product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific)
catalog :
2976S
quantity :
100 ul
price :
274 USD
clonality :
monoclonal
host :
rabbit
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, cat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 35
Published Application/Species/DilutionReference
  • immunohistochemistry; human; 1:100; tbl 2
Menter T, Dickenmann M, Juskevicius D, Steiger J, Dirnhofer S, Tzankov A. Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling. Hematol Oncol. 2016;: pubmed publisher
  • western blot; human; 1:1000; fig 9
E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
  • western blot; human; 1:1000
Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher
  • immunohistochemistry; human; 1:50
Mundim F, Pasini F, Brentani M, Soares F, Nonogaki S, Waitzberg A. MYC is expressed in the stromal and epithelial cells of primary breast carcinoma and paired nodal metastases. Mol Clin Oncol. 2015;3:506-514 pubmed
  • immunohistochemistry - paraffin section; human; 1:50
Tasioudi K, Sakellariou S, Levidou G, Theodorou D, Michalopoulos N, Patsouris E, et al. Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma. APMIS. 2015;123:639-47 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Li X, Tao J, Cigliano A, Sini M, Calderaro J, Azoulay D, et al. Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver. Oncotarget. 2015;6:10102-15 pubmed
  • immunohistochemistry - paraffin section; human; 1:100
McBryan J, Fagan A, McCartan D, Bane F, Varešlija D, Cocchiglia S, et al. Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy. Clin Cancer Res. 2015;21:5371-9 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200
Huang S, Sung C, Chen W, Chen C, Feng C, Yang S, et al. Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. J Neuroinflammation. 2015;12:59 pubmed publisher
  • immunohistochemistry; rat; 1:200
Chen W, Huang S, Liao C, Sung C, Chen J, Wen Z. The use of the antimicrobial peptide piscidin (PCD)-1 as a novel anti-nociceptive agent. Biomaterials. 2015;53:1-11 pubmed publisher
  • immunohistochemistry; human; 1:100
Pócza T, Sebestyen A, Turányi E, Krenacs T, Márk A, Sticz T, et al. mTOR pathway as a potential target in a subset of human medulloblastoma. Pathol Oncol Res. 2014;20:893-900 pubmed publisher
  • western blot; mouse; 1:1000
E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-83 pubmed publisher
  • western blot; human
Chang P, Wang T, Chang Y, Chu C, Lee C, Hsu H, et al. Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells. PLoS ONE. 2014;9:e88556 pubmed publisher
  • immunohistochemistry - paraffin section; cat; 1:50
Maniscalco L, Millan Y, Iussich S, Denina M, Sánchez-Cespedes R, Gattino F, et al. Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas. BMC Vet Res. 2013;9:80 pubmed publisher
  • immunohistochemistry; rat; 1:200
Jiang F, Pang X, Niu Q, Hua L, Cheng M, Ji Y. Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator. Mol Pain. 2013;9:50 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Vazquez-Martin A, Sauri-Nadal T, Menendez O, Oliveras-Ferraros C, Cufí S, Corominas-Faja B, et al. Ser2481-autophosphorylated mTOR colocalizes with chromosomal passenger proteins during mammalian cell cytokinesis. Cell Cycle. 2012;11:4211-21 pubmed publisher
Li S, Chen C, Lu H, Huang W, Tien W, Lan Y, et al. Phosphorylated p70S6K expression is an independent prognosticator for patients with esophageal squamous cell carcinoma. Surgery. 2015;157:570-80 pubmed publisher
Chen Y, Wei M, Wang C, Lee H, Pan S, Gao M, et al. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. Cancer Lett. 2015;357:582-90 pubmed publisher
Haddad A, Kapur P, Singla N, Raman J, Then M, Nuhn P, et al. Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma. Cancer. 2015;121:43-50 pubmed publisher
Gargalionis A, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. Int J Cancer. 2015;136:1515-27 pubmed publisher
Sahin K, Cross B, Sahin N, Ciccone K, Suleiman S, Osunkoya A, et al. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Arch Biochem Biophys. 2015;572:36-9 pubmed publisher
Bitanihirwe B, Meerang M, Friess M, Soltermann A, Frischknecht L, Thies S, et al. PI3K/mTOR signaling in mesothelioma patients treated with induction chemotherapy followed by extrapleural pneumonectomy. J Thorac Oncol. 2014;9:239-47 pubmed publisher
Kumar D, Shankar S, Srivastava R. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Lett. 2014;343:179-89 pubmed publisher
Komori Y, Yada K, Ohta M, Uchida H, Iwashita Y, Fukuzawa K, et al. Mammalian target of rapamycin signaling activation patterns in pancreatic neuroendocrine tumors. J Hepatobiliary Pancreat Sci. 2014;21:288-95 pubmed publisher
Rojo F, Domingo L, Sala M, Zazo S, Chamizo C, Menendez S, et al. Gene expression profiling in true interval breast cancer reveals overactivation of the mTOR signaling pathway. Cancer Epidemiol Biomarkers Prev. 2014;23:288-99 pubmed publisher
Monteiro L, Delgado M, Ricardo S, Garcez F, Do Amaral B, Warnakulasuriya S, et al. Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:638-45 pubmed publisher
Li J, Zhu H, Chen T, Zou L, Wang X, Zhao H, et al. Roles of mTOR and p-mTOR in gastrointestinal stromal tumors. Asian Pac J Cancer Prev. 2013;14:5925-8 pubmed
Leal P, Garcia P, Sandoval A, Letelier P, Brebi P, Ili C, et al. Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma. Arch Pathol Lab Med. 2013;137:552-7 pubmed publisher
Muller J, Ehlers A, Burkhardt L, Sirma H, Steuber T, Graefen M, et al. Loss of pSer2448-mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers. Int J Cancer. 2013;132:1333-40 pubmed publisher
Walsh S, Flanagan L, Quinn C, Evoy D, McDermott E, Pierce A, et al. mTOR in breast cancer: differential expression in triple-negative and non-triple-negative tumors. Breast. 2012;21:178-82 pubmed publisher
Zhan H, Cong L, Zhao Y, Zhang T, Chen G, Zhou L, et al. Activated mTOR/P70S6K signaling pathway is involved in insulinoma tumorigenesis. J Surg Oncol. 2012;106:972-80 pubmed publisher
Chung J, Hong S, Choi B, Cho H, Yu E, Hewitt S. The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. Clin Cancer Res. 2009;15:660-7 pubmed publisher
Lee D, Do I, Choi K, Sung C, Jang K, Choi D, et al. The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. Mod Pathol. 2012;25:131-9 pubmed publisher
Yoon D, Ryu M, Park Y, Lee H, Lee C, Ryoo B, et al. Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum. Br J Cancer. 2012;106:1039-44 pubmed publisher
Li S, Huang E, Lu H, Huang W, Yen C, Huang W, et al. Phosphorylated mammalian target of rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg. 2012;144:1352-9, 1359.e1 pubmed publisher
Murakami A, Gomi K, Tanaka M, Ohyama M, Itani Y, Ishikawa H, et al. Unilateral glomerulocystic kidney disease associated with tuberous sclerosis complex in a neonate. Pathol Int. 2012;62:209-15 pubmed publisher
product information
SKU :
2976S
Product-Name :
Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific)
Size :
100 ul
Price-(USD) :
274 USD
Species-x-Reactivity :
H, (M, R)
Applications :
Immunohistochemistry (Frozen)
Product-Category :
PI3K / Akt Signaling
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
289
Host :
Rabbit
Target :
mTOR (Ser2448) phosphate
Primary-Protein :
mTOR
Alt-Names :
FK506 binding protein 12-rapamycin associated protein 1,FK506 binding protein 12-rapamycin associated protein 2,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP-rapamycin associated protein,FKBP12-rapamycin complex-associated protein,FKBP12-rapamycin complex-associated protein 1,FLJ44809,FRAP,FRAP1,FRAP2,Mammalian target of rapamycin,RAFT1,RAPT1,Rapamycin target protein 1,Serine/threonine-protein kinase mTOR,mTOR,mechanistic target of rapamycin (serine/threonine kinase),rapamycin and FKBP12 target 1,rapamycin associated protein FRAP2
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.