| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; loading ...; fig 5d
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- western blot; mouse; loading ...; fig 2f
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- western blot; mouse; 1:1000; loading ...; fig s1b
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- western blot; mouse; loading ...; fig 3d, 5d, 4f
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- western blot; human; 1:1000; loading ...; fig 7e
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- western blot; mouse; 1:1000; loading ...; fig 8a
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- western blot; mouse; 1:1000; loading ...; fig 7i
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- western blot; human; loading ...; fig 8a
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- western blot; mouse; loading ...; fig 5a
- western blot; human; loading ...; fig 5e
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- western blot; mouse; 1:1000; loading ...; fig 4e
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- western blot; mouse; loading ...; fig 6s2c
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- western blot; mouse; 1:500; loading ...; fig 7c
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- western blot; human; 1:1000; loading ...; fig 8d
| Asha K, Balfe N, Sharma Walia N. Concurrent Control of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: a New Prospect for the Therapeutic Potential of Lipoxin A4. J Virol. 2020;94: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
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- western blot; mouse; 1:1000; loading ...; fig 5a
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- western blot; human; 1:1000; loading ...; fig 4a
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- western blot; mouse; 1:1000; loading ...; fig 5b
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- western blot; mouse; loading ...; fig 4a
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- western blot; human; 1:1000; loading ...; fig 5a
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- western blot; human; 1:1000; loading ...; fig 5b
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- western blot; human; loading ...; fig 2a
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- western blot; human; loading ...; fig 4a
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- western blot; mouse; loading ...; fig 4a
- western blot; rat; loading ...; fig 8a
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- immunocytochemistry; human; loading ...; fig 4h
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- western blot; human; 1:1000; loading ...; fig 6a
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- western blot; mouse; loading ...; fig s3a
| Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher |
- western blot; mouse; 1:1000; fig 8a
| Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher |
- western blot; human; loading ...; fig s9c
| Kong P, Zhu X, Geng Q, Xia L, Sun X, Chen Y, et al. The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer. Mol Ther. 2017;25:1027-1037 pubmed publisher |
- western blot; human; loading ...; fig 3b
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- western blot; mouse; loading ...; fig 4a
| Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
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- western blot; human; 1:1000; loading ...; fig 3d
| Cooper H, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin K, et al. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017;26:1432-1443 pubmed publisher |
- western blot; pigs ; loading ...; fig 2a
- western blot; mouse; loading ...; fig 2b
| Ren W, Yin J, Xiao H, Chen S, Liu G, Tan B, et al. Intestinal Microbiota-Derived GABA Mediates Interleukin-17 Expression during Enterotoxigenic Escherichia coli Infection. Front Immunol. 2016;7:685 pubmed publisher |
- western blot; human; loading ...; fig 4a
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- western blot; rat; 1:1000; loading ...; fig 2a
| Bai H, Lee J, Chen E, Wang M, Xing Y, Fahmy T, et al. Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia. Sci Rep. 2017;7:40142 pubmed publisher |
- western blot; human; 1:1000; loading ...
| Su C, Gao X, Yang W, Zhao Y, Fu X, Cui X, et al. Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules. Biochim Biophys Acta Mol Cell Res. 2017;1864:562-571 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
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- immunohistochemistry - paraffin section; human; loading ...; fig 5
- western blot; human; 1:1000; loading ...; fig 2
| Cabre R, Naudi A, Dominguez Gonzalez M, Ayala V, Jove M, Mota Martorell N, et al. Sixty years old is the breakpoint of human frontal cortex aging. Free Radic Biol Med. 2017;103:14-22 pubmed publisher |
- western blot; mouse; loading ...; fig s4b
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- western blot; human; loading ...; fig 6
| Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn L, Scharager Tapia C, et al. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum. Sci Signal. 2016;9:ra111 pubmed |
- western blot; human; loading ...; fig s3
| Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher |
- western blot; human; 1:1000; loading ...; tbl 1
| Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed |
- western blot; mouse; 1:1000; loading ...; fig 3a
- western blot; human; 1:1000; loading ...; fig s5c
| Zhang Q, Zhang Y, Parsels J, Lohse I, Lawrence T, Pasca di Magliano M, et al. Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Neoplasia. 2016;18:666-673 pubmed publisher |
- western blot; human; loading ...
| Richter E, Harms M, Ventz K, Nölker R, Fraunholz M, Mostertz J, et al. Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus. J Proteome Res. 2016;15:4369-4386 pubmed |
- western blot; human; loading ...; fig 5c
| Zhao Y, Fan D, Ru B, Cheng K, Hu S, Zhang J, et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. Eur J Cancer. 2016;68:38-50 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Mai H, Xu X, Mei G, Hong T, Huang J, Wang T, et al. The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway. Oncogenesis. 2016;5:e260 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6f
| Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, et al. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016;7:12702 pubmed publisher |
- western blot; human; fig 6
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- western blot; mouse; loading ...; fig 7b
| Zhang L, Justus S, Xu Y, Pluchenik T, Hsu C, Yang J, et al. Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa. Hum Mol Genet. 2016;25:4244-4255 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Song M, Wang Y, Shang Z, Liu X, Xie D, Wang Q, et al. Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells. Sci Rep. 2016;6:30165 pubmed publisher |
- western blot; human; 1:500; fig 2c
| Deblois G, Smith H, Tam I, Gravel S, Caron M, Savage P, et al. ERR? mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016;7:12156 pubmed publisher |
- western blot; human; loading ...; fig 7b
| Shen P, Chen M, He M, Chen L, Song Y, Xiao P, et al. Inhibition of ER?/ERK/P62 cascades induces "autophagic switch" in the estrogen receptor-positive breast cancer cells exposed to gemcitabine. Oncotarget. 2016;7:48501-48516 pubmed publisher |
- western blot; mouse; fig s1
| Gómez Sánchez R, Yakhine Diop S, Bravo San Pedro J, Pizarro Estrella E, Rodríguez Arribas M, Climent V, et al. PINK1 deficiency enhances autophagy and mitophagy induction. Mol Cell Oncol. 2016;3:e1046579 pubmed publisher |
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| Dirks M, Wall B, Kramer I, Zorenc A, Goessens J, Gijsen A, et al. A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion. Am J Physiol Endocrinol Metab. 2016;311:E278-85 pubmed publisher |
- western blot; mouse; fig 7
| Wang X, Bey A, Katz B, Badea A, Kim N, David L, et al. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun. 2016;7:11459 pubmed publisher |
- western blot; human; fig 2
| Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher |
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| Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Huang G, Yang X, Chen K, Xing J, Guo L, Zhu L, et al. Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/?-Catenin Pathway by Its GAP Domain. Front Cell Neurosci. 2016;10:85 pubmed publisher |
- western blot; human; loading ...; fig 4d
| Park J, Jung C, Seo M, Otto N, Grunwald D, Kim K, et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy. 2016;12:547-64 pubmed publisher |
- western blot; rat; 1:1000; fig 6
| Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, et al. Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13:3755-62 pubmed publisher |
- western blot; human; fig 4
| Lyabin D, Ovchinnikov L. Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein. Sci Rep. 2016;6:22502 pubmed publisher |
- western blot; mouse; fig s5
| Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher |
- western blot; mouse; 1:1000; tbl 1
| Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher |
- western blot; human; fig 4
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- western blot; human; fig 2
| Gentry E, Henderson B, Arrant A, Gearing M, Feng Y, Riddle N, et al. Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. J Neurosci. 2016;36:1316-23 pubmed publisher |
- western blot; human; fig 2
| Thomassen M, Gunnarsson T, Christensen P, Pavlovic D, Shattock M, Bangsbo J. Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes. Am J Physiol Regul Integr Comp Physiol. 2016;310:R659-69 pubmed publisher |
- western blot; mouse; fig 4a
| Kibe T, Zimmermann M, de Lange T. TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres. Mol Cell. 2016;61:236-46 pubmed publisher |
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| Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher |
- immunocytochemistry; mouse; 1:200; fig 1d
- immunocytochemistry; human; 1:200; fig 1d
- western blot; human; 1:1000; fig 3s1f
| Carroll B, Maetzel D, Maddocks O, Otten G, Ratcliff M, Smith G, et al. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. elife. 2016;5: pubmed publisher |
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| Wang X, Tang Z, Yu D, Cui S, Jiang Y, Zhang Q, et al. Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 2016;7:8823-38 pubmed publisher |
- western blot; mouse; 1:500
| Zarpelon A, Rodrigues F, Lopes A, Souza G, Carvalho T, Pinto L, et al. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB J. 2016;30:54-65 pubmed publisher |
- immunoprecipitation; human; 1:50; loading ...; fig 3a, 4a
- western blot; human; 1:1000; loading ...; fig 3a, 4a
| Machado C, Griesi Oliveira K, Rosenberg C, Kok F, Martins S, Passos Bueno M, et al. Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism. Eur J Hum Genet. 2016;24:59-65 pubmed publisher |
| Zheng Z, Fan S, Zheng J, Huang W, Gasparetto C, Chao N, et al. Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma. J Hematol Oncol. 2018;11:29 pubmed publisher |
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| Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017;43:436-448.e6 pubmed publisher |
| Zhong L, Shu W, Dai W, Gao B, Xiong S. Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction. J Virol. 2017;91: pubmed publisher |
| Pozo M, Rodriguez Rodriguez R, Ramirez S, Seoane Collazo P, Lopez M, Serra D, et al. Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice. Endocrinology. 2017;158:2226-2238 pubmed publisher |
| Bhalla M, Law D, Dowd G, Ireton K. Host Serine/Threonine Kinases mTOR and Protein Kinase C-? Promote InlB-Mediated Entry of Listeria monocytogenes. Infect Immun. 2017;85: pubmed publisher |
| Kwon M, Han J, Kim U, Cha M, Um S, Bai S, et al. Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury. Front Mol Neurosci. 2017;10:79 pubmed publisher |
| Giusto M, Barberi L, Di Sario F, Rizzuto E, Nicoletti C, Ascenzi F, et al. Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride-induced liver cirrhosis. Physiol Rep. 2017;5: pubmed publisher |
| Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder B, et al. Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. Sci Rep. 2017;7:41916 pubmed publisher |
| Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher |
| Yang H, Wang J, Liu M, Chen X, Huang M, Tan D, et al. 4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1. Protein Cell. 2016;7:878-887 pubmed publisher |
| Mera P, Laue K, Wei J, Berger J, Karsenty G. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Mol Metab. 2016;5:1042-1047 pubmed publisher |
| Aparicio I, Espino J, Bejarano I, Gallardo Soler A, Campo M, Salido G, et al. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Sci Rep. 2016;6:33647 pubmed publisher |
| Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher |
| Feng S, Chen Y, Tsai W, Chiou H, Wu S, Huang L, et al. Overexpression of TELO2 decreases survival in human high-grade gliomas. Oncotarget. 2016;7:46056-46066 pubmed publisher |
| Han D, Wan C, Liu F, Xu X, Jiang L, Xu J. Jujuboside A Protects H9C2 Cells from Isoproterenol-Induced Injury via Activating PI3K/Akt/mTOR Signaling Pathway. Evid Based Complement Alternat Med. 2016;2016:9593716 pubmed publisher |
| Luo Y, Han H, Shao J, Gao Y, Yin X, Zhu W, et al. mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine. Sci Rep. 2016;6:27895 pubmed publisher |
| Borges B, García Galiano D, Rorato R, Elias L, Elias C. PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia. Mol Metab. 2016;5:379-391 pubmed publisher |
| Liang D, Han D, Fan W, Zhang R, Qiao H, Fan M, et al. Therapeutic efficacy of apelin on transplanted mesenchymal stem cells in hindlimb ischemic mice via regulation of autophagy. Sci Rep. 2016;6:21914 pubmed publisher |
| Li Z, Yang Z, Passaniti A, Lapidus R, Liu X, Cullen K, et al. A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-kB regulates head and neck squamous cell carcinoma proliferation. Oncotarget. 2016;7:31892-906 pubmed publisher |
| Lindqvist J, Levy Y, Pati Alam A, Hardeman E, Gregorevic P, Ochala J. Modulating myosin restores muscle function in a mouse model of nemaline myopathy. Ann Neurol. 2016;79:717-725 pubmed publisher |
| Choi H, Ahn J, Park J, Won M, Lee C. Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging. Mol Med Rep. 2016;13:2409-14 pubmed publisher |
| Kiessling M, Curioni Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, et al. Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma. PLoS ONE. 2016;11:e0147682 pubmed publisher |
| Zhang B, Zhao R, He Y, Fu X, Fu L, Zhu Z, et al. MicroRNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR. Oncotarget. 2016;7:5702-14 pubmed publisher |
| Guo R, Meng Q, Guo H, Xiao L, Yang X, Cui Y, et al. TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13:1105-10 pubmed publisher |
