| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockdown validation); human; fig 3
| Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher-Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed publisher |
- western blot (knockdown validation); human; fig 3
| Heinemann A, Cullinane C, De Paoli-Iseppi R, Wilmott J, Gunatilake D, Madore J, et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. 2015;6:21507-21 pubmed |
| Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher |
- western blot; human; 1:1000; fig 5
| Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed |
- western blot; human; fig 6
| Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. 2016;7:4062-76 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher |
- flow cytometry; mouse; 1:200
- western blot; mouse; 1:1000; fig 3
| Lai M, Gonzalez-Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher |
- western blot; human; fig 4
| Dupont T, Yang S, Patel J, Hatzi K, Malik A, Tam W, et al. Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma. Oncotarget. 2016;7:3520-32 pubmed publisher |
- western blot; human; 1:5000; fig 4
| Dille S, Kleinschnitz E, Kontchou C, Nölke T, Hacker G. In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport. Infect Immun. 2015;83:3268-80 pubmed publisher |
- western blot; human; fig 2
| Vogel C, Smit M, Maddalo G, Possik P, Sparidans R, van der Burg S, et al. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell Melanoma Res. 2015;28:307-17 pubmed publisher |
- immunohistochemistry - paraffin section; dog
- western blot; dog
| Andersen N, Boguslawski E, Kuk C, Chambers C, Duesbery N. Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts. Int J Oncol. 2015;47:71-80 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015;527:100-4 pubmed publisher |
| Rayavarapu R, Heiden B, Pagani N, Shaw M, Shuff S, Zhang S, et al. The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J Biol Chem. 2015;290:8722-33 pubmed publisher |
| Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed publisher |
| Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Eroglu B, Kimbler D, Pang J, Choi J, Moskophidis D, Yanasak N, et al. Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury. J Neurochem. 2014;130:626-41 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Van Brocklyn J, Wojton J, Meisen W, Kellough D, Ecsedy J, Kaur B, et al. Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma. Cancer Res. 2014;74:5364-70 pubmed publisher |
- western blot; human; 1:1000
| Geissler A, Haun F, Frank D, Wieland K, Simon M, Idzko M, et al. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ. 2013;20:1317-29 pubmed publisher |
| Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher |
| Ma T, Galimberti F, Erkmen C, Memoli V, Chinyengetere F, SEMPERE L, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013;12:1545-55 pubmed publisher |
| Frederick D, Salas Fragomeni R, Schalck A, Ferreiro-Neira I, Hoff T, Cooper Z, et al. Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics. PLoS ONE. 2014;9:e101286 pubmed publisher |
| Ono Y, Tanabe A, Nakamura Y, Yamamoto H, Hayashi A, Tanaka T, et al. A low-testosterone state associated with endometrioma leads to the apoptosis of granulosa cells. PLoS ONE. 2014;9:e115618 pubmed publisher |
| Sharma N, Everingham S, Zeng L, Zhang Z, Kapur R, Craig A. Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice. Oncotarget. 2014;5:6130-41 pubmed |
| Keitel U, Scheel A, Thomale J, Halpape R, Kaulfuß S, Scheel C, et al. Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget. 2014;5:11778-91 pubmed |
| Denoyelle C, Lambert B, Meryet-Figuiere M, Vigneron N, Brotin E, Lecerf C, et al. miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. Cell Death Dis. 2014;5:e1445 pubmed publisher |
| Floyd D, Zhang Y, Dey B, Kefas B, Breit H, Marks K, et al. Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim. PLoS ONE. 2014;9:e96239 pubmed publisher |
| Granato A, Hayashi E, Baptista B, Bellio M, Nobrega A. IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints. J Immunol. 2014;192:5761-75 pubmed publisher |
| Santag S, Jager W, Karsten C, Kati S, Pietrek M, Steinemann D, et al. Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. 2013;32:3676-85 pubmed publisher |
| Humphreys K, Cobiac L, Le Leu R, Van der Hoek M, Michael M. Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. Mol Carcinog. 2013;52:459-74 pubmed publisher |
| Yau I, Cato M, Jellusova J, Hurtado de Mendoza T, Brink R, Rickert R. Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol. 2013;191:1082-90 pubmed publisher |
| Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum. 2013;65:2996-3006 pubmed publisher |
| Endo A, Koizumi H, Takahashi M, Tamura T, Tatsunami S, Watanabe Y, et al. A significant imbalance in mitosis versus apoptosis accelerates the growth rate of sessile serrated adenoma/polyps. Virchows Arch. 2013;462:131-9 pubmed publisher |
| Tzelepis F, Joseph J, Haddad E, MacLean S, Dudani R, Agenes F, et al. Intrinsic role of FoxO3a in the development of CD8+ T cell memory. J Immunol. 2013;190:1066-75 pubmed publisher |
| Sharma N, Kumar V, Everingham S, Mali R, Kapur R, Zeng L, et al. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol Cell Biol. 2012;32:2653-63 pubmed publisher |
| Pritchard J, Gilbert L, Meacham C, Ricks J, Jiang H, Lauffenburger D, et al. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Res. 2011;71:5850-8 pubmed publisher |
| Wang X, Wu Y, Tan L, Tian Z, Liu J, Zhu D, et al. Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis. J Biol Chem. 2012;287:10166-77 pubmed publisher |
| Clayton K, Podlesniy P, Figueiro-Silva J, López-Doménech G, Benitez L, Enguita M, et al. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. J Neurosci. 2012;32:1453-66 pubmed publisher |
| Faber A, Corcoran R, Ebi H, Sequist L, Waltman B, Chung E, et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 2011;1:352-65 pubmed publisher |
| May K, Paton J, Paton A. Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak. Infect Immun. 2010;78:4691-6 pubmed publisher |
