| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; loading ...; fig 1i
| Albanese F, Mercatelli D, Finetti L, Lamonaca G, Pizzi S, Shimshek D, et al. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. Neurobiol Dis. 2021;159:105487 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 7
| Xiao X, Li W, Rong D, Xu Z, Zhang Z, Ye H, et al. Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis. Cell Death Discov. 2021;7:212 pubmed publisher |
- western blot; mouse; loading ...; fig 2f
| Christidis G, Karatayli E, Hall R, Weber S, Reichert M, Hohl M, et al. Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s1b
- western blot; human; 1:1000; loading ...; fig 5d
| Chen C, Wang S, Yu L, Mueller J, Fortunato F, Rausch V, et al. H2O2-mediated autophagy during ethanol metabolism. Redox Biol. 2021;46:102081 pubmed publisher |
- western blot; mouse; loading ...; fig 3d, 5d, 4f
| Chen H, Zhang Brotzge X, Morozov Y, Li Y, Wang S, Zhang H, et al. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI Insight. 2021;6: pubmed publisher |
- western blot; mouse; loading ...; fig s3a
| Pérez Sisqués L, Sancho Balsells A, Solana Balaguer J, Campoy Campos G, Vives Isern M, Soler Palazón F, et al. RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease. Cell Death Dis. 2021;12:616 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| Wu Q, Tian A, Li B, Leduc M, Forveille S, Hamley P, et al. IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. J Immunother Cancer. 2021;9: pubmed publisher |
- western blot; mouse; loading ...; fig 1a, 1b
| Ying L, Zhang M, Ma X, Si Y, Li X, Su J, et al. Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure. Front Cell Dev Biol. 2021;9:672032 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 7i
| López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Mou S, Zhou Z, Feng H, Zhang N, Lin Z, Aiyasiding X, et al. Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway. Front Pharmacol. 2021;12:648688 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Misra J, Holmes M, T Mirek E, Langevin M, Kim H, Carlson K, et al. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021;49:5726-5742 pubmed publisher |
- western blot; human; loading ...; fig 8a
| Sun L, Liu S, Wang X, Zheng X, Chen Y, Shen H. eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway. J Transl Med. 2021;19:216 pubmed publisher |
- western blot; rat; loading ...; fig 2a
| Li T, Zhao X, Duan J, Cui S, Zhu K, Wan Y, et al. Targeted inhibition of STAT3 in neural stem cells promotes neuronal differentiation and functional recovery in rats with spinal cord injury. Exp Ther Med. 2021;22:711 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3d
| Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed publisher |
- western blot; human; loading ...; fig 4e
| Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, et al. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021;296:100624 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4e
| Chung L, Liu S, Huang S, Salter D, Lee H, Hsu Y. High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling. Aging (Albany NY). 2020;12:21446-21468 pubmed publisher |
- western blot; mouse; loading ...; fig 6s2c
| Marmol P, Krapacher F, Ibanez C. Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7. elife. 2020;9: pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 7c
| Zhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, et al. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging (Albany NY). 2020;12:5590-5611 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 8d
| Asha K, Balfe N, Sharma Walia N. Concurrent Control of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: a New Prospect for the Therapeutic Potential of Lipoxin A4. J Virol. 2020;94: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
| Ye X, Zhu M, Che X, Wang H, Liang X, Wu C, et al. Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation. J Neuroinflammation. 2020;17:18 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Si J, Ma Y, Bi J, Xiong Y, Lv C, Li S, et al. Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties. J Exp Clin Cancer Res. 2019;38:481 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5a
| Wang X, Zhao L, Ajay A, Jiao B, Zhang X, Wang C, et al. QiDiTangShen Granules Activate Renal Nutrient-Sensing Associated Autophagy in db/db Mice. Front Physiol. 2019;10:1224 pubmed publisher |
- western blot; human; loading ...; fig s3c
| Lin T, Chan H, Chen S, Sarvagalla S, Chen P, Coumar M, et al. BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. Autophagy. 2019;:1-18 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 4a
| El Kott A, Shati A, Al Kahtani M, Alqahtani S. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. Anal Cell Pathol (Amst). 2019;2019:9627810 pubmed publisher |
- western blot; mouse; loading ...; fig 3b
| Uddin G, Zhang L, Shah S, Fukushima A, Wagg C, Gopal K, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019;18:86 pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Cai Y, Xue F, Qin H, Chen X, Liu N, Fleming C, et al. Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation. Cell Rep. 2019;27:3034-3048.e5 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Kumar V, Ayasolla K, Jha A, Mishra A, Vashistha H, Lan X, et al. Disrupted APOL1-miR193a Axis Dedifferentiates Podocytes through Autophagy Blockade in APOL1 Risk Milieu. Am J Physiol Cell Physiol. 2019;: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5b
| Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Wang S, Ni H, Chao X, Wang H, Bridges B, Kumer S, et al. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy. 2019;15:1954-1969 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5b
| Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, et al. Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency. Nat Commun. 2019;10:632 pubmed publisher |
- western blot; human; loading ...; fig 2d
| Mukhopadhyay U, Chanda S, Patra U, Mukherjee A, Rana S, Mukherjee A, et al. Synchronized Orchestration of miR-99b and let-7g Positively Regulates Rotavirus Infection by Modulating Autophagy. Sci Rep. 2019;9:1318 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4e
| Laurenzana A, Margheri F, Biagioni A, Chillà A, Pimpinelli N, Ruzzolini J, et al. EGFR/uPAR interaction as druggable target to overcome vemurafenib acquired resistance in melanoma cells. EBioMedicine. 2019;39:194-206 pubmed publisher |
- western blot; human; 1:600; loading ...; fig 3e
| Ran Z, Zhang Y, Wen X, Ma J. Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway. Mol Med Rep. 2019;19:1024-1031 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a
| Guerrini V, Prideaux B, Blanc L, Bruiners N, Arrigucci R, Singh S, et al. Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific. PLoS Pathog. 2018;14:e1007223 pubmed publisher |
- western blot; mouse; loading ...; fig s3a
| Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; bovine; 1:1000; fig 5a
| Chen D, Yuan X, Liu L, Zhang M, Qu B, Zhen Z, et al. Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway. Cell Biol Int. 2018;42:533-542 pubmed publisher |
- western blot; human; loading ...; fig 2e
| Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher |
- western blot; rat; loading ...; fig 10c
| Gasparotto J, Girardi C, Somensi N, Ribeiro C, Moreira J, Michels M, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem. 2018;293:226-244 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher |
- western blot; pigs ; loading ...; fig 4a
| Fan Q, Long B, Yan G, Wang Z, Shi M, Bao X, et al. Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets. Br J Nutr. 2017;117:1222-1234 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 3f
| Vidoni C, Secomandi E, Castiglioni A, Melone M, Isidoro C. Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation. Neurochem Int. 2018;117:174-187 pubmed publisher |
- western blot; mouse; fig 4a
| Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Xiao Y, Yang Z, Wu Q, Jiang X, Yuan Y, Chang W, et al. Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy. J Cell Biochem. 2017;118:3899-3910 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Zhang X, Fan J, Wang S, Li Y, Wang Y, Li S, et al. Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer. Cancer Immunol Res. 2017;5:363-375 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig st6
| Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher |
- western blot; human; loading ...; fig 3b
| Møller A, Kampmann U, Hedegaard J, Thorsen K, Nordentoft I, Vendelbo M, et al. Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes. Sci Rep. 2017;7:43775 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Qiao A, Jin X, Pang J, Moskophidis D, Mivechi N. The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017;216:723-741 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhang L, Dai F, Cui L, Zhou B, Guo Y. Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:613-624 pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:50; loading ...; fig 2a
- western blot; rat; 1:1000; loading ...; fig 2a
| Bai H, Lee J, Chen E, Wang M, Xing Y, Fahmy T, et al. Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia. Sci Rep. 2017;7:40142 pubmed publisher |
- western blot; human; 1:1000; loading ...
| Su C, Gao X, Yang W, Zhao Y, Fu X, Cui X, et al. Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules. Biochim Biophys Acta Mol Cell Res. 2017;1864:562-571 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Li Y, Buijs Gladdines J, Cant Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
| Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 2
| Cabre R, Naudi A, Dominguez Gonzalez M, Ayala V, Jove M, Mota Martorell N, et al. Sixty years old is the breakpoint of human frontal cortex aging. Free Radic Biol Med. 2017;103:14-22 pubmed publisher |
- western blot; human; loading ...; fig s3
| Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher |
- western blot; human; fig 2e
| Cramer S, Saha A, Liu J, Tadi S, Tiziani S, Yan W, et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med. 2017;23:120-127 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher |
- western blot; human; 1:1000; loading ...; tbl 1
| Cardoso R, Burns A, Moeller J, Skinner D, Padmanabhan V. Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology. 2016;157:4641-4653 pubmed |
- western blot; human; 1:1000; loading ...; fig 3a
| Li R, Xu J, Fu C, Zhang J, Zheng Y, Jia H, et al. Regulation of mTORC1 by lysosomal calcium and calmodulin. elife. 2016;5: pubmed publisher |
- western blot; human; loading ...
| Richter E, Harms M, Ventz K, Nölker R, Fraunholz M, Mostertz J, et al. Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus. J Proteome Res. 2016;15:4369-4386 pubmed |
- western blot; mouse; loading ...; fig 4a
| Gómez Salinero J, López Olañeta M, Ortiz Sánchez P, Larrasa Alonso J, Gatto A, Felkin L, et al. The Calcineurin Variant CnA?1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation. Cell Chem Biol. 2016;23:1372-1382 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Zhao Y, Fan D, Ru B, Cheng K, Hu S, Zhang J, et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. Eur J Cancer. 2016;68:38-50 pubmed publisher |
- western blot; human; loading ...; fig 5c
| Mai H, Xu X, Mei G, Hong T, Huang J, Wang T, et al. The interplay between HPIP and casein kinase 1? promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway. Oncogenesis. 2016;5:e260 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Liu Y, Wang T, Zhang R, Fu W, Wang X, Wang F, et al. Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016;213:2473-2488 pubmed |
- western blot; human; 1:1000; loading ...; fig 2b
| Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher |
- western blot; human; 1:1000; fig st1
| Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher |
- western blot; mouse; loading ...; fig s20
| Conlon D, Thomas T, Fedotova T, Hernandez Ono A, Di Paolo G, Chan R, et al. Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis. J Clin Invest. 2016;126:3852-3867 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6f
| Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, et al. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016;7:12702 pubmed publisher |
- western blot; mouse; 1:500; fig 4
| Suman S, Kumar S, Fornace A, Datta K. Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine. Sci Rep. 2016;6:31853 pubmed publisher |
- western blot; human; fig 6
| Weikel K, Cacicedo J, Ruderman N, Ido Y. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016;36: pubmed publisher |
- western blot; rat; fig 4c
| Bartlett J, Trivedi P, Yeung P, Kienesberger P, Pulinilkunnil T. Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Biochem J. 2016;473:3769-3789 pubmed |
- western blot; human; fig s2
| Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher |
- western blot; mouse; fig s1
| Gómez Sánchez R, Yakhine Diop S, Bravo San Pedro J, Pizarro Estrella E, Rodríguez Arribas M, Climent V, et al. PINK1 deficiency enhances autophagy and mitophagy induction. Mol Cell Oncol. 2016;3:e1046579 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Dirks M, Wall B, Kramer I, Zorenc A, Goessens J, Gijsen A, et al. A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion. Am J Physiol Endocrinol Metab. 2016;311:E278-85 pubmed publisher |
- western blot; rat; 1:1000; fig 5
| Liu L, Wang C, Lin Y, Xi Y, Li H, Shi S, et al. Suppression of calcium?sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy. Mol Med Rep. 2016;14:111-20 pubmed publisher |
- western blot; rat; fig 10
| Song J, Sun Y, Peluso I, Zeng Y, Yu X, Lu J, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016;12:1372-89 pubmed publisher |
- western blot; mouse; fig 7
| Wang X, Bey A, Katz B, Badea A, Kim N, David L, et al. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun. 2016;7:11459 pubmed publisher |
- western blot; human; fig 2
| Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 7a
| Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed publisher |
- western blot; mouse; fig s8c
| Zanos P, Moaddel R, Morris P, Georgiou P, Fischell J, Elmer G, et al. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. 2016;533:481-6 pubmed publisher |
- western blot; mouse; 1:1000; fig 2
| Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher |
- western blot; mouse; 1:750; fig 5
| Cui J, Zhang F, Wang Y, Liu J, Ming X, Hou J, et al. Macrophage migration inhibitory factor promotes cardiac stem cell proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK pathways. Int J Mol Med. 2016;37:1299-309 pubmed publisher |
- western blot; dogs; 1:1000; fig 3A
| DomÃnguez Calderón A, Ãvila Flores A, Ponce A, López Bayghen E, Calderón Salinas J, Luis Reyes J, et al. ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway. Mol Biol Cell. 2016;27:1581-95 pubmed publisher |
- western blot; human; fig 5
| Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei F, et al. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016;6:23372 pubmed publisher |
- western blot; human; fig 4
| Lyabin D, Ovchinnikov L. Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein. Sci Rep. 2016;6:22502 pubmed publisher |
- western blot; mouse; fig 6
| Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher |
- western blot; mouse; 1:1000; tbl 1
| Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher |
- western blot; mouse; fig 4
| Li M, Lu G, Hu J, Shen X, Ju J, Gao Y, et al. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports. 2016;6:396-410 pubmed publisher |
- western blot; mouse; loading ...; fig 1a
| Lakshmipathi J, Alvarez Perez J, Rosselot C, Casinelli G, Stamateris R, Rausell Palamos F, et al. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016;65:1283-96 pubmed publisher |
- western blot; mouse; loading ...; fig 6c
| Liu Y, Takahashi Y, Desai N, Zhang J, Serfass J, Shi Y, et al. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep. 2016;6:20453 pubmed publisher |
- western blot; human; fig 2
| Gentry E, Henderson B, Arrant A, Gearing M, Feng Y, Riddle N, et al. Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. J Neurosci. 2016;36:1316-23 pubmed publisher |
- western blot; human; fig 2
| Thomassen M, Gunnarsson T, Christensen P, Pavlovic D, Shattock M, Bangsbo J. Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes. Am J Physiol Regul Integr Comp Physiol. 2016;310:R659-69 pubmed publisher |
- western blot; human; fig 5d
| Wang X, Tang Z, Yu D, Cui S, Jiang Y, Zhang Q, et al. Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 2016;7:8823-38 pubmed publisher |
- western blot; human; 1:1000; tbl 1
| Oudart J, Doué M, Vautrin A, Brassart B, Sellier C, Dupont Deshorgue A, et al. The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction. Oncotarget. 2016;7:1516-28 pubmed publisher |
- western blot; human; 1:1000; fig 6
| Verbrugge S, Al M, Assaraf Y, Kammerer S, Chandrupatla D, Honeywell R, et al. Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR. Oncotarget. 2016;7:5240-57 pubmed publisher |
- western blot; human; fig 3
| Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher |
- western blot; mouse; 1:500
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- western blot; human; 1:1000; loading ...; fig 3b, 4b
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