Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; human; fig 1
| Overton K, Spencer S, Noderer W, Meyer T, Wang C. Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014;111:E4386-93 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 5
| Thangaraj K, Balasubramanian B, Park S, Natesan K, Liu W, Manju V. Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Biomolecules. 2019;9: pubmed publisher
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- western blot; human; loading ...; fig e1b, e1d
| Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher
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- western blot; human; loading ...; fig s3f
| Mohni K, Wessel S, Zhao R, Wojciechowski A, Luzwick J, Layden H, et al. HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Cell. 2019;176:144-153.e13 pubmed publisher
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- western blot; human; loading ...; fig 2b
| Matyskiela M, Couto S, Zheng X, Lu G, Hui J, Stamp K, et al. SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate. Nat Chem Biol. 2018;14:981-987 pubmed publisher
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- western blot; human; loading ...; fig 1c
| Sorokina I, Denisenko T, Imreh G, Tyurin Kuzmin P, Kaminskyy V, Gogvadze V, et al. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep. 2017;7:14571 pubmed publisher
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- western blot; human; loading ...; fig 2g
| Zhou Y, Huang T, Zhang J, Wong C, Zhang B, Dong Y, et al. TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene. 2017;36:6518-6530 pubmed publisher
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- western blot; human; loading ...; fig 5e
| Xu J, Wu Y, Lu G, Xie S, Ma Z, Chen Z, et al. Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B. Redox Biol. 2017;12:198-207 pubmed publisher
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- western blot; mouse; loading ...; fig 1a
| Barilari M, Bonfils G, Treins C, Koka V, De Villeneuve D, Fabrega S, et al. ZRF1 is a novel S6 kinase substrate that drives the senescence programme. EMBO J. 2017;36:736-750 pubmed publisher
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- western blot; human; loading ...; fig 2f
| Shiina M, Hashimoto Y, Kato T, Yamamura S, Tanaka Y, Majid S, et al. Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. Oncotarget. 2017;8:8356-8368 pubmed publisher
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- western blot; human; fig 4d
| Van Roosbroeck K, Fanini F, Setoyama T, Ivan C, Rodriguez Aguayo C, Fuentes Mattei E, et al. Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers. Clin Cancer Res. 2017;23:2891-2904 pubmed publisher
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- western blot; human; 1:2000; fig 7d
| Benkafadar N, Menardo J, Bourien J, Nouvian R, François F, Decaudin D, et al. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. EMBO Mol Med. 2017;9:7-26 pubmed publisher
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- western blot; human; loading ...; fig 4a
| Ramos P, Guerra A, Guerreiro O, Santos S, Oliveira H, Freire C, et al. Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts. Int J Mol Sci. 2016;18: pubmed publisher
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- western blot; human; loading ...; fig 6b
| Sikora M, Jacobsen B, Levine K, Chen J, Davidson N, Lee A, et al. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016;18:92 pubmed publisher
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- western blot; human; loading ...; fig 7e
| Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, et al. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Mol Med. 2016;8:1019-38 pubmed publisher
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- western blot; human; loading ...; fig s2a
| Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling. J Mol Med (Berl). 2016;94:1167-1179 pubmed
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- western blot; human; fig 5
| Jeong A, Han S, Lee S, Su Park J, Lu Y, Yu S, et al. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway. Sci Rep. 2016;6:27391 pubmed publisher
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- western blot; human; 1:1000; fig 6
| O Santos A, Parrini M, Camonis J. RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases. PLoS ONE. 2016;11:e0154840 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:100; fig s1
| Koussounadis A, Langdon S, Um I, Kay C, Francis K, Harrison D, et al. Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models. BMC Cancer. 2016;16:205 pubmed publisher
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- western blot; human; loading ...; fig 1e
| Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
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- western blot; human; fig 3
| Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher
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- immunoprecipitation; human; 1:50; fig 2
| Nakakido M, Deng Z, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget. 2015;6:30957-67 pubmed publisher
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- western blot; human; fig 6
| Pacini L, Savini C, Ghittoni R, Saidj D, Lamartine J, Hasan U, et al. Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control. J Virol. 2015;89:11396-405 pubmed publisher
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- western blot; human; fig 6
| Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS ONE. 2015;10:e0132767 pubmed publisher
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- western blot; human; fig 3
| Pozo K, Hillmann A, Augustyn A, Plattner F, Hai T, Singh T, et al. Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis. Oncotarget. 2015;6:12080-93 pubmed
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- immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1a
| Li Y, Li B, Xu B, Han B, Xia H, Chen Q, et al. Expression of p53, p21(CIP1/WAF1) and eIF4E in the adjacent tissues of oral squamous cell carcinoma: establishing the molecular boundary and a cancer progression model. Int J Oral Sci. 2015;7:161-8 pubmed publisher
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| Wang B, Wu S, Tang S, Lai C, Ou C, Wu M, et al. Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells. Mutat Res. 2015;773:1-8 pubmed publisher
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- western blot; human; 1:1000; fig 4c
- immunohistochemistry - paraffin section; mouse; fig 9c
| Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed publisher
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- western blot; human; 1:500; fig 5
| Chong K, Hsu C, Hung T, Hu H, Huang T, Wang T, et al. Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells. Cancer Biol Ther. 2015;16:149-59 pubmed publisher
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| Yang Z, Broz D, Noderer W, Ferreira J, Overton K, Spencer S, et al. p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress. Cell Death Differ. 2015;22:560-73 pubmed publisher
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- western blot; human; fig 6
| Zhang X, Ma W, Cui J, Yao H, Zhou H, Ge Y, et al. Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia. Oncogene. 2015;34:3000-10 pubmed publisher
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- western blot; human; fig 5
| Brohl A, Solomon D, Chang W, Wang J, Song Y, Sindiri S, et al. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet. 2014;10:e1004475 pubmed publisher
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| Rockfield S, Flores I, Nanjundan M. Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Oncotarget. 2018;9:5344-5367 pubmed publisher
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| Pacini L, Ceraolo M, Venuti A, Melita G, Hasan U, Accardi R, et al. UV Radiation Activates Toll-Like Receptor 9 Expression in Primary Human Keratinocytes, an Event Inhibited by Human Papillomavirus 38 E6 and E7 Oncoproteins. J Virol. 2017;91: pubmed publisher
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| Zhou Y, Huang T, Siu H, Wong C, Dong Y, Wu F, et al. IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. Mol Cancer. 2017;16:77 pubmed publisher
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| Matos L, Gouveia A, Almeida H. Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis. Oxid Med Cell Longev. 2017;2017:3793817 pubmed publisher
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| Chiang K, Yeh T, Huang C, Chang Y, Juang H, Cheng C, et al. MART-10 represses cholangiocarcinoma cell growth and high vitamin D receptor expression indicates better prognosis for cholangiocarcinoma. Sci Rep. 2017;7:43773 pubmed publisher
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| Townsend E, Murakami M, Christodoulou A, Christie A, Köster J, Desouza T, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016;29:574-586 pubmed publisher
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| Kollarovic G, Studencka M, Ivanova L, Lauenstein C, Heinze K, Lapytsko A, et al. To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage. Aging (Albany NY). 2016;8:158-77 pubmed
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| Maya Mendoza A, Bartek J, Jackson D, Streuli C. Cellular microenvironment controls the nuclear architecture of breast epithelia through ?1-integrin. Cell Cycle. 2016;15:345-56 pubmed publisher
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| Huang T, Kang W, Zhang B, Wu F, Dong Y, Tong J, et al. miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis. Mol Cancer. 2016;15:9 pubmed publisher
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| Testoni E, Stephenson N, Torres Ayuso P, Marusiak A, Trotter E, Hudson A, et al. Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. EMBO Mol Med. 2016;8:105-16 pubmed publisher
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| Tian Y, Yu Y, Hou L, Chi J, Mao J, Xia L, et al. Serum deprivation response inhibits breast cancer progression by blocking transforming growth factor-β signaling. Cancer Sci. 2016;107:274-80 pubmed publisher
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| Tsai C, Kao Y, Chiang I, Wang J, Young T. Chitosan Treatment Delays the Induction of Senescence in Human Foreskin Fibroblast Strains. PLoS ONE. 2015;10:e0140747 pubmed publisher
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| Huang C, Chang C, Chen C, Chuang C, Chiang C, Shu W, et al. Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway. PLoS ONE. 2014;9:e104732 pubmed publisher
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| Maya Mendoza A, Merchut Maya J, Bartkova J, Bartek J, Streuli C, Jackson D. Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state. Cell Death Dis. 2014;5:e1351 pubmed publisher
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| Wang J, Jenkins S, Lamartiniere C. Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein. BMC Cancer. 2014;14:379 pubmed publisher
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| Cheung H, Liu X, Canterel Thouennon L, Li L, Edmonson C, Rennert O. Telomerase protects werner syndrome lineage-specific stem cells from premature aging. Stem Cell Reports. 2014;2:534-46 pubmed publisher
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| Havel J, Li Z, Cheng D, Peng J, Fu H. Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene. 2015;34:1487-98 pubmed publisher
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| Wong P, Yeoh C, Ahmad A, Chelala C, Gillett C, Speirs V, et al. Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer. Oncogene. 2014;33:4579-88 pubmed publisher
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| Laget S, Miotto B, Chin H, Esteve P, Roberts R, Pradhan S, et al. MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress. Epigenetics. 2014;9:546-56 pubmed publisher
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| Yen Y, Shiah S, Chu H, Hsu Y, Hsiao J, Chang J, et al. Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Mol Cancer. 2014;13:6 pubmed publisher
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| Lee S, Woo T, Lee S, Kim J, Ha N, Park B. Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system. Oncotarget. 2013;4:2523-31 pubmed
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| Magnussen G, Hellesylt E, Nesland J, Trope C, Flørenes V, Holm R. High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients. BMC Cancer. 2013;13:288 pubmed publisher
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| Yan G, Eller M, Elm C, Larocca C, Ryu B, Panova I, et al. Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol. 2013;133:2444-2452 pubmed publisher
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| Amir S, Ma A, Shi X, Xue L, Kung H, deVere White R. Oncomir miR-125b suppresses p14(ARF) to modulate p53-dependent and p53-independent apoptosis in prostate cancer. PLoS ONE. 2013;8:e61064 pubmed publisher
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| Chiang K, Yeh C, Chen S, Shen S, Hsu J, Yeh T, et al. MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1?,25-Dihydroxyvitamin D(3) in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells. Evid Based Complement Alternat Med. 2012;2012:310872 pubmed publisher
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| Gao M, Shih I, Wang T. The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas. Int J Mol Sci. 2012;13:13881-93 pubmed publisher
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| Ferraz da Costa D, Casanova F, Quarti J, Malheiros M, Sanches D, Dos Santos P, et al. Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells. PLoS ONE. 2012;7:e48746 pubmed publisher
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| Zhang Y, Fan K, Sun Q, Chen A, Shen W, Zhao Z, et al. Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-? signalling pathway. Nucleic Acids Res. 2012;40:9286-97 pubmed publisher
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| Sims A, Zweemer A, Nagumo Y, Faratian D, Muir M, Dodds M, et al. Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer. Br J Cancer. 2012;106:1779-89 pubmed publisher
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| Zhou Y, Li G, Ji Y, Liu C, Zhu J, Lu Y. Cytoplasmic p21 induced by p65 prevents doxorubicin-induced cell death in pancreatic carcinoma cell line. J Biomed Sci. 2012;19:15 pubmed publisher
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| He Z, Campolmi N, Ha Thi B, Dumollard J, Peoc h M, Garraud O, et al. Optimization of immunolocalization of cell cycle proteins in human corneal endothelial cells. Mol Vis. 2011;17:3494-511 pubmed
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| Lee S, Jung Y, Chung J, Oh A, Lee S, Choi D, et al. Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway. Cell Death Dis. 2011;2:e235 pubmed publisher
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| Taft R, Hawkins P, Mattick J, Morris K. The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization. Epigenetics Chromatin. 2011;4:13 pubmed publisher
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| Thapa D, Li X, Jamieson B, Martinez Maza O. Overexpression of microRNAs from the miR-17-92 paralog clusters in AIDS-related non-Hodgkin's lymphomas. PLoS ONE. 2011;6:e20781 pubmed publisher
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| Haubold M, Weise A, Stephan H, Dünker N. Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. Int J Biol Sci. 2010;6:700-15 pubmed
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| Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009;13:701-11 pubmed publisher
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