product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb
catalog :
3007
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
27B7
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry
citations: 29
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse
Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
  • western blot; human; loading ...; fig 6c
Bouhaddou M, Memon D, Meyer B, White K, Rezelj V, Correa Marrero M, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020;182:685-712.e19 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5f
Wu Y, Chou T, Young L, Hsieh F, Pan H, Mo S, et al. Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation. Cell Death Dis. 2020;11:305 pubmed publisher
  • western blot; dogs; 1:2000; loading ...; fig 3b
Wu Q, Li G, Wen C, Zeng T, Fan Y, Liu C, et al. Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis. Sci Adv. 2020;6:eaay9819 pubmed publisher
  • western blot; human; loading ...; fig 1a
Slobodnyuk K, Radic N, Ivanova S, Lladó A, Trempolec N, Zorzano A, et al. Autophagy-induced senescence is regulated by p38α signaling. Cell Death Dis. 2019;10:376 pubmed publisher
  • western blot; mouse; loading ...; fig 7d
Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s1
Loo L, Bougen Zhukov N, Tan W. Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatments. Sci Rep. 2017;7:43541 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig S20A
Li C, Bi Y, Li Y, Yang H, Yu Q, Wang J, et al. Dendritic cell MST1 inhibits Th17 differentiation. Nat Commun. 2017;8:14275 pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani R, Jiménez Andrade G, et al. Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292:1762-1772 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Herbert B, Steinkamp H, Gaestel M, Kirkwood K. Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss. Infect Immun. 2017;85: pubmed publisher
  • western blot; human; fig s2
Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed
  • western blot; human; fig 7c
Mason J, Davison Versagli C, Leliaert A, Pape D, McCallister C, Zuo J, et al. Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death Differ. 2016;23:1271-82 pubmed publisher
  • western blot; human; loading ...; fig 5a
Li K, Gao B, Li J, Chen H, Li Y, Wei Y, et al. ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription. Oncotarget. 2015;6:38107-26 pubmed publisher
  • western blot; human; 1:1000; fig 5b
Rastetter R, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, et al. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 2015;15:638 pubmed publisher
  • western blot; human; loading ...; fig S4b
Gupta J, Igea A, Papaioannou M, López Casas P, Llonch E, Hidalgo M, et al. Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget. 2015;6:8539-51 pubmed
  • flow cytometry; mouse; fig 2
Woods S, Waite A, O Dea K, Halford P, Takata M, Wilson M. Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation. Am J Physiol Lung Cell Mol Physiol. 2015;308:L912-21 pubmed publisher
  • western blot; human; fig 1a
Nishi H, Maeda N, Izumi S, Higa Nakamine S, Toku S, Kakinohana M, et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. Eur J Pharmacol. 2015;748:133-42 pubmed publisher
  • western blot; mouse
Korhonen R, Hömmö T, Keränen T, Laavola M, Hamalainen M, Vuolteenaho K, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013;169:1525-36 pubmed publisher
Shah M, Smolko C, Kinicki S, Chapman Z, Brautigan D, Janes K. Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Mol Cell Proteomics. 2017;16:S244-S262 pubmed publisher
Brunen D, Garcia Barchino M, Malani D, Jagalur Basheer N, Lieftink C, Beijersbergen R, et al. Intrinsic resistance to PIM kinase inhibition in AML through p38?-mediated feedback activation of mTOR signaling. Oncotarget. 2016;7:37407-37419 pubmed publisher
Eales K, Palygin O, O Loughlin T, Rasooli Nejad S, Gaestel M, M Ller J, et al. The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat Commun. 2014;5:4701 pubmed publisher
Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, et al. ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. Nucleic Acids Res. 2014;42:10037-49 pubmed publisher
Evans J, Ko Y, Mata W, Saquib M, Eldridge J, Cohen Gadol A, et al. Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling. Microvasc Res. 2015;98:145-58 pubmed publisher
Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher
Pereira L, Igea A, Canovas B, Dolado I, Nebreda A. Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK. EMBO Mol Med. 2013;5:1759-74 pubmed publisher
Noguchi N, Kondo Y, Maeda N, Higa Nakamine S, Toku S, Maruyama J, et al. Phosphorylation of epidermal growth factor receptor at serine 1047 by MAP kinase-activated protein kinase-2 in cultured lung epithelial cells treated with flagellin. Arch Biochem Biophys. 2013;529:75-85 pubmed publisher
Huotari N, Hömmö T, Taimi V, Nieminen R, Moilanen E, Korhonen R. Regulation of tristetraprolin expression by mitogen-activated protein kinase phosphatase-1. APMIS. 2012;120:988-99 pubmed publisher
Turpeinen T, Nieminen R, Taimi V, Heittola T, Sareila O, Clark A, et al. Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase. Mediators Inflamm. 2011;2011:127587 pubmed publisher
product information
SKU :
3007S
Product-Name :
Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
49
Host :
Rabbit
Target :
MAPKAPK-2 (Thr334) phosphate
Primary-Protein :
MAPKAPK2
Alt-Names :
MAP kinase-activated protein kinase 2,MAPK-activated protein kinase 2,MAPK2,MAPKAP kinase 2,MAPKAPK-2,MAPKAPK2,MK2,mitogen-activated protein kinase-activated protein kinase 2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.