product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
p21 Waf1/Cip1 (12D1) Rabbit mAb
catalog :
2947S
quantity :
100 ul
price :
235 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 87
Published Application/Species/DilutionReference
  • western blot (knockout validation); human; 1:1000; fig 6
Vétillard A, Jonchère B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
  • western blot (knockdown validation); human; 1:2000; fig 5F
Kang M, Park K, Yang J, Lee C, Oh S, Yun J, et al. miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. PLoS ONE. 2016;11:e0160961 pubmed publisher
  • western blot (knockdown validation); human; fig 1
Le Pen J, Laurent M, Sarosiek K, Vuillier C, Gautier F, Montessuit S, et al. Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Cell Death Dis. 2016;7:e2083 pubmed publisher
  • western blot (knockdown validation); human; fig 6A
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed publisher
  • western blot (knockdown validation); human; 1:500; fig 1
Ge F, Chen W, Qin J, Zhou Z, Liu R, Liu L, et al. Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5). Oncotarget. 2015;6:21369-78 pubmed
  • western blot; human; 1:1000; fig 2
Meitinger F, Anzola J, Kaulich M, Richardson A, Stender J, Benner C, et al. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016;214:155-66 pubmed publisher
  • western blot; human; 1:200; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; human; fig 8
Chaudhary S, Madhukrishna B, Adhya A, Keshari S, Mishra S. Overexpression of caspase 7 is ERα dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip). Oncogenesis. 2016;5:e219 pubmed publisher
  • immunohistochemistry - paraffin section; human; 0.5 ug/ml; fig st1
Kaur A, Webster M, Marchbank K, Behera R, Ndoye A, Kugel C, et al. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016;532:250-4 pubmed publisher
  • western blot; human; 1:2000; fig s5
Hong A, Tseng Y, Cowley G, Jonas O, Cheah J, Kynnap B, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016;7:11987 pubmed publisher
  • western blot; human; fig 2
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, et al. Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. Oncotarget. 2016;7:1717-31 pubmed publisher
  • western blot; human; 1:1000; fig 1
Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed publisher
  • western blot; human; 1:1000; fig s1
Chen P, Qin L, Li G, Tellides G, Simons M. Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO Mol Med. 2016;8:712-28 pubmed publisher
  • western blot; human; fig 3
Kan H, Huang Y, Li X, Liu D, Chen J, Shu M. Zinc finger protein ZBTB20 is an independent prognostic marker and promotes tumor growth of human hepatocellular carcinoma by repressing FoxO1. Oncotarget. 2016;7:14336-49 pubmed publisher
  • western blot; human; fig 5
Vartanian S, Ma T, Lee J, Haverty P, Kirkpatrick D, Yu K, et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol Cell Proteomics. 2016;15:1220-31 pubmed publisher
  • western blot; human; fig 1c
Randles L, Anchoori R, Roden R, Walters K. Proteasome Ubiquitin Receptor hRpn13 and its Interacting Deubiquitinating Enzyme Uch37 are Required for Proper Cell Cycle Progression. J Biol Chem. 2016;: pubmed
  • immunohistochemistry - paraffin section; human; 1:100; fig 3
Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, et al. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Sci Rep. 2016;6:22996 pubmed publisher
  • western blot; human; fig 5
Nakayama R, Zhang Y, Czaplinski J, Anatone A, Sicinska E, Fletcher J, et al. Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma. Oncotarget. 2016;7:16581-92 pubmed publisher
  • western blot; human; fig s9
Nicolas E, Parisot P, Pinto-Monteiro C, de Walque R, De Vleeschouwer C, Lafontaine D. Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress. Nat Commun. 2016;7:11390 pubmed publisher
  • western blot; human; fig s2
Dey A, Mustafi S, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016;12:659-70 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151 pubmed publisher
  • western blot; human; fig 3
Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, et al. Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells. Cancer Sci. 2016;107:734-45 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton J, et al. Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. BMC Cancer. 2015;15:444 pubmed publisher
  • western blot; human; 1:1000
Andries V, Vandepoele K, Staes K, Berx G, Bogaert P, Van Isterdael G, et al. NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest. BMC Cancer. 2015;15:391 pubmed publisher
  • western blot; mouse
Azimzadeh O, Sievert W, Sarioglu H, Merl-Pham J, Yentrapalli R, Bakshi M, et al. Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction. J Proteome Res. 2015;14:1203-19 pubmed publisher
  • western blot; human; 1:1000; fig 2
Nakakido M, Deng Z, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget. 2015;6:30957-67 pubmed publisher
  • western blot; human; 1:1000; fig s8
Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed publisher
  • western blot; rat; 1:1000; fig 9b
Xu J, Huang Z, Lin L, Fu M, Song Y, Shen Y, et al. miRNA-130b is required for the ERK/FOXM1 pathway activation-mediated protective effects of isosorbide dinitrate against mesenchymal stem cell senescence induced by high glucose. Int J Mol Med. 2015;35:59-71 pubmed publisher
  • western blot; human
Howlin J, Cirenajwis H, Lettiero B, Staaf J, Lauss M, Saal L, et al. Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours. Peerj. 2015;3:e788 pubmed publisher
  • western blot; human
Yang H, Hwangbo K, Zheng M, Cho J, Son J, Kim H, et al. Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts. Arch Pharm Res. 2015;38:876-84 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Wang Y, Han A, Chen E, Singh R, Chichester C, Moore R, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol. 2015;46:1924-34 pubmed publisher
  • western blot; human
Saha K, Eckert R. Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression. J Biol Chem. 2015;290:13521-30 pubmed publisher
  • immunohistochemistry; human; 1:50
Cuevas-Ramos D, Carmichael J, Cooper O, Bonert V, Gertych A, Mamelak A, et al. A structural and functional acromegaly classification. J Clin Endocrinol Metab. 2015;100:122-31 pubmed publisher
  • western blot; human; 1:1000; fig s8
Ross J, Huh D, Noble L, Tavazoie S. Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer. Nat Cell Biol. 2015;17:651-64 pubmed publisher
  • western blot; human
Rodríguez-Sureda V, Vilches A, Sanchez O, Audi L, Dominguez C. Intracellular oxidant activity, antioxidant enzyme defense system, and cell senescence in fibroblasts with trisomy 21. Oxid Med Cell Longev. 2015;2015:509241 pubmed publisher
  • western blot; human
Markkanen E, Fischer R, Ledentcova M, Kessler B, Dianov G. Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability. Nucleic Acids Res. 2015;43:3667-79 pubmed publisher
  • western blot; human; fig S1B
Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, et al. Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS ONE. 2015;10:e0145023 pubmed publisher
  • western blot; human; 1:1000
Tao Y, Xu L, Lu J, Hu S, Fang F, Cao L, et al. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia. J Exp Clin Cancer Res. 2015;34:4 pubmed publisher
  • western blot; human; 1:1000; fig 3
Cañeque T, Gomes F, Mai T, Maestri G, Malacria M, Rodriguez R. Synthesis of marmycin A and investigation into its cellular activity. Nat Chem. 2015;7:744-51 pubmed publisher
  • western blot; human; fig 4
Chiang K, Chen H, Hsu S, Pang J, Wang S, Hsu J, et al. PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. Drug Des Devel Ther. 2015;9:4631-8 pubmed publisher
  • western blot; human; 1:1000; fig 1
Jonchère B, Vétillard A, Toutain B, Lam D, Bernard A, Henry C, et al. Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. Oncotarget. 2015;6:409-26 pubmed
  • western blot; human
Shen L, Qu X, Ma Y, Zheng J, Chu D, Liu B, et al. Tumor suppressor NDRG2 tips the balance of oncogenic TGF-β via EMT inhibition in colorectal cancer. Oncogenesis. 2014;3:e86 pubmed publisher
  • western blot; human; fig 2
Lau H, Ramanujulu P, Guo D, Yang T, Wirawan M, Casey P, et al. An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. Cancer Biol Ther. 2014;15:1280-91 pubmed publisher
  • western blot; human
Fiori M, Barbini C, Haas T, Marroncelli N, Patrizii M, Biffoni M, et al. Antitumor effect of miR-197 targeting in p53 wild-type lung cancer. Cell Death Differ. 2014;21:774-82 pubmed publisher
  • western blot; human; 1:1000
Qiu M, Liu L, Chen L, Tan G, Liang Z, Wang K, et al. microRNA-183 plays as oncogenes by increasing cell proliferation, migration and invasion via targeting protein phosphatase 2A in renal cancer cells. Biochem Biophys Res Commun. 2014;452:163-9 pubmed publisher
  • western blot; human
Kim H, Jung G. Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. FEBS Lett. 2014;588:4413-21 pubmed publisher
  • western blot; human; 1:2000
Wei H, Nickoloff J, Chen W, Liu H, Lo W, Chang Y, et al. FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells. Oncotarget. 2014;5:9514-29 pubmed
  • immunoprecipitation; human
  • western blot; human
Feng Y, Wu H, Xu Y, Zhang Z, Liu T, Lin X, et al. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling. J Biol Chem. 2014;289:2072-83 pubmed publisher
  • western blot; human; 1:1000; fig 3
Van Brocklyn J, Wojton J, Meisen W, Kellough D, Ecsedy J, Kaur B, et al. Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma. Cancer Res. 2014;74:5364-70 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; 1:1000
Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher
  • western blot; human
Yang C, Chung A, Ku C, Brill L, Williams R, Wolf D. Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation. F1000Res. 2014;3:115 pubmed publisher
  • western blot; human; fig s3
Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh A, et al. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc Natl Acad Sci U S A. 2014;111:E3287-96 pubmed publisher
  • western blot; human
Ram R, Mendiratta S, Bodemann B, Torres M, Eskiocak U, White M. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol Cell Biol. 2014;34:2350-8 pubmed publisher
  • western blot; human; 1:1000
Miyake M, Goodison S, Urquidi V, Gomes Giacoia E, Rosser C. Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1/2 and EGF pathways. Lab Invest. 2013;93:768-78 pubmed publisher
  • western blot; human
Andrews P, He Z, Tzenov Y, Popadiuk C, Kao K. Evidence of a novel role for Pygopus in rRNA transcription. Biochem J. 2013;453:61-70 pubmed publisher
  • western blot; human
Nakamura K, Aizawa K, Nakabayashi K, Kato N, Yamauchi J, Hata K, et al. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. PLoS ONE. 2013;8:e54036 pubmed publisher
  • western blot; mouse
Ma T, Galimberti F, Erkmen C, Memoli V, Chinyengetere F, SEMPERE L, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013;12:1545-55 pubmed publisher
  • western blot; human
Song J, Peng X, Ji M, Ai M, Zhang J, Dong W. Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo. World J Gastroenterol. 2013;19:4127-36 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Du W, Jiang P, Mancuso A, Stonestrom A, Brewer M, Minn A, et al. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol. 2013;15:991-1000 pubmed publisher
  • western blot; human
Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher
  • western blot; human
Sanders Y, Liu H, Zhang X, Hecker L, Bernard K, Desai L, et al. Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biol. 2013;1:8-16 pubmed publisher
  • western blot; human
Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, et al. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2013;7:484-96 pubmed publisher
  • immunohistochemistry - paraffin section; human; 0.1 ug/ml
  • western blot; human; 1:1000
Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher
Yeo S, Itahana Y, Guo A, Han R, Iwamoto K, Nguyen H, et al. Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. elife. 2016;5: pubmed publisher
Moussa R, Kovacevic Z, Richardson D. Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types. Oncotarget. 2015;6:29694-711 pubmed publisher
Hou L, Liu T, Wang J. Isoflurane suppresses the self-renewal of normal mouse neural stem cells in a p53-dependent manner by activating the Lkb1-p53-p21 signalling pathway. Mol Med Rep. 2015;12:7412-8 pubmed publisher
Wang N, Li Z, Zhao H, Tao Y, Xu L, Lu J, et al. Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int J Mol Sci. 2015;16:1266-92 pubmed publisher
Hedbrant A, Erlandsson A, Delbro D, Wijkander J. Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5‑fluorouracil on the HT‑29 colon cancer cell line. Int J Oncol. 2015;46:37-46 pubmed publisher
Mohan M, Kumar V, Lackner A, Alvarez X. Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. J Immunol. 2015;194:291-306 pubmed publisher
Samal S, Routray S, Veeramachaneni G, Dash R, Botlagunta M. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015;5:9982 pubmed publisher
Farooqi A, Dagg R, Choi L, Shay J, Reynolds C, Lau L. Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations. J Neurooncol. 2014;119:17-26 pubmed publisher
Yang H, Hwangbo K, Zheng M, Cho J, Son J, Kim H, et al. Quercetin-3-O-β-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Arch Pharm Res. 2014;37:1219-33 pubmed publisher
Pesonen M, Häkkinen M, Rilla K, Juvonen R, Kuitunen T, Pasanen M, et al. Chloropicrin-induced toxic responses in human lung epithelial cells. Toxicol Lett. 2014;226:236-44 pubmed publisher
Narla A, Payne E, Abayasekara N, Hurst S, Raiser D, Look A, et al. L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. Br J Haematol. 2014;167:524-8 pubmed publisher
Al-Moujahed A, Nicolaou F, Brodowska K, Papakostas T, Marmalidou A, Ksander B, et al. Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014;55:4175-85 pubmed publisher
Zhang N, Ying M, Wu Y, Zhou Z, Ye Z, Li H, et al. Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells. PLoS ONE. 2014;9:e98973 pubmed publisher
Cardus A, Uryga A, Walters G, Erusalimsky J. SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res. 2013;97:571-9 pubmed publisher
Davis A, Cabello C, Qiao S, Azimian S, Wondrak G. Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells. Int J Mol Sci. 2013;14:4185-202 pubmed publisher
Rommer A, Steinmetz B, Herbst F, Hackl H, Heffeter P, Heilos D, et al. EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells. PLoS ONE. 2013;8:e56308 pubmed publisher
Humphreys K, Cobiac L, Le Leu R, Van der Hoek M, Michael M. Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. Mol Carcinog. 2013;52:459-74 pubmed publisher
Shum C, Lau S, Tsoi L, Chan L, Yam J, Ohira M, et al. Krüppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation. Oncogene. 2013;32:4086-99 pubmed publisher
Ene C, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, et al. Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS ONE. 2012;7:e51407 pubmed publisher
Li L, Cheng W, Li H, Li W, Yang H, Wen D, et al. Expression of proteasome activator REGγ in human laryngeal carcinoma and associations with tumor suppressor proteins. Asian Pac J Cancer Prev. 2012;13:2699-703 pubmed
Kong B, Michalski C, Hong X, Valkovskaya N, Rieder S, Abiatari I, et al. AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-β-mediated ERK signaling. Oncogene. 2010;29:5146-58 pubmed publisher
Chew Y, Adhikary G, Wilson G, Reece E, Eckert R. Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism. J Biol Chem. 2011;286:28772-82 pubmed publisher
Morimoto Y, Takeuchi O, Takizawa A, Yoneyama H, Asanuma F, Suzuki Y, et al. Effect of a combination of S-1 and gemcitabine on cell cycle regulation in pancreatic cancer cell lines. Anticancer Drugs. 2012;23:505-14 pubmed publisher
Wang G, He J, Zhao J, Yun W, Xie C, Taub J, et al. Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer. PLoS ONE. 2012;7:e52095 pubmed publisher
product information
SKU :
2947S
Product-Name :
p21 Waf1/Cip1 (12D1) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, Mk
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
21
Host :
Rabbit
Target :
p21 Waf1/Cip1
Primary-Protein :
p21Cip1
Alt-Names :
CAP20,CDK-interacting protein 1,CDK-interaction protein 1,CDKN1,CDKN1A,CDN1A,CIP1,Cyclin-dependent kinase inhibitor 1,DNA synthesis inhibitor,MDA-6,MDA6,Melanoma differentiation-associated protein 6,PIC1,SDI1,WAF1,cyclin-dependent kinase inhibitor 1A (p21, Cip1),melanoma differentiation associated protein 6,p21,p21CIP1,p21Cip1/Waf1,wild-type p53-activated fragment 1
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.