shimosegawa T, Taguchi K, Nabeshima T, Yamamoto M, Masamune A. Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma. Am J Physiol Gastrointest Liver Physiol. 2018;314:G65-G74 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 3b
Wang D, Ding X, Xue W, Zheng J, Tian X, Li Y, et al. A new scaffold containing small intestinal submucosa and mesenchymal stem cells improves pancreatic islet function and survival in vitro and in vivo. Int J Mol Med. 2017;39:167-173 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 5
  • immunohistochemistry - paraffin section; human; 1:200; fig 5
Bruin J, Saber N, O Dwyer S, Fox J, Mojibian M, Arora P, et al. Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice. Diabetes. 2016;65:1297-309 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1e
Tate M, Robinson E, Green B, McDermott B, Grieve D. Exendin-4 attenuates adverse cardiac remodelling in streptozocin-induced diabetes via specific actions on infiltrating macrophages. Basic Res Cardiol. 2016;111:1 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat Med. 2015;21:1364-71 pubmed publisher
  • western blot; mouse; fig 5
Costes S, Gurlo T, Rivera J, Butler P. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014;10:1004-14 pubmed publisher
Wei S, Han R, Zhao J, Wang S, Huang M, Wang Y, et al. Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutr Metab (Lond). 2018;15:80 pubmed publisher
Balboa D, Saarimäki Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, et al. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. elife. 2018;7: pubmed publisher
Hollenbach M, Kloting N, Sommerer I, Lorenz J, Heindl M, Kern M, et al. p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet. PLoS ONE. 2018;13:e0201159 pubmed publisher
Wan X, Zinselmeyer B, Zakharov P, Vomund A, Taniguchi R, Santambrogio L, et al. Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. Nature. 2018;560:107-111 pubmed publisher
Kee A, Chagan J, Chan J, Bryce N, Lucas C, Zeng J, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism. Sci Rep. 2018;8:4604 pubmed publisher
D souza A, Johnson J, Clee S, Kieffer T. Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice. Mol Metab. 2016;5:1103-1112 pubmed publisher
Khoriaty R, Everett L, Chase J, Zhu G, Hoenerhoff M, McKnight B, et al. Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. Sci Rep. 2016;6:27802 pubmed publisher
Yang B, Li X, Zhang C, Yan S, Wei W, Wang X, et al. Design, synthesis and biological evaluation of novel peptide MC2 analogues from Momordica charantia as potential anti-diabetic agents. Org Biomol Chem. 2015;13:4551-61 pubmed publisher
Bluteau G, Zhuang L, Amann R, Trueb B. Targeted disruption of the intracellular domain of receptor FgfrL1 in mice. PLoS ONE. 2014;9:e105210 pubmed publisher
Wu L, Li X, Zhu H, Xu P, Gao X. A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet. PLoS ONE. 2013;8:e60262 pubmed publisher
Gao J, He J, Shi X, Stefanovic Racic M, Xu M, O Doherty R, et al. Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes. Diabetes. 2012;61:1543-51 pubmed publisher
product information
SKU :
3014S
Product-Name :
Insulin (C27C9) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R
Applications :
Flow cytometry
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
6
Host :
Rabbit
Target :
insulin
Primary-Protein :
insulin
Alt-Names :
ins,insulin,insulin (A chain, B chain)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.